Caffeic acid phenethyl ester inhibits nuclear factor-κB and protein kinase B signalling pathways and induces caspase-3 expression in primary human CD4+ T cells

Clinical and Experimental Immunology

Volumn 160, Issue 2, 2010, Pages 223-232

  Wang, L C ^a   Chu, K H ^b   Liang, Y C ^c   Lin, Y L ^a   Chiang, B L ^a  

^a NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Akt; Caffeic acid phenethyl ester; Caspase 3; CD4+ T cells; NF B

Indexed keywords

CAFFEIC ACID PHENETHYL ESTER; CASPASE 3; CHEMOKINE RECEPTOR CCR4; CHEMOKINE RECEPTOR CXCR3; GAMMA INTERFERON; I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 5; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE B;

ADULT; ALLERGIC DISEASE; ARTICLE; ASTHMA; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; HUMAN; HUMAN CELL; IMMUNOREGULATION; LYMPHOCYTE PROLIFERATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANTIGENS, DERMATOPHAGOIDES; ASTHMA; CAFFEIC ACIDS; CASPASE 3; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; CYTOKINES; DRUG EVALUATION, PRECLINICAL; ENZYME ACTIVATION; ENZYME INDUCTION; HUMANS; LYMPHOCYTE ACTIVATION; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHENYLETHYL ALCOHOL; PHOSPHORYLATION; PROPOLIS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, CCR4; RECEPTORS, CXCR3; SIGNAL TRANSDUCTION; T-LYMPHOCYTE SUBSETS;

EID: 77950657523     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2009.04067.x     Document Type: Article

References (49)

