Structures of a minimal human CFTR first nucleotide-binding domain as a monomer, head-to-tail homodimer, and pathogenic mutant

Protein Engineering, Design and Selection

Volumn 23, Issue 5, 2010, Pages 375-384

  Atwell, Shane ^a   Brouillette, Christie G ^b   Conners, Kris ^a   Emtage, Spencer ^a   Gheyi, Tarun ^a   Guggino, William B ^c   Hendle, Jorg ^a   Hunt, John F ^d   Lewis, Hal A ^f   Lu, Frances ^a   Protasevich, Irina I ^b   Rodgers, Logan A ^a   Romero, Rich ^a   Wasserman, Stephen R ^a   Weber, Patricia C ^g   Wetmore, Diana ^e   Zhang, Feiyu F ^a   Zhao, Xun ^a  

^a ELI LILLY AND COMPANY   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d Och Spine at New York Presbyterian Hospitals   (United States)

^e CYSTIC FIBROSIS FOUNDATION   (United States)

^f BRISTOL MYERS SQUIBB   (United States)

^g Imiplex   (United States)

Author keywords

F508; ABC transporter; CFTR; NBD1; Regulatory insert

Indexed keywords

ABC TRANSPORTER; ATP BINDING; BIOPHYSICAL STUDIES; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATORS; HOMODIMERS; INTRACELLULAR LOOP; MAIN EFFECT; MONOMERIC STRUCTURES; NUCLEOTIDE BINDING; NUCLEOTIDE-BINDING DOMAIN; SIGNATURE SEQUENCES; STABILIZING AGENTS; TRANS-MEMBRANE DOMAINS; WILD TYPES; X-RAY STRUCTURE;

ACTIVATION ANALYSIS; BIOLOGICAL MEMBRANES; CONFORMATIONS; MONOMERS; NUCLEOTIDES; PROTEINS;

LAWS AND LEGISLATION;

ADENOSINE TRIPHOSPHATE; TRANSMEMBRANE CONDUCTANCE REGULATOR;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CRYSTAL STRUCTURE; CRYSTALLIZATION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PURIFICATION; PROTEIN STRUCTURE;

BINDING SITES; CLONING, MOLECULAR; CRYSTALLIZATION; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; DIMERIZATION; DNA PRIMERS; HUMANS; MODELS, MOLECULAR; MUTATION; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY;

EID: 77951118320     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzq004     Document Type: Article

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