Infections and autoimmunity: The multifaceted relationship

Journal of Leukocyte Biology

Volumn 87, Issue 3, 2010, Pages 385-395

  Sfriso, Paolo ^a   Ghirardello, Anna ^a   Botsios, Costantino ^a   Tonon, Michele ^a   Zen, Margherita ^a   Bassi, Nicola ^a   Bassetto, Franco ^a   Doria, Andrea ^a  

^a UNIVERSITY OF PADOVA   (Italy)

Author keywords

Autoimmune diseases; Biologic agents; Bystander activation; Immunosuppressive therapy; Molecular mimicry; Self tolerance loss

Indexed keywords

AUTOANTIGEN; AZATHIOPRINE; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; CYTOMEGALOVIRUS ANTIBODY; DISEASE MODIFYING ANTIRHEUMATIC DRUG; GAMMA INTERFERON; GLUCOCORTICOID; INFLIXIMAB; INFLUENZA VACCINE; INTERFERON; INTERLEUKIN 1; INTERLEUKIN 12; INTERLEUKIN 6; LEFLUNOMIDE; METHOTREXATE; PNEUMOCOCCUS VACCINE; RITUXIMAB; SUPERANTIGEN; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA ANTIBODY; TUMOR NECROSIS FACTOR ALPHA INHIBITOR;

ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ANTIGEN SPECIFICITY; APOPTOSIS; ASPERGILLOSIS; AUTOIMMUNE DISEASE; AUTOIMMUNITY; CELL DEATH; CLINICAL TRIAL; COCCIDIOIDOMYCOSIS; CRYPTOCOCCOSIS; CYTOKINE RELEASE; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTION; DERMATOMYOSITIS; DISEASE ASSOCIATION; DNA METHYLATION; DRUG EFFECT; DRUG SAFETY; ENDOGENOUS RETROVIRUS; ENVIRONMENTAL FACTOR; ERYTHEMA INFECTIOSUM; GENETIC SUSCEPTIBILITY; GRAM NEGATIVE BACTERIUM; GRAM NEGATIVE INFECTION; GROUP A STREPTOCOCCAL INFECTION; HEPATITIS B; HEPATITIS B VIRUS; HEPATITIS C; HEPATITIS C VIRUS; HERPES ZOSTER; HISTOPLASMOSIS; HOST PATHOGEN INTERACTION; HUMAN; IMMUNOGENICITY; IMMUNOMODULATION; IMMUNOPATHOGENESIS; INFECTION; INFECTION RISK; INFECTION SENSITIVITY; INFLUENZA; INFLUENZA VACCINATION; INNATE IMMUNITY; KLEBSIELLA PNEUMONIAE; KLEBSIELLA PNEUMONIAE INFECTION; LISTERIOSIS; LOW DRUG DOSE; MOLECULAR MECHANICS; MOLECULAR MIMICRY; MYCOBACTERIOSIS; NATURAL KILLER T CELL; PARVOVIRUS; PNEUMOCOCCAL INFECTION; PNEUMOCYSTIS PNEUMONIA; PNEUMONIA; POLYMYOSITIS; PRIORITY JOURNAL; PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY; PROTEIN DENATURATION; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN PROCESSING; RETROVIRUS INFECTION; REVIEW; RHEUMATIC FEVER; RHEUMATOID ARTHRITIS; SIDE EFFECT; SJOEGREN SYNDROME; SPIROCHETE INFECTION; STREPTOCOCCUS PYOGENES; SYSTEMIC LUPUS ERYTHEMATOSUS; SYSTEMIC SCLEROSIS; T LYMPHOCYTE ACTIVATION; TUBERCULOSIS; VACCINATION; VIRUS REACTIVATION; ANIMAL; DISEASE PREDISPOSITION; IMMUNOLOGY;

BACTERIA (MICROORGANISMS);

ANIMALS; AUTOIMMUNITY; DISEASE SUSCEPTIBILITY; HOST-PATHOGEN INTERACTIONS; HUMANS; INFECTION; VACCINATION;

EID: 77950347321     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0709517     Document Type: Review

References (128)

1. Selgrade, M. K., Cooper, G. S., Germolec, D. R., Heindel, J. J. (1999) Linking environmental agents and autoimmune disease: an agenda for future research. Environ. Health Perspect. 107 (Suppl. 5), 811-813.
2. Harel, M., Shoenfeld, Y. (2006) Predicting and preventing autoimmunity, myth or reality? Ann. N. Y. Acad. Sci. 1069, 322-345. (Pubitemid 43989876)
3. Shoenfeld, Y., Gilburd, B., Abu-Shakra, M., Amital, H., Barzilai, O., Berkun, Y., Blank, M., Zandman-Goddard, G., Katz, U., Krause, I., Langevitz, P., Levy, Y., Orbach, H., Pordeus, V., Ram, M., Sherer, Y., Toubi, E., Tomer,Y. (2008) The mosaic of autoimmunity: genetic factors involved in autoimmune diseases. Isr. Med. Assoc. J. 10, 3-7.
