Chemokine-receptor expression on T cells in lung compartments of challenged asthmatic patients

Clinical and Experimental Allergy

Volumn 35, Issue 1, 2005, Pages 26-33

  Kallinich, Tilmann ^a,b   Schmidt, S ^c,d   Hamelmann, E ^a   Fischer, A ^a   Qin, S ^e   Luttmann, W ^d   Virchow, J C ^d   Kroczek, R A ^b  

^a HUMBOLDT UNIVERSITY   (Germany)

^b ROBERT KOCH INSTITUTE   (Germany)

^c UNIVERSITY OF OLDENBURG   (Germany)

^d ROSTOCK UNIVERSITY MEDICAL CENTER   (Germany)

^e MILLENNIUM PHARMACEUTICALS INC   (United States)

Author keywords

Bronchial hyper reactivity; Chemokines; Chemotaxis; Leucocyte; Segmental allergen challenge

Indexed keywords

ALLERGEN; CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CCR4; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CCR6; CHEMOKINE RECEPTOR CCR7; CHEMOKINE RECEPTOR CXCR3;

ADULT; ARTICLE; ASTHMA; BRONCHUS HYPERREACTIVITY; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; INFLAMMATION; LEUKOCYTE MIGRATION; LUNG ALVEOLUS; LUNG LAVAGE; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROVOCATION TEST; RESPIRATORY TRACT MUCOSA; SUBMUCOSA; T LYMPHOCYTE;

ADULT; ASTHMA; BRONCHI; BRONCHIAL HYPERREACTIVITY; BRONCHIAL PROVOCATION TESTS; BRONCHOALVEOLAR LAVAGE FLUID; CASE-CONTROL STUDIES; CHEMOTAXIS, LEUKOCYTE; FEMALE; FLOW CYTOMETRY; HUMANS; LUNG; MALE; PULMONARY ALVEOLI; RECEPTORS, CHEMOKINE; T-LYMPHOCYTES;

EID: 13244279525     PISSN: 09547894     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2222.2004.02132.x     Document Type: Article

References (56)

