Oxidative/nitrosative stress selectively altered A2B adenosine receptors in chronic obstructive pulmonary disease

FASEB Journal

Volumn 24, Issue 4, 2010, Pages 1192-1204

  Varani, Katia ^a   Caramori, Gaetano ^a   Vincenzi, Fabrizio ^a   Tosi, Alice ^a   Barczyk, Adam ^b   Contoli, Marco ^a   Casolari, Paolo ^a   Triggiani, Massimo ^d   Hansel, Trevor ^e   Leung, Edward ^c   MacLennan, Stephen ^c   Barnes, Peter J ^e   Chung, Kian Fan ^e   Adcock, Ian ^e   Papi, Alberto ^a   Borea, Pier Andrea ^a  

^a UNIVERSITY OF FERRARA   (Italy)

^b MEDICAL UNIVERSITY OF SILESIA   (Poland)

^c King Pharmaceuticals   (United States)

^d UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^e NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

Alveolar macrophages; COPD; Macrophages; Proinflammatory cytokines; Proliferation; U937 cells

Indexed keywords

ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE A2A RECEPTOR; ADENOSINE A2B RECEPTOR; CYCLIC AMP; CYTOKINE; INTERLEUKIN 1BETA; PHORBOL 13 ACETATE 12 MYRISTATE; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR ALPHA; ACETYLCYSTEINE; SCAVENGER; VASODILATOR AGENT;

ADULT; AGED; ARTICLE; CELL PROLIFERATION; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; LUNG ALVEOLUS MACROPHAGE; LUNG FUNCTION; LUNG LAVAGE; MALE; NITROSATIVE STRESS; OXIDATIVE STRESS; PRIORITY JOURNAL; SMOKING; BIOSYNTHESIS; CELL STRAIN U937; DOWN REGULATION; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; GENE SILENCING; GENETICS; METABOLISM; MIDDLE AGED; PATHOLOGY;

ACETYLCYSTEINE; ADENOSINE-5'-(N-ETHYLCARBOXAMIDE); AGED; BRONCHOALVEOLAR LAVAGE; CELL PROLIFERATION; CYCLIC AMP; CYTOKINES; DOWN-REGULATION; FEMALE; FREE RADICAL SCAVENGERS; GENE KNOCKDOWN TECHNIQUES; HUMANS; MACROPHAGES, ALVEOLAR; MALE; MIDDLE AGED; OXIDATIVE STRESS; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RECEPTOR, ADENOSINE A2B; RNA, SMALL INTERFERING; SMOKING; U937 CELLS; VASODILATOR AGENTS;

EID: 77951642313     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.09-139485     Document Type: Article

References (44)

