Kinetics of chemical degradation in monoclonal antibodies: Relationship between rates at the molecular and peptide levels

Analytical Chemistry

Volumn 82, Issue 8, 2010, Pages 3198-3206

  Ionescu, Roxana ^a   Vlasak, Josef ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL DEGRADATION; DATA SETS; DEGRADATION PATHWAYS; DEGRADATION RATE; FIRST ORDER REACTIONS; MODEL PREDICTION; MOLECULAR LEVELS; SIMPLE MODEL;

ALLERGIES; CHROMATOGRAPHIC ANALYSIS; MONOCLONAL ANTIBODIES; PEPTIDES; POPULATION STATISTICS; SURFACE PLASMON RESONANCE;

DEGRADATION;

MONOCLONAL ANTIBODY; PEPTIDE;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; KINETICS;

ANTIBODIES, MONOCLONAL; KINETICS; MODELS, MOLECULAR; PEPTIDES;

EID: 77951034970     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac902752e     Document Type: Article

References (35)

1. Beck, A., Wagner-Rousset, E., Bussat, M. C., Lokteff, M., Klinguer-Hamour, C., Haeuw, J. F., Goetsch, L., Wurch, T., Van Dorsselaer, A., and Corvaia, N. Curr. Pharm. Biotechnol. 2008, 9, 482-501
2. Harris, R. J., Kabakoff, B., Macchi, F. D., Shen, F. J., Kwong, M., Andya, J. D., Shire, S. J., Bjork, N., Totpal, K., and Chen, A. B. J. Chromatogr., B 2001, 752, 233-245
3. Vlasak, J., Bussat, M. C., Wang, S., Wagner-Rousset, E., Schaefer, M., Klinguer-Hamour, C., Kirchmeier, M., Corvaia, N., Ionescu, R., and Beck, A. Anal. Biochem. 2009, 392, 145-154
4. Aswad, D. W., Paranandi, M. V., and Schurter, B. T. J. Pharm. Biomed. Anal. 2000, 21, 1129-1136
5. Xiao, G., Bondarenko, P. V., Jacob, J., Chu, G. C., and Chelius, D. Anal. Chem. 2007, 79, 2714-2721
6. Wei, Z., Feng, J., Lin, H. Y., Mullapudi, S., Bishop, E., Tous, G. I., Casas-Finet, J., Hakki, F., Strouse, R., and Schenerman, M. A. Anal. Chem. 2007, 79, 2797-2805
7. Lam, X. M., Yang, J. Y., and Cleland, J. L. J. Pharm. Sci. 1997, 86, 1250-1255
8. Liu, D., Ren, D., Huang, H., Dankberg, J., Rosenfeld, R., Cocco, M. J., Li, L., Brems, D. N., and Remmele, R. L. Biochemistry 2008, 47, 5088-5100
9. Banks, D. D., Gadgil, H. S., Pipes, G. D., Bondarenko, P. V., Hobbs, V., Scavezze, J. L., Kim, J., Jiang, X. R., Mukku, V., and Dillon, T. M. J. Pharm. Sci. 2008, 97, 775-790
10. Brady, L. J., Martinez, T., and Balland, A. Anal. Chem. 2007, 79, 9403-9413
11. Yu, L., Vizel, A., Huff, M. B., Young, M., Remmele, R. L., and He, B. J. Pharm. Biomed. Anal. 2006, 42, 455-463
12. Dick, L. W., Kim, C., Qiu, D. F., and Cheng, K. C. Biotechnol. Bioeng. 2007, 97, 544-553
13. Liu, Y. D., Chen, X., Enk, J. Z., Plant, M., Dillon, T. M., and Flynn, G. C. J. Biol. Chem. 2008, 283, 29266-29272
14. Davagnino, J., Wong, C., Shelton, L., and Mankarious, S. J. Immunol. Methods 1995, 185, 177-180
15. Harris, R. J. J. Chromatogr., A 1995, 705, 129-134
16. Liu, H., Gaza-Bulseco, G., Faldu, D., Chumsae, C., and Sun, J. J. Pharm. Sci. 2008, 97, 2426-2447
17. Jenkins, N., Meleady, P., Tyther, R., and Murphy, L. Biotechnol. Appl. Biochem. 2009, 53, 73-83
18. Vlasak, J. and Ionescu, R. M. Curr. Pharm. Biotechnol. 2008, 9, 468-481
19. Valliere-Douglass, J., Wallace, A., and Balland, A. J. Chromatogr., A 2008, 1214, 81-89
20. Bilsel, O., Zitzewitz, J. A., Bowers, K. E., and Matthews, C. R. Biochemistry 1999, 38, 1018-1029
21. Ikai, A. and Tanford, C. J. Mol. Biol. 1973, 73, 145-163
22. Roberts, C. J., Darrington, R. T., and Whitley, M. B. J. Pharm. Sci. 2003, 92, 1095-1111
23. Shen, J. F., Kwong, M. Y., Keck, R. G., and Harris, R. J. Techniques in Protein Chemistry VII; Academic Press, Inc.: San Diego, CA, 1996.
24. Chu, G. C., Chelius, D., Xiao, G., Khor, H. K., Coulibaly, S., and Bondarenko, P. V. Pharm. Res. 2007, 24, 1145-1156
25. Cordoba, A. J., Shyong, B. J., Breen, D., and Harris, R. J. J. Chromatogr., B: Anal. Technol. Biomed. Life Sci. 2005, 818, 115-121
26. Cohen, S. L., Price, C., and Vlasak, J. J. Am. Chem. Soc. 2007, 129, 6976-6977
27. Perkins, M., Theiler, R., Lunte, S., and Jeschke, M. Pharm. Res. 2000, 17, 1110-1117
28. Liu, H., Gaza-Bulseco, G., and Zhou, L. J. Am. Soc. Mass Spectrom. 2009, 20, 525-528
29. Patel, K. and Borchardt, R. T. Pharm. Res. 1990, 7, 703-711
30. Sinha, S., Zhang, L., Duan, S., Williams, T. D., Vlasak, J., Ionescu, R., and Topp, E. M. Protein Sci. 2009, 18, 1573-1584
31. Robinson, N. E. and Robinson, A. B. Molecular Clocks: Deamidation of Asparaginyl and Glutaminyl Residues in Peptides and Proteins; Althouse Press: Cave Junction, OR, 2004.
32. Robinson, N. E. and Robinson, A. B. Proc. Natl. Acad. Sci. U.S.A 2001, 98, 4367-4372
33. Henderson, K. N., Tye-Din, J. A., Reid, H. H., Chen, Z., Borg, N. A., Beissbarth, T., Tatham, A., Mannering, S. I., Purcell, A. W., Dudek, N. L., van Heel, D. A., McCluskey, J., Rossjohn, J., and Anderson, R. P. Immunity 2007, 27, 23-34
34. Peters, B. and Trout, B. L. Biochemistry 2006, 45, 5384-5392
35. Capasso, S. and Di Cerbo, P. J. Pept. Res. 2000, 56, 382-387