Intracellular chloride regulates cell proliferation through the activation of stress-activated protein kinases in MKN28 human gastric cancer cells

Journal of Cellular Physiology

Volumn 223, Issue 3, 2010, Pages 764-770

  Ohsawa, Rumi ^a   Miyazaki, Hiroaki ^a   Niisato, Naomi ^a   Shiozaki, Atsushi ^a   Iwasaki, Yoshinobu ^a   Otsuji, Eigo ^a   Marunaka, Yoshinori ^a  

^a KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORIDE; CYCLIN DEPENDENT KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN P21; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; MESSENGER RNA; PROTEIN KINASE INHIBITOR;

ARTICLE; CANCER CELL; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; STOMACH CANCER; UPREGULATION; CELL CYCLE; CULTURE MEDIUM; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; INTRACELLULAR SPACE; METABOLISM; PATHOLOGY; PHOSPHORYLATION; STOMACH TUMOR; TUMOR CELL LINE;

CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CHLORIDES; CULTURE MEDIA; CYCLIN-DEPENDENT KINASE INHIBITOR P21; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTRACELLULAR SPACE; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; RNA, MESSENGER; STOMACH NEOPLASMS;

EID: 77951212838     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.22088     Document Type: Article

References (37)

1. Abdel-Ghany M, Cheng HC, Elble RC, Pauli BU. 2001. The breast cancer beta 4 integrin and endothelial human CLCA2 mediate lung metastasis. J Biol Chem 276:25438-25446. (Pubitemid 37413033)
2. 2+-activated chloride channel genes CLCA1 and CLCA2 is downregulated in human colorectal cancer. DNA Cell Biol 20:331-338.
3. Cheng HF, Wang JL, Zhang MZ, McKanna JA, Harris RC. 2000. Role of p38 in the regulation of renal cortical cyclooxygenase-2 expression by extracellular chloride. JClin Invest 106:681-688.
4. English J, Pearson G, Wilsbacher J, Swantek J, Karandikar M, Xu S, Cobb MH. 1999. New insights into the control of MAP kinase pathways. Exp Cell Res 253:255-270.
5. Esposito F, Cuccovillo F, Vanoni M, Cimino F, Anderson CW, Appella E, Russo T. 1997. Redox-mediated regulation of p21(waf1/cip1) expression involves a post-transcriptional mechanism and activation of the mitogen-activated protein kinase pathway. Eur J Biochem 245:730-737. (Pubitemid 27223907)
6. Gartel AL, Radhakrishnan SK. 2005. Lost in transcription: p21 repression, mechanisms, and consequences. Cancer Res 65:3980-3985.
7. Gartel AL, Tyner AL. 1999. Transcriptional regulation of the p21((WAF1/CIP1)) gene. Exp Cell Res 246:280-289.
8. Gartel AL, Goufman E, Najmabadi F, Tyner AL. 2000. Sp1 and Sp3 activate p21 (WAF1/CIP1) gene transcription in the Caco-2 colon adenocarcinoma cell line. Oncogene 19:5182-5188.
9. Hu PP, Shen X, Huang D, Liu Y, Counter C, Wang XF. 1999. The MEK pathway is required for stimulation of p21(WAF1/CIP1) by transforming growth factor-beta. J Biol Chem 274:35381-35387. (Pubitemid 129512827)
10. Ichijo H. 1999. From receptors to stress-activated MAP kinases. Oncogene 18:6087-6093.
11. + channels and volume-regulated anion channels in multidrug-resistant small cell lung cancer cells. Cancer Res 53:4156-4160.
12. Kim GY, Mercer SE, Ewton DZ, Yan Z, Jin K, Friedman E. 2002. The stress-activated protein kinases p38 alpha and JNK1 stabilize p21(Cip1) by phosphorylation. J Biol Chem 277:29792-29802.
13. Kishi H, Nakagawa K, Matsumoto M, Suga M, Ando M, Taya Y, Yamaizumi M. 2001. Osmotic shock induces G1 arrest through p53 phosphorylation at Ser33 by activated p38MAPK without phosphorylation at Ser15 and Ser20. J Biol Chem 276:39115-39122.
14. Kunzelmann K. 2005. Ion channels and cancer. J Membr Biol 205:159-173.
15. Kyriakis JM, Avruch J. 2001. Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol Rev 81:807-869. (Pubitemid 32267078)
16. Lee B, Kim CH, Moon SK. 2006. Honokiol causes the p21WAF1-mediated G(1)-phase arrest of the cell cycle through inducing p38 mitogen activated protein kinase in vascular smooth muscle cells. FEBS Lett 580:5177-5184. (Pubitemid 44437592)