4. Shoenfeld, Y., Zandman-Goddard, G., Stojanovich, L., Cutolo, M., Amital, H., Levy, Y., Abu-Shakra, M., Barzilai, O., Berkun, Y., Blank, M., de Carvalho, J. F., Doria, A., Gilburd, B., Katz, U., Krause, I., Langevitz, P., Orbach, H., Pordeus, V., Ram, M., Toubi, E., Sherer, Y. (2008) The mosaic of autoimmunity: hormonal and environmental factors involved in autoimmune diseases. Isr. Med. Assoc. J. 10, 8-12.
5. Shoenfeld, Y., Blank, M., Abu-Shakra, M., Amital, H., Barzilai, O., Berkun, Y., Bizzaro, N., Gilburd, B., Zandman-Goddard, G., Katz, U., Krause, I., Langevitz, P., Mackay, I. R., Orbach, H., Ram, M., Sherer, Y., Toubi, E., Gershwin, M. E. (2008) The mosaic of autoimmunity: prediction, autoantibodies, and therapy in autoimmune diseases. Isr. Med. Assoc. J. 10, 13-19.
6. Sarzi-Puttini, P., Atzeni, F., Iaccarino, L., Doria, A. (2005) Environment and systemic lupus erythematosus: an overview. Autoimmunity 38, 465-472. (Pubitemid 43101780)
7. Zampieri, S., Ghirardello, A., Iaccarino, L., Briani, C., Sarzi-Puttini, P., Atzeni, F., Arienti, S., Todesco, S., Doria, A. (2006) Polymyositis- dermatomyositis and infections. Autoimmunity 39, 191-196.
8. Chevrel, G., Calvet, A., Belin, V., Miossec, P. (2000) Dermatomyositis associated with the presence of parvovirus B19 DNA in muscle. Rheumatology 39, 1037-1039.
9. Yousef, G. E., Isenberg, D. A., Mowbray, J. F. (1990) Detection of enterovirus specific RNA sequences in muscle biopsy specimens from patients with adult onset of myositis. Ann. Rheum. Dis. 49, 310-315.
10. Doria, A., Sarzi-Puttini, P., Shoenfeld, Y. (2008) Infections, rheumatism and autoimmunity: the conflicting relationship between humans and their environment. Autoimmun. Rev. 8, 1-4.
11. Doria, A., Canova, M., Tonon, M., Zen, M., Rampudda, E., Bassi, N., Atzeni, F., Zampieri, S., Ghirardello, A. (2008) Infections as triggers and complications of systemic lupus erythematosus. Autoimmun. Rev. 8, 24-28.
12. Randone, S. B., Guiducci, S., Cerinic, M. M. (2008) Systemic sclerosis and infections. Autoimmun. Rev. 8, 36-40.
13. Kallenberg, C. G., Tadema, H. (2008) Vasculitis and infections: contribution to the issue of autoimmunity reviews devoted to "autoimmunity and infection". Autoimmun. Rev. 8, 29-32.
14. Patole, P. S., Pawar, R. D., Lichtnekert, J., Lech, M., Kulkarni, O. P., Ramanjaneyulu, A., Segerer, S., Anders, H. J. (2007) Coactivation of Tolllike receptor-3 and -7 in immune complex glomerulonephritis. J. Autoimmun. 29, 52-59. (Pubitemid 47016916)
15. Shoenfeld, Y. (2003) Systemic antiphospholipid syndrome. Lupus 12, 497-498.
16. Edwards, C. J., Cooper, C. (2006) Early environmental exposure and the development of lupus. Lupus 15, 814-819.
17. Mohan, C. (2006) Environment versus genetics in autoimmunity: a geneticist's perspective. Lupus 15, 791-793.
18. Albani, S. (1994) Infection and molecular mimicry in autoimmune disease of childhood. Clin. Exp. Rheumatol. 12 (Suppl. 10), S35-S41. (Pubitemid 24254532)
19. Yong, Z., Zhang, J. J., Schaack, T., Chen, S., Nakayama, A., Yu, D. T. (1989) A monoclonal anti-HLA-B27 antibody which is reactive with a linear sequence of the HLA-B27 protein is useful for the study of molecular mimicry. Clin. Exp. Rheumatol. 7, 513-519.
