-
1
-
-
44449085539
-
Paul Ehrlich's magic bullet concept: 100 years of progress
-
10.1038/nrc2394, 18469827
-
Strebhardt K, Ullrich A. Paul Ehrlich's magic bullet concept: 100 years of progress. Nat Rev Cancer 2008, 8:473-480. 10.1038/nrc2394, 18469827.
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 473-480
-
-
Strebhardt, K.1
Ullrich, A.2
-
2
-
-
33749073242
-
An anniversary for cancer chemotherapy
-
10.1001/jama.296.12.1518, 17003400
-
Hirsch J. An anniversary for cancer chemotherapy. JAMA 2006, 296:1518-1520. 10.1001/jama.296.12.1518, 17003400.
-
(2006)
JAMA
, vol.296
, pp. 1518-1520
-
-
Hirsch, J.1
-
3
-
-
0021754941
-
Landmark article Sept. 21, 1946: Nitrogen mustard therapy. Use of methyl-bis(beta-chloroethyl)amine hydrochloride and tris(beta-chloroethyl)amine hydrochloride for Hodgkin's disease, lymphosarcoma, leukemia and certain allied and miscellaneous disorders
-
10.1001/jama.251.17.2255, 6368885
-
Goodman L. Landmark article Sept. 21, 1946: Nitrogen mustard therapy. Use of methyl-bis(beta-chloroethyl)amine hydrochloride and tris(beta-chloroethyl)amine hydrochloride for Hodgkin's disease, lymphosarcoma, leukemia and certain allied and miscellaneous disorders. JAMA 1984, 251:2255-2261. 10.1001/jama.251.17.2255, 6368885.
-
(1984)
JAMA
, vol.251
, pp. 2255-2261
-
-
Goodman, L.1
-
4
-
-
78651010566
-
Temporary remissions in acute leukemia in children produced by folic antagonist, 4-aminopteroylglutamic acid (aminopterin)
-
Farber S, Diamond L, Mercer R, Sylvester R, Wolff J. Temporary remissions in acute leukemia in children produced by folic antagonist, 4-aminopteroylglutamic acid (aminopterin). N Engl J Med 1948, 238:787-793.
-
(1948)
N Engl J Med
, vol.238
, pp. 787-793
-
-
Farber, S.1
Diamond, L.2
Mercer, R.3
Sylvester, R.4
Wolff, J.5
-
5
-
-
0003183507
-
The chemistry and biochemistry of purine analogs
-
10.1111/j.1749-6632.1954.tb40008.x, 14350523
-
Hitchings G, Elion G. The chemistry and biochemistry of purine analogs. Ann NY Acad Sci 1954, 60:195-199. 10.1111/j.1749-6632.1954.tb40008.x, 14350523.
-
(1954)
Ann NY Acad Sci
, vol.60
, pp. 195-199
-
-
Hitchings, G.1
Elion, G.2
-
6
-
-
0000502679
-
The vinca alkaloids: a new class of oncolytic agents
-
Johnson IS, Armstrong JG, Gorman M, Burnett JP. The vinca alkaloids: a new class of oncolytic agents. Cancer Res 1963, 23:1390-1427.
-
(1963)
Cancer Res
, vol.23
, pp. 1390-1427
-
-
Johnson, I.S.1
Armstrong, J.G.2
Gorman, M.3
Burnett, J.P.4
-
7
-
-
0000909726
-
A comparative study of two regimens of combination chemotherapy in acute leukemia
-
Frei E. A comparative study of two regimens of combination chemotherapy in acute leukemia. Blood 1958, 13:1126-1148.
-
(1958)
Blood
, vol.13
, pp. 1126-1148
-
-
Frei, E.1
-
8
-
-
0015069359
-
A new anti-oestrogenic agent in late breast cancer. An early clinical appraisal of ICI46474
-
2008453, 5115829
-
Cole MP, Jones CT, Todd ID. A new anti-oestrogenic agent in late breast cancer. An early clinical appraisal of ICI46474. Br J Cancer 1971, 25:270-275. 2008453, 5115829.
-
(1971)
Br J Cancer
, vol.25
, pp. 270-275
-
-
Cole, M.P.1
Jones, C.T.2
Todd, I.D.3
-
9
-
-
0000358195
-
Case of hypertrophy of the spleen and liver in which death took place from suppuration of the blood
-
Bennett J. Case of hypertrophy of the spleen and liver in which death took place from suppuration of the blood. Edinburgh Med Surgical J 1845, 64:413-423.
-
(1845)
Edinburgh Med Surgical J
, vol.64
, pp. 413-423
-
-
Bennett, J.1
-
10
-
-
0033869862
-
The story of chronic myeloid leukaemia
-
10.1046/j.1365-2141.2000.02137.x, 10930974
-
Geary CG. The story of chronic myeloid leukaemia. Br J Haematol 2000, 110:2-11. 10.1046/j.1365-2141.2000.02137.x, 10930974.
-
(2000)
Br J Haematol
, vol.110
, pp. 2-11
-
-
Geary, C.G.1
-
11
-
-
0000286732
-
A minute chromosome in human chronic granulocytic leukemia
-
Nowell P, Hungerford D. A minute chromosome in human chronic granulocytic leukemia. Science 1960, 132:1497.
-
(1960)
Science
, vol.132
, pp. 1497
-
-
Nowell, P.1
Hungerford, D.2
-
12
-
-
0015694748
-
Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining
-
10.1038/243290a0, 4126434
-
Rowley JD. Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. Nature 1973, 243:290-293. 10.1038/243290a0, 4126434.
-
(1973)
Nature
, vol.243
, pp. 290-293
-
-
Rowley, J.D.1
-
13
-
-
0014837635
-
Lymphosarcoma: virus-induced thymic-independent disease in mice
-
Abelson HT, Rabstein LS. Lymphosarcoma: virus-induced thymic-independent disease in mice. Cancer Res 1970, 30:2213-2222.
-
(1970)
Cancer Res
, vol.30
, pp. 2213-2222
-
-
Abelson, H.T.1
Rabstein, L.S.2
-
14
-
-
0019127191
-
Structure of the Abelson murine leukemia virus genome and the homologous cellular gene: studies with cloned viral DNA
-
10.1016/0092-8674(80)90554-1, 6257398
-
Goff SP, Gilboa E, Witte ON, Baltimore D. Structure of the Abelson murine leukemia virus genome and the homologous cellular gene: studies with cloned viral DNA. Cell 1980, 22:777-785. 10.1016/0092-8674(80)90554-1, 6257398.
-
(1980)
Cell
, vol.22
, pp. 777-785
-
-
Goff, S.P.1
Gilboa, E.2
Witte, O.N.3
Baltimore, D.4
-
15
-
-
0020333906
-
A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia
-
10.1038/300765a0, 6960256
-
de Klein A, van Kessel AG, Grosveld G, Bartram CR, Hagemeijer A, Bootsma D, Spurr NK, Heisterkamp N, Groffen J, Stephenson JR. A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia. Nature 1982, 300:765-767. 10.1038/300765a0, 6960256.
