Caffeic Acid Phenethyl Ester Inhibits T-Cell Activation by Targeting Both Nuclear Factor of Activated T-Cells and NF-κB Transcription Factors

Journal of Pharmacology and Experimental Therapeutics

Volumn 308, Issue 3, 2004, Pages 993-1001

  Márquez, Nieves ^a   Sancho, Rocío ^a   Macho, Antonio ^a   Calzado, Marco A ^a   Fiebich, Bernd L ^b,c   Muñoz, Eduardo ^a  

^a Universidad de Cordoba   (Spain)

^b UNIVERSITY OF FREIBURG   (Germany)

^c VIVACELL BIOTECHNOLOGY GMBH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CAFFEIC ACID PHENETHYL ESTER; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 2; IONOMYCIN; LUCIFERASE; PHENOL DERIVATIVE; PHORBOL 13 ACETATE 12 MYRISTATE; PROPOLIS; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR NFAT;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; BEE EXTRACT; CONTROLLED STUDY; CYTOFLUOROMETRY; CYTOKINE RELEASE; DNA BINDING; GEL MOBILITY SHIFT ASSAY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOMODULATION; INFLAMMATION; LEUKEMIA CELL LINE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEPHOSPHORYLATION; T LYMPHOCYTE ACTIVATION; TRANSCRIPTION REGULATION; WESTERN BLOTTING;

CAFFEIC ACIDS; CELL CYCLE; CELL DIVISION; DNA-BINDING PROTEINS; HUMANS; INTERLEUKIN-2; JURKAT CELLS; LYMPHOCYTE ACTIVATION; NF-KAPPA B; NFATC TRANSCRIPTION FACTORS; NUCLEAR PROTEINS; PHENYLETHYL ALCOHOL; PHOSPHORYLATION; PROMOTER REGIONS (GENETICS); T-LYMPHOCYTES; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS;

EID: 1342280967     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.103.060673     Document Type: Article

References (41)

