A3 adenosine receptor activation inhibits cell proliferation via phosphatidylinositol 3-kinase/Akt-dependent inhibition of the extracellular signal-regulated kinase 1/2 phosphorylation in A375 human melanoma cells

Journal of Biological Chemistry

Volumn 280, Issue 20, 2005, Pages 19516-19526

  Merighi, Stefania ^a   Benini, Annalisa ^a   Mirandola, Prisco ^b   Gessi, Stefania ^a   Varani, Katia ^a   Leung, Edward ^c   Maclennan, Stephen ^c   Borea, Pier Andrea ^a,d  

^a UNIVERSITY OF FERRARA   (Italy)

^b UNIVERSITY OF PARMA   (Italy)

^c King Pharmaceuticals   (United States)

^d Pharmacology Unit   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; ENZYME INHIBITION; ENZYMES; RNA;

ADENOSINE; ANTAGONISTS; CELL DEATH; CELL PROLIFERATION;

PROTEINS;

1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; 2 MORPHOLINO 8 PHENYLCHROMONE; ADENOSINE; ADENOSINE A2A RECEPTOR; ADENOSINE A2B RECEPTOR; ADENOSINE A3 RECEPTOR; ADENOSINE A3 RECEPTOR ANTAGONIST; G PROTEIN COUPLED RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RAF PROTEIN; RAS PROTEIN; SMALL INTERFERING RNA; 2 CHLORO N(6) (3 IODOBENZYL) 5' N METHYLCARBOXAMIDOADENOSINE; 2-CHLORO-N(6)-(3-IODOBENZYL)-5'-N-METHYLCARBOXAMIDOADENOSINE; AKT1 PROTEIN, HUMAN; DRUG DERIVATIVE; ONCOPROTEIN; PROTEIN SERINE THREONINE KINASE;

APOPTOSIS; ARTICLE; CELL DEATH; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; FLOW CYTOMETRY; GENE SILENCING; HUMAN; HUMAN CELL; MELANOMA CELL; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RECEPTOR UPREGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; CELL DIVISION; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; GENETICS; MELANOMA; METABOLISM; NUCLEOTIDE SEQUENCE; PATHOLOGY; PHOSPHORYLATION; TUMOR CELL LINE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADENOSINE; BASE SEQUENCE; CELL DIVISION; CELL LINE, TUMOR; HUMANS; MAP KINASE SIGNALING SYSTEM; MELANOMA; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, ADENOSINE A3; RNA, SMALL INTERFERING;

EID: 21244447990     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M413772200     Document Type: Article

References (52)

