메뉴 건너뛰기




Volumn 67, Issue 5, 2007, Pages 805-820

Imatinib: A review of its use in the management of gastrointestinal stromal tumours

Author keywords

[No Author keywords available]

Indexed keywords

HYPERICUM PERFORATUM EXTRACT; IMATINIB; KETOCONAZOLE; PARACETAMOL; RIFAMPICIN; SIMVASTATIN; SUNITINIB;

EID: 34047192180     PISSN: 00126667     EISSN: 00126667     Source Type: Journal    
DOI: 10.2165/00003495-200767050-00012     Document Type: Review
Times cited : (46)

References (73)
  • 1
    • 27644482942 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumours: An update
    • Sabah M, Leader M, Kay E. Gastrointestinal stromal tumours: an update. Curr Diagn Pathol 2005; 11 (6): 400-10
    • (2005) Curr Diagn Pathol , vol.11 , Issue.6 , pp. 400-410
    • Sabah, M.1    Leader, M.2    Kay, E.3
  • 2
    • 20944443259 scopus 로고    scopus 로고
    • Consensus meeting for the management of gastrointestinal stromal tumors
    • Consensus Conference of 20-21 March 2004, under the auspices of ESMO. Ann Oncol 2005 Apr; 16 4, 566-78
    • Blay JY, Bonvalot S, Casali P, et al. Consensus meeting for the management of gastrointestinal stromal tumors. Report of the GIST Consensus Conference of 20-21 March 2004, under the auspices of ESMO. Ann Oncol 2005 Apr; 16 (4): 566-78
    • Report of the GIST
    • Blay, J.Y.1    Bonvalot, S.2    Casali, P.3
  • 3
    • 27244439258 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumor: 5 years later
    • Nov;
    • van der Zwan SM, Dematteo RP. Gastrointestinal stromal tumor: 5 years later. Cancer 2005 Nov; 104 (9): 1781-8
    • (2005) Cancer , vol.104 , Issue.9 , pp. 1781-1788
    • van der Zwan, S.M.1    Dematteo, R.P.2
  • 4
    • 4644312266 scopus 로고    scopus 로고
    • Biology of gastrointestinal stromal tumors
    • Corless CL, Fletcher JA, Heinrich MC. Biology of gastrointestinal stromal tumors. J Clin Oncol 2004; 22 (18): 3813-25
    • (2004) J Clin Oncol , vol.22 , Issue.18 , pp. 3813-3825
    • Corless, C.L.1    Fletcher, J.A.2    Heinrich, M.C.3
  • 5
    • 0035890740 scopus 로고    scopus 로고
    • KIT activation is a ubiquitous feature of gastrointestinal stromal tumors
    • Nov;
    • Rubin BP, Singer S, Tsao C, et al. KIT activation is a ubiquitous feature of gastrointestinal stromal tumors. Cancer Res 2001 Nov; 61 (22): 8118-21
    • (2001) Cancer Res , vol.61 , Issue.22 , pp. 8118-8121
    • Rubin, B.P.1    Singer, S.2    Tsao, C.3
  • 6
    • 23944476156 scopus 로고    scopus 로고
    • PDGFRA mutations in gastrointestinal stromal tumors: Frequency, spectrum and in vitro sensitivity to imatinib
    • Aug 10;
    • Corless CL, Schroeder A, Griffith D, et al. PDGFRA mutations in gastrointestinal stromal tumors: frequency, spectrum and in vitro sensitivity to imatinib. J Clin Oncol 2005 Aug 10; 23 (23): 5357-64
    • (2005) J Clin Oncol , vol.23 , Issue.23 , pp. 5357-5364
    • Corless, C.L.1    Schroeder, A.2    Griffith, D.3
  • 7
    • 25144443610 scopus 로고    scopus 로고
    • Pathophysiology, diagnosis, and treatment of gastrointestinal stromal tumors
    • Shinomura Y, Kinoshita H, Tsutsui S, et al. Pathophysiology, diagnosis, and treatment of gastrointestinal stromal tumors. J Gastroenterol 2005; 40: 775-80
    • (2005) J Gastroenterol , vol.40 , pp. 775-780
    • Shinomura, Y.1    Kinoshita, H.2    Tsutsui, S.3
  • 8
    • 0642368571 scopus 로고    scopus 로고
    • Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor
    • Dec 1;
    • Heinrich MC, Corless CL, Demetri GD, et al. Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor. J Clin Oncol 2003 Dec 1; 21 (23): 4342-9
    • (2003) J Clin Oncol , vol.21 , Issue.23 , pp. 4342-4349
    • Heinrich, M.C.1    Corless, C.L.2    Demetri, G.D.3
  • 9
    • 0242670019 scopus 로고    scopus 로고
    • PDGFRA activating mutations in gastrointestinal stromal tumors
    • Jan 31;