1. Azzawi M, Bradley B, Jeffery PK et al. Identification of activated T lymphocytes and eosinophils in bronchial biopsies in stable atopic asthma. Am Rev Respir Dis 1990; 142:1407-13.
2. Gavett SH, Chen X, Finkelman F, Wills-Karp M. Depletion of murine CD4+ T lymphocytes prevents antigen-induced airway hyperreactivity and pulmonary eosinophilia. Am J Respir Cell Mol Biol 1994; 10:587-93.
3. Krug N, Tschernig T, Holgate S, Pabst R. How do lymphocytes get into the asthmatic airways? Lymphocyte traffic into and within the lung in asthma. Clin Exp Allergy 1998; 28:10-8.
4. Moser B, Loetscher P. Lymphocyte traffic control by chemokines. Nat Immunol 2001; 2:123-8.
5. Mackay CR. Chemokines: immunology's high impact factors. Nat Immunol 2001; 2:95-101.
6. Lamkhioued B, Garcia-Zepeda EA, Abi-Younes S et al. Monocyte chemoattractant protein (MCP)-4 expression in the airways of patients with asthma. Induction in epithelial cells and mononuclear cells by proinflammatory cytokines. Am J Respir Crit Care Med 2000; 162:723-32.
7. Miotto D, Christodoulopoulos P, Olivenstein R et al. Expression of IFN-gamma-inducible protein; monocyte chemotactic proteins 1, 3, and 4; and eotaxin in TH1- and TH2-mediated lung diseases. J Allergy Clin Immunol 2001; 107:664-70.
8. Powell N, Humbert M, Durham SR, Assoufi B, Kay AB, Corrigan CJ. Increased expression of mRNA encoding RANTES and MCP-3 in the bronchial mucosa in atopic asthma. Eur Respir J 1996; 9:2454-60.
9. Folkard SG, Westwick J, Millar AB. Production of interleukin-8, RANTES and MCP-1 in intrinsic and extrinsic asthmatics. Eur Respir J 1997; 10:2097-104.
10. Berin MC, Eckmann L, Broide DH, Kagnoff MF. Regulated production of the T helper 2-type T-cell chemoattractant TARC by human bronchial epithelial cells in vitro and in human lung xenografts. Am J Respir Cell Mol Biol 2001; 24:382-9.
11. Rozyk KJ, Plusa T, Kuna P, Pirozynska E. Monocyte chemotactic and activating factor/monocyte chemoattractant protein in bronchoalveolar lavage fluid from patients with atopic asthma and chronic bronchitis. Relationship to lung function tests, bronchial hyper-responsiveness and cytology of bronchoalveolar lavage fluid. Immunol Lett 1997; 58:47-52.
12. Tillie-Leblond I, Hammad H, Desurmont S et al. CC chemokines and interleukin-5 in bronchial lavage fluid from patients with status asthmaticus. Potential implication in eosinophil recruitment. Am J Respir Crit Care Med 2000; 162:586-92.
13. Berkman N, Ohnona S, Chung FK, Breuer R. Eotaxin-3 but not eotaxin gene expression is upregulated in asthmatics 24h after allergen challenge. Am J Respir Cell Mol Biol 2001; 24:682-7.
14. Holgate ST, Bodey KS, Janezic A, Frew AJ, Kaplan AP, Teran LM. Release of RANTES, MIP-1 alpha, and MCP-1 into asthmatic airways following endobronchial allergen challenge. Am J Respir Crit Care Med 1997; 156:1377-83.
15. Teran LM, Noso N, Carroll M, Davies DE, Holgate S, Schroder JM. Eosinophil recruitment following allergen challenge is associated with the release of the chemokine RANTES into asthmatic airways. J Immunol 1996; 157:1806-12.
16. Ying S, Meng Q, Zeibecoglou K et al. Eosinophil chemotactic chemokines (eotaxin, eotaxin-2, RANTES, monocyte chemoattractant protein-3 (MCP-3), and MCP-4), and C-C chemokine receptor 3 expression in bronchial biopsies from atopic and nonatopic (intrinsic) asthmatics. J Immunol 1999; 163:6321-9.
17. Nouri-Aria KT, Wilson D, Francis JN et al. CCR4 in human allergen-induced late responses in the skin and lung. Eur J Immunol 2002; 32:1933-8.
18. Panina-Bordignon P, Papi A, Mariani M et al. The C-C chemokine receptors CCR4 and CCR8 identify airway T cells of allergen-challenged atopic asthmatics. J Clin Invest 2001; 107:1357-64.
19. International consensus report on diagnosis and treatment of asthma. National Heart, Lung, and Blood Institute, National Institutes of Health. Bethesda, Maryland 20892. Publication no. 92-3091, March 1992. Eur Respir J 1992; 5:601-41.
20. Virchow JC Jr, Julius P, Matthys H, Kroegel C, Luttmann W. CD14 expression and soluble CD14 after segmental allergen provocation in atopic asthma. Eur Respir J 1998; 11:317-23.
21. Virchow JC Jr., Walker C, Hafner D et al. T cells and cytokines in bronchoalveolar lavage fluid after segmental allergen provocation in atopic asthma. Am J Respir Crit Care Med 1995; 151:960-8.
22. Luttmann W, Herzog V, Virchow JC Jr., Matthys H, Thierauch KH, Kroegel C. Prostacyclin modulates granulocyte/macrophage colony-stimulating factor release by human blood mononuclear cells. Pulm Pharmacol 1996; 9:43-8.
23. Ponath PD, Kassam N, Qin S. Monoclonal antibodies to chemokine receptors. Methods Mol Biol 2000; 138:231-42.
24. Beier KC, Hutloff A, Dittrich AM et al. Induction, binding specificity and function of human ICOS. Eur J Immunol 2000; 30:3707-17.
25. Mages HW, Hutloff A, Heuck C et al. Molecular cloning and characterization of murine ICOS and identification of B7h as ICOS ligand. Eur J Immunol 2000; 30:1040-7.
26. Cordell JL, Falini B, Erber WN et al. Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes). J Histochem Cytochem 1984; 32:219-29.
27. Campbell JJ, Brightling CE, Symon FA et al. Expression of chemokine receptors by lung T cells from normal and asthmatic subjects. J Immunol 2001; 166:2842-8.
28. Qin S, Rottman JB, Myers P et al. The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions. J Clin Invest 1998; 101:746-54.
