Synthesis and evaluation of 7H-8,9-dihydropyrano[2,3-c]imidazo[1,2-a] pyridines as potassium-competitive acid blockers

Journal of Medicinal Chemistry

Volumn 50, Issue 24, 2007, Pages 6240-6264

  Palmer, Andreas M ^a   Grobbel, Burkhard ^a   Jecke, Cornelia ^a   Brehm, Christof ^a   Zimmermann, Peter J ^a   Buhr, Wilm ^a   Feth, Martin P ^a   Simon, Wolfgang Alexander ^a   Kromer, Wolfgang ^a  

^a Nycomed GmbH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

7H 8,9 DIHYDROPYRANO[2,3 C]IMIDAZO[1,2 A]PYRIDINE DERIVATIVE; 8 BENZYLOXY 2 METHYLIMIDAZO[1,2 A]PYRIDINE 3 ACETONITRILE; AMIDE; FLUORINE; HYDROGEN; HYDROGEN POTASSIUM ADENOSINE TRIPHOSPHATASE; KETONE DERIVATIVE; METHYL GROUP; PENTAGASTRIN; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; POTASSIUM COMPETITIVE ACID BLOCKER; UNCLASSIFIED DRUG;

ALKALINITY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHEMICAL MODIFICATION; CHIRALITY; CLAISEN REARRANGEMENT; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENANTIOMER; ENANTIOSELECTIVITY; ENZYME INHIBITION; IN VIVO STUDY; LIPOPHILICITY; NONHUMAN; PHYSICAL CHEMISTRY; RAT; REACTION ANALYSIS; REDUCTION; RING CLOSING METATHESIS; STOMACH ACID SECRETION; STRUCTURE ACTIVITY RELATION;

ANIMALS; BINDING, COMPETITIVE; GASTRIC ACID; GASTRIC MUCOSA; H(+)-K(+)-EXCHANGING ATPASE; IMIDAZOLES; POTASSIUM; PYRANS; PYRIDINES; RABBITS; RATS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SWINE;

EID: 37849046429     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm7010063     Document Type: Article

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