-
(1982)
Nature
, vol.300
, pp. 765-767
-
-
de Klein, A.1
van Kessel, A.G.2
Grosveld, G.3
Bartram, C.R.4
Hagemeijer, A.5
Bootsma, D.6
Spurr, N.K.7
Heisterkamp, N.8
Groffen, J.9
Stephenson, J.R.10
-
16
-
-
0021346853
-
Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22
-
10.1016/0092-8674(84)90077-1, 6319012
-
Groffen J, Stephenson JR, Heisterkamp N, de Klein A, Bartram CR, Grosveld G. Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22. Cell 1984, 36:93-99. 10.1016/0092-8674(84)90077-1, 6319012.
-
(1984)
Cell
, vol.36
, pp. 93-99
-
-
Groffen, J.1
Stephenson, J.R.2
Heisterkamp, N.3
de Klein, A.4
Bartram, C.R.5
Grosveld, G.6
-
17
-
-
0021802841
-
Fused transcript of abl and bcr genes in chronic myelogenous leukaemia
-
10.1038/315550a0, 2989692
-
Shtivelman E, Lifshitz B, Gale RP, Canaani E. Fused transcript of abl and bcr genes in chronic myelogenous leukaemia. Nature 1985, 315:550-554. 10.1038/315550a0, 2989692.
-
(1985)
Nature
, vol.315
, pp. 550-554
-
-
Shtivelman, E.1
Lifshitz, B.2
Gale, R.P.3
Canaani, E.4
-
18
-
-
0019428315
-
Evidence that the Abelson virus protein functions in vivo as a protein kinase that phosphorylates tyrosine
-
10.1073/pnas.78.3.1552, 319169, 6262813
-
Sefton BM, Hunter T, Raschke WC. Evidence that the Abelson virus protein functions in vivo as a protein kinase that phosphorylates tyrosine. Proc Natl Acad Sci USA 1981, 78:1552-1556. 10.1073/pnas.78.3.1552, 319169, 6262813.
-
(1981)
Proc Natl Acad Sci USA
, vol.78
, pp. 1552-1556
-
-
Sefton, B.M.1
Hunter, T.2
Raschke, W.C.3
-
19
-
-
0021674862
-
An alteration of the human c-abl protein in K562 leukemia cells unmasks associated tyrosine kinase activity
-
10.1016/0092-8674(84)90438-0, 6204766
-
Konopka JB, Watanabe SM, Witte ON. An alteration of the human c-abl protein in K562 leukemia cells unmasks associated tyrosine kinase activity. Cell 1984, 37:1035-1042. 10.1016/0092-8674(84)90438-0, 6204766.
-
(1984)
Cell
, vol.37
, pp. 1035-1042
-
-
Konopka, J.B.1
Watanabe, S.M.2
Witte, O.N.3
-
20
-
-
0025209916
-
Acute leukaemia in bcr/abl transgenic mice
-
10.1038/344251a0, 2179728
-
Heisterkamp N, Jenster G, ten Hoeve J, Zovich D, Pattengale PK, Groffen J. Acute leukaemia in bcr/abl transgenic mice. Nature 1990, 344:251-253. 10.1038/344251a0, 2179728.
-
(1990)
Nature
, vol.344
, pp. 251-253
-
-
Heisterkamp, N.1
Jenster, G.2
ten Hoeve, J.3
Zovich, D.4
Pattengale, P.K.5
Groffen, J.6
-
21
-
-
0025117392
-
Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome
-
10.1126/science.2406902, 2406902
-
Daley GQ, Van Etten RA, Baltimore D. Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome. Science 1990, 247:824-830. 10.1126/science.2406902, 2406902.
-
(1990)
Science
, vol.247
, pp. 824-830
-
-
Daley, G.Q.1
Van Etten, R.A.2
Baltimore, D.3
-
22
-
-
3242804413
-
Biology of chronic myelogenous leukemia-signaling pathways of initiation and transformation
-
vii-viii., 10.1016/j.hoc.2004.03.008, 15271392
-
Melo JV, Deininger MW. Biology of chronic myelogenous leukemia-signaling pathways of initiation and transformation. Hematol Oncol Clin North Am 2004, 18:545-568. vii-viii., 10.1016/j.hoc.2004.03.008, 15271392.
-
(2004)
Hematol Oncol Clin North Am
, vol.18
, pp. 545-568
-
-
Melo, J.V.1
Deininger, M.W.2
-
23
-
-
0024240990
-
Blocking of EGF-dependent cell proliferation by EGF receptor kinase inhibitors
-
10.1126/science.3263702, 3263702
-
Yaish P, Gazit A, Gilon C, Levitzki A. Blocking of EGF-dependent cell proliferation by EGF receptor kinase inhibitors. Science 1988, 242:933-935. 10.1126/science.3263702, 3263702.
-
(1988)
Science
, vol.242
, pp. 933-935
-
-
Yaish, P.1
Gazit, A.2
Gilon, C.3
Levitzki, A.4
-
24
-
-
0025191918
-
Regulation of pp60c-src and its interaction with polyomavirus middle T antigen in insect cells
-
249044, 2152834
-
Piwnica-Worms H, Williams NG, Cheng SH, Roberts TM. Regulation of pp60c-src and its interaction with polyomavirus middle T antigen in insect cells. J Virol 1990, 64:61-68. 249044, 2152834.
-
(1990)
J Virol
, vol.64
, pp. 61-68
-
-
Piwnica-Worms, H.1
Williams, N.G.2
Cheng, S.H.3
Roberts, T.M.4
-
25
-
-
0029947186
-
Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells
-
10.1038/nm0596-561, 8616716
-
Druker BJ, Tamura S, Buchdunger E, Ohno S, Segal GM, Fanning S, Zimmermann J, Lydon NB. Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nat Med 1996, 2:561-566. 10.1038/nm0596-561, 8616716.
-
(1996)
Nat Med
, vol.2
, pp. 561-566
-
-
Druker, B.J.1
Tamura, S.2
Buchdunger, E.3
Ohno, S.4
Segal, G.M.5
Fanning, S.6
Zimmermann, J.7
Lydon, N.B.8
-
26
-
-
0035810147
-
Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
-
10.1056/NEJM200104053441401, 11287972
-
Druker BJ, Talpaz M, Resta DJ, Peng B, Buchdunger E, Ford JM, Lydon NB, Kantarjian H, Capdeville R, Ohno-Jones S, Sawyers CL. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med 2001, 344:1031-1037. 10.1056/NEJM200104053441401, 11287972.
-
(2001)
N Engl J Med
, vol.344
, pp. 1031-1037
-
-
Druker, B.J.1
Talpaz, M.2
Resta, D.J.3
Peng, B.4
Buchdunger, E.5
Ford, J.M.6
Lydon, N.B.7
Kantarjian, H.8
Capdeville, R.9
Ohno-Jones, S.10
Sawyers, C.L.11
-
27
-
-
0035800507
-
Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification
-
10.1126/science.1062538, 11423618
-
Gorre ME, Mohammed M, Ellwood K, Hsu N, Paquette R, Rao PN, Sawyers CL. Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification. Science 2001, 293:876-880. 10.1126/science.1062538, 11423618.
