Metabolic activation of the tumorigenic pyrrolizidine alkaloid, monocrotaline, leading to DNA adduct formation in vivo

Cancer Letters

Volumn 226, Issue 1, 2005, Pages 27-35

  Wang, Yu Ping ^a   Yan, Jian ^a   Beger, Richard D ^a   Fu, Peter P ^a   Chou, Ming W ^a  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

Author keywords

DNA adducts; Monocrotaline; Pyrrolizidine alkaloid

Indexed keywords

6,7 DIHYDRO 7 HYDROXY 1 HYDROXYMETHYL 5H PYRROLIZINE; DEXAMETHASONE; DNA; DRUG METABOLITE; ENZYME INHIBITOR; MONOCRATALINE N OXIDE; MONOCROTALINE; PHOSPHORUS 32; PYRROLIZIDINE ALKALOID; PYRROLIZINE DERIVATIVE; RETRONECINE; RIDDELLINE; TROLEANDOMYCIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CARCINOGENIC ACTIVITY; CARCINOGENICITY; CATTLE; CONTROLLED STUDY; DNA ADDUCT; DOSE RESPONSE; DOSE TIME EFFECT RELATION; DRUG ACTIVATION; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME INDUCTION; FEEDING; FEMALE; GENOTOXICITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VIVO STUDY; LIVER MICROSOME; LUNG; METABOLIC ACTIVATION; MICROSOME; NONHUMAN; PRIORITY JOURNAL; RAT; RAT STRAIN; THYMUS;

ANIMALS; DICARBETHOXYDIHYDROCOLLIDINE; DNA ADDUCTS; FEMALE; LIVER; MONOCROTALINE; NEOPLASMS; PYRROLIZIDINE ALKALOIDS; RATS; RATS, INBRED F344;

ANIMALIA; BOS TAURUS;

EID: 21744446236     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2004.11.039     Document Type: Article

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