Investigation of the bioactive conformation of histamine H3 receptor antagonists by the cyclopropylic strain-based conformational restriction strategy

Journal of Medicinal Chemistry

Volumn 53, Issue 9, 2010, Pages 3585-3593

  Watanabe, Mizuki ^a   Hirokawa, Takatsugu ^b   Kobayashi, Takaaki ^a   Yoshida, Akira ^c   Ito, Yoshihiko ^c   Yamada, Shizuo ^c   Orimoto, Naoki ^d   Yamasaki, Yasundo ^d   Arisawa, Mitsuhiro ^a   Shuto, Satoshi ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^c UNIVERSITY OF SHIZUOKA   (Japan)

^d TAIHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 [1 ETHYL 2 (4 CHLOROBENZYLAMINO)ETHYL] 1 (1H IMIDAZOL 4 YL)CYCLOPROPANE; 2 [2 (4 CHLOROBENZYLAMINO)ETHYL] 1 (1H IMIDAZOL 4 YL)CYCLOPROPANE; CYCLOPROPANE DERIVATIVE; HISTAMINE H3 RECEPTOR; HISTAMINE H3 RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CONFORMATIONAL TRANSITION; DRUG CONFORMATION; DRUG SCREENING; DRUG SYNTHESIS; ENANTIOMER; MOLECULAR DOCKING; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RECEPTOR BINDING; SIMULATION;

COMPUTER SIMULATION; CYCLOPROPANES; HISTAMINE H3 ANTAGONISTS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR CONFORMATION; PROTEIN BINDING; STEREOISOMERISM;

EID: 77952042259     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm901848b     Document Type: Article

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