1. Global Initiative for Chronic Obstructive Lung Disease. (2001) Global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease. NHLBI/WHO Workshop Report, NIH Publication No. 2701 pp. 1-100, National Heart, Lung and Blood Institute, Bethesda, MD, April 2001. Last update 2008. Accessibility verified April 9, 2009; http://www.goldcopd.com
2. Zhou, Y., Schneider, D. J., and Blackburn, M. R. (2009) Adenosine signaling and the regulation of chronic lung disease. Pharmacol. Ther. 123, 105-116
3. 2B receptor: its role in inflammation. Endocr. Metab. Immune. Disord. Drug Targets 8, 244-254
4. Varani, K., Caramori, G., Vincenzi, F., Adcock, I., Casolari, P., Leung, E., Maclennan, S., Gessi, S., Morello, S., Barnes, P. J., Ito, K., Chung, K. F., Cavallesco, G., Azzena, G., Papi, A., and Borea, P. A. (2006) Alteration of adenosine receptors in patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 173, 398-406 (Pubitemid 43228327)
5. Psarras, S., Caramori, G., Contoli, M., Papadopoulos, N., and Papi, A. (2005) Oxidants in asthma and in chronic obstructive pulmonary disease (COPD). Curr. Pharm. Des. 11, 2053-2062 (Pubitemid 40766841)
6. Ricciardolo, F. L., Caramori, G., Ito, K., Capelli, A., Brun, P., Abatangelo, G., Papi, A., Chung, K. F., Adcock, I., Barnes, P. J., Donner, C. F., Rossi, A., and Di Stefano, A. (2005) Nitrosative stress in the bronchial mucosa of severe chronic obstructive pulmonary disease. J. Allergy Clin. Immunol. 116, 1028-1035 (Pubitemid 41571783)
7. MacNee, W. (2005) Pulmonary and systemic oxidant/antioxidant imbalance in chronic obstructive pulmonary disease. Proc. Am. Thorac. Soc. 2, 50-60
8. Ochs-Balcom, H. M., Grant, B. J., Muti, P., Sempos, C. T., Freudenheim, J. L., Browne, R. W., McCann, S. E., Trevisan, M., Cassano, P. A., Iacoviello, L., and Schünemann, H. J. (2006) Antioxidants, oxidative stress, and pulmonary function in individuals diagnosed with asthma or COPD. Eur. J. Clin. Nutr. 60, 991-999
9. Pinho, R. A., Chiesa, D., Mezzomo, K. M., Andrades, M. E., Bonatto, F., Gelain, D., Dal Pizzol, F., Knorst, M. M., and Moreira, J. C. (2007) Oxidative stress in chronic obstructive pulmonary disease patients submitted to a rehabilitation program. Respir. Med. 101, 1830-1835
10. Hogg, J. C., Chu, F., Utokaparch, S., Woods, R., Elliot, M., Buzatu, L., Cherniack, R. M., Rogers, R. M., Sciurba, F. C., Coxson, H. O., and Parè, P. D. (2004) The nature of small airway obstruction in chronic obstructive pulmonary disease. N. Engl. J. Med. 350, 2645-2653
11. Barnes, P. J. (2005) Emerging targets for COPD therapy. Curr. Drug Targets Inflamm. Allergy. 4, 675-683
12. Di Stefano, A., Caramori, G., Ricciardolo, F. L., Capelli, A., Adcock, I. M., and Donner, C. F. (2004) Cellular and molecular mechanisms in chronic obstructive pulmonary disease: an overview. Clin. Exp. Allergy 34, 1156-1167 (Pubitemid 39093053)
13. Caramori, G., Pandit, A., and Papi, A. (2005) Is there a difference between chronic airway inflammation in chronic severe asthma and chronic obstructive pulmonary disease?. Curr. Opin. Allergy Clin. Immunol. 5, 77-83 (Pubitemid 40175500)
14. Papi, A., Romagnoli, M., Baraldo, S., Braccioni, F., Guzzinati, I., Saetta, M., Ciaccia, A., and Fabbri, L. M. (2000) Partial reversibility of airflow limitation and increased exhaled NO and sputum eosinophilia in chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 162, 1773-1777
15. Quanjer, P., Tammeling, G. J., Cotes, J. E., Pedersen, O. F., Peslin, R., and Yernault, J. C. (1993) Lung volumes and forced ventilatory flows. Report Working Party, standardization of lung function tests, European Community for Steel and Coal, official statement of the European Respiratory Society. Eur. Respir. J. 16, 5-40
16. Cosio, B. G., Tsaprouni, L., Ito, K., Jazrawi, E., Adcock, I. M., and Barnes, P. J. (2004) Theophylline restores histone deacetylase activity and steroid responses in COPD macrophages. J. Exp. Med. 200, 689-695
17. Ito, K., Jazrawi, B., Cosio, B., Barnes, P. J., and Adcock, I. M. (2001) p65-activated histone acetyltransferase activity is repressed by glucocorticoids: mifepristone fails to recruit HDAC2 to the p65-HAT complex. J. Biol. Chem. 276, 30208-30215
18. Ito, K., Barnes, P. J., and Adcock, I. M. (2000) Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits interleukin-1beta-induced histone H4 acetylation on lysines 8 and 12. Mol. Cell. Biol. 20, 6891-6903
