Joint homeostasis, restoration, and remodeling in osteoarthritis

Best Practice and Research: Clinical Rheumatology

Volumn 22, Issue 2, 2008, Pages 209-220

  Lories, Rik J U ^a  

^a Laboratory for Skeletal Development and Joint Disorders   (Belgium)

Author keywords

bone; bone morphogenetic protein; cartilage; frizzled related protein; osteoarthritis; synovium; wingless type (WNT)

Indexed keywords

ANTIINFLAMMATORY AGENT; BONE MORPHOGENETIC PROTEIN; ENZYME INHIBITOR; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR RECEPTOR; FRIZZLED PROTEIN; GROWTH FACTOR; MATRIX METALLOPROTEINASE INHIBITOR; NOGGIN; TRANSFORMING GROWTH FACTOR BETA; WNT PROTEIN;

ADAPTIVE IMMUNITY; ARTICULAR CARTILAGE; BONE DEVELOPMENT; BONE METABOLISM; BONE REMODELING; EVIDENCE BASED MEDICINE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; HIGH RISK PATIENT; HOMEOSTASIS; HUMAN; INNATE IMMUNITY; JOINT DESTRUCTION; JOINT EFFUSION; NONHUMAN; OSSIFICATION; OSTEOARTHRITIS; OSTEOPHYTE; OSTEOPOROSIS; PATHOPHYSIOLOGY; PERINATAL PERIOD; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; REVIEW; SIGNAL TRANSDUCTION; SYNOVITIS; SYNOVIUM; TISSUE INTERACTION; TREATMENT PLANNING; UNSPECIFIED SIDE EFFECT;

BONE REMODELING; CARTILAGE, ARTICULAR; HOMEOSTASIS; HUMANS; JOINTS; OSTEOARTHRITIS; SIGNAL TRANSDUCTION; SYNOVIAL MEMBRANE;

EID: 42949118331     PISSN: 15216942     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.berh.2007.12.001     Document Type: Review

References (67)