    • Heinrich MC, Corless CL, Duensing A, et al. PDGFRA activating mutations in gastrointestinal stromal tumors. Science 2003 Jan 31; 299 (5607): 708-10
    • (2003) Science , vol.299 , Issue.5607 , pp. 708-710
    • Heinrich, M.C.1    Corless, C.L.2    Duensing, A.3
  • 10
    • 33847057304 scopus 로고    scopus 로고
    • Imatinib: A review of its use in chronic myeloid leukaemia
    • Moen MD, McKeage K, Plosker GL, et al. Imatinib: a review of its use in chronic myeloid leukaemia. Drugs 2007; 67 (2): 299-320
    • (2007) Drugs , vol.67 , Issue.2 , pp. 299-320
    • Moen, M.D.1    McKeage, K.2    Plosker, G.L.3
  • 11
    • 0742320300 scopus 로고    scopus 로고
    • Imatinib mesylate: A review of its use in chronic myeloid leukemia
    • Curran MP, Croom KF, Goa KL. Imatinib mesylate: a review of its use in chronic myeloid leukemia. Am J Cancer 2003; 2 (6): 439-54
    • (2003) Am J Cancer , vol.2 , Issue.6 , pp. 439-454
    • Curran, M.P.1    Croom, K.F.2    Goa, K.L.3
  • 12
    • 0034775647 scopus 로고    scopus 로고
    • Lyseng-Williamson K, Jarvis B. Imatinib. Drugs 2001; 61 (12): 1765-74; discussion 1775-6
    • Lyseng-Williamson K, Jarvis B. Imatinib. Drugs 2001; 61 (12): 1765-74; discussion 1775-6
  • 13
    • 0035810148 scopus 로고    scopus 로고
    • Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor
    • Apr 5;
    • Joensuu H, Roberts PJ, Sarlomo-Rikala M, et al. Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor. N Engl J Med 2001 Apr 5; 344 (14): 1052-6
    • (2001) N Engl J Med , vol.344 , Issue.14 , pp. 1052-1056
    • Joensuu, H.1    Roberts, P.J.2    Sarlomo-Rikala, M.3
  • 14
    • 0037225829 scopus 로고    scopus 로고
    • Imatinib mesylate: In the treatment of gastrointestinal stromal tumours
    • Croom KF, Perry CM. Imatinib mesylate: in the treatment of gastrointestinal stromal tumours. Drugs 2003; 63 (5): 513-22
    • (2003) Drugs , vol.63 , Issue.5 , pp. 513-522
    • Croom, K.F.1    Perry, C.M.2
  • 15
    • 24344482346 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of imatinib
    • Peng B, Lloyd P, Schran H. Clinical pharmacokinetics of imatinib. Clin Pharmacokinet 2005; 44 (9): 879-94
    • (2005) Clin Pharmacokinet , vol.44 , Issue.9 , pp. 879-894
    • Peng, B.1    Lloyd, P.2    Schran, H.3
  • 16
    • 0033816156 scopus 로고    scopus 로고
    • Abl protein-tyrosine kinase inhibitor ST1571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors
    • Buchdunger E, Cioffi CL, Law N, et al. Abl protein-tyrosine kinase inhibitor ST1571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors. J Pharmacol Exp Ther 2000; 295 (1): 139-45
    • (2000) J Pharmacol Exp Ther , vol.295 , Issue.1 , pp. 139-145
    • Buchdunger, E.1    Cioffi, C.L.2    Law, N.3
  • 17
    • 0035899418 scopus 로고    scopus 로고
    • STI571 inactivation of the gastrointestinal stromal tumor c-KIT oncoprotein: Biological and clinical implications
    • Aug 16;
    • Tuveson DA, Willis NA, Jacks T, et al. STI571 inactivation of the gastrointestinal stromal tumor c-KIT oncoprotein: biological and clinical implications. Oncogene 2001 Aug 16; 20 (36): 5054-8
    • (2001) Oncogene , vol.20 , Issue.36 , pp. 5054-5058
    • Tuveson, D.A.1    Willis, N.A.2    Jacks, T.3
  • 18
    • 0034254249 scopus 로고    scopus 로고
    • Inhibition of c-kit receptor tyrosine kinase activity by STI 571, a selective tyrosine kinase inhibitor
    • Heinrich MC, Griffith DJ, Druker BJ, et al. Inhibition of c-kit receptor tyrosine kinase activity by STI 571, a selective tyrosine kinase inhibitor. Blood 2000; 96 (3): 925-32
    • (2000) Blood , vol.96 , Issue.3 , pp. 925-932
    • Heinrich, M.C.1    Griffith, D.J.2    Druker, B.J.3
  • 19
    • 33645807197 scopus 로고    scopus 로고
    • Prenen H, Deroose C, Vermaelen P, et al. Establishment of a mouse gastrointestinal stromal tumour model and evaluation of response to imatinib by small animal positron emission tomography. Anticancer Res 2006 Mar 30; 26 (2A): 1247-52