-
(2001)
Science
, vol.293
, pp. 876-880
-
-
Gorre, M.E.1
Mohammed, M.2
Ellwood, K.3
Hsu, N.4
Paquette, R.5
Rao, P.N.6
Sawyers, C.L.7
-
28
-
-
0037199996
-
Analysis of the structural basis of specificity of inhibition of the Abl kinase by STI571
-
10.1074/jbc.M111525200, 12077114
-
Corbin AS, Buchdunger E, Pascal F, Druker BJ. Analysis of the structural basis of specificity of inhibition of the Abl kinase by STI571. J Biol Chem 2002, 277:32214-32219. 10.1074/jbc.M111525200, 12077114.
-
(2002)
J Biol Chem
, vol.277
, pp. 32214-32219
-
-
Corbin, A.S.1
Buchdunger, E.2
Pascal, F.3
Druker, B.J.4
-
29
-
-
0034665713
-
Structural mechanism for STI-571 inhibition of abelson tyrosine kinase
-
10.1126/science.289.5486.1938, 10988075
-
Schindler T, Bornmann W, Pellicena P, Miller WT, Clarkson B, Kuriyan J. Structural mechanism for STI-571 inhibition of abelson tyrosine kinase. Science 2000, 289:1938-1942. 10.1126/science.289.5486.1938, 10988075.
-
(2000)
Science
, vol.289
, pp. 1938-1942
-
-
Schindler, T.1
Bornmann, W.2
Pellicena, P.3
Miller, W.T.4
Clarkson, B.5
Kuriyan, J.6
-
30
-
-
13844251975
-
Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl
-
10.1016/j.ccr.2005.01.007, 15710326
-
Weisberg E, Manley PW, Breitenstein W, Bruggen J, Cowan-Jacob SW, Ray A, Huntly B, Fabbro D, Fendrich G, Hall-Meyers E, Kung AL, Mestan J, Daley GQ, Callahan L, Catley L, Cavazza C, Azam M, Neuberg D, Wright RD, Gilliland DG, Griffin JD. Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl. Cancer Cell 2005, 7:129-141. 10.1016/j.ccr.2005.01.007, 15710326.
-
(2005)
Cancer Cell
, vol.7
, pp. 129-141
-
-
Weisberg, E.1
Manley, P.W.2
Breitenstein, W.3
Bruggen, J.4
Cowan-Jacob, S.W.5
Ray, A.6
Huntly, B.7
Fabbro, D.8
Fendrich, G.9
Hall-Meyers, E.10
Kung, A.L.11
Mestan, J.12
Daley, G.Q.13
Callahan, L.14
Catley, L.15
Cavazza, C.16
Azam, M.17
Neuberg, D.18
Wright, R.D.19
Gilliland, D.G.20
Griffin, J.D.21
more..
-
31
-
-
19944428353
-
Discovery of N-(2-chloro-6-methyl-phenyl)-2-(6-(4-(2-hydroxyethyl)-piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays
-
10.1021/jm049486a, 15615512
-
Lombardo LJ, Lee FY, Chen P, Norris D, Barrish JC, Behnia K, Castaneda S, Cornelius LA, Das J, Doweyko AM, Fairchild C, Hunt JT, Inigo I, Johnston K, Kamath A, Kan D, Klei H, Marathe P, Pang S, Peterson R, Pitt S, Schieven GL, Schmidt RJ, Tokarski J, Wen ML, Wityak J, Borzilleri RM. Discovery of N-(2-chloro-6-methyl-phenyl)-2-(6-(4-(2-hydroxyethyl)-piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays. J Med Chem 2004, 47:6658-6661. 10.1021/jm049486a, 15615512.
-
(2004)
J Med Chem
, vol.47
, pp. 6658-6661
-
-
Lombardo, L.J.1
Lee, F.Y.2
Chen, P.3
Norris, D.4
Barrish, J.C.5
Behnia, K.6
Castaneda, S.7
Cornelius, L.A.8
Das, J.9
Doweyko, A.M.10
Fairchild, C.11
Hunt, J.T.12
Inigo, I.13
Johnston, K.14
Kamath, A.15
Kan, D.16
Klei, H.17
Marathe, P.18
Pang, S.19
Peterson, R.20
Pitt, S.21
Schieven, G.L.22
Schmidt, R.J.23
Tokarski, J.24
Wen, M.L.25
Wityak, J.26
Borzilleri, R.M.27
more..
-
32
-
-
75749146563
-
Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors
-
10.1038/nature08675, 20072125
-
Zhang J, Adrian FJ, Jahnke W, Cowan-Jacob SW, Li AG, Iacob RE, Sim T, Powers J, Dierks C, Sun F, Guo GR, Ding Q, Okram B, Choi Y, Wojciechowski A, Deng X, Liu G, Fendrich G, Strauss A, Vajpai N, Grzesiek S, Tuntland T, Liu Y, Bursulaya B, Azam M, Manley PW, Engen JR, Daley GQ, Warmuth M, Gray NS. Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors. Nature 2010, 463:501-506. 10.1038/nature08675, 20072125.
-
(2010)
Nature
, vol.463
, pp. 501-506
-
-
Zhang, J.1
Adrian, F.J.2
Jahnke, W.3
Cowan-Jacob, S.W.4
Li, A.G.5
Iacob, R.E.6
Sim, T.7
Powers, J.8
Dierks, C.9
Sun, F.10
Guo, G.R.11
Ding, Q.12
Okram, B.13
Choi, Y.14
Wojciechowski, A.15
Deng, X.16
Liu, G.17
Fendrich, G.18
Strauss, A.19
Vajpai, N.20
Grzesiek, S.21
Tuntland, T.22
Liu, Y.23
Bursulaya, B.24
Azam, M.25
Manley, P.W.26
Engen, J.R.27
Daley, G.Q.28
Warmuth, M.29
Gray, N.S.30
more..
-
33
-
-
34047192180
-
Imatinib: a review of its use in the management of gastrointestinal stromal tumours
-
10.2165/00003495-200767050-00012, 17385949
-
Siddiqui MA, Scott LJ. Imatinib: a review of its use in the management of gastrointestinal stromal tumours. Drugs 2007, 67:805-820. 10.2165/00003495-200767050-00012, 17385949.
-
(2007)
Drugs
, vol.67
, pp. 805-820
-
-
Siddiqui, M.A.1
Scott, L.J.2
-
34
-
-
0037103624
-
Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the platelet-derived growth factor receptor beta
-
10.1056/NEJMoa020150, 12181402
-
Apperley JF, Gardembas M, Melo JV, Russell-Jones R, Bain BJ, Baxter EJ, Chase A, Chessells JM, Colombat M, Dearden CE, Dimitrijevic S, Mahon FX, Marin D, Nikolova Z, Olavarria E, Silberman S, Schultheis B, Cross NC, Goldman JM. Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the platelet-derived growth factor receptor beta. N Engl J Med 2002, 347:481-487. 10.1056/NEJMoa020150, 12181402.
