Latent Epstein-Barr virus (EBV) infection and cytomegalovirus (CMV) infection in synovial tissue of autoimmune chronic arthritis determined by RNA- and DNA-in situ hybridization

Modern Pathology

Volumn 17, Issue 7, 2004, Pages 781-789

  Mehraein, Yasmin ^a   Lennerz, Carsten ^a   Ehlhardt, Sandra ^a   Kemberger, Klaus ^a   Ojak, Andreas ^b   Zang, Klaus D ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b Department of Orthopedic Surgery   (Germany)

Author keywords

Autoimmune arthritis; Cytomegalovirus; Epstein Barr virus; in situ hybridization; Rheumatoid arthritis

Indexed keywords

DNA; EARLY ANTIGEN; EBER1 RNA; EBER2 RNA; RNA; UNCLASSIFIED DRUG; VIRUS ANTIGEN; VIRUS DNA; VIRUS RNA;

ADOLESCENT; ADULT; AGED; ARTICLE; AUTOIMMUNE CHRONIC ARTHRITIS; AUTOIMMUNE DISEASE; CHRONIC ARTHRITIS; CONTROLLED STUDY; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTION; DNA HYBRIDIZATION; EPSTEIN BARR VIRUS; FEMALE; FIBROBLAST; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LATENT VIRUS INFECTION; LYMPHOCYTIC INFILTRATION; MAJOR CLINICAL STUDY; MALE; MIXED INFECTION; PARVOVIRUS; PERSISTENT VIRUS INFECTION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PSORIATIC ARTHRITIS; REACTIVE ARTHRITIS; RHEUMATOID ARTHRITIS; RNA HYBRIDIZATION; SYNOVITIS; VIRUS REPLICATION;

ADOLESCENT; ADULT; AGED; ARTHRITIS, RHEUMATOID; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; DNA, VIRAL; DNA-BINDING PROTEINS; EPSTEIN-BARR VIRUS INFECTIONS; EPSTEIN-BARR VIRUS NUCLEAR ANTIGENS; FEMALE; HERPESVIRUS 4, HUMAN; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MALE; MIDDLE AGED; PHOSPHOPROTEINS; RNA, VIRAL; SYNOVIAL MEMBRANE; TRANS-ACTIVATORS; VIRAL MATRIX PROTEINS; VIRAL PROTEINS;

EID: 3042523729     PISSN: 08933952     EISSN: None     Source Type: Journal    
DOI: 10.1038/modpathol.3800119     Document Type: Article

References (36)