    • Prenen H, Deroose C, Vermaelen P, et al. Establishment of a mouse gastrointestinal stromal tumour model and evaluation of response to imatinib by small animal positron emission tomography. Anticancer Res 2006 Mar 30; 26 (2A): 1247-52
  • 20
    • 1842579584 scopus 로고    scopus 로고
    • Serum KIT and KIT ligand levels in patients with gastrointestinal stromal tumors treated with imatinib
    • Apr 15;
    • Bono P, Krause A, von Mehren M, et al. Serum KIT and KIT ligand levels in patients with gastrointestinal stromal tumors treated with imatinib. Blood 2004 Apr 15; 103 (8): 2929-35
    • (2004) Blood , vol.103 , Issue.8 , pp. 2929-2935
    • Bono, P.1    Krause, A.2    von Mehren, M.3
  • 21
    • 34247646062 scopus 로고    scopus 로고
    • The anticancer drug imatinib induces cellular autophagy
    • Mar 1 [Epub ahead of print
    • Ermer A, Huber V, Gilch S, et al. The anticancer drug imatinib induces cellular autophagy. Leukemia 2007 Mar 1 [Epub ahead of print]
    • (2007) Leukemia
    • Ermer, A.1    Huber, V.2    Gilch, S.3
  • 22
    • 0037103424 scopus 로고    scopus 로고
    • Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors
    • Aug 15;
    • Demetri GD, von Mehren M, Blanke CD, et al. Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. N Engl J Med 2002 Aug 15; 347 (7): 472-80
    • (2002) N Engl J Med , vol.347 , Issue.7 , pp. 472-480
    • Demetri, G.D.1    von Mehren, M.2    Blanke, C.D.3
  • 23
    • 24944529613 scopus 로고    scopus 로고
    • Initial and late resistance to imatinib in advanced gastrointestinal stromal tumors are predicted by different prognostic factors: A European Organisation for Research and Treatment of Cancer-Italian Sarcoma Group-Australasian Gastrointestinal Trials Group study
    • Aug 20;
    • Van Glabbeke M, Verweij J, Casali PG, et al. Initial and late resistance to imatinib in advanced gastrointestinal stromal tumors are predicted by different prognostic factors: a European Organisation for Research and Treatment of Cancer-Italian Sarcoma Group-Australasian Gastrointestinal Trials Group study. J Clin Oncol 2005 Aug 20; 23 (24): 5795-804
    • (2005) J Clin Oncol , vol.23 , Issue.24 , pp. 5795-5804
    • Van Glabbeke, M.1    Verweij, J.2    Casali, P.G.3
  • 24
    • 20844433223 scopus 로고    scopus 로고
    • Progression-free survival in gastrointestinal stromal tumours with high-dose imatinib: Randomised trial
    • Verweij J, Casali PG, Zalcberg J, et al. Progression-free survival in gastrointestinal stromal tumours with high-dose imatinib: randomised trial. Lancet 2004; 364 (9440): 1127-34
    • (2004) Lancet , vol.364 , Issue.9440 , pp. 1127-1134
    • Verweij, J.1    Casali, P.G.2    Zalcberg, J.3
  • 25
    • 0242691165 scopus 로고    scopus 로고
    • Mechanisms of resistance to imatinib mesylate in advanced gastrointestinal stromal tumor [Abstract no. 3275]
    • Fletcher JA, Corless CL, Dimitrijevic S, et al. Mechanisms of resistance to imatinib mesylate in advanced gastrointestinal stromal tumor [Abstract no. 3275]. Proc Am Soc Clin Oncol 2003; 22: 815
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 815
    • Fletcher, J.A.1    Corless, C.L.2    Dimitrijevic, S.3
  • 26
    • 14944352767 scopus 로고    scopus 로고
    • Mechanisms of resistance to imatinib mesylate in gastrointestinal stromal tumors and activity of the PKC412 inhibitor against imatinib-resistant mutants
    • Feb 1;
    • Debiec-Rychter M, Cools J, Dumez H, et al. Mechanisms of resistance to imatinib mesylate in gastrointestinal stromal tumors and activity of the PKC412 inhibitor against imatinib-resistant mutants. Gastroenterology 2005 Feb 1; 128 (2): 270-9
    • (2005) Gastroenterology , vol.128 , Issue.2 , pp. 270-279
    • Debiec-Rychter, M.1    Cools, J.2    Dumez, H.3
  • 27
    • 33750595859 scopus 로고    scopus 로고
    • Molecular correlates of imatinib resistance in gastrointestinal stromal tumors
    • Oct 10;
