Neurons generated from APP/APLP1/APLP2 triple knockout embryonic stem cells behave normally in vitro and in vivo: Lack of evidence for a cell autonomous role of the amyloid precursor protein in neuronal differentiation

Stem Cells

Volumn 28, Issue 3, 2010, Pages 399-406

  Bergmans, Bruno A ^a,d,e   Shariati, S Ali M ^a,d,e   Habets, Ron L P ^c,d,e   Verstreken, Patrik ^c,d,e   Schoonjans, Luc ^f   Müller, Ulrike ^g   Dotti, Carlos G ^b,d,e   De Strooper, Bart ^a,d,e  

^a Laboratory of Neuronal Cell Biology and Gene Transfer   (Belgium)

^b Laboratory of Neuronal Differentiation   (Belgium)

^c Laboratory of Neuronal Communication   (Belgium)

^d DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^e UNIVERSITY OF LEUVEN   (Belgium)

^f UNIVERSITY HOSPITAL BRUSSELS   (Belgium)

^g UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Alzheimer's disease; Amyloid precursor protein; Chimeric mouse; Embryonic stem cell; Glutamatergic neuron; Neuronal differentiation

Indexed keywords

AMYLOID PRECURSOR PROTEIN; AMYLOID PRECURSOR PROTEIN LIKE PROTEIN 1; AMYLOID PRECURSOR PROTEIN LIKE PROTEIN 2; ENHANCED GREEN FLUORESCENT PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL MIGRATION; CELL POLARITY; CONTROLLED STUDY; EMBRYO; EMBRYONIC STEM CELL; IN VITRO STUDY; IN VIVO STUDY; KNOCKOUT GENE; MOUSE; NERVE CELL CULTURE; NERVE CELL DIFFERENTIATION; NERVE FIBER GROWTH; NEWBORN; NONHUMAN; PROTEIN EXPRESSION; SYNAPTOGENESIS; WILD TYPE;

AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BRAIN; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELL MOVEMENT; CELL POLARITY; CELLS, CULTURED; CHIMERA; COBBLESTONE LISSENCEPHALY; EMBRYONIC STEM CELLS; FEMALE; GREEN FLUORESCENT PROTEINS; MALE; MICE; MICE, KNOCKOUT; NERVOUS SYSTEM MALFORMATIONS; NEURAL PATHWAYS; NEURITES; NEUROGENESIS; NEURONS;

MUS;

EID: 77950558348     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.296     Document Type: Article

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