19. Butterfield, J. H., Weiler, D., Dewald, G., and Gleich, G. J. (1988) Establishment of an immature cell line from a patient with mast cell leukemia. Leukemia Res. 12, 345-355
20. 3 adenosine receptors. Mol. Pharmacol. 57, 968-975
21. 2A adenosine receptors in chronic heart failure and cardiac transplantation. FASEB J. 17, 280-282
22. 3H]-MRE 2029-F20. Mol. Pharmacol. 67, 1-11
23. 2B receptors. Biochem. Pharmacol. 70, 1601-1612
24. 3 adenosine receptor activation inhibits cell proliferation via phosphatidylinositol 3-kinase (PI3K)/AKT-dependent inhibition of the extracellular signal-regulated kinase (ERK)1/2 phosphorylation in A375 human melanoma cells. J. Biol. Chem. 280, 19516-19526
25. Ito, K., Ito, M., Elliott, W. M., Cosio, B., Caramori, G., Kon, O. M., Barczyk, A., Hayashi, S., Adcock, I. M., Hogg, J. C., and Barnes, P. J. (2005) Decreased histone deacetylase activity in chronic obstructive pulmonary disease. N. Engl. J. Med. 12, 1967-1976 (Pubitemid 40638367)
26. Martinet, W., Schrijvers, D. M., and Kockx, M. M. (2003) Nucleofection as an efficient nonviral transfection method for human monocytic cells. Biotechnol. Lett. 25, 1025-1029
27. Bradford, M. (1976) A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein dye-binding. Anal. Biochem. 72, 248-254
28. Munson, P. J., and Rodbard, D. (1980) Ligand: a versatile computerized approach for the characterization of ligand binding systems. Anal. Biochem. 107, 220-239
29. De Boer, W. I., Sont, J. K., van Schadewijk, A., Stolk, J., van Krieken, J. H., and Hiemstra, P. S. (2000) Monocyte chemoattractant protein 1, interleukin 8, and chronic airways inflammation in COPD. J. Pathol. 190, 619-626
30. Brozyna, S., Ahern, J., Hodge, G., Nairn, J., Holmes, M., Reynolds, P. N., and Hodge, S. (2009) Chemotactic mediators of Th1 T-cell trafficking in smokers and COPD patients. COPD 6, 4-16
31. CIP1/WAF1 and bcl-xL expression and reduced apoptosis in alveolar macrophages from smokers. Am. J. Respir. Crit. Care 166, 724-731
32. 2A receptors in human monocytic THP-1 cells. J. Immunol. 167, 4026-4032
33. Morello, S., Ito, K., Yamamura, S., Lee, K. Y., Jazrawi, E., Desouza, P., Barnes, P., Cicala, C., and Adcock, I. M. (2006) IL-1 beta and TNF-alpha regulation of the adenosine receptor (A2A) expression: differential requirement for NF-κB binding to the proximal promoter. J. Immunol. 177, 7173-7183
34. Adenuga, D., Yao, H., March, T. H., Seagrave, J., and Rahman, I. (2009) Histone deacetylase 2 is phosphorylated, ubiquitinated, and degraded by cigarette smoke. Am. J. Respir. Cell. Mol. Biol. 40, 464-473
35. Pluemsampant, S., Safronova, O. S., Nakahama, K., and Morita, I. (2008) Protein kinase CK2 is a key activator of histone deacetylase in hypoxia-associated tumors. Int. J. Cancer. 122, 333-341
36. Ito, K., Hanazawa, T., Tomita, K., Barnes, P. J., and Adcock, I. M. (2004) Oxidative stress reduces histone deacetylase 2 activity and enhances IL-8 gene expression: role of tyrosine nitration. Biochem. Biophys. Res. Commun. 315, 240-245
37. Anderson, G. P., and Bozinovski, S. (2003) Acquired somatic mutations in the molecular pathogenesis of COPD. Trends Pharmacol. Sci. 24, 71-76
38. Paschen, W., Mengesdorf, T., Althausen, S., and Hotop, S. (2001) Peroxidative stress selectively down-regulates the neuronal stress response activated under conditions of endoplasmic reticulum dysfunction. J. Neurochem. 76, 1916-1924
39. Chung, K. F. (2006) Phosphodiesterase inhibitors in airways disease. Eur. J. Pharmacol. 533, 110-117
40. Calverley, P. M., Anderson, J. A., Celli, B., Ferguson, G. T., Jenkins, C., Jones, P. W., Yates, J. C., Vestbo, J., and TORCH investigators. (2007) Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease. N. Engl. J. Med. 356, 775-789
41. Rabe, K. F., Bateman, E. D., O'Donnell, D., Witte, S., Bredenbröker, D., and Bethke, T. D. (2005) Roflumilast - an oral anti-inflammatory treatment for chronic obstructive pulmonary disease: a randomised controlled trial. Lancet 366, 563-571
42. 2B adenosine receptor signaling in adenosine-dependent pulmonary inflammation and injury. J. Clin. Invest. 116, 2173-2182
43. 2B receptors ameliorates murine colitis. Br. J. Pharmacol. 155, 127-137
44. 2B adenosine receptor. J. Immunol. 182, 8037-8046