-
(2002)
N Engl J Med
, vol.347
, pp. 481-487
-
-
Apperley, J.F.1
Gardembas, M.2
Melo, J.V.3
Russell-Jones, R.4
Bain, B.J.5
Baxter, E.J.6
Chase, A.7
Chessells, J.M.8
Colombat, M.9
Dearden, C.E.10
Dimitrijevic, S.11
Mahon, F.X.12
Marin, D.13
Nikolova, Z.14
Olavarria, E.15
Silberman, S.16
Schultheis, B.17
Cross, N.C.18
Goldman, J.M.19
-
35
-
-
57749188299
-
Targeting cancer with small molecule kinase inhibitors
-
10.1038/nrc2559, 19104514
-
Zhang J, Yang PL, Gray NS. Targeting cancer with small molecule kinase inhibitors. Nat Rev Cancer 2009, 9:28-39. 10.1038/nrc2559, 19104514.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 28-39
-
-
Zhang, J.1
Yang, P.L.2
Gray, N.S.3
-
36
-
-
67649472398
-
Novel anticancer targets: revisiting ERBB2 and discovering ERBB3
-
10.1038/nrc2656, 19536107
-
Baselga J, Swain SM. Novel anticancer targets: revisiting ERBB2 and discovering ERBB3. Nat Rev Cancer 2009, 9:463-475. 10.1038/nrc2656, 19536107.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 463-475
-
-
Baselga, J.1
Swain, S.M.2
-
37
-
-
70349238733
-
Inhibition of the hedgehog pathway in advanced basal-cell carcinoma
-
10.1056/NEJMoa0905360, 19726763
-
Von Hoff DD, LoRusso PM, Rudin CM, Reddy JC, Yauch RL, Tibes R, Weiss GJ, Borad MJ, Hann CL, Brahmer JR, Mackey HM, Lum BL, Darbonne WC, Marsters JC, de Sauvage FJ, Low JA. Inhibition of the hedgehog pathway in advanced basal-cell carcinoma. N Engl J Med 2009, 361:1164-1172. 10.1056/NEJMoa0905360, 19726763.
-
(2009)
N Engl J Med
, vol.361
, pp. 1164-1172
-
-
Von Hoff, D.D.1
LoRusso, P.M.2
Rudin, C.M.3
Reddy, J.C.4
Yauch, R.L.5
Tibes, R.6
Weiss, G.J.7
Borad, M.J.8
Hann, C.L.9
Brahmer, J.R.10
Mackey, H.M.11
Lum, B.L.12
Darbonne, W.C.13
Marsters, J.C.14
de Sauvage, F.J.15
Low, J.A.16
-
38
-
-
70349244812
-
Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449
-
10.1056/NEJMoa0902903, 19726761
-
Rudin CM, Hann CL, Laterra J, Yauch RL, Callahan CA, Fu L, Holcomb T, Stinson J, Gould SE, Coleman B, LoRusso PM, Von Hoff DD, de Sauvage FJ, Low JA. Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449. N Engl J Med 2009, 361:1173-1178. 10.1056/NEJMoa0902903, 19726761.
-
(2009)
N Engl J Med
, vol.361
, pp. 1173-1178
-
-
Rudin, C.M.1
Hann, C.L.2
Laterra, J.3
Yauch, R.L.4
Callahan, C.A.5
Fu, L.6
Holcomb, T.7
Stinson, J.8
Gould, S.E.9
Coleman, B.10
LoRusso, P.M.11
Von Hoff, D.D.12
de Sauvage, F.J.13
Low, J.A.14
-
39
-
-
0019133661
-
Mutations affecting segment number and polarity in Drosophila
-
10.1038/287795a0, 6776413
-
Nusslein-Volhard C, Wieschaus E. Mutations affecting segment number and polarity in Drosophila. Nature 1980, 287:795-801. 10.1038/287795a0, 6776413.
-
(1980)
Nature
, vol.287
, pp. 795-801
-
-
Nusslein-Volhard, C.1
Wieschaus, E.2
-
40
-
-
57049089995
-
Hedgehog signaling in development and cancer
-
10.1016/j.devcel.2008.11.010, 19081070
-
Jiang J, Hui CC. Hedgehog signaling in development and cancer. Dev Cell 2008, 15:801-812. 10.1016/j.devcel.2008.11.010, 19081070.
-
(2008)
Dev Cell
, vol.15
, pp. 801-812
-
-
Jiang, J.1
Hui, C.C.2
-
41
-
-
33847220364
-
Melanoma biology and new targeted therapy
-
10.1038/nature05661, 17314971
-
Gray-Schopfer V, Wellbrock C, Marais R. Melanoma biology and new targeted therapy. Nature 2007, 445:851-857. 10.1038/nature05661, 17314971.
-
(2007)
Nature
, vol.445
, pp. 851-857
-
-
Gray-Schopfer, V.1
Wellbrock, C.2
Marais, R.3
-
42
-
-
65649090993
-
BRAF signaling and targeted therapies in melanoma
-
ix., 10.1016/j.hoc.2009.04.001, 19464601
-
Dhomen N, Marais R. BRAF signaling and targeted therapies in melanoma. Hematol Oncol Clin North Am 2009, 23:529-545. ix., 10.1016/j.hoc.2009.04.001, 19464601.
-
(2009)
Hematol Oncol Clin North Am
, vol.23
, pp. 529-545
-
-
Dhomen, N.1
Marais, R.2
-
43
-
-
76149102749
-
Early efficacy signal demonstrated in advanced melanoma in a phase I trial of the oncogenic BRAF-selective inhibitor PLX4032
-
Chapman P, Puzano V, Sosman J, Kim K, Ribas A, McArthur G, Lee R, Grippo J, Nolop K, Flaherty KR. Early efficacy signal demonstrated in advanced melanoma in a phase I trial of the oncogenic BRAF-selective inhibitor PLX4032. Eur J Cancer Suppl 2009, 7:5.
-
(2009)
Eur J Cancer Suppl
, vol.7
, pp. 5
-
-
Chapman, P.1
Puzano, V.2
Sosman, J.3
Kim, K.4
Ribas, A.5
McArthur, G.6
Lee, R.7
Grippo, J.8
Nolop, K.9
Flaherty, K.R.10
-
44
-
-
74849109743
-
Kinase-dead BREF and oncogenic RAS cooperate to drive tumor progression through CRAF
-
10.1016/j.cell.2009.12.040, 20141835
-
Heidorn SJ, Milagre C, Whittaker S, Nourry A, Niculescu-Duvas I, Dhomen N, Hussain J, Reis Filho JS, Springer CS, Pritchard C, Marais R. Kinase-dead BREF and oncogenic RAS cooperate to drive tumor progression through CRAF. Cell 2010, 140:209-21. 10.1016/j.cell.2009.12.040, 20141835.
