Inhibitor of IκB kinase activity, BAY 11-7082, interferes with interferon regulatory factor 7 nuclear translocation and type i interferon production by plasmacytoid dendritic cells

Arthritis Research and Therapy

Volumn 12, Issue 3, 2010, Pages

  Miyamoto, Rie ^a   Ito, Tomoki ^a   Nomura, Shosaku ^a   Amakawa, Ryuichi ^a   Amuro, Hideki ^a   Katashiba, Yuichi ^a   Ogata, Makoto ^a   Murakami, Naoko ^a   Shimamoto, Keiko ^a   Yamazaki, Chihiro ^b,c   Hoshino, Katsuaki ^b   Kaisho, Tsuneyasu ^b,c,d   Fukuhara, Shirou ^a  

^a KANSAI MEDICAL UNIVERSITY   (Japan)

^b RIKEN Center for Integrative Medical Sciences   (Japan)

^c OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d YOKOHAMA CITY UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3 (4 METHYLPHENYLSULFONYL) 2 PROPENENITRILE; ALPHA INTERFERON; INTERFERON REGULATORY FACTOR 7; TOLL LIKE RECEPTOR 7; TUMOR NECROSIS FACTOR ALPHA; I KAPPA B KINASE; INTERFERON; LOXORIBINE; POLYURIDYLIC ACID; TOLL LIKE RECEPTOR; 3-(4-METHYLPHENYLSULFONYL)-2-PROPENENITRILE; NITRILE; SULFONE;

ANIMAL CELL; ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; FLOW CYTOMETRY; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PLASMACYTOID DENDRITIC CELL; SYSTEMIC LUPUS ERYTHEMATOSUS; CELL FUNCTION; HUMAN CELL; IMMUNOMODULATION; ADULT; ANIMAL; ANIMAL MODEL; C57BL MOUSE; CELL CULTURE; CELL NUCLEUS; CYTOLOGY; DENDRITIC CELL; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; MONONUCLEAR CELL; PATHOLOGY; TRANSPORT AT THE CELLULAR LEVEL;

ADULT; ANIMALS; BIOLOGICAL TRANSPORT; CELL NUCLEUS; CELLS, CULTURED; DENDRITIC CELLS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; I-KAPPA B KINASE; INTERFERON REGULATORY FACTOR-7; INTERFERON TYPE I; INTERFERON-ALPHA; LEUKOCYTES, MONONUCLEAR; LUPUS ERYTHEMATOSUS, SYSTEMIC; MICE; MICE, INBRED C57BL; MODELS, ANIMAL; NITRILES; SULFONES;

EID: 77952054608     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar3014     Document Type: Article

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