Developing a general strategy for the solid supported synthesis of heterocycles: Applications to the generation of molecular diversity and drug discovery

Pure and Applied Chemistry

Volumn 69, Issue 3, 1997, Pages 447-452

  Nuss, John M ^a   Desai, Manoj C ^a   Zuckermann, Ronald N ^a   Singh, Rajinder ^a   Renhowe, Paul A ^a   Goff, Dane A ^a   Chinn, Jason P ^a   Wang, Liang ^a   Dorr, Hilary ^a   Brown, Edward G ^a   Subramanian, Sharadha ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0000912653     PISSN: 00334545     EISSN: None     Source Type: Journal    
DOI: 10.1351/pac199769030447     Document Type: Article

References (22)

1. For recent overviews of this field, see: (a) M.C. Desai; R.N. Zuckermann; W.H. Moos. Drug Dev. Res. 33, 174 (1995); (b) E. Felder Chimia 48, 531 (1995); (c) E.M. Gordon, R.W. Barrett, W.J. Dower, S.P.A. Fodor, M.A. Gallop J. Med.Chem. 37, 1233 and 1385 (1994).
2. For recent overviews of this field, see: (a) M.C. Desai; R.N. Zuckermann; W.H. Moos. Drug Dev. Res. 33, 174 (1995); (b) E. Felder Chimia 48, 531 (1995); (c) E.M. Gordon, R.W. Barrett, W.J. Dower, S.P.A. Fodor, M.A. Gallop J. Med.Chem. 37, 1233 and 1385 (1994).
3. For recent overviews of this field, see: (a) M.C. Desai; R.N. Zuckermann; W.H. Moos. Drug Dev. Res. 33, 174 (1995); (b) E. Felder Chimia 48, 531 (1995); (c) E.M. Gordon, R.W. Barrett, W.J. Dower, S.P.A. Fodor, M.A. Gallop J. Med.Chem. 37, 1233 and 1385 (1994).
4. See, for example Annu. Rep. Med. Chem. (1995),Volume 30, J.A. Bristol, Ed. Academic Press, San Diego, CA.
5. A wide-ranging electronic bibliography of articles in the field of molecular diversity is maintained by the journal Molecular Diversity. This can be accessed at http://vesta.pd.com/index.html.
6. R. Simon, R.S. Kania, R.N. Zuckermann, V.D. Huebner, D.A. Jewell, S. Banville, S. Ng, L. Wang, S. Rosenberg, C.K. Marlowe, D.C. Spellmeyer, A.D. Frankel, D.V. Santi, F.E. Cohen, P.A. Bartlett. Proc. Nat. Acad.Sci. U.S.A. 89, 9367 (1992).
7. R.N. Zuckermann, J.M. Kerr, S.B.H. Kent, W.H. Moos. J. Am. Chem. Soc. 111, 10646 (1995).
8. E.J. Martin, J.M. Blaney, M.A. Siani, D.C. Spellmeyer, A.K. Wong, W.H. Moos. J. Med. Chem. 38,1431 (1995).
9. R.N. Zuckermann, E.J. Martin, D.C. Spellmeyer, G.B. Stauber, K.R. Shoemaker, J.M. Kerr, G.M. Figliozzi, D.A. Goff, M.A. Siani, R.J. Simon, S.C. Banville, E.G. Brown, L. Wang, L.S. Richter, W.H. Moos. J.. Med. Chem. 37, 2678 (1994).
10. Y.H. Pei, W.H. Moos. Tetrahedron Lett. 35, 5825 (1995).
11. D.A. Goff, R.N. Zuckermann. J. Org. Chem. 50 5744 (1995).
12. D.A. Goff, R.N. Zuckermann. J. Org. Chem. 50, 5748 (1995).
13. For perhaps the most comprehensive and up to date review on solid phase organic synthesis, see: J. Ellman, L.A. Thompson. Chem. Rev. 96, 555 (1996). See also: P.H.H. Hermkens, H.C.J. Ottenheijm, D. Rees. Tetrahedron 52, 4527 (1996).
14. For perhaps the most comprehensive and up to date review on solid phase organic synthesis, see: J. Ellman, L.A. Thompson. Chem. Rev. 96, 555 (1996). See also: P.H.H. Hermkens, H.C.J. Ottenheijm, D. Rees. Tetrahedron 52, 4527 (1996).
15. J.M. Ostrech, G.M. Husar, S.E. Blondelle, B. Dorner, P.A. Weber, R.A. Houghten. Proc. Natl. Acad.Sci. U.S.A. 91, 11138 (1994).
16. H. Rink. Tetrahedron Lett. 28, 3787 (1987).
17. E.G. Brown, J.M. Nuss. manuscript in preparation.
18. C.C. Leznoff. Acc. Chem. Res. 11, 327 (1978).
19. R. Singh, J.M. Nuss. manuscript in preparation.
20. H. Dorr, J.M. Nuss. manuscript in preparation.
21. J.P. Chinn, M.C. Desai. unpublished results from these laboratories.
22. K. Achiwa, T. Motoyama, M. Sekiya. Chem. Pharm. Bull. 31, 3383 (1983).