Stereospecific deuterium substitution attenuates the tumorigenicity and metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)

Chemical Research in Toxicology

Volumn 16, Issue 6, 2003, Pages 794-806

  Jalas, John R ^a,b   McIntee, Edward J ^b   Kenney, Patrick M J ^b   Upadhyaya, Pramod ^b   Peterson, Lisa A ^b,c   Hecht, Stephen S ^b  

^a University of Minnesota   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (METHYLNITROSAMINO) 1 (3 PYRIDYL) 1 BUTANONE; 4 OXO 4 (3 PYRIDYL)BUTANAL; 6 O METHYLGUANINE; BUTYRALDEHYDE; CYTOCHROME P450 2A4; CYTOCHROME P450 2A5; CYTOCHROME P450 ISOENZYME; DEUTERIUM; DNA; NITROSAMINE; UNCLASSIFIED DRUG;

ADOLESCENT; ANIMAL CELL; ANIMAL TISSUE; ARMYWORM; ARTICLE; CARCINOGENICITY; CHIRALITY; ENZYME SUBSTRATE; FEMALE; HYDROXYLATION; ISOMER; LIQUID CHROMATOGRAPHY; LUNG CARCINOGENESIS; MASS SPECTROMETRY; METABOLIC ACTIVATION; MICROSOME; MOUSE; NONHUMAN; STEREOCHEMISTRY; STEREOSPECIFICITY; TOXICOKINETICS;

ANIMALIA; MYTHIMNA UNIPUNCTA; NICOTIANA TABACUM; SPODOPTERA; SPODOPTERA FRUGIPERDA;

EID: 0038311604     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx034022l     Document Type: Article

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