1. Ansorge S, Reinhold D, and Lendeckel U (2003) Propolis and some of its constituents down-regulate DNA synthesis and inflammatory cytokine production but induce TGF-beta1 production of human immune cells. Z Naturforsch [C] 58:580-589.
2. Baier G (2003) The PKC gene module: molecular biosystematics to resolve its T-cell functions. Immunol Rev 192:64-79.
3. Chiao C, Carothers AM, Grunberger D, Solomon G, Preston GA, and Barrett JC (1995) Apoptosis and altered redox state induced by caffeic acid phenethyl ester (CAPE) in transformed rat fibroblast cells. Cancer Res 55:3576-3583.
4. Chiao PJ, Miyamoto S, and Verma IM (1994) Autoregulation of I kappa B alpha activity. Proc Natl Acad Sci USA 91:28-32.
5. Crabtree GR and Clipstone NA (1994) Signal transmission between the plasma membrane and nucleus of T lymphocytes. Annu Rev Biochem 63:1045-1083.
6. de Gregorio R, Iñiguez MA, Fresno M, and Alemany S (2001) Cot kinase induces cyclooxygenase-2 expression in T-cells through activation of the nuclear factor of activated T-cells. J Biol Chem 276:27003-27009.
7. Dinkova-Kostova AT, Massiah MA, Bozak RE, Hicks RJ, and Talalay P (2001) Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups. Proc Natl Acad Sci USA 98:3404-3409.
8. Durand DB, Shaw JP, Bush MR, Replogle RE, Belagaje R, and Crabtree GR (1988) Characterization of antigen receptor response elements within the interleukin-2 enhancer. Mol Cell Biol 8:1715-1724.
9. Edmead CE, Patel YI, Wilson A, Boulougouris G, Hall ND, Ward SG, and Sansom DM (1996) Induction of activator protein (AP)-1 and nuclear factor-kappaB by CD28 stimulation involves both phosphatidylinositol 3-kinase and acidic sphingomyelinase signals. J Immunol 157:3290-3297.
10. Fitzpatrick LR, Wang J, and Le T (2001) Caffeic acid phenethyl ester, an inhibitor of nuclear factor-kappaB, attenuates bacterial peptidoglycan polysaccharide-induced colitis in rats. J Pharmacol Exp Ther 299:915-920.
11. Garcia-Piñeres AJ, Castro V, Mora G, Schmidt TJ, Strunck E, Pahl HL, and Merfort I (2001) Cysteine 38 in p65/NF-kappaB plays a crucial role in DNA binding inhibition by sesquiterpene lactones. J Biol Chem 276:39713-39720.
12. Goldberg J, Huang HB, Kwon YG, Greengard P, Nairn AC, and Kuriyan J (1995) Three-dimensional structure of the catalytic subunit of protein serine/threonine phosphatase-1. Nature (Lond) 376:745-753.
13. Hernandez GL, Volpert OV, Iñiguez MA, Lorenzo E, Martinez-Martinez S, Grau R, Fresno M, and Redondo JM (2001) Selective inhibition of vascular endothelial growth factor-mediated angiogenesis by cyclosporin A: roles of the nuclear factor of activated T-cells and cyclooxygenase 2. J Exp Med 193:607-620.
14. Huang MT, Ma W, Yen P, Xie JG, Han J, Frenkel K, Grunberger D, and Conney AH (1996) Inhibitory effects of caffeic acid phenethyl ester (CAPE) on 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion in mouse skin and the synthesis of DNA, RNA and protein in HeLa cells. Carcinogenesis 17:761-765.
15. Iñiguez MA, Martinez-Martinez S, Punzon C, Redondo JM, and Fresno M (2000) An essential role of the nuclear factor of activated T-cells in the regulation of the expression of the cyclooxygenase-2 gene in human T lymphocytes. J Biol Chem 275:23627-23635.
16. Karin M and Ben-Neriah Y (2000) Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. Annu Rev Immunol 18:621-663.
17. Kiani A, Rao A, and Aramburu J (2000) Manipulating immune responses with immunosuppressive agents that target NFAT. Immunity 12:359-372.
18. Lewis RS (2001) Calcium signaling mechanisms in T lymphocytes. Annu Rev Immunol 19:497-521.
19. Luo C, Burgeon E, and Rao A (1996) Mechanisms of transactivation by nuclear factor of activated T-cells-1. J Exp Med 184:141-147.
20. Macian F, Lopez-Rodriguez C, and Rao A (2001) Partners in transcription: NFAT and AP-1. Oncogene 20:2476-2489.
21. Maggirwar SB, Harhaj EW, and Sun SC (1997) Regulation of the interleukin-2 CD28-responsive element by NFATp and various NF-kappaB/Rel transcription factors. Mol Cell Biol 17:2605-2614.
22. Marrack P and Kappler J (1990) The staphylococcal enterotoxins and their relatives. Science (Wash DC) 248:705-711.
23. Michaluart P, Masferrer JL, Carothers AM, Subbaramaiah K, Zweifel BS, Koboldt C, Mestre JR, Grunberger D, Sacks PG, Tanabe T, et al. (1999) Inhibitory effects of caffeic acid phenethyl ester on the activity and expression of cyclooxygenase-2 in human oral epithelial cells and in a rat model of inflammation. Cancer Res 59:2347-2352.
24. Mirzoeva OK and Calder PC (1996) The effect of propolis and its components on eicosanoid production during the inflammatory response. Prostaglandins Leukotrienes Essent Fatty Acids 55:441-449.
25. Nagaoka T, Banskota AH, Tezuka Y, Midorikawa K, Matsushige K, and Kadota S (2003) Caffeic acid phenethyl ester (CAPE) analogues: potent nitric oxide inhibitors from the Netherlands propolis. Biol Pharm Bull 26:487-491.
26. Natarajan K, Singh S, Burke TR, Jr., Grunberger D, and Aggarwal BB (1996) Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B. Proc Natl Acad Sci USA 93:9090-9095.
27. Nishi T, Shimizu N, Hiramoto M, Sato I, Yamaguchi Y, Hasegawa M, Aizawa S, Tanaka H, Kataoka K, Watanabe H, and Handa H (2002) Spatial redox regulation of a critical cysteine residue of NF-kappa B in vivo. J Biol Chem 277:44548-44556.
28. Rao A, Luo C, and Hogan PG (1997) Transcription factors of the NFAT family: regulation and function. Annu Rev Immunol 15:707-747.
29. Reiter TA, Abraham RT, Choi M, and Rusnak F (1999) Redox regulation of calcineurin in T-lymphocytes. J Biol Inorg Chem 4:632-644.
30. Sancho R, Calzado MA, Di Marzo V, Appendino G, and Muñoz E (2003) Anandamide inhibits nuclear factor-kappaB activation through a cannabinoid receptor-independent pathway. Mol Pharmacol 63:429-438.
31. Schmitz ML, dos Santos Silva MA, and Baeuerle PA (1995) Transactivation domain 2 (TA2) of p65 NF-kappa B. Similarity to TA1 and phorbol ester-stimulated activity and phosphorylation in intact cells. J Biol Chem 270:15576-15584.
32. Shaw JP, Utz PJ, Durand DB, Toole JJ, Emmel EA, and Crabtree GR (1988) Identification of a putative regulator of early T-cell activation genes. Science (Wash DC) 241:202-205.
33. Sommer D, Fakata KL, Swanson SA, and Stemmer PM (2000) Modulation of the phosphatase activity of calcineurin by oxidants and antioxidants in vitro. Eur J Biochem 267:2312-2322.
34. Song YS, Park EH, Hur GM, Ryu YS, Lee YS, Lee JY, Kim YM, and Jin C (2002) Caffeic acid phenethyl ester inhibits nitric oxide synthase gene expression and enzyme activity. Cancer Lett 175:53-61.
35. Sullivan DC and Bicknell R (2003) New molecular pathways in angiogenesis. Br J Cancer 89:228-231.
36. Tan RY, Mabuchi Y, and Grabarek Z (1996) Blocking the Ca2+-induced conformational transitions in calmodulin with disulfide bonds. J Biol Chem 271:7479-7483.
37. Vermeulen L, De Wilde G, Notebaert S, Vanden Berghe W, and Haegeman G (2002) Regulation of the transcriptional activity of the nuclear factor-kappaB p65 subunit. Biochem Pharmacol 64:963-970.
38. Weiss A and Littman DR (1994) Signal transduction by lymphocyte antigen receptors. Cell 76:263-274.
39. Woods JM, Mogollon A, Amin MA, Martinez RJ, and Koch AE (2003) The role of COX-2 in angiogenesis and rheumatoid arthritis. Exp Mol Pathol 74:282-290.
40. Yamamoto Y, Verma UN, Prajapati S, Kwak YT, and Gaynor RB (2003) Histone H3 phosphorylation by IKK-alpha is critical for cytokine-induced gene expression. Nature (Lond) 423:655-659.
41. Yano O, Kanenopoulos J, Kieran M, Le Bail O, Israel A, and Kourilsky P (1987) Purification of KBF1, a common factor binding to both H-2 and beta 2-microglobulin enhancers. EMBO (Eur Mol Biol Organ) J 6:3317-3324.