20. Poole, B. D., Scofield, R. H., Harley, J. B., James, J. A. (2006) Epstein-Barr virus and molecular mimicry in systemic lupus erythematosus. Autoimmunity 39, 63-70. (Pubitemid 43878521)
21. Samarkos, M., Vaiopoulos, G. (2005) The role of infections in the pathogenesis of autoimmune diseases. Curr. Drug Targets Inflamm. Allergy 4, 99-103. (Pubitemid 40584859)
22. Zampieri, S., Degen, W., Ghirardello, A., Doria, A., van Venrooij, W. J. (2001) Dephosphorylation of autoantigenic ribosomal P proteins during FAS-L induced apoptosis; a possible trigger for the development of the autoimmune response in SLE patients. Ann. Rheum. Dis. 60, 72-76. (Pubitemid 32038959)
23. Gershwin, M. E. (2008) The mosaic of autoimmunity. Autoimmun. Rev. 7, 161-163.
24. Vidalino, L., Doria, A., Quarta, S., Zen, M., Gatta, A., Pontisso, P. (2009) SERPINB3, apoptosis and autoimmunity. Autoimmun. Rev. 9, 108-112.
25. Schulze, C., Munoz, L. E., Franz, S., Sarter, K., Chaurio, R. A., Gaipl, U. S., Herrmann, M. (2008) Clearance deficiency-a potential link between infections and autoimmunity. Autoimmun. Rev. 8, 5-8.
26. Janko, C., Schorn, C., Grossmayer, G. E., Frey, B., Herrmann, M., Gaipl, U. S., Munoz, L. E. (2008) Inflammatory clearance of apoptotic remnants in systemic lupus erythematosus (SLE). Autoimmun. Rev. 8, 9-12.
27. Baccala, R., Hoebe, K., Kono, D. H., Beutler, B., Theofilopoulos, A. N. (2007) TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity. Nat. Med. 13, 543-551. (Pubitemid 46828489)
28. Marshak-Rothstein, A. (2006) Toll-like receptors in systemic autoimmune disease. Nat. Rev. Immunol. 6, 823-835. (Pubitemid 44631651)
29. Efthimiou, P., Flavell, R. A., Furlan, A., Gasbarrini, G., Gava, A., Koné-Paut, I., Manna, R., Punzi, L., Sutterwala, F. S., Touitou, I., Doria, A. (2008) Autoinflammatory syndromes and infections: pathogenetic and clinical implications. Clin. Exp. Rheumatol. 26 (Suppl. 48), S53-S61.
30. Koutouzov, S., Mathian, A., Dalloul, A. (2006) Type-I interferons and systemic lupus erythematosus. Autoimmun. Rev. 5, 554-562. (Pubitemid 44508854)
31. Gottenberg, J. E., Cagnard, N., Lucchesi, C., Letourneur, F., Mistou, S., Lazure, T., Jacques, S., Ba, N., Ittah, M., Lepajolec, C., Labetoulle, M., Ardizzone, M., Sibilia, J., Fournier, C., Chiocchia, G., Mariette, X. (2006) Activation of IFN pathways and plasmacytoid dendritic cell recruitment in targetorgans of primary Sjögren's syndrome. Proc. Natl. Acad. Sci. USA 103, 2770-2775. (Pubitemid 43306624)
32. Walsh, R. J., Kong, S. W., Yao, Y., Jallal, B., Kiener, P. A., Pinkus, J. L., Beggs, A. H., Amato, A. A., Greenberg, S. A. (2007) Type I interferoninducible gene expression in blood is present and reflects disease activity in dermatomyositis and polymyositis. Arthritis Rheum. 56, 3784-3792. (Pubitemid 350100711)
33. Bennett, L., Palucka, A. K., Arce, E., Cantrell, V., Borvak, J., Banchereau, J., Pascual, V. (2003) Interferon and granulopoiesis signatures in systemic lupus erythematosus blood. J. Exp. Med. 197, 711-723. (Pubitemid 36350866)
34. Marshak-Rothstein, A. (2006) Toll-like receptors in systemic autoimmune disease. Nat. Rev. Immunol. 6, 823-835. (Pubitemid 44631651)
35. Giordani, L., Sanchez, M., Libri, I., Quaranta, M. G., Mattioli, B., Viora, M. (2009) IFN-α amplifies human naive B cell TLR-9-mediated activation and Ig production. J. Leukoc. Biol. 86, 261-271.
36. Pisetsky, D. S. (2008) The role of innate immunity in the induction of autoimmunity. Autoimmun. Rev. 8, 69-72.
37. Leadbetter, E. A., Rifkin, I. R., Hohlbaum, A. M., Beaudette, B. C., Shlomchik, M. J., Marshak-Rothstein, A. (2002) Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors. Nature 416, 603-607.
38. Vollmer, J., Tluk, S., Schmitz, C., Hamm, S., Jurk, M., Forsbach, A., Akira, S., Kelly, K. M., Reeves, W. H., Bauer, S., King, A. M. (2005) Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8. J. Exp. Med. 202, 1575-1585. (Pubitemid 41746603)
39. Lau, C. M., Broughton, C., Tabor, A. S., Akira, S., Flavell, R. A., Mamula, M. J., Christensen, S. R., Shlomchik, M. J., Viglianti, G. A., Rifkin, I. R., Marshak-Rothstein, A. (2005) RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement. J. Exp. Med. 202, 1171-1177. (Pubitemid 41586947)
40. Malathi, K., Dong, B., Gale, M. J., Silverman, R. H. (2007) Small self-RNA generated by RNase L amplifies antiviral innate immunity. Nature 448, 816-819. (Pubitemid 47266340)
41. Banchereau, J., Briere, F., Caux, C., Davoust, J., Lebecque, S., Liu, Y. J., Pulendran, B., Palucka, K. (2000) Immunobiology of dendritic cells. Annu. Rev. Immunol. 18, 767-811.