    • Heinrich MC, Corless CL, Blanke CD, et al. Molecular correlates of imatinib resistance in gastrointestinal stromal tumors. J Clin Oncol 2006 Oct 10; 24 (29): 4764-74
    • (2006) J Clin Oncol , vol.24 , Issue.29 , pp. 4764-4774
    • Heinrich, M.C.1    Corless, C.L.2    Blanke, C.D.3
  • 28
    • 9444282642 scopus 로고    scopus 로고
    • Active transport of imatinib into and out of cells: Implications for drug resistance
    • Dec 1;
    • Thomas J, Wang L, Clark RE, et al. Active transport of imatinib into and out of cells: implications for drug resistance. Blood 2004 Dec 1; 104 (12): 3739-45
    • (2004) Blood , vol.104 , Issue.12 , pp. 3739-3745
    • Thomas, J.1    Wang, L.2    Clark, R.E.3
  • 29
    • 20144364602 scopus 로고    scopus 로고
    • Imatinib pharmacokinetics in patients with gastrointestinal stromal tumour: A retrospective population pharmacokinetic study over time. EORTC Soft Tissue and Bone Sarcoma Group
    • Apr;
    • Judson I, Ma P, Peng B, et al. Imatinib pharmacokinetics in patients with gastrointestinal stromal tumour: a retrospective population pharmacokinetic study over time. EORTC Soft Tissue and Bone Sarcoma Group. Cancer Chemother Pharmacol 2005 Apr; 55 (4): 379-86
    • (2005) Cancer Chemother Pharmacol , vol.55 , Issue.4 , pp. 379-386
    • Judson, I.1    Ma, P.2    Peng, B.3
  • 30
    • 17144381630 scopus 로고    scopus 로고
    • Pharmacokinetic resistance to imatinib mesylate: Role of the ABC drug pumps ABCG2 (BCRP) and ABCB1 (MDR1) in the oral bioavailability of imatinib
    • Dec;
    • Burger H, Nooter K. Pharmacokinetic resistance to imatinib mesylate: role of the ABC drug pumps ABCG2 (BCRP) and ABCB1 (MDR1) in the oral bioavailability of imatinib. Cell Cycle 2004 Dec; 3 (12): 1502-5
    • (2004) Cell Cycle , vol.3 , Issue.12 , pp. 1502-1505
    • Burger, H.1    Nooter, K.2
  • 31
    • 0142241268 scopus 로고    scopus 로고
    • Interaction of imatinib mesilate with human p-glycoprotein
    • Hamada A, Miyano H, Watanabe H, et al. Interaction of imatinib mesilate with human p-glycoprotein. J Pharmacol Exp Ther 2003; 307 (2): 824-8
    • (2003) J Pharmacol Exp Ther , vol.307 , Issue.2 , pp. 824-828
    • Hamada, A.1    Miyano, H.2    Watanabe, H.3
  • 32
    • 33750735723 scopus 로고    scopus 로고
    • Pharmacokinetic-pharmacodynamic relationships of imatinib and its main metabolite in patients with advanced gastrointestinal stromal tumors
    • Oct 15;
    • Delbaldo C, Chatelut E, Re M, et al. Pharmacokinetic-pharmacodynamic relationships of imatinib and its main metabolite in patients with advanced gastrointestinal stromal tumors. Clin Cancer Res 2006 Oct 15; 12 (20 Pt 1): 6073-8
    • (2006) Clin Cancer Res , vol.12 , Issue.20 PART 1 , pp. 6073-6078
    • Delbaldo, C.1    Chatelut, E.2    Re, M.3
  • 33
    • 0344373777 scopus 로고    scopus 로고
    • Committee for Proprietary Medicinal Products, discussion. London: European Agency for the Evaluation of Medicinal Products, CPMP/2418/01
    • Committee for Proprietary Medicinal Products. European public assessment report on Glivec (revision 1): scientific discussion. London: European Agency for the Evaluation of Medicinal Products, 2002; CPMP/2418/01
    • (2002) European public assessment report on Glivec (revision 1): Scientific
  • 35
    • 34047231138 scopus 로고    scopus 로고
    • Novartis Europharm Limited. Product information (EU): Glivec® (imatinib mesylate) tablets 100 and 400mg [online]. Available from URL: http://www.emea.eu.int/ [Accessed 2007 Jan 22]
    • Novartis Europharm Limited. Product information (EU): Glivec® (imatinib mesylate) tablets 100 and 400mg [online]. Available from URL: http://www.emea.eu.int/ [Accessed 2007 Jan 22]
  • 36
    • 34047210501 scopus 로고    scopus 로고
    • Glivec® GIST clinical monograph. Basel: Novartis Pharma AG, 2002
    • Glivec® GIST clinical monograph. Basel: Novartis Pharma AG, 2002
  • 37
