Oxidation of N-nitrosoalkylamines by human cytochrome p450 2a6: Sequential oxidation to aldehydes and carboxylic acids and analysis of reaction steps

Journal of Biological Chemistry

Volumn 285, Issue 11, 2010, Pages 8031-8044

  Chowdhury, Goutam ^a   Calcutt, M Wade ^a   Peter Guengerich, F ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATING AGENTS; COMPETITIVE EXPERIMENTS; CONFORMATIONAL CHANGE; CYTOCHROME P450 2A6; DEALKYLATION; DEUTERIUM ISOTOPE EFFECT; DIETHYLNITROSAMINE; HUMAN CYTOCHROME; INTRINSIC KINETICS; KINETIC MODELS; REACTION STEPS; SEQUENTIAL OXIDATION; SPECTRAL ANALYSIS; SUBSTRATE BINDING; SUBSTRATE COMPLEXES;

CARBOXYLIC ACIDS; DEUTERIUM; EXPERIMENTS; HYDROCARBONS; ORGANIC ACIDS; OXIDATION; SPECTRUM ANALYSIS; SPECTRUM ANALYZERS;

ALDEHYDES;

ACETALDEHYDE; ALDEHYDE DERIVATIVE; CARBOXYLIC ACID DERIVATIVE; CYTOCHROME P450 2A6; DEUTERIUM; DIETHYLNITROSAMINE; DIMETHYLNITROSAMINE; FORMALDEHYDE; ISOTOPE; NITROSAMINE; PYRAZINE DIAZOHYDROXIDE; ALDEHYDE; CARBON; CARBOXYLIC ACID; COUMARIN 7 HYDROXYLASE; COUMARIN 7-HYDROXYLASE; DIAGNOSTIC AGENT; METHANE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNSPECIFIC MONOOXYGENASE;

ARTICLE; BINDING AFFINITY; COMPETITIVE INHIBITION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DEALKYLATION; ENZYME ACTIVATION; ENZYME SUBSTRATE COMPLEX; EQUILIBRIUM CONSTANT; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OXIDATION KINETICS; PRIORITY JOURNAL; REACTION ANALYSIS; STEADY STATE; STOICHIOMETRY; BINDING COMPETITION; CHEMICAL MODEL; CHEMISTRY; ENZYME SPECIFICITY; HUMAN; KINETICS; MASS SPECTROMETRY; METABOLISM; OXIDATION REDUCTION REACTION;

ALDEHYDES; ARYL HYDROCARBON HYDROXYLASES; BINDING, COMPETITIVE; CARBON RADIOISOTOPES; CARBOXYLIC ACIDS; DEUTERIUM; DIETHYLNITROSAMINE; DIMETHYLNITROSAMINE; HUMANS; KINETICS; MASS SPECTROMETRY; METHANE; MODELS, CHEMICAL; NADP; OXIDATION-REDUCTION; SUBSTRATE SPECIFICITY;

EID: 77950908768     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.088039     Document Type: Article

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