42. Foti, M., Granucci, F., Pelizzola, M., Beretta, O., Ricciardi-Castagnoli, P. (2006) Dendritic cells in pathogen recognition and induction of immune responses: a functional genomics approach. J. Leukoc. Biol. 79, 913-916.
43. Maldonado-López, R., De Smedt, T., Michel, P., Godfroid, J., Pajak, B., Heirman, C., Thielemans, K., Leo, O., Urbain, J., Moser, M. (1999) CD8α+ and CD8α- subclasses of dendritic cells direct the development of distinct T helper cells in vivo. J. Exp. Med. 189, 587-592. (Pubitemid 29187380)
44. Hubert, P., Jacobs, N., Caberg, J. H., Boniver, J., Delvenne, P. (2007) The cross-talk between dendritic and regulatory T cells: good or evil? J. Leukoc. Biol. 82, 781-794. (Pubitemid 47511037)
45. Bianchi, M. E. (2007) DAMPs, PAMPs and alarmins: all we need to know about danger. J. Leukoc. Biol. 81, 1-5.
46. Ehrchen, J. M., Sunderkötter, C., Foell, D., Vogl, T., Roth, J. (2009) The endogenous Toll-like receptor 4 agonist S100A8/S100A9 (calprotectin) as innate amplifier of infection, autoimmunity, and cancer. J. Leukoc. Biol. 86, 557-566.
47. Liu, Y., Jones, B., Aruffo, A., Sullivan, K. M., Linsley, P. S., Janeway Jr., C. A. (1992) Heat-stable antigen is a costimulatory molecule for CD4 T cell growth. J. Exp. Med. 175, 437-445.
48. Liu, Y., Zheng, P. (2007) CD24: a genetic checkpoint in T cell homeostasis and autoimmune diseases. Trends Immunol. 28, 315-320. (Pubitemid 46963136)
49. Bai, X. F., Liu, J. Q., Liu, X., Guo, Y., Cox, K., Wen, J., Zheng, P., Liu, Y. (2000) The heat-stable antigen determines pathogenicity of self-reactive T cells in experimental autoimmune encephalomyelitis. J. Clin. Invest. 105, 1227-1232. (Pubitemid 30266075)
50. Wang, L., Lin, S., Rammohan, K. W., Liu, Z., Liu, J. Q., Liu, R. H., Guinther, N., Lima, J., Zhou, Q., Wang, T., Zheng, X., Birmingham, D. J., Rovin, B. H., Hebert, L. A., Wu, Y., Lynn, D. J., Cooke, G., Yu, C. Y., Zheng, P., Liu, Y. (2007) A dinucleotide deletion in CD24 confers protection against autoimmune diseases. PLoS Genet. 3, e49.
51. Zhou, Q., Rammohan, K., Lin, S., Robinson, N., Li, O., Liu, X., Bai, X. F., Yin, L., Scarberry, B., Du, P., You, M., Guan, K., Zheng, P., Liu, Y. (2003) CD24 is a genetic modifier for risk and progression of multiple sclerosis. Proc. Natl. Acad. Sci. USA 100, 15041-15046. (Pubitemid 37518013)
52. Chen, G. Y., Tang, J., Zheng, P., Liu, Y. (2009) CD24 and Siglec-10 selectively repress tissue damage-induced immune responses. Science 323, 1722-1725.
53. Abou-Raya, A., Abou-Raya, S. (2006) Inflammation: a pivotal link between autoimmune diseases and atherosclerosis. Autoimmun. Rev. 5, 331-337. (Pubitemid 44202201)
54. Eklund, K. K., Leirisalo-Repo, M., Ranta, P., Mäki, T., Kautiainen, H., Hannonen, P., Korpela, M., Hakala, M., Järvinen, P., Möttönen, T. (2007) Serum IL-1β levels are associated with the presence of erosions in recent onset rheumatoid arthritis. Clin. Exp. Rheumatol. 25, 684-689. (Pubitemid 350284840)
55. Ljung, L., Olsson, T., Engstrand, S., Wållberg-Jonsson, S., Söderberg, S., Rantapää-Dahlqvist, S. (2007) Interleukin-1 receptor antagonist is associated with both lipid metabolism and inflammation in rheumatoid arthritis. Clin. Exp. Rheumatol. 25, 617-620. (Pubitemid 47455471)
56. Croker, B. A., Lawson, B. R., Rutschmann, S., Berger, M., Eidenschenk, C., Blasius, A. L., Moresco, E. M., Sovath, S., Cengia, L., Shultz, L. D., Theofilopoulos, A. N., Pettersson, S., Beutler, B. A. (2008) Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger. Proc. Natl. Acad. Sci. USA 105, 15028-15033.