    • 1542608328 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of imatinib in a phase I trial with chronic myeloid leukemia patients
    • Mar;
    • Peng B, Hayes M, Resta D, et al. Pharmacokinetics and pharmacodynamics of imatinib in a phase I trial with chronic myeloid leukemia patients. J Clin Oncol 2004 Mar; 22 (5): 935-42
    • (2004) J Clin Oncol , vol.22 , Issue.5 , pp. 935-942
    • Peng, B.1    Hayes, M.2    Resta, D.3
  • 38
    • 1642494654 scopus 로고    scopus 로고
    • Absolute bioavailability of imatinib (Glivec) orally versus intravenous infusion
    • Feb;
    • Peng B, Dutreix C, Mehring G, et al. Absolute bioavailability of imatinib (Glivec) orally versus intravenous infusion. J Clin Pharmacol 2004 Feb; 44 (2): 158-62
    • (2004) J Clin Pharmacol , vol.44 , Issue.2 , pp. 158-162
    • Peng, B.1    Dutreix, C.2    Mehring, G.3
  • 39
    • 24944581623 scopus 로고    scopus 로고
    • Metabolism and disposition of imatinib mesylate in healthy volunteers
    • Oct;
    • Gschwind HP, Pfaar U, Waldmeier F, et al. Metabolism and disposition of imatinib mesylate in healthy volunteers. Drug Metab Dispos 2005 Oct; 33 (10): 1503-12
    • (2005) Drug Metab Dispos , vol.33 , Issue.10 , pp. 1503-1512
    • Gschwind, H.P.1    Pfaar, U.2    Waldmeier, F.3
  • 40
    • 4644287353 scopus 로고    scopus 로고
    • Pharmacokinetic interaction between ketoconazole and imatinib mesylate (Glivec) in healthy subjects
    • Oct;
    • Dutreix C, Peng B, Mehring G, et al. Pharmacokinetic interaction between ketoconazole and imatinib mesylate (Glivec) in healthy subjects. Cancer Chemother Pharmacol 2004 Oct; 54 (4): 290-4
    • (2004) Cancer Chemother Pharmacol , vol.54 , Issue.4 , pp. 290-294
    • Dutreix, C.1    Peng, B.2    Mehring, G.3
  • 41
    • 4744338886 scopus 로고    scopus 로고
    • Effect of St John's wort on imatinib mesylate pharmacokinetics
    • Oct;
    • Frye RF, Fitzgerald SM, Lagattuta TF, et al. Effect of St John's wort on imatinib mesylate pharmacokinetics. Clin Pharmacol Ther 2004 Oct; 76 (4): 323-9
    • (2004) Clin Pharmacol Ther , vol.76 , Issue.4 , pp. 323-329
    • Frye, R.F.1    Fitzgerald, S.M.2    Lagattuta, T.F.3
  • 42
    • 0442313672 scopus 로고    scopus 로고
    • Effect of rifampicin on the pharmacokinetics of imatinib mesylate (Gleevec, STI571) in healthy subjects
    • Feb;
    • Bolton AE, Peng B, Hubert M, et al. Effect of rifampicin on the pharmacokinetics of imatinib mesylate (Gleevec, STI571) in healthy subjects. Cancer Chemother Pharmacol 2004 Feb; 53 (2): 102-6
    • (2004) Cancer Chemother Pharmacol , vol.53 , Issue.2 , pp. 102-106
    • Bolton, A.E.1    Peng, B.2    Hubert, M.3
  • 43
    • 10744231436 scopus 로고    scopus 로고
    • O'Brien SG, Meinhardt P, Bond E, et al. Effects of imatinib mesylate (STI571, Glivec) on the pharmacokinetics of simvastatin, a cytochrome p450 3A4 substrate, in patients with chronic myeloid leukaemia. Br J Cancer 2003 Nov 17; 89 (10): 1855-9
    • O'Brien SG, Meinhardt P, Bond E, et al. Effects of imatinib mesylate (STI571, Glivec) on the pharmacokinetics of simvastatin, a cytochrome p450 3A4 substrate, in patients with chronic myeloid leukaemia. Br J Cancer 2003 Nov 17; 89 (10): 1855-9
  • 46
    • 0036769721 scopus 로고    scopus 로고
    • Update of phase I study of imatinib (STI571) in advanced soft tissue sarcomas and gastrointestinal stromal tumours: A report of the EORTC soft tissue and bone sarcoma group
    • van Oosterom AT, Judson IR, Verweij J, et al. Update of phase I study of imatinib (STI571) in advanced soft tissue sarcomas and gastrointestinal stromal tumours: a report of the EORTC soft tissue and bone sarcoma group. Eur J Cancer 2002; 38 Suppl. 5: S83-7
    • (2002) Eur J Cancer , vol.38 , Issue.SUPPL. 5
    • van Oosterom, A.T.1    Judson, I.R.2    Verweij, J.3
  • 47
    • 0142121411 scopus 로고    scopus 로고