-
(2010)
Cell
, vol.140
, pp. 209-221
-
-
Heidorn, S.J.1
Milagre, C.2
Whittaker, S.3
Nourry, A.4
Niculescu-Duvas, I.5
Dhomen, N.6
Hussain, J.7
Reis Filho, J.S.8
Springer, C.S.9
Pritchard, C.10
Marais, R.11
-
45
-
-
0034614637
-
The hallmarks of cancer
-
10.1016/S0092-8674(00)81683-9, 10647931
-
Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000, 100:57-70. 10.1016/S0092-8674(00)81683-9, 10647931.
-
(2000)
Cell
, vol.100
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
46
-
-
61449182121
-
Principles of cancer therapy: oncogene and non-oncogene addiction
-
10.1016/j.cell.2009.02.024, 19269363
-
Luo J, Solimini NL, Elledge SJ. Principles of cancer therapy: oncogene and non-oncogene addiction. Cell 2009, 136:823-837. 10.1016/j.cell.2009.02.024, 19269363.
-
(2009)
Cell
, vol.136
, pp. 823-837
-
-
Luo, J.1
Solimini, N.L.2
Elledge, S.J.3
-
47
-
-
44449147036
-
Tumor cell metabolism: cancer's Achilles' heel
-
10.1016/j.ccr.2008.05.005, 18538731
-
Kroemer G, Pouyssegur J. Tumor cell metabolism: cancer's Achilles' heel. Cancer Cell 2008, 13:472-482. 10.1016/j.ccr.2008.05.005, 18538731.
-
(2008)
Cancer Cell
, vol.13
, pp. 472-482
-
-
Kroemer, G.1
Pouyssegur, J.2
-
48
-
-
70349859881
-
DNA damage, aging, and cancer
-
10.1056/NEJMra0804615, 19812404
-
Hoeijmakers JH. DNA damage, aging, and cancer. N Engl J Med 2009, 361:1475-1485. 10.1056/NEJMra0804615, 19812404.
-
(2009)
N Engl J Med
, vol.361
, pp. 1475-1485
-
-
Hoeijmakers, J.H.1
-
49
-
-
44849094781
-
Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging
-
10.1101/gad.1657108, 2732416, 18519635
-
Morimoto RI. Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging. Genes Dev 2008, 22:1427-1438. 10.1101/gad.1657108, 2732416, 18519635.
-
(2008)
Genes Dev
, vol.22
, pp. 1427-1438
-
-
Morimoto, R.I.1
-
50
-
-
67649522162
-
Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis
-
10.1038/nrm2718, 19546858
-
Holland AJ, Cleveland DW. Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis. Nat Rev Mol Cell Biol 2009, 10:478-487. 10.1038/nrm2718, 19546858.
-
(2009)
Nat Rev Mol Cell Biol
, vol.10
, pp. 478-487
-
-
Holland, A.J.1
Cleveland, D.W.2
-
51
-
-
12444279265
-
On the origin of cancer cells
-
10.1126/science.123.3191.309, 13298683
-
Warburg O. On the origin of cancer cells. Science 1956, 123:309-314. 10.1126/science.123.3191.309, 13298683.
-
(1956)
Science
, vol.123
, pp. 309-314
-
-
Warburg, O.1
-
52
-
-
54549093803
-
Ageing, oxidative stress and cancer: paradigms in parallax
-
10.1038/nrc2522, 2603471, 18948997
-
Benz CC, Yau C. Ageing, oxidative stress and cancer: paradigms in parallax. Nat Rev Cancer 2008, 8:875-879. 10.1038/nrc2522, 2603471, 18948997.
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 875-879
-
-
Benz, C.C.1
Yau, C.2
-
53
-
-
40749163248
-
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
-
10.1038/nature06734, 18337823
-
Christofk HR, Vander Heiden MG, Harris MH, Ramanathan A, Gerszten RE, Wei R, Fleming MD, Schreiber SL, Cantley LC. The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature 2008, 452:230-233. 10.1038/nature06734, 18337823.
-
(2008)
Nature
, vol.452
, pp. 230-233
-
-
Christofk, H.R.1
Vander Heiden, M.G.2
Harris, M.H.3
Ramanathan, A.4
Gerszten, R.E.5
Wei, R.6
Fleming, M.D.7
Schreiber, S.L.8
Cantley, L.C.9
-
54
-
-
17244373777
-
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
-
10.1038/nature03445, 15829967
-
Farmer H, McCabe N, Lord CJ, Tutt AN, Johnson DA, Richardson TB, Santarosa M, Dillon KJ, Hickson I, Knights C, Martin NM, Jackson SP, Smith GC, Ashworth A. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature 2005, 434:917-921. 10.1038/nature03445, 15829967.
-
(2005)
Nature
, vol.434
, pp. 917-921
-
-
Farmer, H.1
McCabe, N.2
Lord, C.J.3
Tutt, A.N.4
Johnson, D.A.5
Richardson, T.B.6
Santarosa, M.7
Dillon, K.J.8
Hickson, I.9
Knights, C.10
Martin, N.M.11
Jackson, S.P.12
Smith, G.C.13
Ashworth, A.14
-
55
-
-
25444497278
-
The concept of synthetic lethality in the context of anticancer therapy
-
10.1038/nrc1691, 16110319
-
Kaelin WG. The concept of synthetic lethality in the context of anticancer therapy. Nat Rev Cancer 2005, 5:689-698. 10.1038/nrc1691, 16110319.
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 689-698
-
-
Kaelin, W.G.1
-
56
-
-
67650471685
-
Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers
-
10.1056/NEJMoa0900212, 19553641
-
Fong PC, Boss DS, Yap TA, Tutt A, Wu P, Mergui-Roelvink M, Mortimer P, Swaisland H, Lau A, O'Connor MJ, Ashworth A, Carmichael J, Kaye SB, Schellens JH, de Bono JS. Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. N Engl J Med 2009, 361:123-134. 10.1056/NEJMoa0900212, 19553641.
-
(2009)
N Engl J Med
, vol.361
, pp. 123-134
-
-
Fong, P.C.1
Boss, D.S.2
Yap, T.A.3
Tutt, A.4
Wu, P.5
Mergui-Roelvink, M.6
Mortimer, P.7
Swaisland, H.8
Lau, A.9
O'Connor, M.J.10
Ashworth, A.11
Carmichael, J.12
Kaye, S.B.13
Schellens, J.H.14
de Bono, J.S.15
-
57
-
-
0031417677
-
Disorders in cell circuitry associated with multistage carcinogenesis: exploitable targets for cancer prevention and therapy
-
Weinstein IB, Begemann M, Zhou P, Han EK, Sgambato A, Doki Y, Arber N, Ciaparrone M, Yamamoto H. Disorders in cell circuitry associated with multistage carcinogenesis: exploitable targets for cancer prevention and therapy. Clin Cancer Res 1997, 3:2696-2702.