57. Choi, H. J., Xu, H., Geng, Y., Colmone, A., Cho, H., Wang, C. R. (2008) Bacterial infection alters the kinetics and function of iNKT cell responses. J. Leukoc. Biol. 84, 1462-1471. (Pubitemid 352774481)
58. Nakae, S., Iwakura, Y., Suto, H., Galli, S. J. (2007) Phenotypic differences between Th1 and Th17 cells and negative regulation of Th1 cell differentiation by IL-17. J. Leukoc. Biol. 81, 1258-1268. (Pubitemid 46702045)
59. Romani, L. (2008) Parasites and autoimmunity: the case of fungi. Autoimmun. Rev. 8, 129-133.
60. Romani, L., Puccetti, P. (2007) Controlling pathogenic inflammation to fungi. Expert Rev. Anti Infect. Ther. 5, 1007-1017.
61. Kivity, S., Agmon-Levin, N., Blank, M., Shoenfeld, Y. (2009) Infections and autoimmunity-friends or foes? Trends Immunol. 30, 409-414.
62. Strachan, D. P. (1989) Hay fever, hygiene, and household size. BMJ 299, 1259-1260.
63. Christen, U., Benke, D., Wolfe, T., Rodrigo, E., Rhode, A., Hughes, A. C., Oldstone, M. B., von Herrath, M. G. (2004) Cure of prediabetic mice by viral infections involves lymphocyte recruitment along an IP-10 gradient. J. Clin. Invest. 113, 74-84. (Pubitemid 38541634)
64. Walsh, K. P., Brady, M. T., Finlay, C. M., Boon, L., Mills, K. H. (2009) Infection with a helminth parasite attenuates autoimmunity through TGF-β-mediated suppression of Th17 and Th1 responses. J. Immunol. 183, 1577-1586.
65. Liu, Q., Sundar, K., Mishra, P. K., Mousavi, G., Liu, Z., Gaydo, A., Alem, F., Lagunoff, D., Bleich, D., Gause, W. C. (2009) Helminth infection can reduce insulitis and type 1 diabetes through CD25- and IL-10-independent mechanisms. Infect. Immun. 77, 5347-5358.
66. Toyoda, M., Galfayan, K., Galera, O. A., Petrosian, A., Czer, L. S., Jordan, S. C. (1997) Cytomegalovirus infection induces anti-endothelial cell antibodies in cardiac and renal allograft recipients. Transpl. Immunol. 5, 104-111. (Pubitemid 27359387)
67. Varani, S., Muratori, L., De Ruvo, N., Vivarelli, M., Lazzarotto, T., Gabrielli, L., Bianchi, F. B., Bellusci, R., Landini, M. P. (2002) Autoantibody appearance in cytomegalovirus-infected liver transplant recipients: correlation with antigenemia. J. Med. Virol. 66, 56-62. (Pubitemid 34183718)
68. Kantor, G. L., Goldberg, L. S., Johnson Jr., B. L., Derechin, M. M., Barnett, E. V. (1970) Immunologic abnormalities induced by postperfusion cytomegalovirus infection. Ann. Intern. Med. 73, 553-558.
69. Wager, O., Räsänen, J. A., Hagman, A., Klemola, E. (1968) Mixed cryoimmunoglobulinemia in infectious mononucleosis and Cytomegalovirus mononucleosis. Int. Arch. Allergy Appl. Immunol. 34, 345-361.
70. Einsele, H., Steidle, M., Müller, C.A., Fritz, P., Zacher, J., Schmidt, H., Saal, J. G. (1992) Demonstration of cytomegalovirus (CMV) DNA and anti-CMV response in the synovial membrane and serum of patients with rheumatoid arthritis. J. Rheumatol. 19, 677-681.
71. Hamerman, D., Gresser, I., Smith, C. (1982) Isolation of cytomegalovirus from synovial cells of a patient with rheumatoid arthritis. J. Rheumatol. 9, 658-664.
72. Mehraein, Y., Lennerz, C., Ehlhardt, S., Remberger, K., Ojak, A., Zang, K. D. (2004) Latent Epstein-Barr virus (EBV) infection and cytomegalovirus (CMV) infection in synovial tissue of autoimmune chronic arthritis determined by RNA- and DNA-in situ hybridization. Mod. Pathol. 17, 781-789. (Pubitemid 38843360)
73. Murayama, T., Jisaki, F., Ayata, M., Sakamuro, D., Hironaka, T., Hirai, K., Tsuchiya, N., Ito, K., Furukawa, T. (1992) Cytomegalovirus genomes demonstrated by polymerase chain reaction in synovial fluid from rheumatoid arthritis patients. Clin. Exp. Rheumatol. 10, 161-164.
