Inhibitory Effect of Caffeic Acid Phenethyl Ester on Angiogenesis, Tumor Invasion, and Metastasis

Journal of Agricultural and Food Chemistry

Volumn 51, Issue 27, 2003, Pages 7907-7912

  Liao, Hui Fen ^a,b   Chen, Yu Ywan ^c   Liu, Jun Jen ^d   Hsu, Ming Ling ^a   Shieh, Hui Ju ^a   Liao, Hung Jen ^a   Shieh, Chwen Jen ^e   Shiao, Ming Shi ^b   Chen, Yu Jen ^a,f  

^a MACKAY MEMORIAL HOSPITAL   (Taiwan)

^b TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^c NATIONAL KAOHSIUNG UNIVERSITY OF APPLIED SCIENCES   (Taiwan)

^d NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^e DA YEH UNIVERSITY   (Taiwan)

^f CHINESE CULTURE UNIVERSITY   (Taiwan)

Author keywords

Angiogenesis; CAPE (caffeic acid phenethyl ester); Human umbilical vein endothelial cell; Matrix metalloproteinase; Metastasis; Tumor invasion; Vascular endothelial growth factor

Indexed keywords

ANGIOGENESIS INHIBITOR; CAFFEIC ACID PHENETHYL ESTER; GELATINASE A; GELATINASE B; MATRIGEL; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD LEVEL; CANCER INVASION; CELL VIABILITY; COLON ADENOCARCINOMA; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG CYTOTOXICITY; HONEYBEE; HUMAN; HUMAN CELL; LUNG METASTASIS; MALE; METASTASIS; METASTASIS INHIBITION; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SURVIVAL; TRADITIONAL MEDICINE;

ADENOCARCINOMA; ANIMALS; CAFFEIC ACIDS; CELL DIVISION; CELL SURVIVAL; COLONIC NEOPLASMS; ENDOTHELIAL CELLS; HUMANS; MICE; MICE, INBRED BALB C; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; NEOPLASM TRANSPLANTATION; NEOVASCULARIZATION, PATHOLOGIC; PHENYLETHYL ALCOHOL; UMBILICAL VEINS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

ANIMALIA; APIS MELLIFERA; PROPOLIS;

EID: 0346336175     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf034729d     Document Type: Article

References (36)