1. Luyten F.P., Lories R.J., Verschueren P., et al. Contemporary concepts of inflammation, damage and repair in rheumatic diseases. Best Practice & Research. Clinical Rheumatology 20 (2006) 829-848
2. De Vlam K., Lories R.J., and Luyten F.P. Mechanisms of Pathologic New Bone Formation. Current Rheumatology Reports 8 (2006) 332-337
3. Hunter D.J., and Felson D.T. Osteoarthritis. BMJ 332 (2006) 639-642
4. Goldring M.B. Update on the biology of the chondrocyte and new approaches to treating cartilage diseases. Best Practice & Research. Clinical Rheumatology 20 (2006) 1003-1025
5. Brandt K.D., Radin E.L., Dieppe P.A., et al. Yet more evidence that osteoarthritis is not a cartilage disease. Annals of the Rheumatic Diseases 65 (2006) 1261-1264
6. Lajeunesse D., and Reboul P. Subchondral bone in osteoarthritis: a biologic link with articular cartilage leading to abnormal remodeling. Current Opinion in Rheumatology 15 (2003) 628-633
7. Lories R.J., and Luyten F.P. Bone Morphogenetic Protein signaling in joint homeostasis and disease. Cytokine & Growth Factor Reviews 16 (2005) 287-298
8. Li M.O., Wan Y.Y., Sanjabi S., et al. Transforming growth factor-beta regulation of immune responses. Annual Review of Immunology 24 (2006) 99-146
9. Verrecchia F., Mauviel A., and Farge D. Transforming growth factor-beta signaling through the Smad proteins: role in systemic sclerosis. Autoimmunity Reviews 5 (2006) 563-569
10. Urist M.R. Bone: formation by autoinduction. Science 150 (1965) 893-899
11. Wozney J.M., Rosen V., Celeste A.J., et al. Novel regulators of bone formation: molecular clones and activities. Science 242 (1988) 1528-1534
12. Mishina Y. Function of bone morphogenetic protein signaling during mouse development. Frontiers in Bioscience 8 (2003) D855-D869
13. Chang S.C., Hoang B., Thomas J.T., et al. Cartilage-derived morphogenetic proteins. New members of the transforming growth factor-beta superfamily predominantly expressed in long bones during human embryonic development. The Journal of Biological Chemistry 269 (1994) 28227-28234
14. Storm E.E., Huynh T.V., Copeland N.G., et al. Limb alterations in brachypodism mice due to mutations in a new member of the TGF beta-superfamily. Nature 368 (1994) 639-643
15. Thomas J.T., Lin K., Nandedkar M., et al. A human chondrodysplasia due to a mutation in a TGF-beta superfamily member. Nature Genetics 12 (1996) 315-317
16. Thomas J.T., Kilpatrick M.W., Lin K., et al. Disruption of human limb morphogenesis by a dominant negative mutation in CDMP1. Nature Genetics 17 (1997) 58-64
17. Polinkovsky A., Robin N.H., Thomas J.T., et al. Mutations in CDMP1 cause autosomal dominant brachydactyly type C. Nature Genetics 17 (1997) 18-19
18. Miyamoto Y., Mabuchi A., Shi D., et al. A functional polymorphism in the 5 UTR of GDF5 is associated with susceptibility to osteoarthritis. Nature Genetics 39 (2007) 529-533
19. Erlacher L., Ng C.K., Ullrich R., et al. Presence of cartilage-derived morphogenetic proteins in articular cartilage and enhancement of matrix replacement in vitro. Arthritis & Rheumatism 41 (1998) 263-273
20. Erlacher L., McCartney J., Piek E., et al. Cartilage-derived morphogenetic proteins and osteogenic protein-1 differentially regulate osteogenesis. Journal of Bone and Mineral Research 13 (1998) 383-392
21. Rountree R.B., Schoor M., Chen H., et al. BMP Receptor Signaling Is Required for Postnatal Maintenance of Articular Cartilage. PLoS Biology 2 (2004) e355
22. Lories R.J., Daans M., Matthys P., et al. Noggin haploinsufficiency differentially affects tissue responses in destructive and remodeling arthritis. Arthritis & Rheumatism 54 (2006) 1736-1746
23. Tylzanowski P., Mebis L., and Luyten F.P. The Noggin null mouse phenotype is strain dependent and haploinsufficiency leads to skeletal defects. Developmental Dynamics 235 (2006) 1599-1607
24. Fukui N., Zhu Y., Maloney W.J., et al. Stimulation of BMP-2 expression by pro-inflammatory cytokines IL-1 and TNF-alpha in normal and osteoarthritic chondrocytes. The Journal of Bone and Joint Surgery. American Volume 85A (2003) 59-66
25. Lories R.J., Derese I., Ceuppens J.L., et al. Bone morphogenetic proteins 2 and 6, expressed in arthritic synovium, are regulated by proinflammatory cytokines and differentially modulate fibroblast-like synoviocyte apoptosis. Arthritis & Rheumatism 48 (2003) 2807-2818