    • Imatinib mesylate (STI-571 Glivec®, Gleevec™) is an active agent for gastrointestinal stromal tumours, but does not yield responses in other soft-tissue sarcomas that are unselected for a molecular target: Results from an EORTC Soft Tissue and Bone Sarcoma Group phase II study
    • Sep;
    • Verweij J, van Oosterom A, Blay JY, et al. Imatinib mesylate (STI-571 Glivec®, Gleevec™) is an active agent for gastrointestinal stromal tumours, but does not yield responses in other soft-tissue sarcomas that are unselected for a molecular target: results from an EORTC Soft Tissue and Bone Sarcoma Group phase II study. Eur J Cancer 2003 Sep; 39 (14): 2006-11
    • (2003) Eur J Cancer , vol.39 , Issue.14 , pp. 2006-2011
    • Verweij, J.1    van Oosterom, A.2    Blay, J.Y.3
  • 48
    • 0027076295 scopus 로고
    • Southwest Oncology Group standard response criteria, endpoint definitions and toxicity criteria
    • Green S, Weiss GR. Southwest Oncology Group standard response criteria, endpoint definitions and toxicity criteria. Invest New Drugs 1992; 10: 239-53
    • (1992) Invest New Drugs , vol.10 , pp. 239-253
    • Green, S.1    Weiss, G.R.2
  • 49
    • 0034594628 scopus 로고    scopus 로고
    • New guidelines to evaluate the response to treatment in solid tumors
    • Therasse P, Arbuck SG, Eisenhauer EA, et al. New guidelines to evaluate the response to treatment in solid tumors. J Natl Cancer Inst 2000; 92 (3): 205-16
    • (2000) J Natl Cancer Inst , vol.92 , Issue.3 , pp. 205-216
    • Therasse, P.1    Arbuck, S.G.2    Eisenhauer, E.A.3
  • 51
    • 23644452642 scopus 로고    scopus 로고
    • Outcome of patients with advanced gastro-intestinal stromal tumours crossing over to a daily imatinib dose of 800 mg after progression on 400 mg
    • Aug;
    • Zalcberg JR, Verweij J, Casali PG, et al. Outcome of patients with advanced gastro-intestinal stromal tumours crossing over to a daily imatinib dose of 800 mg after progression on 400 mg. Eur J Cancer 2005 Aug; 41 (12): 1751-7
    • (2005) Eur J Cancer , vol.41 , Issue.12 , pp. 1751-1757
    • Zalcberg, J.R.1    Verweij, J.2    Casali, P.G.3
  • 52
    • 34047216757 scopus 로고    scopus 로고
    • Interruption of imatinib in responding patients after one year treatment does not influence overall survival of patients with advanced GIST: Updated results of the French Sarcoma Group randomized phase III BFR14 trial
    • Oct;
    • Le Cesne A, Ray-Coquard I, Bui B, et al. Interruption of imatinib in responding patients after one year treatment does not influence overall survival of patients with advanced GIST: updated results of the French Sarcoma Group randomized phase III BFR14 trial. Eur J Cancer Suppl 2005 Oct; 3 (2): 202
    • (2005) Eur J Cancer Suppl , vol.3 , Issue.2 , pp. 202
    • Le Cesne, A.1    Ray-Coquard, I.2    Bui, B.3
  • 53
    • 4544351070 scopus 로고    scopus 로고
    • Continuous vs intermittent imatinib treatment in advanced GIST after one year: A prospective randomized phase III trial of the French Sarcoma Group
    • Abstract no. 9006, Jun 5-8; New Orleans LA
    • Blay JY, Berthaud P, Perol D, et al. Continuous vs intermittent imatinib treatment in advanced GIST after one year: a prospective randomized phase III trial of the French Sarcoma Group. [Abstract no. 9006 plus oral presentation]. 40th Annual Meeting of the American Society of Clinical Oncology; 2004 Jun 5-8; New Orleans (LA)
    • (2004) plus oral presentation]. 40th Annual Meeting of the American Society of Clinical Oncology
    • Blay, J.Y.1    Berthaud, P.2    Perol, D.3
  • 54
    • 12144291080 scopus 로고    scopus 로고
    • Use of c-KIT/PDGFRA mutational analysis to predict the clinical response to imatinib in patients with advanced gastrointestinal stromal tumours entered on phase I and II studies of the EORTC Soft Tissue and Bone Sarcoma Group
    • Mar;