1. Son, S.; Lewis, B. A. Free radical scavenging and antioxidative activity of caffeic acid amide and ester analogues: Structure-activity relationship. J. Agric. Food Chem. 2002, 50, 468-472.
2. Koltuksuz, U.; Mutus, H. M.; Kutlu, R.; Ozyurt, H.; Cetin, S.; Karaman, A.; Gurbuz, N.; Akyol, O.; Aydin, N. E. Effects of caffeic acid phenethyl ester and epidermal growth factor on the development of caustic esophageal stricture in rats. J. Pediatr. Surg. 2001, 36, 1504-1509.
3. Michaluart, P.; Masferrer, J. L.; Carothers, A. M.; Subbaramaiah, K.; Zweifel, B. S.; Koboldt, C.; Mestre, J. R.; Grunberger, D.; Sacks, P. G.; Tanabe, T.; Dannenberg, A. J. Inhibitory effects of caffeic acid phenethyl ester on the activity and expression of cyclooxygenase-2 in human oral epithelial cells and in a rat model of inflammation. Cancer Res. 1999, 59, 2347-2352.
4. Borrelli, F.; Izzo, A. A.; Di Carlo, G.; Maffia, P.; Russo, A.; Maiello, F. M.; Capasso, F.; Mascolo, N. Effect of a propolis extract and caffeic acid phenethyl ester on formation of aberrant crypt foci and tumors in the rat colon. Fitoterapia 2002, 73, S38-S43.
5. Hepsen, I. F.; Bayramlar, H.; Gultek, A.; Ozen, S.; Tilgen, F.; Evereklioglu, C. Caffeic acid phenethyl ester to inhibit posterior capsule opacification in rabbits. J. Catar. Refract. Surg. 1997, 23, 1572-1576.
6. Doganay, S.; Turkoz, Y.; Evereklioglu, C.; Er, H.; Bozaran, M.; Ozerol, E. Use of caffeic acid phenethyl ester to prevent sodium-selenite-induced cataract in rat eyes. J. Catar. Refract. Surg. 2002, 28, 1457-1462.
7. Totan, Y.; Aydin, E.; Cekic, O.; Cihan Dagloglu, M.; Borazan, M.; Daglioglu, K.; Gultek, A. Effect of caffeic acid phenethyl ester on corneal neovascularization in rats. Curr. Eye Res. 2001, 23, 291-297.
8. Li, D.; Saldeen, T.; Romeo, F.; Mehta, J. L. Oxidized LDL upregulates angiotensin II type 1 receptor expression in cultured human coronary artery endothelial cells: The potential role of transcription factor NF-kappaB. Circulation 2000, 102, 1970-1976.
9. Ozyurt, H.; Irmak, M. K.; Akyol, O.; Sogut, S. Caffeic acid phenethyl ester changes the indices of oxidative stress in serum of rats with renal ischaemia-reperfusion injury. Cell Biochem. Funct. 2001, 19, 259-263.
10. Mahmoud, N. N.; Carothers, A. M.; Grunberger, D.; Bilinski, R. T.; Churchill, M. R.; Martucci, C.; Newmark, H. L.; Bertagnolli, M. M. Plant phenolics decrease intestinal tumors in an animal model of familial adenomatous polyposis. Carcinogenesis 2000, 21, 921-927.
11. Lee, Y. J.; Liao, P. H.; Chen, W. K.; Yang, C. Y. Preferential cytotoxicity of caffeic acid phenethyl ester analogues on oral cancer cells. Cancer Lett. 2000, 153, 51-56.
12. Lee, S. K.; Song, L.; Mata-Greenwood, E.; Kelloff, G. J.; Steele, V. E.; Pezzuto, J. M. Modulation of in vitro biomarkers of the carcinogenic process by chemopreventive agents. Anticancer Res. 1999, 19, 35-44.
13. Bhimani, R. S.; Troll, W.; Grunberger, D.; Frenkel, K. Inhibition of oxidative stress in HeLa cells by chemopreventive agents. Cancer Res. 1993, 53, 4528-4533.
14. Chen, Y. J.; Shiao, M. S.; Wang, S. Y. The anti-oxidant caffeic acid phenethyl ester induces apoptosis associated with selective scavenging of hydrogen peroxide in human leukemic HL-60 cells. Anti-cancer Drug 2001, 12, 143-149.
15. Chen, Y. J.; Shiao, M. S.; Hsu, M. L.; Tsai, T. H.; Wang, S. Y. Induction of apoptosis by caffeic acid phenethyl ester through activation of caspase-3, downregulation of bcl-2 and upregulation of Bax in human leukemic HL-60 cells. J. Agri. Food Chem. 2001, 49, 5615-5619.
16. Tonini, T.; Rossi, F.; Claudio, P. P. Molecular basis of angiogenesis and cancer. Oncogene 2003, 22, 6549-6556.