74. Barzilai, O., Sherer, Y., Ram, M., Izhaky, D., Anaya, J. M., Shoenfeld, Y. (2007) Epstein-Barr virus and cytomegalovirus in autoimmune diseases: are they truly notorious? A preliminary report. Ann. N. Y. Acad. Sci. 1108, 567-577. (Pubitemid 47528770)
75. Su, B. Y., Su, C. Y., Yu, S. F., Chen, C. J. (2007) Incidental discovery of high systemic lupus erythematosus disease activity associated with cytomegalovirus viral activity. Med. Microbiol. Immunol. 196, 165-170. (Pubitemid 47300254)
76. Lunardi, C., Dolcino, M., Peterlana, D., Bason, C., Navone, R., Tamassia, N., Beri, R., Corrocher, R., Puccetti, A. (2006) Antibodies against human cytomegalovirus in the pathogenesis of systemic sclerosis: a gene array approach. PLoS Med. 3, e2. (Pubitemid 43200636)
77. Lunardi, C., Tinazzi, E., Bason, C., Dolcino, M., Corrocher, R., Puccetti, A. (2008) Human parvovirus B19 infection and autoimmunity. Autoimmun. Rev. 8, 116-120.
78. International Human Genome Sequencing Consortium (2001) Initial sequencing and analysis of the human genome. Nature 409, 860-921.
79. Tai, A. K., O'Reilly, E. J., Alroy, K. A., Simon, K. C., Munger, K. L., Huber, B. T., Ascherio, A. (2008) Human endogenous retrovirus-K18 Env as a risk factor in multiple sclerosis. Mult. Scler. 14, 1175-1180.
80. Sutkowski, N., Palkama, T., Ciurli, C., Sekaly, R. P., Thorley-Lawson, D. A., Huber, B. T. (1996) An Epstein-Barr virus-associated superantigen. J. Exp. Med. 184, 971-980.
81. Stauffer, Y., Marguerat, S., Meylan, F., Ucla, C., Sutkowski, N., Huber, B., Pelet, T., Conrad, B. (2001) Interferon-α-induced endogenous superantigen. A model linking environment and autoimmunity. Immunity 15, 591-601. (Pubitemid 33016444)
82. Turcanova, V. L., Bundgaard, B., Höllsberg, P. (2009) Human herpesvirus-6B induces expression of the human endogenous retrovirus K18-encoded superantigen. J. Clin. Virol. 46, 15-19.
83. Zignego, A. L., Piluso, A., Giannini, C. (2008) HBV and HCV chronic infection: autoimmune manifestations and lymphoproliferation. Autoimmun. Rev. 8, 107-111.
84. Antonelli, A., Ferri, C., Ferrari, S. M., Colaci, M., Fallahi, P. (2008) Immunopathogenesis of HCV related endocrine manifestations in chronic hepatitis and mixed cryoglobulinemia. Autoimmun. Rev. 8, 18-23.
85. Palazzi, C., D'Angelo, S., Olivieri, I. (2008) Hepatitis C virus-related arthritis. Autoimmun. Rev. 8, 48-51.
86. Alpa, M., Ferrero, B., Cavallo, R., Naretto, C., Menegatti, E., Di Simone, D., Napoli, F., La Grotta, R., Rossi, D., Baldovino, S., Sena, L. M., Roccatello, D. (2008) Antineuronal antibodies in patients with HCV-related mixed cryoglobulinemia. Autoimmun. Rev. 8, 56-58.
87. De Vita, S., Quartuccio, L., Fabris, M. (2008) Hepatitis C virus infection, mixed cryoglobulinemia and BlyS upregulation: targeting the infectious trigger, the autoimmune response, or both? Autoimmun. Rev. 8, 95-99.
88. Whitton, J. L., Feuer, R. (2004) Myocarditis, microbes and autoimmunity. Autoimmunity. 37, 375-386.
89. Cunningham, M. W., McCormack, J. M., Talaber, L. R., Harley, J. B., Ayoub, E. M., Muneer, R. S., Chun, L. T., Reddy, D. V. (1988) Human monoclonal antibodies reactive with antigens of the group A Streptococcus and human heart. J. Immunol. 141, 2760-2766.
90. Adderson, E. E., Shikhman, A. R., Ward, K. E., Cunningham, M. W. (1998) Molecular analysis of polyreactive monoclonal antibodies from rheumatic carditis: human anti-N-acetylglucosamine/anti-myosin antibody V region genes. J. Immunol. 161, 2020-2031.
91. Fenderson, P. G., Fischetti, V. A., Cunningham, M. W. (1989) Tropomyosin shares immunologic epitopes with group A streptococcal M proteins. J. Immunol. 142, 2475-2481.
