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Volumn 15, Issue 4, 2007, Pages 458-465

The mutant frequencies and types of mutations induced by Comfrey in the lungs of transgenic big blue rats

Author keywords

Comfrey; Mutation; Pyrrolizidine alkaloids; Tandem substitution

Indexed keywords

ALANINE; COMFREY EXTRACT; CYSTEINE; GLYCINE; PYRROLIZIDINE ALKALOID; THREONINE;

EID: 40749113182     PISSN: 10219498     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (6)

References (43)
  • 2
    • 0018167714 scopus 로고
    • Carcinogenic activity of Symphytum Officinale
    • Hirono, I., Mori, H. and Haga, M. 1978. Carcinogenic activity of Symphytum Officinale. J. Natl. Cancer Inst. 61: 865-869.
    • (1978) J. Natl. Cancer Inst , vol.61 , pp. 865-869
    • Hirono, I.1    Mori, H.2    Haga, M.3
  • 3
    • 40749119563 scopus 로고
    • New York, Gramercy Publishing Company
    • Buchman, D. D. 1979. Herbal Medicine. pp. 3-8. New York, Gramercy Publishing Company.
    • (1979) Herbal Medicine , pp. 3-8
    • Buchman, D.D.1
  • 4
    • 0036842376 scopus 로고    scopus 로고
    • Comfrey toxicity revisited
    • Rode, D. 2002. Comfrey toxicity revisited. Trends Pharmacol. Sci. 23: 497-499.
    • (2002) Trends Pharmacol. Sci , vol.23 , pp. 497-499
    • Rode, D.1
  • 5
    • 0021932534 scopus 로고
    • Hepatic venocclusive disease associated with the consumption of pyrrolizidine-containing dietary supplements
    • Ridker, P. M., Ohkuma, S., McDermott, W. V., Trey, C. and Huxtable, R. J. 1985. Hepatic venocclusive disease associated with the consumption of pyrrolizidine-containing dietary supplements. Gastroenterology 88: 1050-1054.
    • (1985) Gastroenterology , vol.88 , pp. 1050-1054
    • Ridker, P.M.1    Ohkuma, S.2    McDermott, W.V.3    Trey, C.4    Huxtable, R.J.5
  • 7
    • 0020683122 scopus 로고
    • An evaluation of acetone extracts from six plants in the Ames mutagenicity test
    • White, R. D., Krumperman, P. H., Cheeke, P. R. and Buhler, D. R. 1983. An evaluation of acetone extracts from six plants in the Ames mutagenicity test. Toxicol. Lett. 15: 25-31.
    • (1983) Toxicol. Lett , vol.15 , pp. 25-31
    • White, R.D.1    Krumperman, P.H.2    Cheeke, P.R.3    Buhler, D.R.4
  • 8
    • 16244421977 scopus 로고    scopus 로고
    • Mutagenicity of comfrey (Symphytum Officinale) in rat liver
    • Mei, N., Guo, L., Fu, P. P., Heflich, R. H. and Chen, T. 2005. Mutagenicity of comfrey (Symphytum Officinale) in rat liver. Br. J. Cancer 92: 873-875.
    • (2005) Br. J. Cancer , vol.92 , pp. 873-875
    • Mei, N.1    Guo, L.2    Fu, P.P.3    Heflich, R.H.4    Chen, T.5
  • 9
    • 0011807708 scopus 로고
    • Beware the unknown brew. Herbal teas and toxicity
    • Snider, S. 1991. Beware the unknown brew. Herbal teas and toxicity. FDA Consumer 25: 30-33.
    • (1991) FDA Consumer , vol.25 , pp. 30-33
    • Snider, S.1
  • 10
    • 0019978432 scopus 로고
    • Hepatotoxic pyrrolizidine alkaloids in symphytum preparations
    • Stengl, P., Wiedenfeld, H. and Roeder, E. 1982. Hepatotoxic pyrrolizidine alkaloids in symphytum preparations. Dtsch. Apoth.-Ztg. 122: 851-855.
