Molecular analysis of polyreactive monoclonal antibodies from rheumatic carditis: Human anti-N-acetylglucosamine/anti-myosin antibody V region genes

Journal of Immunology

Volumn 161, Issue 4, 1998, Pages 2020-2031

  Adderson, Elisabeth E ^a   Shikhman, Alexander R ^b   Ward, Kent E ^c   Cunningham, Madeleine W ^d  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c OU Medicine   (United States)

^d UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 1 C8; MONOCLONAL ANTIBODY 1 H9; MONOCLONAL ANTIBODY 3 B6; MONOCLONAL ANTIBODY 5G3; MYOSIN ANTIBODY; N ACETYLGLUCOSAMINE; UNCLASSIFIED DRUG;

ANTIBODY DETECTION; ANTIGEN RECOGNITION; ARTICLE; CARDITIS; CONTROLLED STUDY; EPITOPE MAPPING; GENE MUTATION; HUMAN; IMMUNOGLOBULIN GENE; MYOCARDITIS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RHEUMATIC HEART DISEASE;

ACETYLGLUCOSAMINE; AMINO ACID SEQUENCE; ANTIBODIES, BACTERIAL; ANTIBODIES, MONOCLONAL; AUTOANTIBODIES; BASE SEQUENCE; BINDING SITES, ANTIBODY; CROSS REACTIONS; ENDOCARDITIS, BACTERIAL; GENES, IMMUNOGLOBULIN; HUMANS; IMMUNOGLOBULIN VARIABLE REGION; MOLECULAR SEQUENCE DATA; MYOSINS; RHEUMATIC HEART DISEASE; STREPTOCOCCUS PYOGENES;

EID: 0032529425     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (67)

