Inhibition of γ-secretase by the CK1 inhibitor IC261 does not depend on CK1δ

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 9, 2010, Pages 2958-2963

  Höttecke, Nicole ^a   Liebeck, Miriam ^a   Baumann, Karlheinz ^b   Schubenel, Robert ^b   Winkler, Edith ^c   Steiner, Harald ^c   Schmidt, Boris ^a  

^a DARMSTADT UNIVERSITY OF TECHNOLOGY   (Germany)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

^c UNIVERSITY OF MUNICH   (Germany)

Author keywords

Secretase; Alzheimer's disease; Amyloid b secretion; Casein kinase 1

Indexed keywords

CARPROFEN; CASEIN KINASE I; CASEIN KINASE IDELTA; GAMMA SECRETASE; IC 261; PROTEIN SERINE THREONINE KINASE INHIBITOR; SULINDAC SULFIDE; SULINDAC SULFONE; SUNITINIB; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; NEOPLASM; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

AMYLOID PRECURSOR PROTEIN SECRETASES; BINDING SITES; CASEIN KINASE I; CASEIN KINASE IDELTA; INDOLES; PHLOROGLUCINOL; PROTEASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77950860488     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.02.110     Document Type: Article

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