17. Yang, S. H.; Lin, J. K.; Chen, W. S.; Chiu, J. H. Anti-angiogenic effect of silymarin on colon cancer lovo cell line. J. Surg. Res. 2003, 113, 133-138.
18. Folkman, J. Angiogenesis inhibitors: A new class of drugs. Cancer Biol. Ther. 2003, 2 (4 Suppl 1), S127-S133.
19. Owen, J. L.; Iragavarapu-Charyulu, V.; Gunja-Smith, Z.; Herbert, L. M.; Grosso, J. F.; Lopez, D. M. Up-regulation of matrix metalloproteinase-9 in T lymphocytes of mammary tumor bearers: Role of vascular endothelial growth factor. J. Immunol. 2003, 171, 4340-4351.
20. Novak, E. M.; Metzger, M.; Chammas, R.; Da Costa, M.; Dantas, K.; Manabe, C.; Pires, J.; De Oliveira, A. C.; Bydlowski, S. P. Downregulation of TNF-alpha and VEGF expression by Sp1 decoy oligodeoxynucleotides in mouse melanoma tumor. Gene Ther. 2003, 10, 1992-1997.
21. Song, S. H.; Wientjes, M. G.; Walsh, C.; Au, J. L. S. Nontoxic dose of suramin enhance activity of paclitaxel against lung metastases. Cancer Res. 2001, 61, 6145-6150.
22. Bogenrieder, T.; Herlyn, M. Axis of evil: Molecular mechanisms of cancer metastasis. Oncogene 2003, 22, 6524-6536.
23. Mosmann, T. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J. Immunol. Methods 1983, 69, 55-63.
24. Bhagwat, S. V.; Lahdenranta, J.; Giordano, R.; Arap, W.; Pasqualini, R.; Shapiro, L. H. CD13/APN is activated by angiogenic signals and is essential for capillary tube formation. Blood 2001, 97, 652-659.
25. Duchossoy, Y.; Arnaud, S.; Feldblum, S. Matrix metalloproteinases: Potential therapeutic target in spinal cord injury. Clin. Chem. Lab. Med. 2001, 39, 362-367.
26. Song, Y. S.; Park, E. H.; Jung, K. J.; Jin, C. Inhibition of angiogenesis by propolis. Arch. Pharm. Res. 2002, 25, 500-504.
27. Boedefeld, W. M., 2nd; Bland, K. I.; Heslin, M. J. Recent insights into angiogenesis, apoptosis, invasion, and metastasis in colorectal carcinoma. Ann. Surg. Oncol. 2003, 10, 839-851.
28. Lamszus, K.; Kunkel, P.; Westphal, M. Invasion as limitation to anti-angiogenic glioma therapy. Acta Neurochir. Suppl. 2003, 88, 169-177.
29. Stetler-Stevenson, W. G.; Aznavoorian, S.; Liotta, L. A. Tumor cell interactions with the extracellular matrix during invasion and metastasis. Annu. Rev. Cell Biol. 1993, 9, 541-573.
30. John, A.; Tuszynski, G. The role of matrix metalloproteinases in tumor angiogenesis and tumor metastasis. Pathol. Oncol. Res. 2001, 7, 14-23.
31. Khasigov, P. Z.; Podobed, O. V.; Gracheva, T. S.; Salbiev, K. D.; Grachev, S. V.; Berezov, T. T. Role of matrix metalloproteinases and their inhibitors in tumor invasion and metastasis. Biochemistry (Moscow) 2003, 68, 711-717.
32. Oku, N.; Matsukawa, M.; Yamakawa, S.; Asai, T.; Yahara, S.; Hashimoto, F.; Akizawa, T. Inhibitory effect of green tea polyphenols on membrane-type 1 matrix metalloproteinase, MT1-MMP. Biol. Pharm. Bull. 2003, 26, 1235-1238.
33. Maeda-Yamamoto, M.; Kawahara, H.; Tahara, N.; Tsuji, K.; Hara, Y.; Isemura, M. Effects of tea polyphenols on the invasion and matrix metalloproteinases activities of human fibrosarcoma HT1080 cells. J. Agric. Food Chem. 1999, 47, 2350-2354.
34. Weyant, M. J.; Carothers, A. M.; Bertagnolli, M. E.; Bertagnolli, M. M. Colon cancer chemopreventive drugs modulate integrin-mediated signaling pathways. Clin. Cancer Res. 2000, 6, 949-956.
35. Chiao, C.; Carothers, A.; Grunberger, D.; Solomon, G.; Preston, G.; Barrch, J. Apoptosis and altered redox state induced by caffeic acid phenethyl ester (CAPE) in transformed rat fibroblast cells. Cancer Res. 1995, 55, 3576-3583.
36. Koltuksuz, U.; Ozen, S.; Uz, E.; Aydinc, M.; Karaman, A.; Gultek, A.; Akyol, O.; Gursoy, M. H.; Aydin, E. Caffeic acid phenethyl ester prevents intestinal reperfusion injury in rats. J. Pediatr. Surg. 1999, 34, 1458-1462.