17. Lee SJ, Kim HM, Cho YH, Park K, Kim EJ, Jung KH, Kim CH, Kim WJ, Moon SK. 2007. Aqueous extract of Magnolia officinalis mediates proliferative capacity, p21WAF1 expression and TNF-alpha-induced NF-kappaB activity in human urinary bladder cancer 5637 cells; involvement of p38 MAP kinase. Oncol Rep 18:729-736.
18. Loesch M, Chen G. 2008. The p38 MAPK stress pathway as a tumor suppressor or more? Front Biosci 13:3581-3593.
19. MacCorkle RA, Tan TH. 2005. Mitogen-activated protein kinases in cell-cycle control. Cell Biochem Biophys 43:451-461. (Pubitemid 41506881)
20. McCubrey JA, Steelman LS, Chappell WH, Abrams SL, Wong EW, Chang F, Lehmann B, Terrian DM, Milella M, Tafuri A, Stivala F, Libra M, Basecke J, Evangelisti C, Martelli AM, Franklin RA. 2007. Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance. Biochim Biophys Acta 1773:1263-1284.
21. Miyazaki H, Shiozaki A, Niisato N, Marunaka Y. 2007. Physiological significance of hypotonicity-induced regulatory volume decrease: Reduction in intracellular Cl- concentration acting as an intracellular signaling. Am J Physiol Renal Physiol 292:F1411-F1417.
22. Miyazaki H, Shiozaki A, Niisato N, Ohsawa R, Itoi H, Ueda Y, Otsuji E, Yamagishi H, Iwasaki Y, Nakano T, Nakahari T, Marunaka Y. 2008. Chloride ions control the G1/S cell-cycle checkpoint by regulating the expression of p21 through a p53-independent pathway in human gastric cancer cells. Biochem Biophys Res Commun 366:506-512.
23. Molnar A, Theodoras AM, Zon LI, Kyriakis JM. 1997. Cdc42Hs, but not Rac1, inhibits serum-stimulated cell cycle progression at G1/S through a mechanism requiring p38/RK. J Biol Chem 272:13229-13235. (Pubitemid 27216750)
24. Ohtsubo M, Theodoras AM, Schumacher J, Roberts JM, Pagano M. 1995. Human cyclin E, a nuclear protein essential for the G1-to-S phase transition. Mol Cell Biol 15:2612-2624.
25. Park JS, Qiao L, Gilfor D, Yang MY, Hylemon PB, Benz C, Darlington G, Firestone G, Fisher PB, Dent P. 2000. A role for both Ets and C/EBP transcription factors and mRNA stabilization in the MAPK-dependent increase in p21 (Cip-1/WAF1/mda6) protein levels in primary hepatocytes. Mol Biol Cell 11:2915-2932.
26. Patel R, Bartosch B, Blank JL. 1998. p21WAF1 is dynamically associatedwith JNK in human Tlymphocytes during cell cycle progression. J Cell Sci 111:2247-2255. (Pubitemid 28403529)
27. Philip B, Lu Z, Gao Y. 2005. Regulation of GDF-8 signaling by the p38 MAPK. Cell Signal 17:365-375. (Pubitemid 39574697)
28. Russell JM. 2000. Sodium-potassium-chloride cotransport. Physiol Rev 80:211-276.
29. Schonherr R. 2005. Clinical relevance of ion channels for diagnosis and therapy of cancer. J Membr Biol 205:175-184. (Pubitemid 41803694)
30. Sherr CJ, Roberts JM. 1999. CDK inhibitors: Positive and negative regulators of G1-phase progression. Genes Dev 13:1501-1512.
31. Shim J, Lee H, Park J, Kim H, Choi EJ. 1996. A non-enzymatic p21 protein inhibitor of stressactivated protein kinases. Nature 381:804-806.
32. Shiozaki A, Miyazaki H, Niisato N, Nakahari T, Iwasaki Y, Itoi H, Ueda Y, Yamagishi H, Marunaka Y. 2006. Furosemide, a blocker of Na+/K+/2Cl- cotransporter, diminishes proliferation of poorly differentiated human gastric cancer cells by affecting G0/G1 state. J Physiol Sci 56:401-406.
33. Shuba YM, Prevarskaya N, Lemonnier L, Van Coppenolle F, Kostyuk PG, Mauroy B, Skryma R. 2000. Volume-regulated chloride conductance in the LNCaP human prostate cancer cell line. Am J Physiol Cell Physiol 279:C1144-C1154.
34. Swenson KI, Winkler KE, Means AR. 2003. A new identity for MLK3 as an NIMA-related, cell cycle-regulated kinase that is localized near centrosomes and influences microtubule organization. Mol Biol Cell 14:156-172.
35. vom Dahl S, Schliess F, Graf D, Haussinger D. 2001. Role of p38(MAPK) in cell volume regulation of perfused rat liver. Cell Physiol Biochem 11:285-294.
36. Xia Z, Dickens M, Raingeaud J, Davis RJ, Greenberg ME. 1995. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270:1326-1331.
37. Zeng YX, Somasundaram K, el-Deiry WS. 1997. AP2 inhibits cancer cell growth and activates p21WAF1/CIP1 expression. Nat Genet 15:78-82.