    • (1982) Dtsch. Apoth.-Ztg , vol.122 , pp. 851-855
    • Stengl, P.1    Wiedenfeld, H.2    Roeder, E.3
  • 11
    • 0023868424 scopus 로고
    • Pryrrolizidine alkaloids: Testing for toxic constituents of comfrey
    • Vollmer, J., Steiner, N., Larsen, G., Muirhead, K. and Molyneux, R. 1987. Pryrrolizidine alkaloids: Testing for toxic constituents of comfrey. J. Chem. Educ. 64: 1027-1030.
    • (1987) J. Chem. Educ , vol.64 , pp. 1027-1030
    • Vollmer, J.1    Steiner, N.2    Larsen, G.3    Muirhead, K.4    Molyneux, R.5
  • 12
    • 0029802423 scopus 로고    scopus 로고
    • Analysis, separation, and bioassay of pyrrolizidine alkaloids from comfrey (Symphytum Officinale)
    • Couet, C. E., Crews, C. and Hanley, A. B. 1996. Analysis, separation, and bioassay of pyrrolizidine alkaloids from comfrey (Symphytum Officinale). Nat. Toxins 4: 163-167.
    • (1996) Nat. Toxins , vol.4 , pp. 163-167
    • Couet, C.E.1    Crews, C.2    Hanley, A.B.3
  • 13
    • 0028322182 scopus 로고
    • Determination of pyrrolizidine alkaloids in commercial comfrey products (Symphytum sp)
    • Betz, J. M., Eppley, R. M., Taylor, W. C. and Andrzejewski, D. 1994. Determination of pyrrolizidine alkaloids in commercial comfrey products (Symphytum sp). J. Pharm. Sci. 83: 649-653.
    • (1994) J. Pharm. Sci , vol.83 , pp. 649-653
    • Betz, J.M.1    Eppley, R.M.2    Taylor, W.C.3    Andrzejewski, D.4
  • 14
    • 0034506455 scopus 로고    scopus 로고
    • The efficacy and safety of comfrey
    • Stickel, F. and Seitz, H. K. 2000. The efficacy and safety of comfrey. Public Health Nutr. 3: 501-508.
    • (2000) Public Health Nutr , vol.3 , pp. 501-508
    • Stickel, F.1    Seitz, H.K.2
  • 15
    • 40749089409 scopus 로고    scopus 로고
    • supplement manufacturers to remove coniftey products from the market
    • FDA. 2001. FDA advises dietary supplement manufacturers to remove coniftey products from the market. (http://www.cfsan.fda.gov/~dms/ dspltr06.html)
    • (2001) FDA advises dietary
  • 20
    • 4444280106 scopus 로고    scopus 로고
    • N-ethyl-N-nitrosourea (ENU) increased brain mutations in prenatal and neonatal mice but not in the adults
    • Slikker, W., Mei, N. and Chen, T. 2004. N-ethyl-N-nitrosourea (ENU) increased brain mutations in prenatal and neonatal mice but not in the adults. Toxicol. Sci. 81: 112-120.
    • (2004) Toxicol. Sci , vol.81 , pp. 112-120
    • Slikker, W.1    Mei, N.2    Chen, T.3
  • 21
    • 0036798839 scopus 로고    scopus 로고
    • Mutations induced by alpha-hydroxytamoxifen in the lacI and cII genes of Big Blue transgenic rats
    • Chen, T., Gamboa da Costa, G., Marques, M. M., Shelton, S. D., Beland, F. A. and Manjanatha, M. G. 2002. Mutations induced by alpha-hydroxytamoxifen in the lacI and cII genes of Big Blue transgenic rats. Carcinogenesis 23: 1751-1757.