    • Debiec-Rychter M, Dumez H, Judson I, et al. Use of c-KIT/PDGFRA mutational analysis to predict the clinical response to imatinib in patients with advanced gastrointestinal stromal tumours entered on phase I and II studies of the EORTC Soft Tissue and Bone Sarcoma Group. Eur J Cancer 2004 Mar; 40 (5): 689-95
    • (2004) Eur J Cancer , vol.40 , Issue.5 , pp. 689-695
    • Debiec-Rychter, M.1    Dumez, H.2    Judson, I.3
  • 55
    • 33746401591 scopus 로고    scopus 로고
    • KIT mutations and dose selection for imatinib in patients with advanced gastrointestinal stromal tumours
    • May;
    • Debiec-Rychter M, Sciot R, Le Cesne A, et al. KIT mutations and dose selection for imatinib in patients with advanced gastrointestinal stromal tumours. Eur J Cancer 2006 May; 42 (8): 1093-103
    • (2006) Eur J Cancer , vol.42 , Issue.8 , pp. 1093-1103
    • Debiec-Rychter, M.1    Sciot, R.2    Le Cesne, A.3
  • 56
    • 33746845181 scopus 로고    scopus 로고
    • Cardiotoxicity of the cancer therapeutic agent imatinib mesylate
    • Aug;
    • Kerkelä R, Grazette L, Yacobi R, et al. Cardiotoxicity of the cancer therapeutic agent imatinib mesylate. Nat Med 2006 Aug; 12 (8): 908-16
    • (2006) Nat Med , vol.12 , Issue.8 , pp. 908-916
    • Kerkelä, R.1    Grazette, L.2    Yacobi, R.3
  • 57
    • 33846059080 scopus 로고    scopus 로고
    • In reply to 'Cardiotoxicity of the cancer therapeutic agent imatinib mesylate' [letter]
    • Jan;
    • Force T. In reply to 'Cardiotoxicity of the cancer therapeutic agent imatinib mesylate' [letter]. Nat Med 2007 Jan; 13 (1): 15-6
    • (2007) Nat Med , vol.13 , Issue.1 , pp. 15-16
    • Force, T.1
  • 58
    • 33846091260 scopus 로고    scopus 로고
    • Hatfield A, Owen S, Pilot PR. In reply to 'Cardiotoxicity of the cancer therapeutic agent imatinib mesylate'. Nat Med 2007 Jan; 13 (1): 13
    • Hatfield A, Owen S, Pilot PR. In reply to 'Cardiotoxicity of the cancer therapeutic agent imatinib mesylate'. Nat Med 2007 Jan; 13 (1): 13
  • 59
    • 33646482407 scopus 로고    scopus 로고
    • Berman E, Nicolaides M, Maki RG, et al. Altered bone and mineral metabolism in patients receiving imatinib mesylate. N Engl J Med 2006 May 11; 354 (19): 2006-13
    • Berman E, Nicolaides M, Maki RG, et al. Altered bone and mineral metabolism in patients receiving imatinib mesylate. N Engl J Med 2006 May 11; 354 (19): 2006-13
  • 60
    • 34047217789 scopus 로고    scopus 로고
    • soft tissue sarcoma panel
    • National Comprehensive Cancer Network NCCN, version 3.2006, online, Available from URL:, Accessed Jan 22
    • National Comprehensive Cancer Network (NCCN) soft tissue sarcoma panel. NCCN clinical practice guidelines in oncology: soft tissue sarcoma (version 3.2006) [online]. Available from URL: http://www.nccn.org [Accessed 2007 Jan 22]
    • (2007) NCCN clinical practice guidelines in oncology: Soft tissue sarcoma
  • 62
    • 28244441991 scopus 로고    scopus 로고
    • Incidence of gastrointestinal stromal tumours is underestimated: Results of a nation-wide study
    • Dec;
    • Goettsch WG, Bos SD, Breekveldt-Postma N, et al. Incidence of gastrointestinal stromal tumours is underestimated: results of a nation-wide study. Eur J Cancer 2005 Dec; 41 (18): 2868-72
    • (2005) Eur J Cancer , vol.41 , Issue.18 , pp. 2868-2872
    • Goettsch, W.G.1    Bos, S.D.2    Breekveldt-Postma, N.3
  • 63
    • 0033984319 scopus 로고    scopus 로고
    • Two hundred gastrointestinal stromal tumors: Recurrence patterns and prognostic factors for survival
    • DeMatteo RP, Lewis J, Leung D, et al. Two hundred gastrointestinal stromal tumors: recurrence patterns and prognostic factors for survival. Ann Surg 2000; 231 (1): 51-8
    • (2000) Ann Surg , vol.231 , Issue.1 , pp. 51-58
    • DeMatteo, R.P.1    Lewis, J.2    Leung, D.3
  • 64
    • 33645926705 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumours: Consensus statement on diagnosis and treatment
    • Mar;
    • Blackstein ME, Blay JY, Corless C, et al. Gastrointestinal stromal tumours: consensus statement on diagnosis and treatment. Can J Gastroenterol 2006 Mar; 20 (3): 157-63
