Quantitative production of compound I from a cytochrome P450 enzyme at low temperatures. Kinetics, activation parameters, and kinetic isotope effects for oxidation of benzyl alcohol

Journal of the American Chemical Society

Volumn 131, Issue 30, 2009, Pages 10629-10636

  Wang, Qin ^a,b   Sheng, Xin ^a   Horner, John H ^a   Newcomb, Martin ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b SOUTHWEST MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION PARAMETER; BENZYL ALCOHOL; BENZYLIC; BINDING CONSTANT; BUFFER MIXTURES; COMPOUND I; CORRESPONDING COMPOUNDS; CYTOCHROME P450; FIRST-ORDER RATE CONSTANTS; ISOTOPOMERS; KINETIC ISOTOPE EFFECTS; KINETIC STUDY; LASER FLASH PHOTOLYSIS; LOW TEMPERATURES; OXIDATION REACTIONS; PSEUDO-FIRST-ORDER RATE CONSTANT; RADICAL CATIONS; SATURATION KINETICS; VAN'T HOFF PLOTS;

ARRHENIUS PLOTS; CARRIER MOBILITY; ENZYMES; GLYCEROL; ISOTOPES; OXIDATION; PHOTOLYSIS; PORPHYRINS; RATE CONSTANTS;

SUBSTRATES;

BENZYL ALCOHOL; BUFFER; CYTOCHROME P450; CYTOCHROME P450 119; ENZYME; GLYCEROL; IRON; ISOTOPE; REAGENT; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; COMPARATIVE STUDY; COMPLEX FORMATION; ENZYME ACTIVATION; ENZYME KINETICS; ENZYME SUBSTRATE; EXPERIMENT; LASER; LIGHT; LOW TEMPERATURE; OXIDATION; PARAMETER; PHOTOLYSIS; QUANTITATIVE ANALYSIS; QUANTUM YIELD; SPECIES; TEMPERATURE DEPENDENCE;

ARCHAEAL PROTEINS; BENZYL ALCOHOL; CYTOCHROME P-450 ENZYME SYSTEM; DEUTERIUM; ENZYME ACTIVATION; ISOTOPES; KINETICS; METALLOPORPHYRINS; OXIDATION-REDUCTION; PHOTOLYSIS; SPECTRUM ANALYSIS; TEMPERATURE;

EID: 68049102299     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja9031105     Document Type: Article

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