92. Galvin, J. E., Hemric, M. E., Ward, K., Cunningham, M. W. (2000) Cytotoxic mAb from rheumatic carditis recognizes heart valves and laminin. J. Clin. Invest. 106, 217-224. (Pubitemid 30483125)
93. Kirvan, C. A., Swedo, S. E., Heuser, J. S., Cunningham, M. W. (2003) Mimicry and autoantibody-mediated neuronal cell signaling in Sydenham chorea. Nat. Med. 9, 914-920.
94. Kirvan, C. A., Cox, C. J., Swedo, S. E., Cunningham, M. W. (2007) Tubulin is a neuronal target of autoantibodies in Sydenham's chorea. J. Immunol. 178, 7412-7421.
95. Nocton, J. J., Dressler, F., Rutledge, B. J., Rys, P. N., Persing, D. H., Steere, A. C. (1994) Detection of Borrelia burgdorferi DNA by polymerase chain reaction in synovial fluid from patients with Lyme arthritis. N. Engl. J. Med. 330, 229-234. (Pubitemid 24034134)
96. Steere, A. C., Levin, R. E., Molloy, P. J., Kalish, R. A., Abraham III, J. H., Liu, N. Y., Schmid, C. H. (1994) Treatment of Lyme arthritis. Arthritis Rheum. 37, 878-888.
97. Carlson, D., Hernandez, J., Bloom, B. J., Coburn, J., Aversa, J. M., Steere, A. C. (1999) Lack of Borrelia burgdorferi DNA in synovial samples from patients with antibiotic treatment-resistant Lyme arthritis. Arthritis Rheum. 42, 2705-2709. (Pubitemid 30327194)
98. Gross, D. M., Forsthuber, T., Tary-Lehmann, M., Etling, C., Ito, K., Nagy, Z. A., Field, J. A., Steere, A. C., Huber, B. T. (1998) Identification of LFA-1 as a candidate autoantigen in treatment-resistant Lyme arthritis. Science 281, 703-706. (Pubitemid 28390407)
99. Maier, B., Molinger, M., Cope, A. P., Fugger, L., Schneider-Mergener, J., Sønderstrup, G., Kamradt, T., Kramer, A. (2000) Multiple cross-reactive self-ligands for Borrelia burgdorferi-specific HLA-DR4-restricted T cells. Eur. J. Immunol. 30, 448-457. (Pubitemid 30098837)
100. Ebringer, A., Wilson, C. (2000) HLA molecules, bacteria and autoimmunity. J. Med. Microbiol. 49, 305-311.
101. Leirisalo-Repo, M., Hannu, T., Mattila, L. (2003) Microbial factors in spondyloarthropathies: insights from population studies. Curr. Opin. Rheumatol. 15, 408-412. (Pubitemid 36774251)
102. Schaeverbeke, T., Bebear, C. M., Clerc, M., Lequen, L., Bébéar, C., Dehais, J. (1999) What is the role of mycoplasmas in human inflammatory rheumatic disorders? Rev. Rhum. Engl. Ed. 66, 23S-27S.
103. Frauendorf, E., von Goessel, H., May, E., Märker-Hermann, E. (2003) HLA-B27-restricted T cells from patients with ankylosing spondylitis recognize peptides from B*2705 that are similar to bacteria-derived peptides. Clin. Exp. Immunol. 134, 351-359. (Pubitemid 37372289)
104. Cutolo, M., Seriolo, B., Pizzorni, C., Secchi, M. E., Soldano, S., Paolino, S., Montagna, P., Sulli, A. (2008) Use of glucocorticoids and risk of infections. Autoimmun. Rev. 8, 153-155.
105. Lionakis, M. S., Kontoyiannis, D. P. (2003) Glucocorticoids and invasive fungal infections. Lancet 362, 1828-1838.
106. Caporali, R., Caprioli, M., Bobbio-Pallavicini, F., Montecucco, C. (2008) DMARDs and infections in rheumatoid arthritis. Autoimmun. Rev. 8, 139-143.
107. Doria, A., Iaccarino, L., Ghirardello, A., Zampieri, S., Arienti, S., Sarzi-Puttini, P., Atzeni, F., Piccoli, A., Todesco, S. (2006) Long-term prognosis and causes of death in systemic lupus erythematosus. Am. J. Med. 119, 700-706. (Pubitemid 44128446)
108. Doria, A., Zampieri, S., Sarzi-Puttini, P. (2008) Exploring the complex relationships between infections and autoimmunity. Autoimmun. Rev. 8, 89-91.
109. McLean-Tooke, A., Aldridge, C., Waugh, S., Spickett, G. P., Kay, L. (2009) Methotrexate, rheumatoid arthritis and infection risk - what is the evidence? Rheumatology 48, 867-871.
110. Iaccarino, L., Rampudda, M. E., Canova, M., Della Libera, S., Sarzi-Puttini, P., Doria, A. (2007) Mycophenolate mofetil: what is its place in the treatment of autoimmune rheumatic diseases? Autoimmun. Rev. 6, 190-195. (Pubitemid 46187338)
111. Lalvani, A., Millington, K. A. (2008) Screening for tuberculosis infection prior to initiation of anti-TNF therapy. Autoimmun. Rev. 8, 147-152.
