One oxidant, many pathways: A theoretical perspective of monooxygenation mechanisms by cytochrome P450 enzymes

Journal of Biological Inorganic Chemistry

Volumn 9, Issue 6, 2004, Pages 661-668

  Shaik, Sason ^a   De Visser, Samuël P ^a   Kumar, Devesh ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Compound I; Cytochrome P450; Density functional calculations; Enzyme catalysis; Two state reactivity

Indexed keywords

CYTOCHROME P450; FERRIC HYDROPEROXIDE; FERRIC ION; IRON DERIVATIVE; OXIDIZING AGENT; OXOIRON PORPHYRIN; UNCLASSIFIED DRUG;

CATALYSIS; DENSITY FUNCTIONAL THEORY; ENZYME MECHANISM; HYDROXYLATION; OXIDATION; OXYGENATION; PRIORITY JOURNAL; REVIEW;

CYTOCHROME P-450 ENZYME SYSTEM; HYDROXYLATION; METALLOPORPHYRINS; MODELS, CHEMICAL; ORGANOMETALLIC COMPOUNDS; OXIDANTS; OXIDATION-REDUCTION;

EID: 4644268354     PISSN: 09498257     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00775-004-0576-6     Document Type: Review

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