Animal pharmacology of reversible antagonism of the gastric acid pump, compared to standard antisecretory principles

Pharmacology

Volumn 60, Issue 4, 2000, Pages 179-187

  Kromer, Wolfgang ^a   Postius, Stefan ^a   Riedel, Richard ^a  

^a Department of Pharmacology ^*  (Germany)

Author keywords

Acid output; Acid pump antagonists; Animal experiments; Intragastric pH metry; Omeprazole; Pirenzepine; Pumaprazole; Ranitidine

Indexed keywords

CARBACHOL; MUSCARINIC M1 RECEPTOR; OMEPRAZOLE; PENTAGASTRIN; PIRENZEPINE; PROTON PUMP; PROTON PUMP INHIBITOR; PUMAPRAZOLE; PYRIDINE DERIVATIVE; RANITIDINE; UNCLASSIFIED DRUG;

ACID SECRETION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DOG; DOSE RESPONSE; DRUG EFFICACY; FEMALE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STOMACH ACID; STOMACH PH;

EID: 0034106977     PISSN: 00317012     EISSN: None     Source Type: Journal    
DOI: 10.1159/000028367     Document Type: Article

References (40)

1. Burget DW, Chiverton SG, Hunt RH: Is there an optimal degree of acid suppression for healing of duodenal ulcers? A model of the relationship between ulcer healing and acid suppression. Gastroenterology 1990;99:345-351.
2. Hunt RH: Hp and pH: Implications for the eradication of Helicobacter pylori. Scand J Gastroenterol 1993;28(suppl 196):12-16.
3. Axon ATR: The role of acid inhibition in the treatment of Helicobacter pylori infection. Scand J Gastroenterol 1994;29(suppl 201):16-23.
4. Klinkenberg-Knol EC, Festen HPM, Meuwissen SGM: Pharmacological management of gastro-oesophageal reflux disease. Drugs 1995; 49:695-710.
5. Berstad K, Berstad A: Review. Helicobacter pylori infection in peptic ulcer disease. Scand J Gastroenterol 1993;28:561-567.
6. Marshall BJ: Managing acid peptic disease in the Helicobacter pylori era. J Clin Gastroenterol 1995;21(suppl 1):155-159.
7. 2-receptors. Nature 1972;236: 385-390.
8. Hersey SJ, Sachs G: Gastric acid secretion. Physiol Rev 1995;75:155-189.
9. 2-blockade: Placebo-controlled studies of 24-hour acidity and gastrin. Aliment Pharmacol Ther 1990;4(suppl 1):47-63.
10. Nwokolo CU, Prewett EJ, Sawyerr AM, Hudson M, Lim S, Pounder RE: Tolerance during 5 months of dosing with ranitidine, 150 mg nightly: A placebo-controlled, double-blind study. Gastroenterology 1991;101:948-953.
11. 2-receptor antagonists. An overview. Scand J Gastroenterol 1992;27 (suppl 193):14-19.
12. 2 blockers: An emerging therapeutic problem. Scand J Gastroenterol 1988;23 (suppl. 153):81-88.
13. McTavish D, Buckley MM-T, Heel RC: Omeprazole. An updated review of its pharmacology and therapeutic use in acid-related disorders. Drugs 1991;42:138-170.
14. Huber R, Kohl B, Sachs G, Senn-Bilfinger J, Simon WA, Sturm E: Review article: The continuing development of proton pump inhibitors with particular reference to pantoprazole. Aliment Pharmacol Ther 1995;9:363-378.
15. Kromer W: Similarities and differences in the properties of substituted benzimidazoles: A comparison between pantoprazole and related compounds. Digestion 1995;56:443-454.
16. Fitton A, Wiseman L: Pantoprazole. A review of its pharmacological properties and therapeutic use in acid-related disorders. Drugs 1996;51:460-482.