1. Dale, J. B., and E. H. Beachey. 1985. Epitopes of streptococcal M proteins shared with cardiac myosin. J. Exp. Med. 162:583.
2. Cunningham, M. W., J. M. McCormack, L. R. Talaber, J. B. Harley, E. M. Ayoub, R. S. Muneer, L. T. Chun, and D. V. Reddy. 1988. Human monoclonal antibodies reactive with antigens of the group A Streptococcus and human heart. J. Immunol. 141:2760.
3. Cunningham, M. W., J. M. McCormack, P. G. Fenderson, M. K. Ho, E. H. Beachey, and J. B. Dale. 1989. Human and murine antibodies cross-reactive with streptococcal M protein and myosin recognize the sequence GLN-LYS-SER-LYS-GLN in M protein. J. Immunol. 143:2677.
4. Cunningham, M. W. 1996. Streptococci and rheumatic fever. In Microorganisms and Autoimmune Disease. N. R. Rose and H. Friedman, eds. Plenum Publishing Corp., New York, p. 13.
5. Cunningham, M. W., and R. A. Swerlick. 1986. Polyspecificity of antistreptococcal murine monoclonal antibodies and their implications in autoimmunity. J. Exp. Med. 164:998.
6. Fenderson, P. G., V. A. Fischetti, and M. W. Cunningham. 1989. Tropomyosin shares immunologic epitopes with group A streptococcal M proteins. J. Immunol. 142:2475.
7. Shikhman, A. R., N. S. Greenspan, and M. W. Cunningham. 1993. A subset of mouse monoclonal antibodies cross-reactive with cytoskeletal proteins and group A streptococcal M proteins recognizes N-acetyl-β-D-glucosamine. J. Immunol. 151:3902.
8. Shikhman, A. R., and M. W. Cunningham. 1994. Immunological mimicry between N-acetyl-β-D-glucosamine and cytokeratin peptides: evidence for a microbially driven anti-keratin antibody response. J. Immunol. 152:4375.
9. Shikhman, A. R., N. S. Greenspan, and M. W. Cunningham. 1994. Cytokeratin peptide SFGSGFGGGY mimics N-acetyl-β-D-glucosamine in reaction with antibodies and lectins, and induces in vivo anti-carbohydrate antibody response. J. Immunol. 153:5593.
10. Antone, S. M., E. E. Adderson, N. M. J. Mertens, and M. W. Cunningham. 1997. Molecular analysis of V gene sequences encoding cytotoxic anti-streptococcal/ anti-myosin mAb 36.2.2 that recognizes the heart cell surface protein laminin. J. Immunol. 159:5422.
11. Neu, N., K. W. Beisel, M. D. Traystman, N. R. Rose, and S. W. Craig. 1987. Autoantibodies specific for the cardiac myosin isoform are found in mice susceptible to coxsackievirus B3 induced myocarditis. J. Immunol. 138:2488.
12. Neumann, D. A., N. R. Rose, A. A. Ansari, and A. Herkowitz. 1994. Induction of multiple heart autoantibodies in mice with coxsackievirus B3-and cardiac myosin-induced autoimmune myocarditis. J. Immunol. 152:343.
13. Liao, L., R. Sindhwani, M. Rojkind, S. Factor, L. Leinwand, and B. Diamond. 1995. Antibody-mediated autoimmune myocarditis depends on genetically determined target organ sensitivity. J. Exp. Med. 187:1123.
14. Gauntt, C. J., H. M. Arizpe, A. L. Higdon, M. M. Rozek, R. Crawley, and M. W. Cunningham. 1991. Anti-Coxsackievirus B3 neutralizing antibodies with pathological potential. Eur. Heart J. 12:124.
15. Gauntt, C., H. Arizpe, A. Higdon, D. Bowers, M. Rozek, and R. Crawley. 1995. Molecular mimicry, anti-coxsackievirus B2 neutralizing monoclonal antibodies and myocarditis. J. Immunol. 154:2983.
16. Cunningham, M. W., S. M. Antone, J. M. Gulizia, B. M. McManus, V. A. Fischetti, and C. J. Gauntt. 1992. Cytotoxic and viral neutralizing antibodies crossreact with streptococcal M protein, enteroviruses, and human cardiac myosin. Proc. Natl. Acad. Sci. USA 89:1320.
17. Huber, S. A., A. Moraska, and M. Cunningham. 1994. Alterations in major histocompatibility complex association of myocarditis induced by coxsackievirus B3 mutants selected with monoclonal antibodies to group A streptococci. Proc. Natl. Acad. Sci. USA 91:5543.
18. + T cell-dependent myocarditis in MRL/+ + mice and induces partial tolerance against coxsackieviral myocarditis. J. Immunol. 156:3528.
19. Neu, N., N. R. Rose, K. W. Beisel, A. Herskowitz, G. Gurri-Glass, and S. W. Craig. 1987. Cardiac myosin induces myocarditis in genetically predisposed mice. J. Immunol. 139:3630.
20. Smith, S. C., and P. M. Allen. 1991. Myosin-induced acute myocarditis is aT cell mediated disease. J. Immunol. 147:2141.
21. Quinn, A., E. E. Adderson, P. G. Shackelford, W. L. Carroll, and M. W. Cunningham. 1995. Autoantibody germ-line gene segment encodes VH and VL regions of a human anti-streptococcal mAb recognizing streptococcal M protein and human cardiac myosin epitopes. J. Immunol. 154:4203.
22. Dudding, B. A., and E. M. Ayoub. 1968. Persistence of streptococcal group A antibody in patients with rheumatic valvular disease. J. Exp. Med. 128:1081.