1. Larche M. Immunoregulation by targeting T cells in the treatment of allergy and asthma. Curr Opin Immunol 2006 18 : 745 750. (Pubitemid 44635181)
2. Williams CM, Galli SJ. The diverse potential effector and immunoregulatory roles of mast cells in allergic disease. J Allergy Clin Immunol 2000 105 : 847 859.
3. Gleich GJ, Flavahan NA, Fujisawa T, Vanhoutte PM. The eosinophil as a mediator of damage to respiratory epithelium: a model for bronchial hyperreactivity. J Allergy Clin Immunol 1988 81 : 776 781.
4. Bochner BS, Busse WW. Allergy and asthma. J Allergy Clin Immunol 2005 115 : 953 959.
5. Larche M, Robinson DS, Kay AB. The role of T lymphocytes in the pathogenesis of asthma. J Allergy Clin Immunol 2003 111 : 450 463. (Pubitemid 36337859)
6. Kay AB. The role of T lymphocytes in asthma. Chem Immunol Allergy 2006 91 : 59 75.
7. Cohn L, Elias JA, Chupp GL. Asthma: mechanisms of disease persistence and progression. Annu Rev Immunol 2004 22 : 789 815. (Pubitemid 38680442)
8. Roche WR, Beasley R, Williams JH, Holgate ST. Subepithelial fibrosis in the bronchi of asthmatics. Lancet 1989 1 : 520 524. (Pubitemid 19075206)
9. Leigh R, Ellis R, Wattie JN et al. Type 2 cytokines in the pathogenesis of sustained airway dysfunction and airway remodeling in mice. Am J Respir Crit Care Med 2004 169 : 860 867. (Pubitemid 38402464)
10. Haahtela T, Jarvinen M, Kava T et al. Effects of reducing or discontinuing inhaled budesonide in patients with mild asthma. N Engl J Med 1994 331 : 700 705. (Pubitemid 24275742)
11. Shi HZ, Deng JM, Xu H et al. Effect of inhaled interleukin-4 on airway hyperreactivity in asthmatics. Am J Respir Crit Care Med 1998 157 : 1818 1821. (Pubitemid 28311264)
12. Epstein MM. Targeting memory Th2 cells for the treatment of allergic asthma. Pharmacol Ther 2006 109 : 107 136. (Pubitemid 41742235)
13. Khayyal MT, el-Ghazaly MA, el-Khatib AS et al. A clinical pharmacological study of the potential beneficial effects of a propolis food product as an adjuvant in asthmatic patients. Fundam Clin Pharmacol 2003 17 : 93 102.
14. Sy LB, Wu YL, Chiang BL, Wang YH, Wu WM. Propolis extracts exhibit an immunoregulatory activity in an OVA-sensitized airway inflammatory animal model. Int Immunopharmacol 2006 6 : 1053 1060.
15. Chiao C, Carothers AM, Grunberger D, Solomon G, Preston GA, Barrett JC. Apoptosis and altered redox state induced by caffeic acid phenethyl ester (CAPE) in transformed rat fibroblast cells. Cancer Res 1995 55 : 3576 3583.
16. Huang MT, Ma W, Yen P et al. Inhibitory effects of caffeic acid phenethyl ester (CAPE) on 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion in mouse skin and the synthesis of DNA, RNA and protein in HeLa cells. Carcinogenesis 1996 17 : 761 765. (Pubitemid 26129690)
17. Mirzoeva OK, Calder PC. The effect of propolis and its components on eicosanoid production during the inflammatory response. Prostaglandins Leukot Essent Fatty Acids 1996 55 : 441 449.
18. Michaluart P, Masferrer JL, Carothers AM et al. Inhibitory effects of caffeic acid phenethyl ester on the activity and expression of cyclooxygenase-2 in human oral epithelial cells and in a rat model of inflammation. Cancer Res 1999 59 : 2347 2352. (Pubitemid 29242281)
19. Ahn MR, Kumazawa S, Hamasaka T, Bang KS, Nakayama T. Antioxidant activity and constituents of propolis collected in various areas of Korea. J Agric Food Chem 2004 52 : 7286 7292. (Pubitemid 38604279)
20. Liao HF, Chen YY, Liu JJ et al. Inhibitory effect of caffeic acid phenethyl ester on angiogenesis, tumor invasion, and metastasis. J Agric Food Chem 2003 51 : 7907 7912.
21. Wang LC, Lin YL, Liang YC et al. The effect of caffeic acid phenethyl ester on the functions of human monocyte-derived dendritic cells. BMC Immunol 2009 10 : 39.
22. Ansorge S, Reinhold D, Lendeckel U. Propolis and some of its constituents down-regulate DNA synthesis and inflammatory cytokine production but induce TGF-beta1 production of human immune cells. Z Naturforsch [C] 2003 58 : 580 589. (Pubitemid 36971463)
23. Natarajan K, Singh S, Burke TR Jr., Grunberger D, Aggarwal BB. Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B. Proc Natl Acad Sci USA 1996 93 : 9090 9095. (Pubitemid 26282023)
24. Orban Z, Mitsiades N, Burke TR Jr., Tsokos M, Chrousos GP. Caffeic acid phenethyl ester induces leukocyte apoptosis, modulates nuclear factor-kappa B and suppresses acute inflammation. Neuroimmunomodulation 2000 7 : 99 105. (Pubitemid 30117304)
