Simultaneous single molecule atomic force and fluorescence lifetime imaging

Progress in Biomedical Optics and Imaging - Proceedings of SPIE

Volumn 7571, Issue , 2010, Pages

  Schulz, Olaf ^a   Koberling, Felix ^b   Walters, Deron ^c   Koenig, Marcelle ^b   Viani, Jacob ^c   Ros, Robert ^a  

^a ARIZONA STATE UNIVERSITY   (United States)

^b PICOQUANT GMBH   (Germany)

^c United States   (United States)

Author keywords

AFM; Confocal; DNA; FLIM; Quenching

Indexed keywords

AFM; AFM PROBE; AFM TIP; ATOMIC FORCE; ATOMIC FORCE MICROSCOPES; CONFOCAL; CONFOCAL FLUORESCENCE; CONFOCAL FLUORESCENCE MICROSCOPY; DIFFRACTION LIMITS; DNA SAMPLES; FLUORESCENCE LABEL; FLUORESCENCE LIFETIME IMAGING; FLUORESCENCE LIFETIMES; FLUORESCENCE QUENCHING; LASER FOCUS; MACROMOLECULAR COMPLEXES; MOLECULAR COMPLEXES; NANOMETER RESOLUTIONS; OPTICAL RESOLUTION; ORGANIC FLUOROPHORES; SILICON TIPS; SINGLE MOLECULE; SINGLE-MOLECULE SENSITIVITY; TIME-CORRELATED SINGLE-PHOTON COUNTING;

ATOMS; COMPLEXATION; COPYING; CRYSTAL ATOMIC STRUCTURE; DNA; FLUORESCENCE MICROSCOPY; FLUOROPHORES; GENES; MACROMOLECULES; MICROSCOPES; NANOPHOTONICS; PROBES; QUENCHING;

ATOMIC FORCE MICROSCOPY;

EID: 77951669432     PISSN: 16057422     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1117/12.842502     Document Type: Conference Paper

References (44)