23. Jaenicke, T., K. W. Diederich, W. Haas, J. Scheich, P. Lichter, M. Pfordt, A. Bach, and V. P. Vosberg. 1990. Complete sequence of human β myosin. Genomics 8:194.
24. Carpino, L. A., and G. Y. Han. 1972. The 9-fluorenylmethoxy-carbonyl amino protecting group. J. Org. Chem. 37:3404.
25. Dell, A., S. M. Antone, C. J. Gauntt, C. A. Crossley, W. A. Clark, and M. W. Cunningham. 1991. Autoimmune determinants of rheumatic carditis: localization of epitopes in human cardiac myosin. Eur. Heart J. 12:158.
26. Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 277:680.
27. Adderson, E. E., P. G. Shackelford, A. Quinn, and W. L. Carroll. 1991. Restricted IgH chain V gene usage in the human antibody response to Haemophilus influence type b capsular polysaccharide. J. Immunol. 147:1667.
28. Adderson, E. E., P. G. Shackelford, R. A. Insel, A. Quinn, P. M. Wilson, and W. L. Carroll. 1992. Immunoglobulin light chain variable region gene sequences for human antibodies to Haemophilus influenzae type b capsular polysaccharide are dominated by a limited number of Vκ and Vλ segments and VJ combinations. J. Clin. Invest. 89:729.
29. Ausubel, F. M., R. Brent, R. E. Kingston, D. Moore, F. G. Seidman, J. A. Smith, and K. Struhl. 1991. Current Protocols in Molecular Biology. John Wiley and Sons, New York.
30. Matsuda, F., E. K. Shin, H. Nagaoka, R. Matsumura, M. Haino, Y. Fukita, S. Taka-ishi, T. Imai, J. H. Riley, R. Anand, E. Soeda, and T. Honjo. 1993. Structure and physical map of 64 variable segments in the 3′ 0.8-megabase region of the human immunoglobulin heavy-chain locus. Nat. Genet. 3:88.
31. Ravetch, J. V., U. Siebenlist, S. Korsmeyer, T. Waldmann, and P. Leder. 1981. Structure of the human immunoglobulin μ locus: characterization of embryonic and rearranged J and D genes. Cell 27:583.
32. Lautner-Rieske, A., C. Huber, A. Meindl, W. Pargent, K. F. Schable, R. Thiebe, I. Zocher, and H. G. Zachau. 1992. The human immunoglobulin K locus: characterization of the duplicated A regions. Eur. J. Immunol. 22:1023.
33. Milili, M., F. Le Deist, G. de Saint-Basile, A. Fischer, M. Fougereau, and C. Schiff. 1993. Bone marrow cells in X-linked agammaglobulinemia express pre-B-specific genes (λ-like and V pre-B) and present immunoglobulin V-D-J gene usage strongly biased to a fetal-like repertoire. J. Clin. Invest. 91:1616.
34. Mortari, F., J. A. Newton, J. Y. Wang, and H. W. Schroeder. 1992. The human cord blood antibody repertoire: frequent usage of the VH7 gene family. Eur. J. Immunol. 22:241.
35. Winkler, T. H., H. Fehr, and J. R. Kalden. 1992. Analysis of immunoglobulin variable region genes from human IgG anti-DNA hybridomas. Eur. J. Immunol. 22:1719.
36. Cook, G. P., I. M. Tomlinson, G. Walter, H. Reithman, N. P. Carter, L. Buluwela, G. Winter, and T. H. Rabbits. 1994. A map of the human immunoglobulin VH locus completed by analysis of the telomeric region of chromosome 14q. Nat. Genet. 7:162.
37. Milner, E. C. B., W. O. Hufnagle, A. M. Glas, I. Suzuki, and C. Alexander. 1995. Polymorphism and utilization of human VH genes. Ann. NY Acad. Sci. 764:50.
38. Pohlenz, H.-D., B. Straubinger, R. Theibe, M. Pech, F.-J. Zimmer, and H. G. Zachau. 1987. The human Vκ locus: characterization of extended immunoglobulin gene regions by cosmid cloning. Eur. J. Immunol. 193:241.
39. Williams, S. C., and G. Winter. 1993. Cloning and sequencing of human immunoglobulin Vλ gene segments. J. Immunol. 23:1456.
40. Udey, J. A., and B. Blomberg. 1987. Human λ light chain locus: organization and DNA sequences of three genomic J regions. Immunogenetics 25:63.
41. Kaplan, M. H., R. Bolande, L. Rakita, and J. Blair. 1964. Presence of bound immunoglobulins and complement in the myocardium in acute rheumatic fever: association with cardiac failure. N. Engl. J. Med. 271:637.
42. Wedemayer, G. J., P. A. Patten, L. H. Wang, P. G. Schultz, and R. C. Stevens. 1997. Structural insights into the evolution of an antibody combining site. Science 276:1665.
43. Schroeder, H. W., J. L. Hillson, and R. M. Perlmutter. 1987. Early restriction of the human antibody repertoire. Science 238:791.
44. Schroeder, H. W., and J. Y. Wang. 1990. Preferential utilization of conserved immunoglobulin heavy chain segments during human fetal life. Proc. Natl. Acad. Sci. USA 87:6146.
45. Stewart, A. K., C. Huang, B. D. Stollar, and R. S. Schwartz. 1993. High-frequency representation of a single VH gene in the expressed human B cell repertoire. J. Exp. Med. 177:409.
46. Huang, C., and B. D. Stollar. 1991. Construction of representative immunoglobulin region cDNA libraries from peripheral blood lymphocytes without in vitro stimulation. Immunol. Methods 141:227.