    • (2002) Carcinogenesis , vol.23 , pp. 1751-1757
    • Chen, T.1    Gamboa da Costa, G.2    Marques, M.M.3    Shelton, S.D.4    Beland, F.A.5    Manjanatha, M.G.6
  • 22
    • 0027939870 scopus 로고
    • Database and software for the analysis of mutations at the human hprt gene
    • Cariello, N. F. 1994. Database and software for the analysis of mutations at the human hprt gene. Nucleic Acids Res. 22: 3547-3548.
    • (1994) Nucleic Acids Res , vol.22 , pp. 3547-3548
    • Cariello, N.F.1
  • 23
    • 0023264512 scopus 로고
    • Statistical test for the comparison of samples from mutational spectra
    • Adams, W. T. and Skopek, T. R. 1987. Statistical test for the comparison of samples from mutational spectra. J. Mol. Biol. 194: 391-396.
    • (1987) J. Mol. Biol , vol.194 , pp. 391-396
    • Adams, W.T.1    Skopek, T.R.2
  • 24
    • 0142216466 scopus 로고    scopus 로고
    • Riddelliine N-oxide is a phytochemical and mammalian metabolite with genotoxic activity that is comparable to the parent pyrrolizidine alkaloid riddelliine
    • Chou, M. W., Wang, Y. P., Yan, J., Yang, Y. C., Beger, R. D., Williams, L. D., Doerge, D. R. and Fu, P. P. 2003. Riddelliine N-oxide is a phytochemical and mammalian metabolite with genotoxic activity that is comparable to the parent pyrrolizidine alkaloid riddelliine. Toxicol. Lett. 145: 239-247.
    • (2003) Toxicol. Lett , vol.145 , pp. 239-247
    • Chou, M.W.1    Wang, Y.P.2    Yan, J.3    Yang, Y.C.4    Beger, R.D.5    Williams, L.D.6    Doerge, D.R.7    Fu, P.P.8
  • 25
    • 0141625018 scopus 로고    scopus 로고
    • Identification of DNA adducts derived from riddelliine, a carcinogenic pyrrolizidine alkaloid
    • Chou, M. W., Jian, Y., Williams, L. D., Xia, Q., Churchwell, M., Doerge, D. R., and Fu, P. P. 2003. Identification of DNA adducts derived from riddelliine, a carcinogenic pyrrolizidine alkaloid. Chem. Res. Toxicol. 16: 1130-1137.
    • (2003) Chem. Res. Toxicol , vol.16 , pp. 1130-1137
    • Chou, M.W.1    Jian, Y.2    Williams, L.D.3    Xia, Q.4    Churchwell, M.5    Doerge, D.R.6    Fu, P.P.7
  • 26
    • 22044438516 scopus 로고    scopus 로고
    • Metabolic activation of the tumorigenic pyrrolizidine alkaloid, retrorsine, leading to DNA adduct formation in vivo
    • Wang, Y. P., Fu, P. P. and Chou, M. W. 2005. Metabolic activation of the tumorigenic pyrrolizidine alkaloid, retrorsine, leading to DNA adduct formation in vivo. Int. J. Environ. Res. Public Health 2: 74-79.
    • (2005) Int. J. Environ. Res. Public Health , vol.2 , pp. 74-79
    • Wang, Y.P.1    Fu, P.P.2    Chou, M.W.3
  • 27
    • 0015016975 scopus 로고
    • Hypertensive pulmonary vascular disease produced in rats by administration of the pyrrolizidine alkaloid fulvine
    • Kay, J. M., Heath, D., Smith, P., Bras, G. and Summerell, J. 1971. Hypertensive pulmonary vascular disease produced in rats by administration of the pyrrolizidine alkaloid fulvine. J. Pathol. 103: P3.
    • (1971) J. Pathol , vol.103
    • Kay, J.M.1    Heath, D.2    Smith, P.3    Bras, G.4    Summerell, J.5
  • 28
    • 0024308447 scopus 로고
    • Monocrotaline-induced cardiopulmonary injury in rats. Modification by the neutrophil elastase inhibitor SC39026
    • Molteni, A., Ward, W. F., Ts'ao, C. H. and Hinz, J. M. 1989. Monocrotaline-induced cardiopulmonary injury in rats. Modification by the neutrophil elastase inhibitor SC39026. Biochem. Pharmacol. 38: 2411-2419.
