Synthesis and pharmacological evaluation of potential metabolites of the potassium-competitive acid blocker BYK 405879

Tetrahedron Letters

Volumn 50, Issue 27, 2009, Pages 3917-3919

  Palmer, Andreas Marc ^a   Münch, Gabriela ^a   Grobbel, Burkhard ^a   Kromer, Wolfgang ^a  

^a Nycomed GmbH   (Germany)

Author keywords

Pharmacological activity; Phase I metabolism; Potassium competitive acid blocker; Synthesis of potential metabolites

Indexed keywords

BYK 405879; DRUG METABOLITE; METHYL GROUP; POTASSIUM COMPETITIVE ACID BLOCKER; PYRAN; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG METABOLISM; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; LIPOPHILICITY; OXIDATION; STRUCTURE ACTIVITY RELATION;

EID: 65549167292     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2009.04.070     Document Type: Article

References (10)

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10. The log D values were determined by HPLC.