47. Sanz, I. 1991. Multiple mechanisms participate in the generation of diversity of human H chain CDR3 regions. J. Immunol. 147:1720.
48. Ichihara, Y., H. Matsuoda, and Y. Kurosawa. 1988. Organization of human immunoglobulin heavy chain diversity gene loci. EMBO J. 7:4141.
49. Yamada, M., R. Wasserman, B. A. Reichard, S. Shane, A. J. Caton, and G. Rovera. 1991. Preferential utilization of specific immunoglobulin heavy chain diversity and joining segments in adult human peripheral blood B lymphocytes. J. Exp. Med. 173:395.
50. Lawler, A. M., J. F. Kearney, M. Kuehl, and P. J. Gearhart. 1989. Early rearrangements of genes encoding murine immunoglobulin κ chains, unlike genes encoding heavy chains, use variable gene segments dispersed throughout the locus. Proc. Natl. Acad. Sci. USA 86:6744.
51. Kaushik, A., D. H. Schulze, C. Bona, and G. Kelsoe. 1989. Murine Vκ gene expression does not follow the VH paradigm. J. Exp. Med. 169:1859.
52. Cox, J. P. L., I. M. Tomlinson, and G. Winter. 1994. A directory of human germ-line VK segments reveals a strong bias in their usage. Eur. J. Immunol. 24:827.
53. Holmberg, D., S. Forsgren, L. Forni, F. Ivars, and A. Coutinho. 1984. Reactions among IgM antibodies derived from normal neonatal mice. Eur. J. Immunol. 14:435.
54. Cairns, E., P. C. Kwong, V. Misener, P. Ip, D. A. Bell, and K. A. Siminovitch. 1989. Analysis of variable region genes encoding a human anti-DNA antibody of normal origin. J. Immunol. 143:685.
55. Pascual, V., I. Randen, K. Thompson, M. Sioud, O. Forre, J. Natvig, and J. D. Capra. 1990. The complete nucleotide sequences of the heavy chain variable regions of six monospecific rheumatoid factors derived from Epstein-Barr virus-transformed B cells isolated from the synovial tissue of patients with rheumatoid arthritis: further evidence that some autoantibodies are unmutated copies of germ line genes. J. Clin. Invest. 86:1320.
56. Silberstein, L. E., L. C. Jeffries, J. Goldman, D. Friedman, J. S. Moore, P. C. Nowell, D. Roelcke, W. Pruzanski, J. Roudier, and G. J. Silverman. 1991. Variable region gene analysis of pathologic human autoantibodies to the related I and i red blood cell antigens. Blood 78:2372.
57. Irigoyen, M., B. Manheimer-Lory, B. Gaynor, and B. Diamond. 1994. Molecular analysis of the human immunoglobulin V1 gene family. J. Clin. Invest. 94:532.
58. Adderson, E. E., P. G. Shackelford, A. Quinn, P. M. Wilson, M. W. Cunningham, R. A. Insel, and W. L. Carroll. 1993. Restricted immunoglobulin VH usage and VDJ combinations in the human response to Haemophilus influenzae type b capsular polysaccharide: nucleotide sequences of monospecific anti-Haemophilus antibodies and polyspecific antibodies cross-reacting with self-antigens. J. Clin. Invest. 91:2734.
59. Quinn, A., E. E. Adderson, P. G. Shackelford, W. L. Carroll, and M. W. Cunningham. 1995. Autoantibody germ-line gene segment encodes VH and VL regions of a human anti-streptococcal mAb recognizing streptococcal M protein and human cardiac myosin epitopes. J. Immunol. 154:4203.
60. Twyman, R. E., L. C. Gahring, J. Spiess, and S. W. Rogers. 1995. Glutamate receptor antibodies activate a subset of receptors and reveal an agonist binding site. Neuron 14:755.
61. Wegmann, K. W., W. Zhao, A. C. Griffin, and W. F. Hickey. 1994. Identification of myocarditogenic peptides derived from cardiac myosin capable of inducing experimental allergic myocarditis in the Lewis rat. J. Immunol. 153:892.
62. Huber, S. A., L. P. Job, and J. F. Woodruff. 1980. Lysis of infected myofibers by coxsackievirus B3 immune lymphocytes. Am. J. Pathol. 98:681.
63. Liao, L., R. Sindhwani, M. Rojkind, S. Factor, L. Leinwand, and B. Diamond. 1995. Antibody-mediated autoimmune myocarditis depends on genetically determined target organ sensitivity. J. Exp. Med. 181:1123.
64. Read, S. E., H. Reid, T. Poon-King, and V. A. Fischetti. 1977. HLA and predisposition to the nonsuppurative sequelae of group A streptococcal infections. Transplant. Proc. 9:543.
65. Patarroyo, M. E., R. J. Winchester, A. Vejerano, A. Gibofsky, F. Chalem, J. B. Zabriskie, and H. G. Kunkel. 1979. Association of a B-cell alloantigen with susceptibility to rheumatic fever. Nature 278:173.
66. Ayoub, E. M., D. J. Barrett, N. K. Maclaren, and J. P. Krischer. 1986. Association of class II human histocompatibility leukocyte antigens with rheumatic fever. J. Clin. Invest. 77:2019.
67. Huber, C., E. Huber, A. Lautner-Rieske, K. F. Schable, and H. G. Zachau. 1993. The human immunoglobulin κ locus: characterization of the partially duplicated L regions. J. Immunol. 23:2860.