Propolis and some of its constituents down-regulate DNA synthesis and inflammatory cytokine production but induce TGF-β1 production of human immune cells

Zeitschrift fur Naturforschung - Section C Journal of Biosciences

Volumn 58, Issue 7-8, 2003, Pages 580-589

  Ansorge, Siegfried ^a   Reinhold, Dirk ^a   Lendeckel, Uwe ^a  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

Cytokines; Immune Cells; Propolis

Indexed keywords

APINAE; APOIDEA; PROPOLIS;

EID: 0041655892     PISSN: 09395075     EISSN: None     Source Type: Journal    
DOI: 10.1515/znc-2003-7-823     Document Type: Article

References (35)

1. Banskota A. H., Tezuka Y., Prasain J. K., Matsushige K., Saiki I., and Kadota S. (1998), Chemical constituents of Brazilian propolis and their cytotoxic activities. J. Nat. Prod. 61, 896-900.
2. Banskota A. H., Tezuka Y., and Kadota S. (2001), Recent progress in pharmacological research of propolis. Phytother. Res. 15, 561-571.
3. Boyum A. (1968), Isolation of mononuclear cells and granulocytes from human blood. Scand. J. Clin. Lab., Invest. 97, 77-89.
4. Brätter C., Tregel M., Liebenthal C., and Volk H.-D. (1999), Prophylaktische Wirkungen von Propolis zur Immunstimulation: eine klinische Pilotstudie. Forsch. Komplementärmed. 6, 256-260.
5. Bretz W. A., Chiego Jr. D. J., Marcucci M. C., Cunha I., Custodio A., and Schneider L. G. (1998), Preliminary report on the effects of propolis on wound healing in the dental pulp. Z. Naturforsch. 53c, 1045-1048.
6. Burdock G. A. (1998), Review of the biological properties and toxicity of bee propolis (propolis). Food. Chem. Toxicol. 36,347-363.
7. Danielpour D. (1993), Improved sandwich enzyme-linked immunosorbent assays for transforming growth factor-beta 1. J. Immunol. Methods 158, 17-25.
8. Fitzpatrick L. R., Wang J., Le T. (2001), Caffeic acid phenethyl ester, an inhibitor of nuclear factor kappaB, attenuates bacterial peptidoglycan polysaccharide-induced colitis in rats. J. Pharmacol. Exp. Ther. 299, 915-920.
9. Greeneway W., Scaysbrook T., Whatley F. R. (1990), The composition and plant origins of propolis: a report of work at Oxford. Bee World 71, 107-118.
10. Guardia T.,Rotelli A. E., Juarez A. O., and Pelzer L. E. (2001), Anti-inflammatory properties of plant flavonoids. Effects of rutin, quercetin and hesperidin on adjuvant arthritis in rat. Il Farmaco 56, 683-687.
11. Han S. H., Yea S. S., Jeon Y. J., Yang K-H., and Kaminski N. E. (1998), Transforming growth factor-beta 1 (TGF-β1) promotes IL-2 mRNA expression through the up-regulation of NF-κB, AP-1 and NF-AT in EL4 cells1. J. Pharmacol.Experim. Therapeutics 287, 1105-1112.
12. Hardy K. and Chaudhri G. (1997), Activation and signal transduction via mitogen-activated protein (MAP) kinases in T lymphocytes. Immunol. and Cell Biol. 75, 528-545.
13. Hegazi A. G., Abd El Hady F. K., and Abd Allah F. A. (2000), Chemical composition and antimicrobial activity of European propolis. Z. Naturforsch. 55c, 70-75.
14. Ivanovska N. D., Dimov V. B., Bankova V. S., and Popov S. S. (1995), Immunomodulatory action of propolis. VI. Influence of a water soluble derivative on complement activity in vivo. J. Ethnopharmacol. 47, 145-147.
15. Julius M. H., Simpson E., and Herzenberg, L. A. (1973), A rapid method fort he isolation of functional thymus-derived murine lymphocytes. Eur. J. Immunol. 3, 645-649.
16. Krol W., Scheller S., Czuba Z., Matsuno T., Zydowicz G., Shani J., and Mos M. (1996), Inhibition of neutrophils' chemiluminescence by ethanol extract of propolis (EEP) and its phenolic components. J. Ethnopharmacol. 55, 19-25.