25. Marquez N, Sancho R, Macho A, Calzado MA, Fiebich BL, Munoz E. Caffeic acid phenethyl ester inhibits T-cell activation by targeting both nuclear factor of activated T-cells and NF-kappaB transcription factors. J Pharmacol Exp Ther 2004 308 : 993 1001. (Pubitemid 38263975)
26. Crabtree GR, Clipstone NA. Signal transmission between the plasma membrane and nucleus of T lymphocytes. Annu Rev Biochem 1994 63 : 1045 1083. (Pubitemid 24218655)
27. Hart LA, Krishnan VL, Adcock IM, Barnes PJ, Chung KF. Activation and localization of transcription factor, nuclear factor-kappaB, in asthma. Am J Respir Crit Care Med 1998 158 : 1585 1592. (Pubitemid 28536624)
28. Gloire G, Legrand-Poels S, Piette J. NF-kappaB activation by reactive oxygen species: fifteen years later. Biochem Pharmacol 2006 72 : 1493 1505. (Pubitemid 44666727)
29. Bonizzi G, Karin M. The two NF-kappaB activation pathways and their role in innate and adaptive immunity. Trends Immunol 2004 25 : 280 288. (Pubitemid 38610351)
30. Choi K, Choi C. Differential regulation of c-Jun N-terminal kinase and NF-kappaB pathway by caffeic acid phenethyl ester in astroglial and monocytic cells. J Neurochem 2008 105 : 557 564. (Pubitemid 351490025)
31. Ha J, Choi HS, Lee Y, Lee ZH, Kim HH. Caffeic acid phenethyl ester inhibits osteoclastogenesis by suppressing NF kappaB and downregulating NFATc1 and c-Fos. Int Immunopharmacol 2009 9 : 774 780.
32. Dodeller F, Schulze-Koops H. The p38 mitogen-activated protein kinase signaling cascade in CD4 T cells. Arthritis Res Ther 2006 8 : 205.
33. Chan CB, Ye K. PIKE GTPase are phosphoinositide-3-kinase enhancers, suppressing programmed cell death. J Cell Mol Med 2007 11 : 39 53. (Pubitemid 46439624)
34. DeWire SM, Ahn S, Lefkowitz RJ, Shenoy SK. Beta-arrestins and cell signaling. Annu Rev Physiol 2007 69 : 483 510.
35. Brennan P, Babbage JW, Burgering BM, Groner B, Reif K, Cantrell DA. Phosphatidylinositol 3-kinase couples the interleukin-2 receptor to the cell cycle regulator E2F. Immunity 1997 7 : 679 689. (Pubitemid 28156635)
36. Burgering BM, Kops GJ. Cell cycle and death control: long live Forkheads. Trends Biochem Sci 2002 27 : 352 360.
37. Shigeoka Y, Igishi T, Matsumoto S et al. Sulindac sulfide and caffeic acid phenethyl ester suppress the motility of lung adenocarcinoma cells promoted by transforming growth factor-beta through Akt inhibition. J Cancer Res Clin Oncol 2004 130 : 146 152. (Pubitemid 38392347)
38. Lee ES, Lee JO, Lee SK et al. Caffeic acid phenethyl ester accumulates beta-catenin through GSK-3beta and participates in proliferation through mTOR in C2C12 cells. Life Sci 2009 84 : 755 759.
39. Mantovani A, Sica A, Sozzani S, Allavena P, Vecchi A, Locati M. The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol 2004 25 : 677 686. (Pubitemid 39457982)
40. Sallusto F, Lenig D, Mackay CR, Lanzavecchia A. Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes. J Exp Med 1998 187 : 875 883. (Pubitemid 28141661)
41. Viola A, Contento RL, Molon B. T cells and their partners: the chemokine dating agency. Trends Immunol 2006 27 : 421 427. (Pubitemid 44216192)
42. Panina-Bordignon P, Papi A, Mariani M et al. The C-C chemokine receptors CCR4 and CCR8 identify airway T cells of allergen-challenged atopic asthmatics. J Clin Invest 2001 107 : 1357 1364. (Pubitemid 32522029)
43. Kallinich T, Schmidt S, Hamelmann E et al. Chemokine-receptor expression on T cells in lung compartments of challenged asthmatic patients. Clin Exp Allergy 2005 35 : 26 33. (Pubitemid 40188266)
44. Medina-Tato DA, Watson ML, Ward SG. Leukocyte navigation mechanisms as targets in airway diseases. Drug Discov Today 2006 11 : 866 879.
45. Iellem A, Mariani M, Lang R et al. Unique chemotactic response profile and specific expression of chemokine receptors CCR4 and CCR8 by CD4(+)CD25(+) regulatory T cells. J Exp Med 2001 194 : 847 853. (Pubitemid 32983019)
46. Cohen GM. Caspases: the executioners of apoptosis. Biochem J 1997 326 : 1 16.
47. Jin UH, Song KH, Motomura M et al. Caffeic acid phenethyl ester induces mitochondria-mediated apoptosis in human myeloid leukemia U937 cells. Mol Cell Biochem 2008 310 : 43 8.
48. Chen YJ, Shiao MS, Hsu ML, Tsai TH, Wang SY. Effect of caffeic acid phenethyl ester, an antioxidant from propolis, on inducing apoptosis in human leukemic HL-60 cells. J Agric Food Chem 2001 49 : 5615 5619. (Pubitemid 33089716)
49. Gerke V, Moss SE. Annexins: from structure to function. Physiol Rev 2002 82 : 331 371. (Pubitemid 34654456)