    • (1989) Biochem. Pharmacol , vol.38 , pp. 2411-2419
    • Molteni, A.1    Ward, W.F.2    Ts'ao, C.H.3    Hinz, J.M.4
  • 30
    • 0029046258 scopus 로고
    • The effect of the pyrrolizidine alkaloids, monocrotaline and trichodesmine, on tissue pyrrole binding and glutathione metabolism in the rat
    • Yan, C. C. and Huxtable, R. J. 1995. The effect of the pyrrolizidine alkaloids, monocrotaline and trichodesmine, on tissue pyrrole binding and glutathione metabolism in the rat. Toxicon 33: 627-634.
    • (1995) Toxicon , vol.33 , pp. 627-634
    • Yan, C.C.1    Huxtable, R.J.2
  • 31
    • 0030059519 scopus 로고    scopus 로고
    • Effects of monocrotaline, a pyrrolizidine alkaloid, on glutathione metabolism in the rat
    • Yan, C. C. and Huxtable, R. J. 1996. Effects of monocrotaline, a pyrrolizidine alkaloid, on glutathione metabolism in the rat. Biochem. Pharmacol. 51: 375-379.
    • (1996) Biochem. Pharmacol , vol.51 , pp. 375-379
    • Yan, C.C.1    Huxtable, R.J.2
  • 32
    • 0017329330 scopus 로고
    • Carcinogenic activity of petasitenine, a new pyrrolizidine alkaloid isolated from Petasites japonicus Maxim
    • Hirono, I., Mori, H., Yamada, K., Hirata, Y. and Haga, M. 1977. Carcinogenic activity of petasitenine, a new pyrrolizidine alkaloid isolated from Petasites japonicus Maxim. J. Natl. Cancer Inst. 58: 1155-1157.
    • (1977) J. Natl. Cancer Inst , vol.58 , pp. 1155-1157
    • Hirono, I.1    Mori, H.2    Yamada, K.3    Hirata, Y.4    Haga, M.5
  • 33
    • 0017282474 scopus 로고
    • Carcinogenic activity of coltsfoot, Tussilago farfara 1
    • Hirono, I., Mori, H. and Culvenor, C. C. 1976. Carcinogenic activity of coltsfoot, Tussilago farfara 1. Gann 67: 125-129.
    • (1976) Gann , vol.67 , pp. 125-129
    • Hirono, I.1    Mori, H.2    Culvenor, C.C.3
  • 34
    • 0014354761 scopus 로고
    • Toxicology and carcinogenic action of pyrrolizidine alkaloids
    • Schoental, R. 1968. Toxicology and carcinogenic action of pyrrolizidine alkaloids. Cancer Res. 28: 2237-2246.
    • (1968) Cancer Res , vol.28 , pp. 2237-2246
    • Schoental, R.1
  • 35
    • 33947331672 scopus 로고    scopus 로고
    • Analysis of gene expression changes in relation to toxicity and tumorigenesis in the livers of Big Blue transgenic rats fed comfrey (Symphytum Officinale)
    • Mei, N., Guo, L., Zhang, L., Shi, L., Sun, Y. A., Fung, C., Moland, C. L., Dial, S. L., Fuscoe, J. C. and Chen, T. 2006. Analysis of gene expression changes in relation to toxicity and tumorigenesis in the livers of Big Blue transgenic rats fed comfrey (Symphytum Officinale). BMC Bioinformatics 7: S12-16.
