Investigation of N-terminal glutamate cyclization of recombinant monoclonal antibody in formulation development

Journal of Pharmaceutical and Biomedical Analysis

Volumn 42, Issue 4, 2006, Pages 455-463

  Yu, Lei ^a   Vizel, Alona ^a   Huff, Mary Beth ^a   Young, Meagan ^a   Remmele Jr , Richard L ^a   He, Bing ^a  

^a AMGEN INC   (United States)

Author keywords

Cyclization; Glutamic acid; Liquid chromatography mass spectrometry; Monoclonal antibody; N Pyroglutamic acid; N terminal; Peptide mapping

Indexed keywords

GLUTAMIC ACID; MONOCLONAL ANTIBODY; PYROGLUTAMIC ACID; RECOMBINANT ANTIBODY;

ARTICLE; CYCLIZATION; DRUG FORMULATION; ENZYME KINETICS; HALF LIFE TIME; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PEPTIDE MAPPING; PH; PRIORITY JOURNAL; TEMPERATURE SENSITIVITY;

AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYCLIZATION; DRUG STABILITY; EXCIPIENTS; GLUTAMIC ACID; HYDROGEN-ION CONCENTRATION; KINETICS; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; PROTEIN DENATURATION; PYRROLIDONECARBOXYLIC ACID; RECOMBINANT PROTEINS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SURFACE-ACTIVE AGENTS; TEMPERATURE;

EID: 33748684650     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2006.05.008     Document Type: Article

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