29. Kunkel EJ, Boisvert J, Murphy K et al. Expression of the chemokine receptors CCR4, CCR5, and CXCR3 by human tissue-infiltrating lymphocytes. Am J Pathol 2002; 160:347-55.
30. Campbell JJ, Haraldsen G, Pan J et al. The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells. Nature 1999; 400:776-80.
31. Vestergaard C, Bang K, Gesser B, Yoneyama H, Matsushima K, Larsen CG. A Th2 chemokine, TARC, produced by keratinocytes may recruit CLA+CCR4+lymphocytes into lesional atopic dermatitis skin. J Invest Dermatol 2000; 115:640-6.
32. Rottman JB, Smith TL, Ganley KG, Kikuchi T, Krueger JG. Potential role of the chemokine receptors CXCR3, CCR4, and the integrin alphaEbeta7 in the pathogenesis of psoriasis vulgaris. Lab Invest 2001; 81:335-47.
33. Liao F, Rabin RL, Smith CS, Sharma G, Nutman TB, Farber JM. CC-chemokine receptor 6 is expressed on diverse memory subsets of T cells and determines responsiveness to macrophage inflammatory protein 3 alpha. J Immunol 1999; 162:186-94.
34. Franci C, Gosling J, Tsou CL, Coughlin SR, Charo IF. Phosphorylation by a G protein-coupled kinase inhibits signaling and promotes internalization of the monocyte chemoattractant protein-1 receptor. Critical role of carboxyl-tail serines/threonines in receptor function. J Immunol 1996; 157:5606-12.
35. Zimmermann N, Rothenberg ME. Receptor internalization is required for eotaxin-induced responses in human eosinophils. J Allergy Clin Immunol 2003; 111:97-105.
36. Inngjerdingen M, Damaj B, Maghazachi AA. Human NK cells express CC chemokine receptors 4 and 8 and respond to thymus and activation-regulated chemokine, macrophage-derived chemokine, and I-309. J Immunol 2000; 164:4048-54.
37. Mack M, Luckow B, Nelson PJ et al. Aminooxypentane-RANTES induces CCR5 internalization but inhibits recycling: a novel inhibitory mechanism of HIV infectivity. J Exp Med 1998; 187:1215-24.
38. Bardi G, Lipp M, Baggiolini M, Loetscher P. The T cell chemokine receptor CCR7 is internalized on stimulation with ELC, but not with SLC. Eur J Immunol 2001; 31:3291-7.
39. Loetscher P, Pellegrino A, Gong JH et al. The ligands of CXC chemokine receptor 3, I-TAC, Mig, and IP10, are natural antagonists for CCR3. J Biol Chem 2001; 276:2986-91.
40. Forster R, Kremmer E, Schubel A et al. Intracellular and surface expression of the HIV-1 coreceptor CXCR4/fusin on various leukocyte subsets: rapid internalization and recycling upon activation. J Immunol 1998; 160:1522-31.
41. Liu LY, Jarjour NN, Busse WW, Kelly EA. Chemokine receptor expression on human eosinophils from peripheral blood and bronchoalveolar lavage fluid after segmental antigen challenge. J Allergy Clin Immunol 2003; 112:556-62.
42. Sekiya T, Miyamasu M, Imanishi M et al. Inducible expression of a Th2-type CC chemokine thymus- and activation-regulated chemokine by human bronchial epithelial cells. J Immunol 2000; 165:2205-13.
43. Bonecchi R, Bianchi G, Bordignon PP et al. Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s. J Exp Med 1998; 187:129-34.
44. Sallusto F, Lenig D, Mackay CR, Lanzavecchia A. Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes. J Exp Med 1998; 187:875-83.
45. Forster R, Schubel A, Breitfeld D et al. CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs. Cell 1999; 99:23-33.
46. Lloyd CM, Delaney T, Nguyen T et al. CC chemokine receptor (CCR)3/eotaxin is followed by CCR4/monocyte-derived chemokine in mediating pulmonary T helper lymphocyte type 2 recruitment after serial antigen challenge in vivo. J Exp Med 2000; 191:265-74.
47. Bocchino V, Bertorelli G, Bertrand CP et al. Eotaxin and CCR3 are up-regulated in exacerbations of chronic bronchitis. Allergy 2002; 57:17-22.
48. Sallusto F, Schaerli P, Loetscher P et al. Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturation. Eur J Immunol 1998; 28:2760-9.
49. Qin S, LaRosa G, Campbell JJ et al. Expression of monocyte chemoattractant protein-1 and interleukin-8 receptors on subsets of T cells: correlation with transendothelial chemotactic potential. Eur J Immunol 1996; 26:640-7.
50. Heath H, Qin S, Rao P et al. Chemokine receptor usage by human eosinophils. The importance of CCR3 demonstrated using an antagonistic monoclonal antibody. J Clin Invest 1997; 99: 178-84.
51. Andrew DP, Ruffing N, Kim CH et al. C-C chemokine receptor 4 expression defines a major subset of circulating nonintestinal memory T cells of both Th1 and Th2 potential. J Immunol 2001; 166:103-11.
52. Wu L, LaRosa G, Kassam N et al. Interaction of chemokine receptor CCR5 with its ligands: multiple domains for HIV-1 gp120 binding and a single domain for chemokine binding. J Exp Med 1997; 186:1373-81.
53. Sallusto F, Kremmer E, Palermo B et al. Switch in chemokine receptor expression upon TCR stimulation reveals novel homing potential for recently activated T cells. Eur J Immunol 1999; 29:2037-45.
54. Campbell JJ, Murphy KE, Kunkel EJ et al. CCR7 expression and memory T cell diversity in humans. J Immunol 2001; 166:877-84.
55. Bleul CC, Wu L, Hoxie JA, Springer TA, Mackay CR. The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes. Proc Natl Acad Sci USA 1997; 94:1925-30.
56. Forster R, Mattis AE, Kremmer E, Wolf E, Brem G, Lipp M. A putative chemokine receptor, BLRI, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen. Cell 1996; 87:1037-47.