Bradykinin receptor antagonists containing N-substituted amino acids: In vitro and in vivo B2 and B1 receptor antagonist activity

Journal of Medicinal Chemistry

Volumn 39, Issue 7, 1996, Pages 1472-1484

  Goodfellow, Val S ^a   Marathe, Manoj V ^a   Kuhlman, Karen G ^a   Fitzpatrick, Timothy D ^a   Cuadrado, David ^a   Hanson, Wendy ^a   Zuzack, John S ^a   Ross, Sherman E ^a   Wieczorek, Maciej ^a   Burkard, Michael ^a   Whalley, Eric T ^a  

^a Departments of New Leads Chemistry and Pharmacology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRADYKININ ANTAGONIST; BRADYKININ B1 RECEPTOR; BRADYKININ B2 RECEPTOR; BRADYKININ RECEPTOR; MEMBRANE RECEPTOR;

AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BLOOD PRESSURE MONITORING; DRUG ACTIVITY; DRUG POTENCY; DRUG TISSUE LEVEL; HYPERALGESIA; NONHUMAN; RABBIT; RECEPTOR BLOCKING; SWINE;

AMINO ACID SEQUENCE; AMINO ACIDS; ANIMALS; AORTA; BINDING, COMPETITIVE; BLOOD PRESSURE; FEMALE; GUINEA PIGS; HUMANS; ILEUM; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; OLIGOPEPTIDES; PROTEIN BINDING; RABBITS; RATS; RECEPTOR, BRADYKININ B1; RECEPTOR, BRADYKININ B2; RECEPTORS, BRADYKININ; STRUCTURE-ACTIVITY RELATIONSHIP; UTERUS;

EID: 13344287044     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm950716i     Document Type: Article

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55. Note Added in Proof. High-resolution FAB-MS data for compound 1 were obtained by M-Scan (West Chester, PA) using 3-nitrobenzyl alcohol matrix with PEG1000 as internal standard. The sample signal was measured as 1292.6732, which agrees with the calculated protonated molecular ion of 1292.6686 at 3.5 ppm deviation.