Response of peripheral blood mononuclear cells from lupus patients to stimulation by CpG oligodeoxynucleotides

Rheumatology

Volumn 42, Issue 4, 2003, Pages 563-569

  Zeuner, R A ^a,c   Klinman, D M ^a   Illei, G ^b   Yarboro, C ^b   Ishii, K J ^a   Gursel, M ^a   Verthelyi, D ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^b NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES   (United States)

^c UNIVERSITY OF KIEL   (Germany)

Author keywords

CpG oligodeoxynucleotide; Dendritic cells; Innate immune system; SLE; Toll like receptor

Indexed keywords

CYTOKINE; GAMMA INTERFERON; IMMUNOGLOBULIN M; INTERLEUKIN 10; INTERLEUKIN 6; OLIGODEOXYNUCLEOTIDE;

ADULT; ARTICLE; B LYMPHOCYTE; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; CPG ISLAND; CYTOKINE RELEASE; DENDRITIC CELL; DRUG RESPONSE; HUMAN; HUMAN CELL; IMMUNOGLOBULIN PRODUCTION; IN VITRO STUDY; MONOCYTE; MONONUCLEAR CELL; NATURAL KILLER CELL; PRIORITY JOURNAL; SYSTEMIC LUPUS ERYTHEMATOSUS; UPREGULATION;

AGED; CELL DIVISION; CELLS, CULTURED; CPG ISLANDS; CYTOKINES; DENDRITIC CELLS; FEMALE; HUMANS; IMMUNOGLOBULIN M; LEUKOCYTES, MONONUCLEAR; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; MIDDLE AGED; MONOCYTES; OLIGODEOXYRIBONUCLEOTIDES; UP-REGULATION;

EID: 0037386348     PISSN: 14620324     EISSN: None     Source Type: Journal    
DOI: 10.1093/rheumatology/keg191     Document Type: Article

References (29)

