Metabolic activation of retronecine and retronecine N-oxide – formation of DHP-derived DNA adducts

Toxicology and Industrial Health

Volumn 24, Issue 3, 2008, Pages 181-188

  Yan, J ^a   Xia, Q ^a   Chou, Mw ^a   Fu, Pp ^a  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

Author keywords

DNA adduct; pyrollizidine alkaloid; retronecine; retronecine N oxide

Indexed keywords

6,7 DIHYDRO 7 HYDROXY 1 HYDROXYMETHYL 5H PYRROLIZINE; ALKALOID; BIOLOGICAL MARKER; DEHYDRORETRONECINE; DNA; MICROSOME ENZYME; PHENOBARBITAL; PYRROLIZIDINE ALKALOID; PYRROLIZIDINE DERIVATIVE; RETRONECINE; RETRONECINE N OXIDE; RIDDELLIINE N OXIDE; RIDDELLINE; UNCLASSIFIED DRUG; AMINE OXIDE; CALF THYMUS DNA; DRUG DERIVATIVE; MONOCROTALINE; RIDDELLIINE N-OXIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOTRANSFORMATION; CARCINOGENESIS; CARCINOGENICITY; CONTROLLED STUDY; DNA ADDUCT; FEMALE; FISCHER 344 RAT; IN VITRO STUDY; IN VIVO STUDY; LIVER MICROSOME; LIVER MICROSOME METABOLISM; LIVER TOXICITY; LIVER TUMOR; METABOLIC ACTIVATION; METABOLITE; NONHUMAN; RAT; THYMUS; ANIMAL; BIOSYNTHESIS; LIVER; METABOLISM;

MUS; RATTUS;

ANIMALS; BIOTRANSFORMATION; CYCLIC N-OXIDES; DNA; DNA ADDUCTS; FEMALE; LIVER; MICROSOMES, LIVER; MONOCROTALINE; PYRROLIZIDINE ALKALOIDS; RATS; RATS, INBRED F344;

EID: 59649109236     PISSN: 07482337     EISSN: None     Source Type: Journal    
DOI: 10.1177/0748233708093727     Document Type: Article

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