17. Ledón N., Casacó A., González R., Merino N., González A., and Tolón Z. (1997), Antipsoriatic, anti-inflammatory, and analgesic effects of an extract of red propolis. Acta Pharm. Sinica 18, 274-276.
18. Levings M. K. and Roncarolo M.-G. (2000), T-regulatory 1 cells: A novel subset of CD4+ T cells with immunoregulatory properties. J. Allergy Clin. Immunol. 106, 109-112.
19. Menezes H., Alvarez J. M., and Almeida E. (1999), Mouse ear edema modulation by different propolis ethanol extracts. Arzneimittelforsch. 49, 705-707.
20. Mirzoeva O. K. and Calder P. C. (1996), The effect of propolis and its components on eicosanoid production during the inflammatory response. Prostagland. Leukot. Essent. Fatty Acids 55, 441-449.
21. Natarajan K., Singh S., Burke Jr., T. R., Grunberger D., and Aggarwal B. B. (1996), Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-KB. Proc. Natl. Acad. Sci. USA 93, 9090-9095.
22. Park E. H. and Kahng J. H. (1999), Suppressive effects of propolis in rat adjuvant arthritis Arch. Pharm. Res. 22, 554-558.
23. Peterson J. and Dwyer J. (1998), Flavonoids: Dietary occurrence and biochemical activity. Nutrition Res. 18, 1995-2018.
24. Reinhold D., Bank U., Bühling F., Neubert K., Mattern T., Ulmer A. J., Flad H.-D., and Ansorge S. (1993), Dipeptidyl peptidase IV (CD26) on human lymphocytes. Synthetic inhibitors of and antibodies against dipeptidyl peptidase IV suppress the proliferation of pokeweed mitogen-stimulated peripheral blood mononuclear cells and IL-2 and IL-6 production. Immunobiology 188, 403-414.
25. Reinhold D., Bank U., Bühling F., Lendeckel U., Faust J., Neubert K., and Ansorge S. (1997), Inhibitors of dipeptidyl peptidase IV (DP IV, CD26) induces secretion of Transforming Growth Factor-β1 (TGF-β1) in PWM-stimulated PBMC and T cells. Immunology 91, 354-360.
26. Reinhold D., Bank U., Bühling F., Täger M., Born I., Faust J., Neubert K., and Ansorge S. (1997), Inhibitors of dipeptidyl peptidase IV (DP IV, CD26) induces secretion of Transforming Growth Factor-β1 (TGF-β1) in stimulated mouse splenocytes and thymocytes. Immunol. Lett. 58, 29-35.
27. Reinhold D., Bank U., Bühling F., Junker U., Kekow J., Schleicher E., and Ansorge S. (1997), A detailed protocol for the measurement of TGF-β1 in human blood samples. J. Immunol. Methods 209, 203-206.
28. Rennick D. M., Fort M. M., and Davidson N. J. (1997), Studies with IL-10-/-mice: an overview. J. Leukocyte Biol. 61, 389-396.
29. Romagnani S. (1994), Lymphokine production by human T cells in disease states. Annu. Rev. Immunol. 12, 227-257.
30. Sakaguchi S. (2000), Regulatory T cells: Key controllers of immunologic self-tolerance. Cell. 101, 455-458.
31. Shull M. M., Ormsby I., Kier A. B., Pawlowski S., Diebold R. J., Yin M., Allen R., Sidman C., Proetzel G., Calvin D., Annunziata N., and Doetschman T. (1992), Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease. Nature 359, 693-699.
32. Song Y. S., Park E. H., Hur G. M., Ryu Y. S., Lee Y. S., Lee J. Y., Kim Y. M., and Jin C. (2002), Caffeic acid phenethyl ester inhibits nitric oxide synthase gene expression and enzyme activity. Cancer. Lett. 10, 53-61.
33. Sud'ina G. F., Mirzoeva O. K., Pushkareva M. A., Korshunova G. A., Sumbatyan N. V., and Varfolomeev S. D. (1993), Caffeic acid phenethyl ester as a lipoxygenase inhibitor with antioxidant properties. FEBS Lett. 329, 21-24.
34. Vennat B., Arvouet-Grand A., and Pourrat A. (1998), Skin healing preparations: compared in vitro diffusion of the active ingredients. Drug. Dev. Ind. Pharm. 24, 253-260.
35. Volpert R. and Elstner E. F. (1993), Biochemical activities of propolis extracts. I. Standardization and antioxidative properties of ethanolic and aqueous derivatives. Z. Naturforsch. 48c. 851-857.