Inhibition of Akt/GSK3β signalling pathway by Legionella pneumophila is involved in induction of T-cell apoptosis

Biochemical Journal

Volumn 427, Issue 1, 2010, Pages 57-67

  Takamatsu, Reika ^a   Takeshima, Eriko ^a   Ishikawa, Chie ^a   Yamamoto, Kei ^a   Teruya, Hiromitsu ^a   Heuner, Klaus ^b   Higa, Futoshi ^a   Fujita, Jiro ^a   Mori, Naoki ^a  

^a UNIVERSITY OF THE RYUKYUS   (Japan)

^b ROBERT KOCH INSTITUTE   (Germany)

Author keywords

catenin; Akt protein kinase B; Apoptosis; Dot Icm; Flagellin; Glycogen synthase kinase 3 (GSK3 ); Legionella pneumophila

Indexed keywords

ANTI-APOPTOTIC PROTEIN; APOPTOSIS; APOPTOTIC PROTEINS; CASPASE-3; CASPASES; CAUSATIVE AGENTS; FUNCTIONAL TYPES; GLYCOGEN SYNTHASE KINASE-3; INDUCED APOPTOSIS; LEGIONELLA; LEGIONELLA PNEUMOPHILA; MOLECULAR MECHANISM; PROTEIN KINASE B; SIGNALLING PATHWAYS; T CELLS; T-CELL APOPTOSIS; TRANSCRIPTIONAL ACTIVATORS; WILD TYPES; X-LINKED INHIBITOR OF APOPTOSIS;

CHEMICAL ACTIVATION; ENZYME INHIBITION; PHOSPHORYLATION; PROTEINS;

CELL DEATH;

BETA CATENIN; CASPASE 3; CASPASE 9; FLAGELLIN; GLYCOGEN SYNTHASE KINASE 3; PROTEIN BAX; PROTEIN KINASE B; X LINKED INHIBITOR OF APOPTOSIS; GLYCOGEN SYNTHASE KINASE 3 BETA; MESSENGER RNA;

APOPTOSIS; ARTICLE; BACTERIAL PHENOMENA AND FUNCTIONS; CELL DIVISION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; HUMAN; HUMAN CELL; LEGIONELLA; LEGIONELLA PNEUMOPHILA; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TRANSCRIPTION INITIATION; TYPE IV SECRETION SYSTEM; WILD TYPE; CELL PROLIFERATION; DRUG ANTAGONISM; GENETICS; LEUKEMIA CELL LINE; METABOLISM; MICROBIOLOGY; PATHOLOGY; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

LEGIONELLA; LEGIONELLA PNEUMOPHILA;

APOPTOSIS; BLOTTING, WESTERN; CASPASE 9; CELL PROLIFERATION; FLAGELLIN; GLYCOGEN SYNTHASE KINASE 3; HUMANS; JURKAT CELLS; LEGIONELLA PNEUMOPHILA; PROTO-ONCOGENE PROTEINS C-AKT; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 77950895338     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20091768     Document Type: Article

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