1. Krause A, Kamradt T, Burmester GR. Potential infectious agents in the induction of arthritides. Curr Opin Rheumatol 1996;8:203-209.
2. Newkirk MM, Watanabe DKN, Leclerc J, et al. Detection of cytomegalovirus, Epstein-Barr virus and herpes virus-6 in patients with rheumatoid arthritis with or without Sjögren's syndrome. Br J Rheumatol 1994;33: 317-322.
3. Takahashi Y, Murai C, Shibata S, et al. Human parvovirus B19 as a causative agent for rheumatoid arthritis. Proc Natl Acad Sci USA 1998;95:8227-8232.
4. Sculley TB, Walker PJ, Moss DJ, et al. Identification of multiple Epstein-Barr virus-induced nuclear antigens with sera from patients with rheumatoid arthritis. J Virol 1984;52:88-93.
5. Ferraro AS, Newkirk MM. Correlative studies of rheumatoid factors and anti-viral antibodies in patients with rheumatoid arthritis. Clin Exp Immunol 1993;92:425-431.
6. Blaschke S, Schwarz G, Moneke D, et al. Epstein-Barr virus infection in peripheral blood mononuclear cells, synovial fluid, and synovial membranes of patients with rheumatoid arthritis, J Rheumatol 2000; 27:866-873.
7. Ollier W. Rheumatoid arthritis and Epstein-Barr virus: a case of living with the enemy? Ann Rheum Dis 2000;59:497-499.
8. Roudier J, Petersen J, Rhodes GH, et al. Susceptibility to rheumatoid arthritis maps to a T cell epitope shared by the HLA-Dw4 DRβ1 chain and the Epstein-Barr virus glycoprotein gp110. Proc Natl Acad Sci USA 1989;86:5104-5108.
9. Toussirot E, Wendling D, Tiberghien P, et al. Decreased T cell precursor frequencies to Epstein-Barr virus glycoprotein Gp110 in peripheral blood correlate with disease activity and severity in patients with rheumatoid arthritis. Ann Rheum Dis 2000;59:497-499.
10. Albani S, Carson DA. A multistep molecular mimicry hypothesis for the pathogenesis of rheumatoid arthritis. Immunol Today 1996;17:466-470.
11. Einsele H, Steidle M, Muller CA, et al. Demonstration of cytomegalovirus (CMV) DNA and anti-CMV response in the synovial membrane and serum of patients with rheumatoid arthritis. J Rheumatol 1992;19:677-681.
12. Saal JG, Steidle M, Einsele H, et al. Persistence of B19 parvovirus in synovial membranes of patients with rheumatoid arthritis. Rheumatol Int 1992;12:147-151.
13. Stahl H-D, Hubner B, Seidl B, et al. Detection of multiple viral DNA species in synovial tissue and fluid of patients with early arthritis. Ann Rheum Dis 2000;59:342-346.
14. Modrow S, Falke D, Truyen U. Herpesviren. In: Modrow S, Falke D, Truyen U (eds). Molekulare Virologie, 2nd edn. Heidelberg, Berlin, Spectrum Akademischer Verlag, 2003, pp: 514-613.
15. Bornkamm GW, Hammerschmidt W. Molecular virology of Epstein-Barr virus. Philos Trans R Soc Lond B 2001;356:437-459.
16. Koide J, Takada K, Sugiura M, et al. Spontaneous establishment of an Epstein-Barr virus-infected fibroblast line from the synovial tissue of a rheumatoid arthritis patient. J Virol 1997;7:2478-2481.
17. Vancikova Z, Dvorak P. Cytomegalovirus infection in immunocompetent and immunocomprised individuals - a review. Curr Drug Targets Immune Endocr Metabol Disord 2001;1:179-187.
18. Bonneville M, Scotet E, Peyrat M, et al. Epstein-Barr virus and rheumatoid arthritis. Revue du Rheumatisme 1998;65:365-368.
19. Mousavi-Javi M, Bostrom L, Lovmark C, et al. Infrequent detection of cytomegalovirus and Epstein-Barr virus DNA in synovial membrane of patients with rheumatoid arthritis. J Rheumatol 1998;25: 623-628.
20. Edinger JW, Bonneville M, Scotet E, et al. EBV gene expression not altered in rheumatoid synovia despite the presence of EBV antigen specific T cell clones. J Immunol 1999;162:3694-3701.
21. Takei M, Mitamura K, Fujiwara S, et al. Detection of Epstein-Barr virus encoded small RNA 1 and latent membrane protein 1 in synovial lining cells from rheu matoid arthritis patients. Int Immunol 1997;9:739-743.
22. Niedobitek G, Lisner R, Swoboda B, et al. Lack of evidence for an involvement of Epstein-Barr virus infection of synovial membranes in the pathogenesis of rheumatoid arthritis. Arthritis Rheum 2000;43:151-154.
23. Mehraein Y, Lennerz C, Ehlhardt S, et al. Detection of parvovirus B19 capsid proteins in lymphocytic cells in synovial tissue of autoimmune chronic arthritis. Mod Pathol 2003;16:811-817.
24. Arnett FC, Edworthy SM, Bloch DA, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988;31:315-324.
25. Imai Y, Sato T, Yamakawa M, et al. A morphological and immunohistochemical study of lymphoid germ centers in synovial and lymph node tissues from rheumatoid arthritis patients with special reference to complement components and their receptors. Acta Pathol Jpn 1989;39:127-134.
26. Gladman DD. Psoriatic arthritis. Rheum Dis Clin North Am 1998;24:829-844.
27. Takeda T, Mizugaki Y, Matsubara L, et al. Lytic Epstein-Barr virus infection in the synovial tissue of patients with rheumatoid arthritis. Arthritis Rheum 2000;43:1218-1225.
28. Imai S, Nishikawa J, Takada K. Cell-to-cell contact as an efficiant mode of Epstein-Barr virus infection of diverse human epithelial cells. J Virol 1998;72: 4371-4378.
29. Niedobitek G, Herbst H. In situ detection of Epstein-Barr virus DNA and viral gene products. Methods Mol Biol 2001;174:79-91.
30. Williams RS, Sibbitt WL, Husby G. Oncogenes, viruses, or rheumogenes? Am J Med 1986;80:1011-1016.
31. Yurochko AD, Kowalik TF, Huong S-M, et al. Human cytomegalovirus upregulates NF-κB activity by transactivating the NF-κB p105/p50 and p65 promotors. J virol 1995;69:5391-5400.
32. Johnson RA, Wang X, Ma X-L, et al. Human cytomegalovirus up-regulates the phosphatidylinostol 3-kinase (PI3-K) pathway: inhibition of PI3-K activity inhibits viral replication and virus-induced signaling. J Virol 2001;75:6022-6032.
33. Zhu H, Shen Y, Shenk T. Human cytomegalovirus IE1 and IE2 proteins block apoptosis. J Virol 1995;69: 7960-7970.
34. Goldmacher VS, Bartle LM, Skaletskaya A, et al. A cytomegalovirus-encoded mitochondria-localized inhibitor of apoptosis structurally unrelated to Bcl-2. Proc Natl Acad Sci USA 1999;96:12536-12541.
35. Harkins L, Volk AL, Samanta M, et al. Specific localisation of human cytomegalovirus nucleic acids protein in human colorectal cancer. Lancet 2002;360:1557-1563.
36. Samanta M, Harkins L, Klemm K, et al. High prevalence of human cytomegalovirus in prostatic intra-epithelial neoplasia and prostatic carcinoma. J Urol 2003;170:998-1002.