Substitution of the bordetella pertussis lipid a phosphate groups with glucosamine is required for robust nf-κb activation and release of proinflammatory cytokines in cells expressing human but not murine toll-like receptor 4-MD-2-CD14

Infection and Immunity

Volumn 78, Issue 5, 2010, Pages 2060-2069

  Marr, Nico ^a,d   Hajjar, Adeline M ^b   Shah, Nita R ^a   Novikov, Alexey ^c   Yam, Cathy S ^b   Caroff, Martine ^c   Fernandez, Rachel C ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF WASHINGTON   (United States)

^c CNRS   (France)

^d UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CD14 ANTIGEN; CYTOKINE; ENDOTOXIN; GLUCOSAMINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOMODULATING AGENT; LIPOOLIGOSACCHARIDE; PHOSPHORYL LIPID A; TOLL LIKE RECEPTOR 4;

ARTICLE; BACTERIAL CELL; BACTERICIDAL ACTIVITY; BIOLOGICAL ACTIVITY; BORDETELLA PERTUSSIS; CELL STIMULATION; CELL STRAIN HEK293; CONTROLLED STUDY; CYTOKINE RELEASE; HEAT; HUMAN; HUMAN CELL; IMMUNE RESPONSE; INNATE IMMUNITY; LEUKEMIA CELL LINE; MACROPHAGE; MOLECULE; NONHUMAN; PERTUSSIS; PRIORITY JOURNAL; PROTEIN MODIFICATION; WHOLE CELL;

ANIMALS; ANTIGENS, CD14; BORDETELLA PERTUSSIS; CELL LINE; CYTOKINES; GLUCOSAMINE; HUMANS; LIPID A; LYMPHOCYTE ANTIGEN 96; MACROPHAGES; MICE; NF-KAPPA B; PHOSPHATES; TOLL-LIKE RECEPTOR 4;

EID: 77951228124     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.01346-09     Document Type: Article

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