112. Atzeni, F., Doria, A., Carrabba, M., Turiel, M., Sarzi-Puttini, P. (2007) Potential terget of infliximab in autoimmune and inflammatory diseases. Autoimmun. Rev. 6, 529-536. (Pubitemid 47374618)
113. Ostuni, P., Botsios, C., Punzi, L., Sfriso, P., Todesco, S. (2003) Hepatitis B reactivation in a chronic hepatitis B surface antigen carrier with rheumatoid arthritis treated with infliximab and low dose methotrexate. Ann. Rheum. Dis. 62, 686-687. (Pubitemid 36760576)
114. Botsios, C. (2005) Safety of tumor necrosis factor and interleukin-1 blocking agents in rheumatic diseases. Autoimmun. Rev. 4, 162-170.
115. Bongartz, T., Sutton, A. J., Sweeting, M. J., Buchan, I., Matteson, E. L., Montori, V. (2006) Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: systematic review and meta-analysis of rare harmful effects in randomized controlled trials. JAMA 295, 2275-2285. (Pubitemid 43736578)
116. Dixon, W. G., Watson, K., Lunt, M., Hyrich, K. L., Silman, A. J., Symmons, D. P. (2006) British Society for Rheumatology Biologics Register. Rates of serious infection, including site-specific and bacterial intracellular infection, in rheumatoid arthritis patients receiving anti-tumor necrosis factor therapy: results from the British Society for Rheumatology Biologics Register. Arthritis Rheum. 54, 2368-2376. (Pubitemid 44204996)
117. Askling, J., Fored, C. M., Geborek, P., Jacobsson, L. T., van Vollenhoven, R., Feltelius, N., Lindblad, S., Klareskog, L. (2006) Swedish registers to examine drug safety and clinical issues in RA. Ann. Rheum. Dis. 65, 707-712. (Pubitemid 43799167)
118. Listing, J., Strangfeld, A., Kary, S., Rau, R., von Hinueber, U., Stoyanova-Scholz, M., Gromnica-Ihle, E., Antoni, C., Herzer, P., Kekow, J., Schneider, M., Zink, A. (2005) Infections in patients with rheumatoid arthritis treated with biologic agents. Arthritis Rheum. 52, 3403-3412. (Pubitemid 41612206)
119. Strangfeld, A., Listing, J., Herzer, P., Liebhaber, A., Rockwitz, K., Richter, C., Zink, A. (2009) Risk of herpes zoster in patients with rheumatoid arthritis treated with anti-TNF-α agents. JAMA 301, 737-744.
120. Molloy, E. S., Calabrese, L. H. (2008) Progressive multifocal leukoencephalopathy in patients with rheumatic diseases: are patients with systemic lupus erythematosus at particular risk? Autoimmun. Rev. 8, 144-146.
121. Atzeni, F., Doria, A., Sarzi-Puttini, P. (2007) What is the role of rituximab in the treatment of rheumatoid arthritis? Autoimmun. Rev. 6, 553-558. (Pubitemid 47374616)
122. Doria, A., Arienti, S., Rampudda, M., Canova, M., Tonon, M., Sarzi-Puttini, P. (2008) Preventive strategies in systemic lupus erythematosus. Autoimmun. Rev. 7, 192-197.
123. Doria, A., Briani, C. (2008) Lupus: improving long-term prognosis. Lupus 17, 166-170.
124. Conti, F., Rezai, S., Valesini, G. (2008) Vaccination and autoimmune rheumatic diseases. Autoimmun. Rev. 8, 124-128.
125. Toplak, N., Kveder, T., Trampus-Bakija, A., Subelj, V., Cucnik, S., Avcin, T. (2008) Autoimmune response following annual influenza vaccination in 92 apparently healthy adults. Autoimmun. Rev. 8, 134-138.
126. Galeazzi, M., Giannitti, C., Manganelli, S., Benucci, M., Scarpato, S., Bazzani, C., Caporali, R., Sebastiani, G. D. (2008) Treatment of rheumatic diseases in patients with HCV and HIV infection. Autoimmun. Rev. 8, 100-103.
127. Ansari, A. A., Pereira, L. E., Mayne, A. E., Onlamoon, N., Pattanapanyasat, K., Mori, K., Villinger, F. (2007) The role of disease stage, plasma viral load and regulatory T cells (Tregs) on autoantibody production in SIV-infected non-human primates. J. Autoimmun. 28, 152-159. (Pubitemid 46670693)
128. Cavazzana, I., Ceribelli, A., Cattaneo, R., Franceschini, F. (2008) Treatment with etanercept in six patients with chronic hepatitis C infection and systemic autoimmune diseases. Autoimmun. Rev. 8, 104-106.