Identification of novel protein kinase CK1 delta (CK1δ) inhibitors through structure-based virtual screening

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 20, 2008, Pages 5672-5675

  Cozza, Giorgio ^a   Gianoncelli, Alessandra ^a   Montopoli, Monica ^a   Caparrotta, Laura ^a   Venerando, Andrea ^a   Meggio, Flavio ^a   Pinna, Lorenzo A ^a   Zagotto, Giuseppe ^a   Moro, Stefano ^a  

^a UNIVERSITY OF PADOVA   (Italy)

Author keywords

Kinase inhibitors; Molecular docking; Protein kinase CK1 delta; Structure based virtual screening

Indexed keywords

1 HYDROXY 4 AMINOANTHRAQUINONE; 1,4 DIAMINOANTHRAQUINONE; 3 [(2,4,6 TRIMETHOXYPHENYL)METHYLIDENYL] INDOLIN 2 ONE; ANTHRAQUINONE DERIVATIVE; CISPLATIN; D 4476; IC 261; PROTEIN KINASE; PROTEIN KINASE CK1 DELTA; PROTEIN KINASE CK1 DELTA INHIBITOR; PROTEIN KINASE INHIBITOR; SERINE; THREONINE; TYROSINE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; HUMAN; HUMAN CELL; IC 50; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; STRUCTURE BASED VIRTUAL SCREENING;

ANTHRAQUINONES; CASEIN KINASE I; CHEMISTRY, PHARMACEUTICAL; COMPUTER SIMULATION; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR CONFORMATION; PHOSPHORYLATION; PROTEIN ISOFORMS; SOFTWARE; TYROSINE;

EUKARYOTA;

EID: 53349103029     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.08.072     Document Type: Article

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