Genotoxicity of pyrrolizidine alkaloids

Journal of Applied Toxicology

Volumn 30, Issue 3, 2010, Pages 183-196

  Chen, Tao ^a   Mei, Nan ^a   Fu, Peter P ^a  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

Author keywords

Carcinogenesis; DNA damage; Genotoxicity; Mutation; Mutational signature; Pyrrolizidine alkaloid

Indexed keywords

CLIVORINE; COMFREY EXTRACT; INDICINE N OXIDE; INTEGERRIMINE; K RAS PROTEIN; LASIOCARPINE; MONOCROTALINE; PROTEIN P53; PYRROLIZIDINE ALKALOID; RETRORSINE; SENECIONINE; SENECIPHYLLINE;

CHROMOSOME ABERRATION; CHROMOSOME MUTATION; DNA ADDUCT; DNA CROSS LINKING; DNA DAMAGE; DNA STRAND BREAKAGE; DNA SYNTHESIS; GENE MUTATION; GENOTOXICITY; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INDUCED MUTATION; LIVER TUMOR; METABOLIC ACTIVATION; MICRONUCLEUS TEST; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; PRIORITY JOURNAL; REVIEW; SISTER CHROMATID EXCHANGE;

ANIMALS; CARCINOGENS, ENVIRONMENTAL; CHROMOSOME ABERRATIONS; DNA DAMAGE; DRUG-INDUCED LIVER INJURY; HUMANS; MUTAGENS; MUTATION; PLANTS, TOXIC; PYRROLIZIDINE ALKALOIDS;

RATTUS;

EID: 77951555132     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.1504     Document Type: Review

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