Preparation of tetrahydroimidazo[2,1-a]isoquinolines and their use as inhibitors of gastric acid secretion

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 24, 2007, Pages 7647-7660

  Palmer, Andreas Marc ^a   Grobbel, Burkhard ^a   Brehm, Christof ^a   Zimmermann, Peter Jan ^a   Buhr, Wilm ^a   Feth, Martin Philipp ^a   Holst, Hans Christof ^a   Simon, Wolfgang Alexander ^a  

^a Nycomed GmbH   (Germany)

Author keywords

Antisecretory activity; Gastric acid pump; H+ K+ ATPase; Hetero Diels Alder reaction; Tetrahydroimidazo 2,1 a isoquinolines

Indexed keywords

(2,3 DIMETHYL 9 PHENYL 7,8,9,10 TETRAHYDROIMIDAZO[2,1 A]ISOQUINOLIN 6 YL]PYRROLIDIN 1 YL METHANONE; (2,3 DIMETHYL 9 PHENYL 7,8,9,10 TETRAHYDROIMIDAZO[2,1 A]ISOQUINOLINE 6 YL]METHANOL; (2,3 DIMETHYL 9 PHENYL 7,8,9,10 TETRAHYDROIMIDAZO[2,1 A]ISOQUINOLINE 6 YL]MORPHILIN 4 YL METHANONE; 2 METHYL 9 PHENYL 7,8,9,10 TETRAHYDROIMIDAZO[2,1 A]ISOQUINOLINE 6 CARBOXYLIC ACID DIMETHYLAMIDE; 2,3 DIMETHYL 9 PHENYL 7,8,9,10 TETRAHYDROIMIDAZO[2,1 A]6 CARBOXYLIC ACID DIMETHYLAMIDE; 2,3 DIMETHYL 9 PHENYL 7,8,9,10 TETRAHYDROIMIDAZO[2,1 A]ISOQUINOLIN 6 CARBOXYLIC ACID (2 HYDROXYETHYL)AMIDE; 2,3 DIMETHYL 9 PHENYL 7,8,9,10 TETRAHYDROIMIDAZO[2,1 A]ISOQUINOLINE; 2,3 DIMETHYL 9 PHENYL 7,8,9,10 TETRAHYDROIMIDAZO[2,1 A]ISOQUINOLINE 6 CARBOXYLIC ACID; 2,3 DIMETHYL 9 PHENYL 7,8,9,10 TETRAHYDROIMIDAZO[2,1 A]ISOQUINOLINE 6 CARBOXYLIC ACID (METHOXY ETHYL)AMIDE; 2,3 DIMETHYL 9 PHENYL 7,8,9,10 TETRAHYDROIMIDAZO[2,1 A]ISOQUINOLINE 6 CARBOXYLIC ACID AMIDE; 2,3 DIMETHYL 9 PHENYL 7,8,9,10 TETRAHYDROIMIDAZO[2,1 A]ISOQUINOLINE 6 CARBOXYLIC ACID ETHYLESTER; 2,3 DIMETHYL 9 PHENYL 7,8,9,10 TETRAHYDROIMIDAZO[2,1 A]ISOQUINOLINE 6 CARBOXYLIC ACID METHYLAMIDE; 3 BROMO 2 METHYL 9 PHENYL 7,8,9,10 TETRAHYDROIMIDAZO[2,1 A]ISOQUINOLINE 6 CARBOXYLIC ACID DIMETHYLAMIDE; 3 FORMYL 2 METHYL 9 PHENYL 7,8,9,10 TETRAHYDROIMIDAZO[2,1 A]ISOQUINOLINE 6 CARBOXYLIC ACID DIMETHYLAMIDE; 3 HYDROXYMETHYL 2 METHYL 9 PHENYL 7,8,9,10 TETRAHYDROIMIDAZO[2,1 A]ISOQUINOLINE 6 CARBOXYLIC ACID DIMETHYLAMIDE; 6 BROMO 2 METHYL 9 PHENYL 7,8,9,10 TETRAHYDROIMIDAZO[2,1 A]ISOQUINOLINE; 6 BROMO 2,3 DIMETHYL 9 PHENYL 7,8,9,10 TETRAHYDROIMIDAZO[2,1 A]ISOQUINOLINE HYDROBROMIDE; 6 CHLOROMETHYL 2,3 DIMETHYL 9 PHENYL 7,8,9,10 TETRAHYDROIMIDAZO[2,1 A]ISOQUINOLINE; 6 METHOXYMETHYL 2,3 DIMETHYL 9 PHENYL 7,8,9,10 TETRAHYDROIMIDAZO[2,1 A]ISOQUINOLINE; 7H 8,9 DIHYROPYRANO[2,3 C]IMIDAZO[1,2 A]PYRIDINE; ISOQUINOLINE DERIVATIVE; STOMACH SECRETION INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; DIELS ALDER REACTION; DRUG ACTIVATION; DRUG BINDING; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; LIPOPHILICITY; PHYSICAL CHEMISTRY; PKA; STOMACH ACID SECRETION; STRUCTURE ACTIVITY RELATION;

BIPHENYL COMPOUNDS; DRUG EVALUATION, PRECLINICAL; GASTRIC ACID; GASTROINTESTINAL AGENTS; IMIDAZOLES; ISOQUINOLINES; MOLECULAR STRUCTURE; PROTON PUMPS; STOMACH; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZINES;

ALNUS;

EID: 35348903370     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.08.065     Document Type: Article

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