    • (2006) Can J Gastroenterol , vol.20 , Issue.3 , pp. 157-163
    • Blackstein, M.E.1    Blay, J.Y.2    Corless, C.3
  • 65
    • 34047223986 scopus 로고    scopus 로고
    • Dileo P, Rankin CJ, Benjamin RS, et al. Incidence and reasons for dose modification of standard-dose vs high-dose imatinib mesylate in the phase III intergroup study S0033 of patients with unresectable or metastatic gastrointestinal stromal tumor [abstract no. 9032]. J Clin Oncol 2005 Jun; 23 Suppl. 16S Pt 1: 824. Plus oral presentation made at the 41st Annual Meeting of the American Society of Clinical Oncology; 2005 May 13-17; Orlando (FL)
    • Dileo P, Rankin CJ, Benjamin RS, et al. Incidence and reasons for dose modification of standard-dose vs high-dose imatinib mesylate in the phase III intergroup study S0033 of patients with unresectable or metastatic gastrointestinal stromal tumor [abstract no. 9032]. J Clin Oncol 2005 Jun; 23 Suppl. 16S Pt 1: 824. Plus oral presentation made at the 41st Annual Meeting of the American Society of Clinical Oncology; 2005 May 13-17; Orlando (FL)
  • 66
    • 10744224969 scopus 로고    scopus 로고
    • Is there a role for surgery in patients with "unresectable" cKIT+ gastrointestinal stromal tumors treated with imatinib mesylate?
    • Dec;
    • Scaife CL, Hunt KK, Patel SR, et al. Is there a role for surgery in patients with "unresectable" cKIT+ gastrointestinal stromal tumors treated with imatinib mesylate? Am J Surg 2003 Dec; 186 (6): 665-9
    • (2003) Am J Surg , vol.186 , Issue.6 , pp. 665-669
    • Scaife, C.L.1    Hunt, K.K.2    Patel, S.R.3
  • 67
    • 34047210252 scopus 로고    scopus 로고
    • GIST Support International, trials [online, Available from URL:, Accessed Aug 23
    • GIST Support International. Current trials [online]. Available from URL: http://www.gistsupport.org/ [Accessed 2006 Aug 23]
    • (2006) Current
  • 68
    • 34047207417 scopus 로고    scopus 로고
    • Blackstein ME, Rankin C, Fletcher C, et al. Clinical benefit of imatinib in patients with metastatic gastrointestinal stromal tumors negative for the expression of CD117 in the SOO33 trial [abstract no. 9010]. J Clin Oncol 2005 Jun; 23 Suppl. 16S Pt 1: 818
    • Blackstein ME, Rankin C, Fletcher C, et al. Clinical benefit of imatinib in patients with metastatic gastrointestinal stromal tumors negative for the expression of CD117 in the SOO33 trial [abstract no. 9010]. J Clin Oncol 2005 Jun; 23 Suppl. 16S Pt 1: 818
  • 69
    • 2142747025 scopus 로고    scopus 로고
    • KIT-negative gastrointestinal stromal tumors: Proof of concept and therapeutic implications
    • Jul;
    • Medeiros F, Corless CL, Duensing A, et al. KIT-negative gastrointestinal stromal tumors: proof of concept and therapeutic implications. Am J Surg Pathol 2004 Jul; 28 (7): 889-94
    • (2004) Am J Surg Pathol , vol.28 , Issue.7 , pp. 889-894
    • Medeiros, F.1    Corless, C.L.2    Duensing, A.3
  • 70
    • 33846415876 scopus 로고    scopus 로고
    • Cost effectiveness of imatinib mesylate in the treatment of advanced gastrointestinal stromal tumors
    • Huse DM, von Mehren M, Lenhart G, et al. Cost effectiveness of imatinib mesylate in the treatment of advanced gastrointestinal stromal tumors. Clin Drug Invest 2007; 27 (2): 85-93
    • (2007) Clin Drug Invest , vol.27 , Issue.2 , pp. 85-93
    • Huse, D.M.1    von Mehren, M.2    Lenhart, G.3
  • 72
    • 34047200485 scopus 로고    scopus 로고
    • Imatinib: Cost-effective in the treatment of gastrointestinal stromal tumors [abstract no. 762P]
    • Finketstein SN, Huse DM, Glendenning GA, et al. Imatinib: cost-effective in the treatment of gastrointestinal stromal tumors [abstract no. 762P]. Ann Oncol 2004; 15 Suppl. 3: 201
    • (2004) Ann Oncol , vol.15 , Issue.SUPPL. 3 , pp. 201
    • Finketstein, S.N.1    Huse, D.M.2    Glendenning, G.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.