Tetrahydrochromenoimidazoles as potassium-competitive acid blockers (P-CABs): Structure-activity relationship of their antisecretory properties and their affinity toward the hERG channel

Journal of Medicinal Chemistry

Volumn 53, Issue 9, 2010, Pages 3645-3674

  Palmer, Andreas M ^a   Chiesa, Vittoria ^a   Schmid, Anja ^a   Münch, Gabriela ^a   Grobbel, Burkhard ^a   Zimmermann, Peter J ^a   Brehm, Christof ^a   Buhr, Wilm ^a   Simon, Wolfgang Alexander ^a   Kromer, Wolfgang ^a   Postius, Stefan ^a   Volz, Jürgen ^a   Hess, Dietmar ^b  

^a Nycomed GmbH   (Germany)

^b NMI TT GmbH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

1 [[ 2,3 DIMETHYL 8 ( 2 METHYLPHENYL) 3,6,7,8 TETRAHYDROCHROMENO[ 7,8 D]IMIDAZOL 5 YL]CARBONYL]AZETIDIN 3 YL METHANOL; 2,3 DIMETHYL 8 ( 2 METHYLPHENYL) 3,6,7,8 TETRAHYDROCHROMENO[ 7,8 D]IMIDAZOLE 5 CARBALDEHYDE; 2,3 DIMETHYL 8 ( 2 METHYLPHENYL) 3,6,7,8 TETRAHYDROCHROMENO[ 7,8 D]IMIDAZOLE 5 CARBOXYLIC ACID; 5 [( 3 ETHOXYAZETIDIN 1 YL)CARBONYL] 2,3 DIMETHYL 8 ( 2 METHYLPHENYL) 3,6,7,8 TETRAHYDROCHROMENO[ 7,8 D]IMIDAZOLE; 5 [( 3 FLUOROAZETIDIN 1 YL)CARBONYL] 2,3 DIMETHYL 8 ( 2 METHYLPHENYL) 3,6,7,8 TETRAHYDROCHROMENO[ 7,8 D]IMIDAZOLE; 5 [( 3 HYDROXYAZETIDIN 1 YL)CARBONYL] 2,3 DIMETHYL 8 ( 2 METHYLPHENYL) 3,6,7,8 TETRAHYDROCHROMENO[ 7,8 D]IMIDAZOLE; 5 [( 3 METHOXYAZETIDIN 1 YL)CARBONYL] 2,3 DIMETHYL 8 ( 2 METHYLPHENYL) 3,6,7,8 TETRAHYDROCHROMENO[ 7,8 D]IMIDAZOLE; 5 [( 3 PROPOXYAZETIDIN 1 YL)CARBONYL] 2,3 DIMETHYL ( 2 METHYLPHENYL) 3,6,7,8 TETRAHYDROCHROMENO[ 7,8 D]IMIDAZOLE; 5 [( 3,3 DIFLUOROAZETIDIN 1 YL)CARBONYL] 2,3 DIMETHYL 8 ( 2 METHYLPHENYL) 3,6,7,8 TETRAHYDROCHROMENO[ 7,8 D]IMIDAZOLE; 5 [(AZETIDIN 1 YL)CARBONYL] 2,3 DIMETHYL 8 ( 2 METHYLPHENYL) 3,6,7,8 TETRAHYDROCHROMENO[ 7,8 D]IMIDAZOLE; 8 ( 4 CHLORO 2 METHYLPHENYL) 2,3 DIMETHYL 3,6,7,8 TETRAHYDROCHROMENO[ 7,8 D]IMIDAZOLE 5 CARBALDEHYDE; 8 ( 4 CHLORO 2 METHYLPHENYL) 2,3 DIMETHYL 3,6,7,8 TETRAHYDROCHROMENO[ 7,8 D]IMIDAZOLE 5 CARBOXYLIC ACID; 8 ( 4 CHLOROPHENYL) 2,3 DIMETHYL 3,6,7,8 TETRAHYDROCHROMENO[ 7,8 D]IMIDAZOLE 5 CARBALDEHYDE; 8 ( 4 CHLOROPHENYL) 2,3 DIMETHYL 3,6,7,8 TETRAHYDROCHROMENO[ 7,8 D]IMIDAZOLE 5 CARBOXYLIC ACID; 8 ARYL; [ 2,3 DIMETHYL 8 ( 2 METHYLPHENYL) 3,6,7,8 TETRAHYDROCHROMENO[ 7,8 D]IMIDAZOL 5 YL]METHANOL; [ 8 ( 4 CHLORO 2 METHYLPHENYL) 2,3 DIMETHYL 3,6,7,8 TETRAHYDROCHROMENO[ 7,8 D]IMIDAZOL 5 YL]METHANOL; [ 8 ( 4 CHLOROPHENYL) 2,3 DIMETHYL 3,6,7,8 TETRAHYDROCHROMENO[ 7,8 D]IMIDAZOL 5 YL]METHANOL; AMIDE; AZETIDINE; AZETIDINE DERIVATIVE; BENZIMIDAZOLE DERIVATIVE; BYK 311319; BYK 405879; CARBOXYLIC ACID DERIVATIVE; IMIDAZOLE DERIVATIVE; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; POTASSIUM CHANNEL HERG; POTASSIUM COMPETITIVE ACID BLOCKER; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DOG; DRUG BINDING; DRUG EFFICACY; DRUG INHIBITION; DRUG TARGETING; ENANTIOMER; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PH MEASUREMENT; RAT; SINGLE DRUG DOSE; STOMACH ACID; STOMACH ACID SECRETION; STOMACH FISTULA; STOMACH SECRETION; STRUCTURE ACTIVITY RELATION;

ACIDS; ANIMALS; DOGS; ETHER-A-GO-GO POTASSIUM CHANNELS; HUMANS; IMIDAZOLES; POTASSIUM; RATS; RATS, INBRED STRAINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77952055331     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm100040c     Document Type: Article

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