-
(1997)
Clin Cancer Res
, vol.3
, pp. 2696-2702
-
-
Weinstein, I.B.1
Begemann, M.2
Zhou, P.3
Han, E.K.4
Sgambato, A.5
Doki, Y.6
Arber, N.7
Ciaparrone, M.8
Yamamoto, H.9
-
58
-
-
34347391035
-
Utilizing RNA interference to enhance cancer drug discovery
-
10.1038/nrd2355, 17599085
-
Iorns E, Lord CJ, Turner N, Ashworth A. Utilizing RNA interference to enhance cancer drug discovery. Nat Rev Drug Discov 2007, 6:556-568. 10.1038/nrd2355, 17599085.
-
(2007)
Nat Rev Drug Discov
, vol.6
, pp. 556-568
-
-
Iorns, E.1
Lord, C.J.2
Turner, N.3
Ashworth, A.4
-
59
-
-
65849111219
-
Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells
-
10.1016/j.cell.2009.03.017, 19490892
-
Scholl C, Frohling S, Dunn IF, Schinzel AC, Barbie DA, Kim SY, Silver SJ, Tamayo P, Wadlow RC, Ramaswamy S, Döhner K, Bullinger L, Sandy P, Boehm JS, Root DE, Jacks T, Hahn WC, Gilliland DG. Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells. Cell 2009, 137:821-834. 10.1016/j.cell.2009.03.017, 19490892.
-
(2009)
Cell
, vol.137
, pp. 821-834
-
-
Scholl, C.1
Frohling, S.2
Dunn, I.F.3
Schinzel, A.C.4
Barbie, D.A.5
Kim, S.Y.6
Silver, S.J.7
Tamayo, P.8
Wadlow, R.C.9
Ramaswamy, S.10
Döhner, K.11
Bullinger, L.12
Sandy, P.13
Boehm, J.S.14
Root, D.E.15
Jacks, T.16
Hahn, W.C.17
Gilliland, D.G.18
-
60
-
-
66149091940
-
A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene
-
10.1016/j.cell.2009.05.006, 2768667, 19490893
-
Luo J, Emanuele MJ, Li D, Creighton CJ, Schlabach MR, Westbrook TF, Wong KK, Elledge SJ. A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. Cell 2009, 137:835-848. 10.1016/j.cell.2009.05.006, 2768667, 19490893.
-
(2009)
Cell
, vol.137
, pp. 835-848
-
-
Luo, J.1
Emanuele, M.J.2
Li, D.3
Creighton, C.J.4
Schlabach, M.R.5
Westbrook, T.F.6
Wong, K.K.7
Elledge, S.J.8
-
61
-
-
70449091786
-
Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1
-
10.1038/nature08460, 19847166
-
Barbie DA, Tamayo P, Boehm JS, Kim SY, Moody SE, Dunn IF, Schinzel AC, Sandy P, Meylan E, Scholl C, Fröhling S, Chan EM, Sos ML, Michel K, Mermel C, Silver SJ, Weir BA, Reiling JH, Sheng Q, Gupta PB, Wadlow RC, Le H, Hoersch S, Wittner BS, Ramaswamy S, Livingston DM, Sabatini DM, Meyerson M, Thomas RK, Lander ES, et al. Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1. Nature 2009, 462:108-112. 10.1038/nature08460, 19847166.
-
(2009)
Nature
, vol.462
, pp. 108-112
-
-
Barbie, D.A.1
Tamayo, P.2
Boehm, J.S.3
Kim, S.Y.4
Moody, S.E.5
Dunn, I.F.6
Schinzel, A.C.7
Sandy, P.8
Meylan, E.9
Scholl, C.10
Fröhling, S.11
Chan, E.M.12
Sos, M.L.13
Michel, K.14
Mermel, C.15
Silver, S.J.16
Weir, B.A.17
Reiling, J.H.18
Sheng, Q.19
Gupta, P.B.20
Wadlow, R.C.21
Le, H.22
Hoersch, S.23
Wittner, B.S.24
Ramaswamy, S.25
Livingston, D.M.26
Sabatini, D.M.27
Meyerson, M.28
Thomas, R.K.29
Lander, E.S.30
more..
-
62
-
-
2342495721
-
Synthetic lethal targeting of MYC by activation of the DR5 death receptor pathway
-
10.1016/S1535-6108(04)00113-8, 15144957
-
Wang Y, Engels IH, Knee DA, Nasoff M, Deveraux QL, Quon KC. Synthetic lethal targeting of MYC by activation of the DR5 death receptor pathway. Cancer Cell 2004, 5:501-512. 10.1016/S1535-6108(04)00113-8, 15144957.
-
(2004)
Cancer Cell
, vol.5
, pp. 501-512
-
-
Wang, Y.1
Engels, I.H.2
Knee, D.A.3
Nasoff, M.4
Deveraux, Q.L.5
Quon, K.C.6
-
63
-
-
52949111487
-
CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity
-
10.1038/nature07179, 2587138, 18794900
-
Firestein R, Bass AJ, Kim SY, Dunn IF, Silver SJ, Guney I, Freed E, Ligon AH, Vena N, Ogino S, Chheda MG, Tamayo P, Finn S, Shrestha Y, Boehm JS, Jain S, Bojarski E, Mermel C, Barretina J, Chan JA, Baselga J, Tabernero J, Root DE, Fuchs CS, Loda M, Shivdasani RA, Meyerson M, Hahn WC. CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity. Nature 2008, 455:547-551. 10.1038/nature07179, 2587138, 18794900.
-
(2008)
Nature
, vol.455
, pp. 547-551
-
-
Firestein, R.1
Bass, A.J.2
Kim, S.Y.3
Dunn, I.F.4
Silver, S.J.5
Guney, I.6
Freed, E.7
Ligon, A.H.8
Vena, N.9
Ogino, S.10
Chheda, M.G.11
Tamayo, P.12
Finn, S.13
Shrestha, Y.14
Boehm, J.S.15
Jain, S.16
Bojarski, E.17
Mermel, C.18
Barretina, J.19
Chan, J.A.20
Baselga, J.21
Tabernero, J.22
Root, D.E.23
Fuchs, C.S.24
Loda, M.25
Shivdasani, R.A.26
Meyerson, M.27
Hahn, W.C.28
more..
-
64
-
-
34249993765
-
Integrative genomic approaches identify IKBKE as a breast cancer oncogene
-
10.1016/j.cell.2007.03.052, 17574021
-
Boehm JS, Zhao JJ, Yao J, Kim SY, Firestein R, Dunn IF, Sjostrom SK, Garraway LA, Weremowicz S, Richardson AL, Greulich H, Stewart CJ, Mulvey LA, Shen RR, Ambrogio L, Hirozane-Kishikawa T, Hill DE, Vidal M, Meyerson M, Grenier JK, Hinkle G, Root DE, Roberts TM, Lander ES, Polyak K, Hahn WC. Integrative genomic approaches identify IKBKE as a breast cancer oncogene. Cell 2007, 129:1065-1079. 10.1016/j.cell.2007.03.052, 17574021.