26. van der Kraan P.M., Vitters E.L., van Beuningen H.M., et al. Role of nitric oxide in the inhibition of BMP-2-mediated stimulation of proteoglycan synthesis in articular cartilage. Osteoarthritis Cartilage 8 (2000) 82-86
27. Luyten F.P., Dell Accio F., and De Bari C. Skeletal tissue engineering: opportunities and challenges. Best Practice & Research. Clinical Rheumatology (2002)
28. Serra R., Johnson M., Filvaroff E.H., et al. Expression of a truncated, kinase-defective TGF-beta type II receptor in mouse skeletal tissue promotes terminal chondrocyte differentiation and osteoarthritis. The Journal of Cell Biology 139 (1997) 541-552
29. Yang X., Chen L., Xu X., et al. TGF-beta/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage. The Journal of Cell Biology 153 (2001) 35-46
30. Glansbeek H.L., van Beuningen H.M., Vitters E.L., et al. Bone morphogenetic protein 2 stimulates articular cartilage proteoglycan synthesis in vivo but does not counteract interleukin-1alpha effects on proteoglycan synthesis and content. Arthritis & Rheumatism 40 (1997) 1020-1028
31. van Beuningen H.M., Glansbeek H.L., van der Kraan P.M., et al. Differential effects of local application of BMP-2 or TGF-beta 1 on both articular cartilage composition and osteophyte formation. Osteoarthritis Cartilage 6 (1998) 306-317
32. Bakker A.C., van de Loo F.A., van Beuningen H.M., et al. Overexpression of active TGF-beta-1 in the murine knee joint: evidence for synovial-layer-dependent chondro-osteophyte formation. Osteoarthritis Cartilage 9 (2001) 128-136
33. Scharstuhl A., Glansbeek H.L., van Beuningen H.M., et al. Inhibition of endogenous TGF-beta during experimental osteoarthritis prevents osteophyte formation and impairs cartilage repair. Journal of Immunology 169 (2002) 507-514
34. Scharstuhl A., Diepens R., Lensen J., et al. Adenoviral overexpression of Smad-7 and Smad-6 differentially regulates TGF-beta-mediated chondrocyte proliferation and proteoglycan synthesis. Osteoarthritis and Cartilage 11 (2003) 773-782
35. Scharstuhl A., van Beuningen H.M., Vitters E.L., et al. Loss of transforming growth factor counteraction on interleukin 1 mediated effects in cartilage of old mice. Annals of the Rheumatic Diseases 61 (2002) 1095-1098
36. Hartmann C., and Tabin C.J. Wnt-14 plays a pivotal role in inducing synovial joint formation in the developing appendicular skeleton. Cell 104 (2001) 341-351
37. Tamamura Y., Otani T., Kanatani N., et al. Developmental regulation of Wnt/beta-catenin signals is required for growth plate assembly, cartilage integrity, and endochondral ossification. The Journal of Biological Chemistry 280 (2005) 19185-19195
38. Hens J.R., Wilson K.M., Dann P., et al. TOPGAL mice show that the canonical Wnt signaling pathway is active during bone development and growth and is activated by mechanical loading in vitro. Journal of Bone and Mineral Research 20 (2005) 1103-1113
39. Hoang B., Moos Jr. M., Vukicevic S., et al. Primary structure and tissue distribution of FRZB, a novel protein related to Drosophila frizzled, suggest a role in skeletal morphogenesis. The Journal of Biological Chemistry 271 (1996) 26131-26137
40. Lin K., Wang S., Julius M.A., et al. The cysteine-rich frizzled domain of Frzb-1 is required and sufficient for modulation of Wnt signaling. Proceedings of the National Academy of Sciences of the United States of America 94 (1997) 11196-11200
41. Wang S., Krinks M., Lin K., et al. Frzb, a secreted protein expressed in the Spemann organizer, binds and inhibits Wnt-8. Cell 88 (1997) 757-766
42. Loughlin J., Dowling B., Chapman K., et al. Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females. Proceedings of the National Academy of Sciences of the United States of America 101 (2004) 9757-9762
43. Valdes A.M., Loughlin J., Oene M.V., et al. Sex and ethnic differences in the association of ASPN, CALM1, COL2A1, COMP, and FRZB with genetic susceptibility to osteoarthritis of the knee. Arthritis & Rheumatism 56 (2007) 137-146
44. Min J.L., Meulenbelt I., Riyazi N., et al. Association of the Frizzled-related protein gene with symptomatic osteoarthritis at multiple sites. Arthritis & Rheumatism 52 (2005) 1077-1080
45. Lane N.E., Lian K., Nevitt M.C., et al. Frizzled-related protein variants are risk factors for hip osteoarthritis. Arthritis & Rheumatism 54 (2006) 1246-1254