1. Merighi, S., Mirandola, P., Varani, K, Gessi, S., Leung, E., Baraldi, P. G., Tabrizi, M. A., and Borea, P. A. (2003) Pharmacol. Ther. 100, 31-48
2. Hasko, G., and Cronstein, B.N. (2004) Trends Immunol. 25, 33-39
3. Ohana, G., Bar-Yehuda, S., Barer, F., and Fishman, P. (2001) J. Cell. Physiol. 186, 19-23
4. Ralevic, V., and Burnstock, G. (1998) Pharmacol. Rev. 50, 413-492
5. Fredholm, B. B., Ijzerman, A. P., Jacobson, K. A., Klotz, K. N., and Linden, J. (2001) Pharmacol. Rev. 53, 527-552
6. Sitkovsky, M. V., Lukashev, D., Apasov, S., Kojima, H., Koshiba, M., Caldwell, C., Ohta, A., and Thiel, M. (2004) Annu. Rev. Immunol. 22, 657-682
7. Fishman, P., Bar-Yehuda, S., and Vagman, L. (1998) Cancer Res. 58, 3181-3187
8. Gao, Z., Li, B. S., Day, Y. J., and Linden, J. (2001) Mol. Pharmacol. 59, 76-82
9. Merighi, S., Mirandola, P., Milani, D., Varani, K, Gessi, S., Klotz, K. N., Leung, E., Baraldi, P. G., and Borea, P. A. (2002) J. Invest. Dermatol. 119, 923-933
10. Ohana, G., Bar-Yehuda, S., Arich, A., Madi, L., Dreznick, Z., Rath-Wolfson, L., Silberman, D., Slosman, G., and Fishman, P. (2003) Br. J. Cancer 89, 1552-1558
11. Feoktistov, I., Ryzhov, S., Zhong, H., Goldstein, A. E., Matafonov, A., Zeng, D., and Biaggioni, I. (2004) Hypertension 44, 649-654
12. Fishman, P., Bar-Yehuda, S., Ohana, G., Barer, F., Ochaion, A., Erlanger, A., and Madi, L. (2004) Oncogene 23, 2465-2471
13. Brambilla, R., Cattabeni, F., Ceruti, S., Barbieri, D., Franceschi, C., Kim, Y. C., Jacobson, K. A., Klotz, K. N., Lohse, M. J., and Abbracchio, M. P. (2000) Naunyn Schmiedeberg's Arch. Pharmacol. 361, 225-234
14. Fishman, P., Bar-Yehuda, S., Farbstein, T., Barer, F., and Ohana, G. (2000) J. Cell. Physiol. 183, 393-398
15. Bar-Yehuda, S., Barer, F., Volfsson, L., and Fishman, P. (2001) Neoplasia 3, 125-131
16. Fishman, P., Bar-Yehuda, S., Barer, F., Madi, L., Multani, A.S., and Pathak, S. (2001) Exp. Cell Res. 269, 230-236
17. Linden, J. (2001) Annu. Rev. Pharmacol. Toxicol. 41, 775-787
18. Fredholm, B. B., Irenius, E., Kull, B., and Schulte, G. (2001) Biochem. Pharmacol. 61, 443-448
19. Fishman, P., Madi, L., Bar-Yehuda, S., Barer, F., Del Valle, L., and Khalili, K. (2002) Oncogene 21, 4060-4064
20. Schulte, G., and Fredholm, B. B. (2000) Mol. Pharmacol. 58, 477-482
21. Schulte, G., and Fredholm, B. B. (2002) Mol. Pharmacol. 62, 1137-1146
22. Schulte, G., and Fredholm, B. B. (2003) Cell Signal. 15, 813-827
23. Hammarberg, C., Fredholm, B. B., and Schulte, G. (2004) Biochem. Pharmacol. 67, 129-134
24. Hammarberg, C., Schulte, G., and Fredholm, B. B. (2003) J. Neurochem. 86, 1051-1054
25. Klotz, K. N., Camaioni, E., Volpini, R., Kachler, S., Vittori, S., and Cristalli, G. (1999) Naunyn Schmiedeberg's Arch. Pharmacol. 360, 103-108
26. Rommel, C., Clarke, B.A., Zimmermann, S., Nunez, L., Rossman, R., Reid, K., Moelling, K., Yancopoulos, G. D., and Glass, D. J. (1999) Science 286, 1738-1741
27. Guan, K. L., Figueroa, C., Brtva, T. R., Zhu, T., Taylor, J., Barber, T. D., and Vojtek, A. B. (2000) J. Biol. Chem. 275, 27354-27359
28. Reusch, H. P., Zimmermann, S., Schaefer, M., Paul, M., and Moelling, K. (2001) J. Biol. Chem. 276, 33630-33637
29. Moelling, K., Schad, K., Bosse, M., Zimmermann, S., and Schweneker, M. (2002) J. Biol. Chem. 277, 31099-31106
30. Merighi, S., Mirandola, P., Varani, K., Gessi, S., Capitani, S., Leung, E., Baraldi, P. G., Tabrizi, M. A., and Borea, P. A. (2003) Biochem. Pharmacol. 66, 739-748
31. Elbashir, S. M., Harborth, J., Lendeckel, W., Yalcin, A., Weber, K., and Tuschl, T. (2001) Nature 411, 494-498
32. Mirandola, P., Ponti, C., Gobbi, G., Sponzilli, I., Vaccarezza, M., Cocco, L., Zauli, G., Secchiero, P., Manzoli, F. A., and Vitale, M. (2004) Blood 104, 2418-2424
33. Chomaczynski, P., and Sacchi, N. (1987) Anal. Biochem. 162, 156-159
34. Higuchi, R., Fockler, C., Dollinger, G., and Watson, R. (1993) Biotechnology 11, 1026-1030
35. Gessi, S., Cattabriga, E., Avitabile, A., Gafa', R., Lanza, G., Cavazzini, L., Bianchi, N., Gambari, R., Feo, C., Liboni, A., Gullini, S., Leung, E., Mac Lennan, S., and Borea, P.A. (2004) Clin. Cancer Res. 10, 5895-5901
36. Merighi, S., Varani, K., Gessi, S., Cattabriga, E., Iannotta, V., Ulouglu, C., Leung, E., and Borea, P. A. (2001) Br. J. Pharmacol. 134, 1215-1226
37. Merighi, S., Baraldi, P. G., Gessi, S., Iannotta, V., Klotz, K. N., Leung, E., Mirandola, P., Tabrizi, M. A., Varani, K., and Borea, P. A. (2003) Drug. Dev. Res. 58, 377-385
38. Varani, K., Merighi, S., Gessi, S., Klotz, K. N., Leung, E., Baraldi, P. G., Cacciari, B., Romagnoli, R., Spalluto, G., and Borea, P. A. (2000) Mol. Pharmacol. 57, 968-975
39. Baraldi, P. G., Tabrizi, M. A., Preti, D., Bovero, A., Romagnoli, R., Fruttarolo, F., Zaid, N. A., Moorman, A. R., Varani, K., Gessi, S., Merighi, S., and Borea, P. A. (2004) J. Med. Chem. 47, 1434-1447
40. Gutkind, J. S. (1998) J. Biol. Chem. 273, 1839-1842
41. Marinissen, M. J., and Gutkind, J. S. (2001) Trends Pharmacol. Sci. 22, 368-376
42. Downward, J. (1998) Curr. OpIn. Cell Biol. 10, 262-267
43. Haberberger, R. V., Pfeil, U., Lips, K. S., Kummer, W. (2002) J. Invest. Dermatol. 119, 943-948
44. Slominski, A., Wortsman, J., Kohn, L., Ain, K. B., Venkataraman, G. M., Pisarchik, A., Chung, J. H., Giuliani, C., Thornton, M., Slugocki, G., and Tobin, D. J. (2002) J. Invest. Dermatol. 119, 1449-1455
45. Slominski, A., Pisarchik, A., Semak, I., Sweatman, T., Szczesniewski, A., Wortsman, J. (2002) J. Invest. Dermatol. 119, 934-942
46. Sebolt-Leopold, J. S. (2000) Oncogene 19, 6594-6599
47. Lee, J. T., Jr., and McCubrey, J. A. (2002) Leukemia 16, 486-507
48. Vivanco, I., and Sawyers, C. L. (2002) Nat. Rev. Cancer 2, 489-501
49. West, K. A., Castillo, S. S., and Dennis, P. A. (2002) Drug Resist. Updat. 5, 234-248
50. Begum, N., and Ragolia, L. (2000) Am. J. Physiol. 278, C81-C91
51. Ruiz-Hidalgo, M.J., Gubina, E., Tull, L., Baladron, V., Laborda, J. (2002) Exp. Cell Res. 274, 178-188
52. Zimmermann, S., and Moelling, K. (1999) Science 286, 1741-1744