Spiro(imidazo[1,2-a]pyrano[2,3-c]pyridine-9-indenes) as inhibitors of gastric acid secretion

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 1, 2009, Pages 368-384

  Palmer, Andreas Marc ^a   Chrismann, Sandra ^a   Münch, Gabriela ^a   Brehm, Christof ^a   Zimmermann, Peter Jan ^a   Buhr, Wilm ^a   Senn Bilfinger, Jörg ^a   Feth, Martin Philipp ^a   Simon, Wolfgang Alexander ^a  

^a Nycomed GmbH   (Germany)

Author keywords

7H 8,9 Dihydropyrano 2,3 c imidazo 1,2 a pyridines; Anti secretory activity; Cross metathesis; Gastric acid pump; H+ K+ ATPase

Indexed keywords

5' FLUORO N,N,2,3 TETRAMETHYL 2',3',7,8 TETRAHYDROSPIRO(IMIDAZO[1,2 A]PYRANO[2,3 C]PYRIDINE 9,1 INDENE) 6 CARBOXAMIDE; 6 (AZETIDIN 1 YLCARBONYL) 2,3 DIMETHYL 2',3',7,8 TETRAHYDROSPIRO(IMIDAZO[1,2 A]PYRANO[2,3 C]PYRIDINE 9,1' INDENE); N METHOXY N,2,3 TRIMETHYL 2',3',7,8 TETRAHYDROSPIRO(IMIDAZO[1,2 A]PYRANO[2,3 C]PYRIDINE 9,1 INDENE) 6 CARBOXAMIDE; N,2,3 TETRAMETHYL 2',3',7,8 TETRAHYDROSPIRO(IMIDAZO[1,2 A]PYRANO[2,3 C]PYRIDINE 9,1 INDENE) 6 CARBOXAMIDE; N,N,2,3 TETRAMETHYL 1',3',7,8 TETRAHYDROSPIRO(IMIDAZO[1,2 A]PYRANO[2,3 C]PYRIDINE 9,2' INDENE) 6 CARBOXAMIDE; N,N,2,3 TETRAMETHYL 2',3',7,8 TETRAHYDROSPIRO(IMIDAZO[1,2 A]PYRANO[2,3 C]PYRIDINE 9,1 INDENE) 6 CARBOXAMIDE; POTASSIUM COMPETITIVE ACID BLOCKER; PROTON PUMP INHIBITOR; SPIRO COMPOUND; SPIRO(IMIDAZO[1,2 A]PYRANO[2,3 C]PYRIDINE 9 INDENE) DERIVATIVE; STOMACH SECRETION INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; DRUG POTENCY; DRUG SYNTHESIS; ISOMERIZATION; REACTION ANALYSIS; STOMACH ACID SECRETION;

ANTI-ULCER AGENTS; GASTRIC ACID; HUMANS; IMIDAZOLES; INDENES; PROTON PUMPS; SPIRO COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 57649221315     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.10.055     Document Type: Article

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