46. Lories R.J., Boonen S., Peeters J., et al. Evidence for a differential association of the Arg200Trp single-nucleotide polymorphism in FRZB with hip osteoarthritis and osteoporosis. Rheumatology (Oxford) 45 (2006) 113-114
47. Rodriguez-Lopez J., Pombo-Suarez M., Liz M., et al. Further evidence of the role of frizzled-related protein gene polymorphisms in osteoarthritis. Annals of the Rheumatic Diseases 66 (2007) 1052-1055
48. Lories R.J., Peeters J., Bakker A., et al. Deletion of frizzled related protein affects articular cartilage and biomechanical properties of the long bones. Arthritis & Rheumatism 56 (2007) 4095-4103
49. Zi X., Guo Y., Simoneau A.R., et al. Expression of Frzb/secreted Frizzled-related protein 3, a secreted Wnt antagonist, in human androgen-independent prostate cancer PC-3 cells suppresses tumor growth and cellular invasiveness. Cancer Research 65 (2005) 9762-9770
50. Dell Accio F., De Bari C., El Tawil N.M., et al. Activation of WNT and BMP signaling in adult human articular cartilage following mechanical injury. Arthritis Research & Therapy 8 (2006) R139
51. Chen L., and Deng C.X. Roles of FGF signaling in skeletal development and human genetic diseases. Frontiers in Bioscience 10 (2005) 1961-1976
52. Goldring M.B., Tsuchimochi K., and Ijiri K. The control of chondrogenesis. Journal of Cellular Biochemistry 97 (2006) 33-44
53. Vincent T., Hermansson M., Bolton M., et al. Basic FGF mediates an immediate response of articular cartilage to mechanical injury. Proceedings of the National Academy of Sciences of the United States of America 99 (2002) 8259-8264
54. Vincent T.L., Hermansson M.A., Hansen U.N., et al. Basic fibroblast growth factor mediates transduction of mechanical signals when articular cartilage is loaded. Arthritis & Rheumatism 50 (2004) 526-533
55. Vincent T.L., McLean C.J., Full L.E., et al. FGF-2 is bound to perlecan in the pericellular matrix of articular cartilage, where it acts as a chondrocyte mechanotransducer. Osteoarthritis Cartilage 15 (2007) 752-763
56. Hill C.L., Hunter D.J., Niu J., et al. Synovitis detected on magnetic resonance imaging and its relation to pain and cartilage loss in knee osteoarthritis. Annals of the Rheumatic Diseases (2007)
57. Simkin P.A. The musculoskeletal system: A. Joints 11 (1997) 10-14
58. McGonagle D., Lories R.J., Tan A., et al. The concept of a synovio-entheseal complex and its implications for understanding joint inflammation and damage in psoriatic arthritis and beyond. Arthritis & Rheumatism 56 (2007) 2482-2491
59. Da R.R., Qin Y., Baeten D., et al. B cell clonal expansion and somatic hypermutation of Ig variable heavy chain genes in the synovial membrane of patients with osteoarthritis. Journal of immunology 178 (2007) 557-565
60. Dequeker J., Aerssens J., and Luyten F.P. Osteoarthritis and osteoporosis: clinical and research evidence of inverse relationship. Aging Clinical and Experimental Research 15 (2003) 426-439
61. Bodine P.V., Zhao W., Kharode Y.P., et al. The Wnt antagonist secreted frizzled-related protein-1 is a negative regulator of trabecular bone formation in adult mice. Molecular Endocrinology 18 (2004) 1222-1237
62. Lories R.J., and Luyten F.P. Bone morphogenetic proteins in destructive and remodeling arthritis. Arthritis Research & Therapy 9 (2007) 207
63. Zoricic S., Maric I., Bobinac D., et al. Expression of bone morphogenetic proteins and cartilage-derived morphogenetic proteins during osteophyte formation in humans. Journal of Anatomy 202 (2003) 269-277
64. Nakase T., Miyaji T., Tomita T., et al. Localization of bone morphogenetic protein-2 in human osteoarthritic cartilage and osteophyte. Osteoarthritis Cartilage 11 (2003) 278-284
65. van Lent P.L., Blom A.B., van der K.P., et al. Crucial role of synovial lining macrophages in the promotion of transforming growth factor beta-mediated osteophyte formation. Arthritis & Rheumatism 50 (2004) 103-111
66. Scharstuhl A., Vitters E.L., van der Kraan P.M., et al. Reduction of osteophyte formation and synovial thickening by adenoviral overexpression of transforming growth factor beta/bone morphogenetic protein inhibitors during experimental osteoarthritis. Arthritis & Rheumatism 48 (2003) 3442-3451
67. Lories R.J.U., Derese I., and Luyten F.P. Modulation of Bone Morphogenetic Protein signaling inhibits the onset and progression of ankylosing enthesitis. The Journal of Clinical Investigation 115 (2005) 1571-1579