-
(2007)
Cell
, vol.129
, pp. 1065-1079
-
-
Boehm, J.S.1
Zhao, J.J.2
Yao, J.3
Kim, S.Y.4
Firestein, R.5
Dunn, I.F.6
Sjostrom, S.K.7
Garraway, L.A.8
Weremowicz, S.9
Richardson, A.L.10
Greulich, H.11
Stewart, C.J.12
Mulvey, L.A.13
Shen, R.R.14
Ambrogio, L.15
Hirozane-Kishikawa, T.16
Hill, D.E.17
Vidal, M.18
Meyerson, M.19
Grenier, J.K.20
Hinkle, G.21
Root, D.E.22
Roberts, T.M.23
Lander, E.S.24
Polyak, K.25
Hahn, W.C.26
more..
-
65
-
-
70349445412
-
Proteomic and genetic approaches identify Syk as an AML target
-
10.1016/j.ccr.2009.08.018, 2803063, 19800574
-
Hahn CK, Berchuck JE, Ross KN, Kakoza RM, Clauser K, Schinzel AC, Ross L, Galinsky I, Davis TN, Silver SJ, Root DE, Stone RM, DeAngelo DJ, Carroll M, Hahn WC, Carr SA, Golub TR, Kung AL, Stegmaier K. Proteomic and genetic approaches identify Syk as an AML target. Cancer Cell 2009, 16:281-294. 10.1016/j.ccr.2009.08.018, 2803063, 19800574.
-
(2009)
Cancer Cell
, vol.16
, pp. 281-294
-
-
Hahn, C.K.1
Berchuck, J.E.2
Ross, K.N.3
Kakoza, R.M.4
Clauser, K.5
Schinzel, A.C.6
Ross, L.7
Galinsky, I.8
Davis, T.N.9
Silver, S.J.10
Root, D.E.11
Stone, R.M.12
DeAngelo, D.J.13
Carroll, M.14
Hahn, W.C.15
Carr, S.A.16
Golub, T.R.17
Kung, A.L.18
Stegmaier, K.19
-
66
-
-
44349191457
-
Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing
-
10.1038/ng.128, 2705838, 18438408
-
Campbell PJ, Stephens PJ, Pleasance ED, O'Meara S, Li H, Santarius T, Stebbings LA, Leroy C, Edkins S, Hardy C, Teague JW, Menzies A, Goodhead I, Turner DJ, Clee CM, Quail MA, Cox A, Brown C, Durbin R, Hurles ME, Edwards PA, Bignell GR, Stratton MR, Futreal PA. Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing. Nat Genet 2008, 40:722-729. 10.1038/ng.128, 2705838, 18438408.
-
(2008)
Nat Genet
, vol.40
, pp. 722-729
-
-
Campbell, P.J.1
Stephens, P.J.2
Pleasance, E.D.3
O'Meara, S.4
Li, H.5
Santarius, T.6
Stebbings, L.A.7
Leroy, C.8
Edkins, S.9
Hardy, C.10
Teague, J.W.11
Menzies, A.12
Goodhead, I.13
Turner, D.J.14
Clee, C.M.15
Quail, M.A.16
Cox, A.17
Brown, C.18
Durbin, R.19
Hurles, M.E.20
Edwards, P.A.21
Bignell, G.R.22
Stratton, M.R.23
Futreal, P.A.24
more..
-
67
-
-
70349969478
-
Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution
-
10.1038/nature08489, 19812674
-
Shah SP, Morin RD, Khattra J, Prentice L, Pugh T, Burleigh A, Delaney A, Gelmon K, Guliany R, Senz J, Steidl C, Holt RA, Jones S, Sun M, Leung G, Moore R, Severson T, Taylor GA, Teschendorff AE, Tse K, Turashvili G, Varhol R, Warren RL, Watson P, Zhao Y, Caldas C, Huntsman D, Hirst M, Marra MA, Aparicio S. Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution. Nature 2009, 461:809-813. 10.1038/nature08489, 19812674.
-
(2009)
Nature
, vol.461
, pp. 809-813
-
-
Shah, S.P.1
Morin, R.D.2
Khattra, J.3
Prentice, L.4
Pugh, T.5
Burleigh, A.6
Delaney, A.7
Gelmon, K.8
Guliany, R.9
Senz, J.10
Steidl, C.11
Holt, R.A.12
Jones, S.13
Sun, M.14
Leung, G.15
Moore, R.16
Severson, T.17
Taylor, G.A.18
Teschendorff, A.E.19
Tse, K.20
Turashvili, G.21
Varhol, R.22
Warren, R.L.23
Watson, P.24
Zhao, Y.25
Caldas, C.26
Huntsman, D.27
Hirst, M.28
Marra, M.A.29
Aparicio, S.30
more..
-
68
-
-
74449085934
-
A small-cell lung cancer genome with complex signatures of tobacco exposure
-
10.1038/nature08629, 20016488
-
Pleasance ED, Stephens PJ, O'Meara S, McBride DJ, Meynert A, Jones D, Lin ML, Beare D, Lau KW, Greenman C, Varela I, Nik-Zainal S, Davies HR, Ordoñez GR, Mudie LJ, Latimer C, Edkins S, Stebbings L, Chen L, Jia M, Leroy C, Marshall J, Menzies A, Butler A, Teague JW, Mangion J, Sun YA, McLaughlin SF, Peckham HE, Tsung EF. A small-cell lung cancer genome with complex signatures of tobacco exposure. Nature 2010, 463:184-190. 10.1038/nature08629, 20016488.
-
(2010)
Nature
, vol.463
, pp. 184-190
-
-
Pleasance, E.D.1
Stephens, P.J.2
O'Meara, S.3
McBride, D.J.4
Meynert, A.5
Jones, D.6
Lin, M.L.7
Beare, D.8
Lau, K.W.9
Greenman, C.10
Varela, I.11
Nik-Zainal, S.12
Davies, H.R.13
Ordoñez, G.R.14
Mudie, L.J.15
Latimer, C.16
Edkins, S.17
Stebbings, L.18
Chen, L.19
Jia, M.20
Leroy, C.21
Marshall, J.22
Menzies, A.23
Butler, A.24
Teague, J.W.25
Mangion, J.26
Sun, Y.A.27
McLaughlin, S.F.28
Peckham, H.E.29
Tsung, E.F.30
more..
-
69
-
-
74449093973
-
A comprehensive catalogue of somatic mutations from a human cancer genome
-
10.1038/nature08658, 20016485
-
Pleasance ED, Cheetham RK, Stephens PJ, McBride DJ, Humphray SJ, Greenman CD, Varela I, Lin ML, Ordóñez GR, Bignell GR, Ye K, Alipaz J, Bauer MJ, Beare D, Butler A, Carter RJ, Chen L, Cox AJ, Edkins S, Kokko-Gonzales PI, Gormley NA, Grocock RJ, Haudenschild CD, Hims MM, James T, Jia M, Kingsbury Z, Leroy C, Marshall J, Menzies A, et al. A comprehensive catalogue of somatic mutations from a human cancer genome. Nature 2010, 463:191-196. 10.1038/nature08658, 20016485.
