A system-based comparison of gene expression reveals alterations in oxidative stress, disruption of ubiquitin-proteasome system and altered cell cycle regulation after exposure to cadmium and methylmercury in mouse embryonic fibroblast

Toxicological Sciences

Volumn 114, Issue 2, 2010, Pages 356-377

  Yu, Xiaozhong ^a   Robinson, Joshua F ^a   Sidhu, Jaspreet S ^a,b   Hong, Sungwoo ^a   Faustman, Elaine M ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b Molecular Epidemiology Inc   (United States)

Author keywords

Cell cycle regulation; Gene expression profiling; Metals; Oxidative stress; Ubiquitin proteasome pathway

Indexed keywords

BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CADMIUM; CELL PROTEIN; GLUTATHIONE TRANSFERASE A2; GLUTATHIONE TRANSFERASE A4; METHYLMERCURY; NEUTRAL RED; PROTEASOME; PROTEIN CCNB1; PROTEIN CDC25C; PROTEIN CDC2A; PROTEIN NOQ1; PROTEIN UBE2C; PROTEIN UCHL1; UBIQUITIN; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CYCLE REGULATION; CELL VIABILITY; COMPUTER PROGRAM; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; EMBRYO; ENVIRONMENTAL EXPOSURE; FIBROBLAST CULTURE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PARKINSON DISEASE; SIGNAL TRANSDUCTION;

ANIMALS; CADMIUM CHLORIDE; CELL CYCLE; CELL CYCLE PROTEINS; CELL LINE; CELL SURVIVAL; COMPARATIVE GENOMIC HYBRIDIZATION; CYSTEINE PROTEINASE INHIBITORS; ENVIRONMENTAL POLLUTANTS; FIBROBLASTS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, ENZYMOLOGIC; LEUPEPTINS; METHYLMERCURY COMPOUNDS; MICE; MICROARRAY ANALYSIS; OXIDATIVE STRESS; PROTEASOME ENDOPEPTIDASE COMPLEX; UBIQUITINS;

EID: 77951527967     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfq003     Document Type: Article

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