1. P. Hinterdorfer, and Y. F. Dufrene, "Detection and localization of single molecular recognition events using atomic force microscopy", Nature Methods 3, 347-355 (2006).
2. W. E. Moerner, and D. P. Fromm, "Methods of single-molecule fluorescence spectroscopy and microscopy", Review of Scientific Instruments 74, 3597-3619 (2003).
3. S. W. Hell, "Far-field optical nanoscopy", Science 316, 1153-1158 (2007).
4. P. R. Selvin, "The renaissance of fluorescence resonance energy transfer", Nat.Struct.Biol. 7, 730-734 (2000).
5. I. Rasnik, S. A. McKinney, and T. Ha, "Surfaces and orientations: Much to FRET about?", Accounts of Chemical Research 38, 542-548 (2005).
6. A. R. Clapp, I. L. Medintz, B. R. Fisher, G. P. Anderson, and H. Mattoussi, "Can luminescent quantum dots be efficient energy acceptors with organic dye donors?", Journal of the American Chemical Society 127, 1242-1250 (2005).
7. T. Pons, I. L. Medintz, K. E. Sapsford, S. Higashiya, A. F. Grimes, D. S. English, and H. Mattoussi, "On the quenching of semiconductor quantum dot photoluminescence by proximal gold nanoparticles", Nano Letters 7, 3157-3164 (2007).
8. A. Engel, Y. Lyubchenko, and D. Muller, "Atomic force microscopy: a powerful tool to observe biomolecules at work", Trends in Cell Biology 9, 77-80 (1999).
9. J. Zlatanova, S. M. Lindsay, and S. H. Leuba, "Single molecule force spectroscopy in biology using the atomic force microscope", Progress in Biophysics and Molecular Biology 74, 37-61 (2000).
10. R. Hillenbrand, and F. Keilmann, "Material-specific mapping of metal/semiconductor/dielectric nanosystems at 10 nm resolution by backscattering near-field optical microscopy", Applied Physics Letters 80, 25-27 (2002).
11. J. M. Gerton, L. A. Wade, G. A. Lessard, Z. Ma, and S. R. Quake, "Tip-enhanced fluorescence microscopy at 10 nanometer resolution", Physical Review Letters 93, 180801 (2004).
12. Z. Y. Ma, J. M. Gerton, L. A. Wade, and S. R. Quake, "Fluorescence near-field microscopy of DNA at sub-10 nm resolution", Physical Review Letters 97 (2006).
13. B. D. Mangum, C. Mu, and J. M. Gerton, "Resolving single fluorophores within dense ensembles: contrast limits of tip-enhanced fluorescence microscopy", Optics Express 16, 6183-6193 (2008).
14. B. D. Mangum, E. Shafran, C. Mu, and J. M. Gerton, "Three- Dimensional Mapping of Near-Field Interactions via Single-Photon Tomography", Nano Letters 9, 3440-3446 (2009).
15. V. V. Mkhitaryan, Y. Fang, J. M. Gerton, E. G. Mishchenko, and M. E. Raikh, "Scattering of Plasmons at the Intersection of Two Metallic Nanotubes: Implications for Tunneling", Physical Review Letters 101 (2008).
16. C. A. Xie, C. Mu, J. R. Cox, and J. M. Gerton, "Tip-enhanced fluorescence microscopy of highdensity samples", Applied Physics Letters 89 (2006).
17. R. Eckel, V. Walhorn, J. Martini, T. Nann, D. Anselmetti, and R. Ros, "Combined TIRF-AFM Setup: Controlled Quenching of Individual Quantum Dots", Proc. of SPIE 6092 (2006).
18. R. Eckel, V. Walhorn, C. Pelargus, J. Martini, J. Enderlein, T. Nann, D. Anselmetti, and R. Ros, "Fluorescence-emission control of single CdSe nanocrystals using gold-modified AFM tips", Small 3, 44-49 (2007).
19. V. Walhorn, R. Eckel, C. Pelargus, D. Anselmetti, and R. Ros, "A combined setup for single molecule manipulation and optical spectroscopy", Biophysical Journal, 655A-655A (2007).
20. V. Walhorn, O. Schulz, C. Pelargus, D. Anselmetti, and R. Ros, "Impact of metal-modified AFM tips on the fluorescence of single nanocrystals", Proc. of SPIE 6444 (2007).
21. Y. Ebenstein, T. Mokari, and U. Banin, "Quantum-dot-functionalized scanning probes for fluorescence-energy-transfer-based microscopy", Journal of Physical Chemistry B 108, 93-99 (2004).
22. Y. Ebenstein, E. Yoskovitz, R. Costi, A. Aharoni, and U. Banin, "Interaction of scanning probes with semiconductor nanocrystals; physical mechanism and basis for near-field optical imaging", Journal of Physical Chemistry A 110, 8297-8303 (2006).