1. Scheinecker C, Zwoelfer B, Koeller M, Maenner G, Smolen JS. Alterations of dendritic cells in systemic lupus erythematosus. Arthritis Rheum 2001;44:856-65.
2. Steinbach F, Henke F, Krause B, Thiele B, Burmester GR, Hiepe F. Monocytes from systemic lupus erythematosus patients are severely altered in phenotype and lineage flexibility. Ann Rheum Dis 2000;59:283-8.
3. Yabuhara A, Yang FC, Nakazawa T et al. A killing defect of natural killer cells as an underlying immunologic abnormality in childhood systemic lupus erythematosus. J Rheumatol 1996;23:171-7.
4. Hagiwara E, Gourley MF, Lee S, Klinman DK. Disease severity in patients with systemic lupus erythematosus correlates with an increased ratio of interleukin-10:interferon-γ-secreting cells in the peripheral blood. Arthritis Rheum 1996;39:379-85.
5. Verthelyi D, Ishii KJ, Gursel M, Fumihiko T, Klinman DK. Human peripheral blood cells differentially recognize and respond to two distinct CpG motifs. J Immunol 2001;166:2372-7.
6. Richardson B, Scheinbart L, Strahler J, Gross L, Hanash S, Johnson M. Evidence for impaired T cell DNA methylation in systemic lupus erythematosus and rheumatoid arthritis. Arthritis Rheum 1990;33:1665-73.
7. Yung RL, Richardson BC. Role of T cell DNA methylation in lupus syndromes. Lupus 1994;3:487-91.
8. Sato Y, Miyata M, Nishimaki T, Kochi H, Kasukawa R. CpG motif-containing DNA fragments from sera of patients with systemic lupus erythematosus proliferate mononuclear cells in vitro. J Rheumatol 1999;26:294-301.
9. Napirei M, Karsunky H, Zevnik B, Stephan H, Mannherz HG, Moeroey T. Features of systemic lupus erythematosus in Dnase1-deficient mice. Nat Genet 2000;25:177-81.
10. Walport MJ. Lupus, DNase and defective disposal of cellular debris. Nat Genet 2000;25:135-6.
11. Gilkeson GS, Grudier JP, Karounos DG, Pisetsky DS. Induction of anti-double stranded DNA antibodies in normal mice by immunization with bacterial DNA. J Immunol 1989;142:1482-6.
12. Pisetsky DS, Wenk KS, Reich CF III. The role of cpg sequences in the induction of anti-DNA antibodies. Clin Immunol 2001;100:157-63.
13. Pisetsky D, Drayton D, Wu ZQ. Specificity of antibodies to bacterial DNA in the sera of healthy human subjects and patients with systemic lupus erythematosus. J Rheumatol 1999;26:1934-8.
14. Hochberg MC. Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1997;40:1725.
15. Tan EM, Cohen AS, Fries JF, Masi AT, Mcshane DJ, Rothfield NF. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982;25:1271-7.
16. Krieg AM. Now I know my CpGs. Trends Microbiol 2001;9:249-52.
17. Krug A, Rothenfusser S, Hornung V et al. Identification of CpG oligonucleotide sequences with high induction of IFN-α/β in plasmacytoid dendritic cells. Eur J Immunol 2001;31:2154-63.
18. Decker T, Schneller F, Sparwasser T et al. Immunostimulatory CpG-oligonucleotides cause proliferation, cytokine production, and an immunogenic phenotype in chronic lymphocytic leukemia B cells. Blood 2000;95:999-1006.
19. Hornung V, Rothenfusser S, Britsch S et al. Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. J Immunol 2002;168:4531-7.
20. Riccieri V, Spadaro A, Parisi G et al. Down-regulation of natural killer cells and of γ/δ T cells in systemic lupus erythematosus. Does it correlate to autoimmunity and to laboratory indices of disease activity? Lupus 2000;9:333-7.
21. de la Fuente H, Richaud-Patin Y, Jakez-Ocampo J, Gonzalez-Amaro R, Llorente L. Innate immune mechanisms in the pathogenesis of systemic lupus erythematosus (SLE). Immunol Lett 2001;77:175-80.
22. Vallin H. Anti-double-stranded DNA antibodies and immunostimulatory plasmid DNA in combination mimic the endogenous IFN-α inducer in systemic lupus erythematosus. J Immunol 1999;163:6306-13.
23. Blanco P, Palucka AK, Gill M, Pascual V, Banchereau J. Induction of dendritic cell differentiation by IFN-α in systemic lupus erythematosus. Science 2001;294:1540-3.
24. Piccioli D, Sbrana S, Melandri E, Valiante NM. Contact-dependent stimulation and inhibition of dendritic cells by natural killer cells. J Exp Med 2002;195:335-41.
25. Erkeller-Yuksel FM, Lydyard PM, Isenberg DA. Lack of NK cells in lupus patients with renal involvement. Lupus 1997;6:708-12.
26. Stohl W, Elliott JE, Hamilton AS, Deapen DM, Mack TM, Horwitz DA. Impaired recovery and cytolytic function of CD56 + T and non-T cells in systemic lupus erythematosus following in vitro polyclonal T cell stimulation. Studies in unselected patients and monozygotic disease-discordant twins. Arthritis Rheum 1996;39:1840-51.
27. Verthelyi D, Petri M, Ylamus M, Klinman DM. Disassociation of sex hormone levels and cytokine production in SLE patients. Lupus 2001;10:352-8.
28. Hagiwara E, Abbasi F, Mor G, Ishigatsubo Y, Klinman DM. Phenotype and frequency of cells secreting IL-2, IL-4, IL-6, IL-10, IFNγ and TNFα in human peripheral blood. Cytokine 1995;7:815-22.
29. Verthelyi D, Klinman DM. Sex hormone levels correlate With the activity of cytokine-secreting cells in vivo. Immunology 2000;100:384-90.