Identification of Y118 amino acid residue in Candida albicans sterol 14α-demethylase associated with the enzyme activity and selective antifungal activity of azole analogues

Biological and Pharmaceutical Bulletin

Volumn 30, Issue 7, 2007, Pages 1246-1253

  Chen, Shuang Hong ^b   Sheng, Chun Quan ^a   Xu, Xiao Hui ^a   Jiang, Yuan Ying ^a   Zhang, Wan Nian ^a   He, Cheng ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b NAVAL MEDICAL RESEARCH INSTITUTE   (China)

Author keywords

Candida albicans; CYP51; Gene deletion; Inhibitor binding; Mutation

Indexed keywords

AMINO ACID; FLUCONAZOLE; LANOSTEROL; MICROSOME ENZYME; PHENYL GROUP; PYRROLE DERIVATIVE; STEROL 14ALPHA DEMETHYLASE;

AMINO ACID SUBSTITUTION; ANTIFUNGAL ACTIVITY; ARTICLE; CANDIDA ALBICANS; CATALYSIS; CONTROLLED STUDY; ENZYME ACTIVITY; FUNGAL STRAIN; GENE ACTIVITY; GENE DELETION; GENE MUTATION; MOLECULAR MODEL; MUTANT; NONHUMAN; PROTEIN ANALYSIS; PROTEIN EXPRESSION; SACCHAROMYCES CEREVISIAE; WILD TYPE;

ANTIFUNGAL AGENTS; AZOLES; BASE SEQUENCE; CANDIDA ALBICANS; CATALYSIS; CYTOCHROME P-450 ENZYME SYSTEM; FLUCONAZOLE; FUNGAL PROTEINS; MOLECULAR SEQUENCE DATA; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34447135474     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.30.1246     Document Type: Article

References (33)

1. Lupetti A., Danesi R., Campa M., Tacca M. D., Kelly S., Trends Mol. Med., 8, 76-81 (2002).
2. Lepesheva G. I., Virus C., Waterman M. R., Biochemistry, 42, 9091-9101 (2003).
3. Sheng C. Q., Zhang W. N., Ji H. T., Zhang M., Song Y. L., Xu H., Zhu J., Miao Z. Y., Yao J. H., Zhou Y. J., Lu J. G., J. Med. Chem., 46, 474-485 (2005).
4. Ji H., Zhang W., Zhou Y., Zhang M., Zhu J., Song Y., Lu J., J. Med. Chem., 43, 2493-2505 (2000).
5. Lewis D. F., Wiseman A., Tarbit M. H., J. Enzyme Inhib., 14, 175-192 (1999).
6. Li X., Madison V., Chau A. S., Loebenberg D., Palermo R. E., McNicholas P. M., Antimicrob. Agents Chemother., 48, 568-574 (2004).
7. Fukuoka T., Johnston D. A., Winslow C. A., Antimicrob. Agents Chemother., 47, 1213-1219 (2003).
8. Sheng C. Q., Zhu J., Zhang W. N., Song Y. L., Zhang M., Ji H. T., Yu J. X., Yao J. Z., Yang S., Miao Z. Y., Yaoxue Xue Bao, 39, 984-989 (2004).
9. Sheng C., Zhang W., Zhang M., Song Y., Ji H., Zhu J., Yao J., Yu J., Yang S., Zhou Y., Zhu J., Lu J., J. Biomol. Struct. Dyn., 22, 91-99 (2004).
10. Ji H., Zhang W., Zhang M., Kudo M., Aoyama Y., Yoshida Y., Sheng C., Song Y., Yang S., Zhou Y., Lu J., Zhu J., J. Med. Chem., 46, 474-485 (2003).
11. Lepesheva G. I., Podust L. M., Bellamine A., Waterman M. R., J. Biol. Chem., 276, 28413-28420 (2001).
12. Bellamine A., Mangla A. T., Dennis A. L., Nes W. D., Waterman M. R., J. Lipid Res., 42, 128-136 (2001).
13. Podust L. M., Poulos T. L., Waterman M. R., Proc. Natl. Acad. Sci. U.S.A., 98, 3068-3073 (2001).
14. Sanglard D., Kuchler K., Ischer F., Pagani J. L., Monod M., Bille J., Antimicrob. Agents Chemother., 39, 2378-2386 (1995).
15. Sanglard D., Ischer F. F., Koymans L., Bille J., Antimicrob. Agents Chemother., 42, 241-245 (1998).
16. Kelly S. L., Lamb D. C., Kelly D. E., FEMS Microbiol. Lett., 180, 171-175 (1999).
17. White T. C., Antimicrob. Agents Chemother., 41, 1488-1494 (1997).
18. Geber A., Hitchcock C. A., Swartz J. E., Pullen F. S., Marsden K. E., Kwon-Chung K. J., Bennett J. E., Antimicrob. Agents Chemother., 39, 2708-2717 (1995).
19. Francisco C. H., Maryse T., Nathalie R., Kahn S. B., Alain R., Danieále W. R., Eur. J. Biochem., 262, 435-446 (1999).
20. Lamb D. C., J. Biol. Chem., 272, 5682-5688 (1997).
21. Matsuura K., Yoshioka S., Tosha T., Hori H., Ishimori K., Kitagawa T., Morishima I., Kagawa N., Waterman M. R., J. Biol. Chem., 280, 9088-9096 (2005).
22. Asai K., Tsuchimori N., Okonogi K., Perfect J. R., Gotoh O., Yoshida Y., Antimicrob. Agents Chemother., 43, 1163-1169 (1999).
23. Lamb D. C., Kelly D. E., White T. C., Kelly S. L., Antimicrob. Agents Chemother., 44, 63-67 (2000).
24. Favre B., Didmon M., Ryder N. S., Microbiology, 145, 2715-2725 (1999).
25. Kayeya H., Inoney Sawai Y., Ikuta Y., Ohno Y., Antimicrob. Agents Chemother., 44, 2985-2990 (2000).
26. Chiatogu O., Jill R. B., Maurizio D. P., Joseph H., Antimicrob. Agents Chemother., 47, 956-964 (2003).
27. Brachmann C. B., Davies A., Cost G. J., Caputo E., Li J., Hieter P., Boeke J., Yeast, 14, 115-132 (1998).
28. Alloush H. M., Edwards T. A., Lisboa V. V., Wheals A. E., Yeast, 19, 79-86 (2002).
29. Sanglard D., Ischer F. O., Falconer D., Bille J., Antimicrob. Agents Chemother., 47, 2404-2412 (2003).
30. Bellamine A., Mangla A. T., Nes W. D., Waterman M. R., Proc. Natl. Acad. Sci. U.S.A., 96, 8937-8942 (1999).
31. Jackson C. J., Lamb D. C., Marczylo T. H., Parker J. E., Manning N. L., Kelly D. E., Kelly S. L., Biochem. Biophys. Res. Commun., 301, 558-563 (2003).
32. Aoki Y., Yoshihara F., Kondoh M., Nakamura Y., Nakayama N., Arisawa M., Antimicrob. Agents Chemother., 37, 2662-2667 (1993).
33. Matsumoto M., Ishida K., Konagai A., Maebashi K., Asaoka T., Antimicrob. Agents Chemother., 46, 308-314 (2002).