Structural analysis of the extracellular entrance to the serotonin transporter permeation pathway

Journal of Biological Chemistry

Volumn 285, Issue 20, 2010, Pages 15369-15379

  Torres Altoro, Melissa I ^a   Kuntz, Charles P ^a   Nichols, David E ^a   Barker, Eric L ^a  

^a PURDUE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AQUIFEX AEOLICUS; BIFUNCTIONAL; BIOGENIC AMINES; CONFORMATIONAL SHIFTS; CROSS-LINKERS; EXTRACELLULAR; HIGH RESOLUTION CRYSTAL STRUCTURE; HOMOLOGY MODELS; ION PERMEATION; LIGAND BINDING; METHANETHIOSULFONATE; NEW OPPORTUNITIES; PSYCHOSTIMULANTS; SEROTONIN TRANSPORTERS; STRUCTURAL DETERMINANTS; TRANSMEMBRANE HELICES;

AMINO ACIDS; BIOPHYSICS; BRAIN; STRUCTURAL ANALYSIS; SUBSTRATES; VEHICULAR TUNNELS;

CRYSTAL STRUCTURE;

ALANINE; AMINO ACID TRANSPORTER; BIOGENIC AMINE; COCAINE; CYSTEINE; GLUTAMIC ACID; GLUTAMINE; GLYCINE; ISOLEUCINE; LEUCINE TRANSPORTER; MESYLIC ACID; NEUROTRANSMITTER; NEUROTRANSMITTER TRANSPORTER; SEROTONIN; SEROTONIN TRANSPORTER; UNCLASSIFIED DRUG; VALINE; VESICULAR MONOAMINE TRANSPORTER;

AMINO ACID SUBSTITUTION; AQUIFEX AEOLICUS; ARTICLE; CELL MEMBRANE PERMEABILITY; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CROSS LINKING; CRYSTAL STRUCTURE; EMBRYO; EXTRACELLULAR SPACE; HUMAN; HUMAN CELL; ION TRANSPORT; LIGAND BINDING; NEUROTRANSMITTER RELEASE; NONHUMAN; PREDICTION; PRIORITY JOURNAL; PROTEIN STRUCTURE; PROTEIN TARGETING; SITE DIRECTED MUTAGENESIS; STRUCTURAL HOMOLOGY; SYNAPSE;

BLOTTING, WESTERN; CELL LINE; CRYSTALLOGRAPHY, X-RAY; HUMANS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

AQUIFEX AEOLICUS;

EID: 77952029377     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.088138     Document Type: Article

References (32)

1. Gether, U., Andersen, P. H., Larsson, O. M., and Schousboe, A. (2006) Trends Pharmacol. Sci. 27, 375-383
2. Henry, L. K., Field, J. R., Adkins, E. M., Parnas, M. L., Vaughan, R. A., Zou, M. F., Newman, A. H., and Blakely, R. D. (2006) J. Biol. Chem. 281, 2012-2023
3. Torres, G. E., Gainetdinov, R. R., and Caron, M. G. (2003) Nat. Rev. Neurosci. 4, 13-25
4. Henry, L. K., Meiler, J., and Blakely, R. D. (2007) Mol. Interv. 7, 306-309
5. Yamashita, A., Singh, S. K., Kawate, T., Jin, Y., and Gouaux, E. (2005) Nature 437, 215-223
6. Beuming, T., Shi, L., Javitch, J. A., and Weinstein, H. (2006) Mol. Pharmacol. 70, 1630-1642
7. Henry, L. K., Defelice, L. J., and Blakely, R. D. (2006) Neuron 49, 791-796
8. Ravna, A. W., Jaronczyk, M., and Sylte, I. (2006) Bioorg. Med. Chem. Lett. 16, 5594-5597
9. Torres-Altoro, M. I., White, K. J., Rodríguez, G. J., Nichols, D. E., and Barker, E. L. (2008) Protein Sci. 17, 1761-1770
10. White, K. J., Kiser, P. D., Nichols, D. E., and Barker, E. L. (2006) Protein Sci. 15, 2411-2422
11. Akabas, M. H., Stauffer, D. A., Xu, M., and Karlin, A. (1992) Science 258, 307-310
12. Chen, J. G., Sachpatzidis, A., and Rudnick, G. (1997) J. Biol. Chem. 272, 28321-28327
13. Chen, J. G., Liu-Chen, S., and Rudnick, G. (1998) J. Biol. Chem. 273, 12675-12681
14. Chen, J. G., and Rudnick, G. (2000) Proc. Natl. Acad. Sci. U.S.A. 97, 1044-1049
15. Henry, L. K., Adkins, E. M., Han, Q., and Blakely, R. D. (2003) J. Biol. Chem. 278, 37052-37063
16. Mitchell, S. M., Lee, E., Garcia, M. L., and Stephan, M. M. (2004) J. Biol. Chem. 279, 24089-24099
17. Loo, T. W., and Clarke, D. M. (2001) J. Biol. Chem. 276, 36877-36880
18. Wang, J. B., Moriwaki, A., and Uhl, G. R. (1995) J. Neurochem. 64, 1416-1419
19. Beuming, T., Kniazeff, J., Bergmann, M. L., Shi, L., Gracia, L., Raniszewska, K., Newman, A. H., Javitch, J. A., Weinstein, H., Gether, U., and Loland, C. J. (2008) Nat. Neurosci. 11, 780-789
20. Kaufmann, K. W., Dawson, E. S., Henry, L. K., Field, J. R., Blakely, R. D., and Meiler, J. (2009) Proteins 74, 630-642
21. Indarte, M., Madura, J. D., and Surratt, C. K. (2008) Proteins 70, 1033-1046
22. Chen, J. G., Liu-Chen, S., and Rudnick, G. (1997) Biochemistry 36, 1479-1486
23. Rudnick, G. (2002) Transmembrane Transporters, pp. 125-141, Wiley-Liss, Inc., Hoboken, NJ
24. Kilic, F., and Rudnick, G. (2000) Proc. Natl. Acad. Sci. U.S.A. 97, 3106-3111
25. Keller, P. C., 2nd, Stephan, M., Glomska, H., and Rudnick, G. (2004) Biochemistry 43, 8510-8516
26. Mascia, M. P., Trudell, J. R., and Harris, R. A. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 9305-9310
27. Forrest, L. R., Zhang, Y. W., Jacobs, M. T., Gesmonde, J., Xie, L., Honig, B. H., and Rudnick, G. (2008) Proc. Natl. Acad. Sci. U.S.A. 105, 10338-10343
28. Androutsellis-Theotokis, A., and Rudnick, G. (2002) J. Neurosci. 22, 8370-8378
29. Zarbiv, R., Grunewald, M., Kavanaugh, M. P., and Kanner, B. I. (1998) J. Biol. Chem. 273, 14231-14237
30. Singh, S. K., Piscitelli, C. L., Yamashita, A., and Gouaux, E. (2008) Science 322, 1655-1661
31. Tao, Z., Zhang, Y. W., Agyiri, A., and Rudnick, G. (2009) J. Biol. Chem. 284, 33807-33814
32. Quick, M., Winther, A. M., Shi, L., Nissen, P., Weinstein, H., and Javitch, J. A. (2009) Proc. Natl. Acad. Sci. U.S.A. 106, 5563-5568