23. E. Yoskovitz, D. Oron, I. Shweky, and U. Banin, "Apertureless Near-Field Distance-Dependent Lifetime Imaging and Spectroscopy of Semiconductor Nanocrystals", Journal of Physical Chemistry C 112, 16306-16311 (2008).
24. H. G. Frey, S. Witt, K. Felderer, and R. Guckenberger, "High-resolution imaging of single fluorescent molecules with the optical near-field of a metal tip", Physical Review Letters 93 (2004).
25. H. G. Frey, C. Bolwien, A. Brandenburg, R. Ros, and D. Anselmetti, "Optimized apertureless optical near-field probes with 15 nm optical resolution", Nanotechnology 17, 3105-3110 (2006).
26. H. G. Frey, J. Paskarbeit, and D. Anselmetti, "Tip-enhanced single molecule fluorescence near-field microscopy in aqueous environment", Applied Physics Letters 94 (2009).
27. J. Azoulay, A. Debarre, A. Richard, and P. Tchenio, "Quenching and enhancement of single-molecule fluorescence under metallic and dielectric tips", Europhysics Letters 51, 374-380 (2000).
28. H. G. Frey, F. Keilmann, A. Kriele, and R. Guckenberger, "Enhancing the resolution of scanning nearfield optical microscopy by a metal tip grown on an aperture probe", Applied Physics Letters 81, 5030-5032 (2002).
29. A. Hartschuh, "Tip-Enhanced Near-Field Optical Microscopy", Angewandte Chemie-International Edition 47, 8178-8191 (2008).
30. K. Suhling, P. M. W. French, and D. Phillips, "Time-resolved fluorescence microscopy", Photochemical & Photobiological Sciences 4, 13-22 (2005).
31. D. H. Hu, M. Micic, N. Klymyshyn, Y. D. Suh, and H. P. Lu, "Correlated topographic and spectroscopic imaging by combined atomic force microscopy and optical microscopy", Journal of Luminescence 107, 4-12 (2004).
32. R. Kassies, K. O. Van der Werf, A. Lenferink, C. N. Hunter, J. D. Olsen, V. Subramaniam, and C. Otto, "Combined AFM and confocal fluorescence microscope for applications in bio-nanotechnology", Journal of Microscopy-Oxford 217, 109-116 (2005).
33. A. Noy, and T. R. Huser, "Combined force and photonic probe microscope with single, molecule sensitivity", Review of Scientific Instruments 74, 1217-1221 (2003).
34. C. C. Gradinaru, P. Martinsson, T. J. Aartsma, and T. Schmidt, "Simultaneous atomic-force and twophoton fluorescence imaging of biological specimens in vivo", Ultramicroscopy 99, 235-245 (2004).
35. Y. Ebenstein, T. Mokari, and U. Banin, "Fluorescence quantum yield of CdSe/ZnS nanocrystals investigated by correlated atomic-force and single-particle fluorescence microscopy", Applied Physics Letters 80, 4033-4035 (2002).
36. Y. Ebenstein, N. Gassman, S. Kim, and S. Weiss, "Combining atomic force and fluorescence microscopy for analysis of quantum-dot labeled protein-DNA complexes", Journal of Molecular Recognition 22, 397-402 (2009).
37. C. Mu, B. D. Mangum, C. Xie, and J. M. Gerton, "Nanoscale fluorescence microscopy using carbon nanotubes", Ieee Journal of Selected Topics in Quantum Electronics 14, 206-216 (2008).
38. T. J. Yang, G. A. Lessard, and S. R. Quake, "An apertureless near-field microscope for fluorescence imaging", Applied Physics Letters 76, 378-380 (2000).
39. P. Anger, P. Bharadwaj, and L. Novotny, "Enhancement and Quenching of Single-Molecule Fluorescence", Phys.Rev.Lett. 96, 113002 (2006).
40. L. Novotny, and S. J. Stranick, "Near-field optical microscopy and spectroscopy with pointed probes", Annual Review of Physical Chemistry 57, 303-331 (2006).
41. P. Bharadwaj, and L. Novotny, "Spectral dependence of single molecule fluorescence enhancement", Optics Express 15, 14266-14274 (2007).
42. C. Hoppener, R. Beams, and L. Novotny, "Background Suppression in Near-Field Optical Imaging", Nano Letters 9, 903-908 (2009).
43. L. Danos, R. Greef, and T. Markvart, "Efficient fluorescence quenching near crystalline silicon from Langmuir-Blodgett dye films", Thin Solid Films 516, 7251-7255 (2008).
44. M. Wahl, F. Koberling, M. Patting, and E. H. Rahn, "Time-Resolved Confocal Fluorescence Imaging and Spectrocopy System with Single Molecule Sensitivity and Sub-Micrometer Resolution", Current Pharmaceutical Biotechnology 5, 299-308 (2004).