17. Glise H, Martinson J, Solhaug JH, Carling L, Unge P, Engström G, Hallerbäck B: Two and four weeks' treatment for duodenal ulcer. Symptom relief and clinical remission comparing omeprazole and ranitidine. Scand J Gastroenterol 1991;26:137-145.
18. +-transporting ATPase: A new class of anti-secretory agent. Trends Pharmacol Sci 1993;14:323-325.
19. +-ATPase. J Biol Chem 1990;265:5030-5036.
20. +-competitive photoaffinity inhibitor. J Biol Chem 1991;266:18976-18988.
21. +-competitive photoaffinity inhibitor. Biochemistry 1988;27:3932-3938.
22. Ghosh MN, Schild HO: Continuous recording of acid gastric secretion in the rat. Br J Pharmacol 1958;13:54-61.
23. Metzler CM, Elfring GL, McEwen AJ: A User's Manual for NONLIN and Associated Programs. Kalamazoo, Upjohn, 1974.
24. Unkelbach HD, Wolf T: Qualitative DosisWirkungsanalysen. Stuttgart. Fischer, 1985, pp 13-14.
25. Shay H, Komarov SA, Fels SS, Meranze D, Gruenstein M, Siplet H: A simple method for the uniform production of gastric ulceration in the rat. Gastroenterology 1945;5:43-61.
26. Okabe S, Takeuchi K, Nakamura K, Takagi K: Pathogenesis of gastric lesions induced by aspirin in the pylorus-ligated rat. Jpn J Pharmacol 1974;24:363-371.
27. Heidenhain R: Über die Absonderung der Fundusdrüsen des Magens. Arch Ges Physiol 1879; 19:148-167.
28. Gregory RA, Tracy HJ: Secretory responses of denervated gastric pouches. Am J Dig Dis 1960;5:308-323.
29. Postius S, Bräuer U: Loss of circadian rhythm in luminal acidity of canine stomach by implantation of a gastric fistula. Digestion 1995; 56:35-40.
30. Postius S, Bräuer U, Kromer W: The novel proton pump inhibitor pantoprazole elevates intragastric pH for a prolonged period when administered under conditions of stimulated gastric acid secretion in the gastric fistula dog. Life Sci 1991;49:1047-1052.
31. McLauchlan G, Rawlings JM, Lucas ML, McCloy RF, Crean GP, McColl K: Electrodes for 24 h pH monitoring: A compartative study. Gut 1987;28:935-939.
32. Bauerfeind P, Duroux Ph, Bumm R, Emde C, Blum AL: Fehlerquellen und Standardisierung intragastraler pH-Metrie. Z. Gastroenterol 1988;26(suppl 1):12-19.
33. Hollander M, Wolfe DA (eds): Nonparametric Statistical Methods. New York, Wiley, 1973, pp 75-82.
34. Bell NJV, Hunt RH: Time to maximum effect of lansoprazole on gastric pH in normal male volunteers. Aliment Pharmacol Ther 1996;10: 897-904.
35. Brogden RN, Carmine AA, Heel RC, Speight TM, Avery GS: Ranitidine: A review of its pharmacology and therapeutic use in peptic ulcer disease and other allied diseases. Drugs 1982;24:267-303.
36. Postius S, Bräuer U, Kromer W: The acid pump antagonist (APA) B9106-086 causes a stronger and more reliable pH-elevation in the gastric mucus-layer than ranitidine. Gastroenterology 1997;112(suppl):A261.
37. Black JW, Shankley NP: Pharmacological analysis of the muscarinic receptors involved when McN-A 343 stimulates acid secretion in the mouse isolated stomach. Br J Pharmacol 1985; 86:609-617.
38. 1 muscarine receptors. Naunyn Schmiedebergs Arch Pharmacol 1991;347:7-13.
39. Hakanson R, Sundler F: Histamine-producing cells in the stomach and their role in the regulation of acid secretion. Scand J Gastroenterol 1991;26(suppl 180):88-94.
40. Waldum HL, Brenna E, Kleveland PM, Sandvik AK, Syversen U: The use of gastric acid-inhibitory drugs: Physiological and pathophysiological considerations. Aliment Pharmacol Ther 1993;7:589-596.