5-Substituted 1H-pyrrolo[3,2-b]pyridines as inhibitors of gastric acid secretion

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 3, 2008, Pages 1511-1530

  Palmer, Andreas Marc ^a   Münch, Gabriela ^a   Brehm, Christof ^a   Zimmermann, Peter Jan ^a   Buhr, Wilm ^a   Feth, Martin Philipp ^a   Simon, Wolfgang Alexander ^a  

^a Nycomed GmbH   (Germany)

Author keywords

1H Pyrrolo 3,2 b pyridines; Anti secretory activity; Copper iodide catalyzed cyclization; Gastric acid pump; H+ K+ ATPase

Indexed keywords

1 BENZYL 7 (2,6 DIMETHYLBENZYLAMINO) 2,3 DIMETHYL 1H PYRROLO[3,2 B]PYRIDINE 5 CARBOXYLIC ACID DIMETHYLAMIDE; 1 BENZYL 7 (2,6 DIMETHYLBENZYLAMINO) 3 HYDROXYMETHYL 2 METHYL 1H PYRROLO[3,2 B]PYRIDINE 5 CARBOXYLIC ACID DIMETHYLAMIDE; 3 BROMO 7 (2,6 DIMETHYLBENZYLAMINO) 2 METHYL 1H PYRROLO[3,2 B]PYRIDINE 5 CARBOXYLIC ACID DIMETHYLAMIDE; 3 BROMO 7 (2,6 DIMETHYLBENZYLAMINO) 2 METHYL 1H PYRROLO[3,2 B]PYRIDINE 5 CARBOXYLIC ACID METHYLAMIDE; 3 BROMO 7 (2,6 DIMETHYLBENZYLAMINO) 3 HYDROXYMETHYL 2 METHYL 1H PYRROLO[3,2 B]PYRIDINE 5 CARBOXYLIC ACID METHYLAMIDE; 7 (2 ETHYL 6 METHYLBENZYLAMINO) 2 METHYL 1H PYRROLO[3,2 B]PYRIDINE 5 CARBOXYLIC ACID; 7 (2 ETHYL 6 METHYLBENZYLAMINO) 2,3 DIMETHYL 1H PYRROLO[3,2 B]PYRIDINE 5 CARBOXYLIC ACID DIMETHYLAMIDE; 7 (2 ETHYL 6 METHYLBENZYLAMINO) 3 HYDROXYMETHYL 2 METHYL 1H PYRROLO[3,2 B]PYRIDINE 5 CARBOXYLIC ACID DIMETHYLAMIDE; 7 (2,6 DIMETHYLBENZYLAMINO) 1(2 HYDROXYPROPYL) 2,3 DIMETHYL 1H PYRROLO[3,2 B]PYRIDINE 5 CARBOXYLIC ACID DIMETHYLAMIDE; 7 (2,6 DIMETHYLBENZYLAMINO) 1,2,3 TRIMETHYL 1H PYRROLO[3,2 B]PYRIDINE 5 CARBOXYLIC ACID DIMETHYLAMIDE; 7 (2,6 DIMETHYLBENZYLAMINO) 2 METHYL 1H PYRROLO[3,2 B]PYRIDINE 5 CARBOXYLIC ACID DIMETHYLAMIDE; 7 (2,6 DIMETHYLBENZYLAMINO) 2 METHYL 1H PYRROLO[3,2 B]PYRIDINE 5 CARBOXYLIC ACID METHYLAMIDE; 7 (2,6 DIMETHYLBENZYLAMINO) 2,3 DIMETHYL 1H PYRROLO[3,2 B]PYRIDINE 5 CARBOXYLIC ACID DIMETHYLAMIDE; 7 (2,6 DIMETHYLBENZYLAMINO) 3 HYDROXYMETHYL 2 METHYL 1H PYRROLO[3,2 B]PYRIDINE 5 CARBOXYLIC ACID DIMETHYLAMIDE; AMINE DEHYDROGENASE; COPPER; IODIDE; PYRIDINE DERIVATIVE; STOMACH SECRETION INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CATALYSIS; CONTROLLED STUDY; CYCLIZATION; DRUG ACTIVITY; DRUG POTENCY; LIPOPHILICITY; NONHUMAN; RABBIT; STOMACH ACID; STOMACH ACID SECRETION; STOMACH GLAND; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ANIMALS; GASTRIC ACID; GASTRIC MUCOSA; MOLECULAR STRUCTURE; PYRIDINES; PYRROLES; RABBITS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 38849157901     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.10.017     Document Type: Article

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