Synthesis, cleavage, and antifungal activity of a number of novel, water-soluble ester prodrugs of antifungal triazole CS-758

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 13, 2009, Pages 3559-3563

  Kagoshima, Yoshiko ^a   Mori, Makoto ^a   Suzuki, Eiko ^a   Shibayama, Takahiro ^a   Iida, Tamako ^a   Kamai, Yasuki ^a   Konosu, Toshiyuki ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

Antifungal; CS 758; Parenteral formulation; Phosphoryl ester; Prodrug

Indexed keywords

4 [4 [5 [2 (2,4 DIFLUOROPHENYL) 2 HYDROXY 1 METHYL 3 (1H 1,2,4, TRIAZOL 1 YL)PROPYLTHIO] 1,3 DIOXAN 2 YL] 1,3 BUTADIENYL] 3 FLUOROBENZONITIRLE; ANTIFUNGAL AGENT; PRODRUG; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIFUNGAL ACTIVITY; ARTICLE; CANDIDA ALBICANS; CANDIDIASIS; CONTROLLED STUDY; DRUG HALF LIFE; DRUG METABOLISM; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LIVER MICROSOME METABOLISM; MOUSE; NONHUMAN; RAT; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIFUNGAL AGENTS; CANDIDIASIS; HUMANS; MICE; MICROSOMES, LIVER; PRODRUGS; RATS; TRIAZOLES; WATER;

CANDIDA ALBICANS; MURINAE; RATTUS;

EID: 66349127609     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.04.135     Document Type: Article

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