-
(2010)
Nature
, vol.463
, pp. 191-196
-
-
Pleasance, E.D.1
Cheetham, R.K.2
Stephens, P.J.3
McBride, D.J.4
Humphray, S.J.5
Greenman, C.D.6
Varela, I.7
Lin, M.L.8
Ordóñez, G.R.9
Bignell, G.R.10
Ye, K.11
Alipaz, J.12
Bauer, M.J.13
Beare, D.14
Butler, A.15
Carter, R.J.16
Chen, L.17
Cox, A.J.18
Edkins, S.19
Kokko-Gonzales, P.I.20
Gormley, N.A.21
Grocock, R.J.22
Haudenschild, C.D.23
Hims, M.M.24
James, T.25
Jia, M.26
Kingsbury, Z.27
Leroy, C.28
Marshall, J.29
Menzies, A.30
more..
-
70
-
-
72949119310
-
Complex landscapes of somatic rearrangement in human breast cancer genomes
-
10.1038/nature08645, 20033038
-
Stephens PJ, McBride DJ, Lin ML, Varela I, Pleasance ED, Simpson JT, Stebbings LA, Leroy C, Edkins S, Mudie LJ, Greenman CD, Jia M, Latimer C, Teague JW, Lau KW, Burton J, Quail MA, Swerdlow H, Churcher C, Natrajan R, Sieuwerts AM, Martens JW, Silver DP, Langerød A, Russnes HE, Foekens JA, Reis-Filho JS, van't Veer L, Richardson AL, Børresen-Dale AL, Campbell PJ, Futreal PA, Stratton MR. Complex landscapes of somatic rearrangement in human breast cancer genomes. Nature 2009, 462:1005-1010. 10.1038/nature08645, 20033038.
-
(2009)
Nature
, vol.462
, pp. 1005-1010
-
-
Stephens, P.J.1
McBride, D.J.2
Lin, M.L.3
Varela, I.4
Pleasance, E.D.5
Simpson, J.T.6
Stebbings, L.A.7
Leroy, C.8
Edkins, S.9
Mudie, L.J.10
Greenman, C.D.11
Jia, M.12
Latimer, C.13
Teague, J.W.14
Lau, K.W.15
Burton, J.16
Quail, M.A.17
Swerdlow, H.18
Churcher, C.19
Natrajan, R.20
Sieuwerts, A.M.21
Martens, J.W.22
Silver, D.P.23
Langerød, A.24
Russnes, H.E.25
Foekens, J.A.26
Reis-Filho, J.S.27
van't Veer, L.28
Richardson, A.L.29
Børresen-Dale, A.L.30
Campbell, P.J.31
Futreal, P.A.32
Stratton, M.R.33
more..
-
71
-
-
0034680102
-
Molecular portraits of human breast tumours
-
10.1038/35021093, 10963602
-
Perou CM, Sorlie T, Eisen MB, Rijn M, Jeffrey SS, Rees CA, Pollack JR, Ross DT, Johnsen H, Akslen LA, Fluge O, Pergamenschikov A, Williams C, Zhu SX, Lønning PE, Børresen-Dale AL, Brown PO, Botstein D. Molecular portraits of human breast tumours. Nature 2000, 406:747-752. 10.1038/35021093, 10963602.
-
(2000)
Nature
, vol.406
, pp. 747-752
-
-
Perou, C.M.1
Sorlie, T.2
Eisen, M.B.3
Rijn, M.4
Jeffrey, S.S.5
Rees, C.A.6
Pollack, J.R.7
Ross, D.T.8
Johnsen, H.9
Akslen, L.A.10
Fluge, O.11
Pergamenschikov, A.12
Williams, C.13
Zhu, S.X.14
Lønning, P.E.15
Børresen-Dale, A.L.16
Brown, P.O.17
Botstein, D.18
-
72
-
-
74049132731
-
Label-free, normalized quantification of complex mass spectrometry data for proteomic analysis
-
10.1038/nbt.1592, 20010810
-
Griffin NM, Yu J, Long F, Oh P, Shore S, Li Y, Koziol JA, Schnitzer JE. Label-free, normalized quantification of complex mass spectrometry data for proteomic analysis. Nat Biotechnol 2010, 28:83-89. 10.1038/nbt.1592, 20010810.
-
(2010)
Nat Biotechnol
, vol.28
, pp. 83-89
-
-
Griffin, N.M.1
Yu, J.2
Long, F.3
Oh, P.4
Shore, S.5
Li, Y.6
Koziol, J.A.7
Schnitzer, J.E.8
-
73
-
-
0036463681
-
Metabonomics: a platform for studying drug toxicity and gene function
-
10.1038/nrd728, 12120097
-
Nicholson JK, Connelly J, Lindon JC, Holmes E. Metabonomics: a platform for studying drug toxicity and gene function. Nat Rev Drug Discov 2002, 1:153-161. 10.1038/nrd728, 12120097.
-
(2002)
Nat Rev Drug Discov
, vol.1
, pp. 153-161
-
-
Nicholson, J.K.1
Connelly, J.2
Lindon, J.C.3
Holmes, E.4
-
74
-
-
39849097680
-
Resistance to therapy caused by intragenic deletion in BRCA2
-
10.1038/nature06548, 18264088
-
Edwards SL, Brough R, Lord CJ, Natrajan R, Vatcheva R, Levine DA, Boyd J, Reis-Filho JS, Ashworth A. Resistance to therapy caused by intragenic deletion in BRCA2. Nature 2008, 451:1111-1115. 10.1038/nature06548, 18264088.
-
(2008)
Nature
, vol.451
, pp. 1111-1115
-
-
Edwards, S.L.1
Brough, R.2
Lord, C.J.3
Natrajan, R.4
Vatcheva, R.5
Levine, D.A.6
Boyd, J.7
Reis-Filho, J.S.8
Ashworth, A.9
-
75
-
-
0034670036
-
The molecular biology of chronic myeloid leukemia
-
Deininger MW, Goldman JM, Melo JV. The molecular biology of chronic myeloid leukemia. Blood 2000, 96:3343-3356.
-
(2000)
Blood
, vol.96
, pp. 3343-3356
-
-
Deininger, M.W.1
Goldman, J.M.2
Melo, J.V.3
-
76
-
-
58149398623
-
Translation of the Philadelphia chromosome into therapy for CML
-
10.1182/blood-2008-07-077958, 19064740
-
Druker BJ. Translation of the Philadelphia chromosome into therapy for CML. Blood 2008, 112:4808-4817. 10.1182/blood-2008-07-077958, 19064740.
-
(2008)
Blood
, vol.112
, pp. 4808-4817
-
-
Druker, B.J.1
|