    • (2006) BMC Bioinformatics , vol.7
    • Mei, N.1    Guo, L.2    Zhang, L.3    Shi, L.4    Sun, Y.A.5    Fung, C.6    Moland, C.L.7    Dial, S.L.8    Fuscoe, J.C.9    Chen, T.10
  • 36
    • 1042291959 scopus 로고    scopus 로고
    • Evaporative light scattering detection of pyrrolizidine alkaloids
    • Schaneberg, B. T., Molyneux, R. J. and Khan, I. A. 2004. Evaporative light scattering detection of pyrrolizidine alkaloids. Phytochem. Anal. 15: 36-39.
    • (2004) Phytochem. Anal , vol.15 , pp. 36-39
    • Schaneberg, B.T.1    Molyneux, R.J.2    Khan, I.A.3
  • 37
    • 0035093419 scopus 로고    scopus 로고
    • Isolation of symlandine from the roots of common comfrey (Symphytum Officinale) using countercurrent chromatography
    • Kim, N. C., Oberlies, N. H., Brine, D. R., Handy, R. W., Wani, M. C. and Wall, M. E. 2001. Isolation of symlandine from the roots of common comfrey (Symphytum Officinale) using countercurrent chromatography. J. Nat. Prod. 64: 251-253.
    • (2001) J. Nat. Prod , vol.64 , pp. 251-253
    • Kim, N.C.1    Oberlies, N.H.2    Brine, D.R.3    Handy, R.W.4    Wani, M.C.5    Wall, M.E.6
  • 39
    • 0016139164 scopus 로고
    • Laslocarpine-induced, transplantable squamous cell carcinoma of rat skin
    • Svoboda, D. J. and Reddy, J. K. 1974. Laslocarpine-induced, transplantable squamous cell carcinoma of rat skin. J. Natl. Cancer Inst. 53: 1415-1418.
    • (1974) J. Natl. Cancer Inst , vol.53 , pp. 1415-1418
    • Svoboda, D.J.1    Reddy, J.K.2
  • 40
    • 3042768117 scopus 로고    scopus 로고
    • Mutations induced by the carcinogenic pyrrolizidine alkaloid riddelliine in the liver cII gene of transgenic big blue rats
    • Mei, N., Heflich, R. H., Chou, M. W. and Chen, T. 2004. Mutations induced by the carcinogenic pyrrolizidine alkaloid riddelliine in the liver cII gene of transgenic big blue rats. Chem. Res. Toxicol. 17: 814-818.
    • (2004) Chem. Res. Toxicol , vol.17 , pp. 814-818
    • Mei, N.1    Heflich, R.H.2    Chou, M.W.3    Chen, T.4
  • 41
    • 1642323484 scopus 로고    scopus 로고
    • Pyrrolizidine alkaloids--genotoxicity, metabolism enzymes, metabolic activation, and mechanisms
    • Fu, P. P., Xia, Q., Lin, G. and Chou, M. W. 2004. Pyrrolizidine alkaloids--genotoxicity, metabolism enzymes, metabolic activation, and mechanisms. Drug Metab. Rev. 36: 1-55.
    • (2004) Drug Metab. Rev , vol.36 , pp. 1-55
    • Fu, P.P.1    Xia, Q.2    Lin, G.3    Chou, M.W.4
  • 42
    • 0017856185 scopus 로고
    • Malignant neoplasms in rats fed lasiocarpine
    • Rao, M. S. and Reddy, J. K. 1978. Malignant neoplasms in rats fed lasiocarpine. Br. J. Cancer 37: 289-293.
    • (1978) Br. J. Cancer , vol.37 , pp. 289-293
    • Rao, M.S.1    Reddy, J.K.2
  • 43
    • 0020356450 scopus 로고
    • Carcinogenicity of some pyrrolic pyrrolizidine alkaloid metabolites and analogues
    • Mattocks, A. R. and Cabral, J. R. 1982. Carcinogenicity of some pyrrolic pyrrolizidine alkaloid metabolites and analogues. Cancer Lett. 17: 61-66.
    • (1982) Cancer Lett , vol.17 , pp. 61-66
    • Mattocks, A.R.1    Cabral, J.R.2


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