Infiltration of Foxp3-and Toll-like receptor-4-positive cells in the intestines of children with food allergy

Journal of Pediatric Gastroenterology and Nutrition

Volumn 50, Issue 4, 2010, Pages 367-376

  Westerholm Ormio, Mia ^a   Vaarala, Outi ^b   Tiittanen, Minna ^b   Savilahti, Erkki ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

Author keywords

CD4+CD25+ regulatory T cells; Cytokines; Food allergy; Foxp3; Toll like receptor

Indexed keywords

CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 4; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CELIAC DISEASE; CELL INFILTRATION; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DIET; DUODENUM BIOPSY; FEMALE; FOOD ALLERGY; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INFANT; INNATE IMMUNITY; INTESTINE FLORA; LAMINA PROPRIA; MALE; MUCOSAL IMMUNITY; PRESCHOOL CHILD; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STATISTICAL ANALYSIS;

ANTIGENS, CD; BIOLOGICAL MARKERS; CELIAC DISEASE; CHILD; CHILD, PRESCHOOL; DIET; DUODENUM; FEMALE; FOOD HYPERSENSITIVITY; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION; HUMANS; INFANT; INTESTINAL MUCOSA; MALE; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; T-LYMPHOCYTES, REGULATORY; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4;

BACTERIA (MICROORGANISMS);

EID: 77950247356     PISSN: 02772116     EISSN: None     Source Type: Journal    
DOI: 10.1097/MPG.0b013e3181cd2636     Document Type: Article

References (60)

1. Sakaguchi S. Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. Nat Immunol 2005;6:345-352
2. Sampson HA. Update on food allergy. J Allergy Clin Immunol 2004; 113:805-819
3. Fontenot JD, Rudensky AY. A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3. Nat Immunol 2005;6:331-337
4. Fontenot JD, Gavin MA, Rudensky AY. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol 2003;4:330-336
5. Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003;299:1057-1061
6. Khattri R, Cox T, Yasayko SA, et al. An essential role for Scurfin in CD4+CD25+ T regulatory cells. Nat Immunol 2003;4:337-342
7. Mottet C, Uhlig HH, Powrie F. Cutting edge: cure of colitis by CD4+CD25+ regulatory T cells. J Immunol 2003;170:3939-3943
8. Uhlig HH, Coombes J, Mottet C, et al. Characterization of Foxp3+ CD4+CD25+ and IL-10-secreting CD4+CD25+ T cells during cure of colitis. J Immunol 2006;177:5852-5860
9. Izcue A, Powrie F. Special regulatory T-cell review: regulatory T cells and the intestinal tract-patrolling the frontier. Immunology 2008; 123:6-10.
10. Gambineri E, Torgerson TR, Ochs HD. Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasis. Curr Opin Rheumatol 2003; 15:430-435
11. Torgerson TR, Linane A, Moes N, et al. Severe food allergy as a variant of IPEX syndrome caused by a deletion in a noncoding region of the FOXP3 gene. Gastroenterology 2007;132:1705-1717
12. Karlsson MR, Rugtveit J, Brandtzaeg P. Allergen-responsive CD4+CD25+ regulatory T cells in children who have outgrown cow's milk allergy. J Exp Med 2004;199:1679-1688
13. Ziegler SF. FOXP3: of mice and men. Annu Rev Immunol 2006;24: 209-226
14. Cario E, Podolsky DK. Intestinal epithelial TOLLerance versus in TOLLerance of commensals. Mol Immunol 2005;42:887-893
15. Takeda K, Akira S. Toll-like receptors in innate immunity. Int Immunol 2005;17:1-14.
16. Abreu MT, Fukata M, Arditi M. TLR signaling in the gut in health and disease. J Immunol 2005;174:4453-4460
17. Hausmann M, Kiessling S, Mestermann S, et al. Toll-like receptors 2 and 4 are up-regulated during intestinal inflammation. Gastroenterology 2002;122:1987-2000.
18. Cario E, Podolsky DK. Differential alteration in intestinal epithelial cell expression of toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease. Infect Immun 2000;68:7010-7017
19. Caramalho I, Lopes-Carvalho T, Ostler D, et al. Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide. J Exp Med 2003;197:403-411
20. Cario E. Bacterial interactions with cells of the intestinal mucosa: tolllike receptors and NOD2. Gut 2005;54:1182-1193
21. Otte JM, Cario E, Podolsky DK. Mechanisms of cross hyporesponsiveness to Toll-like receptor bacterial ligands in intestinal epithelial cells. Gastroenterology 2004;126:1054-1070
22. Szebeni B, Veres G, Dezsofi A, et al. Increased expression of Toll-like receptor (TLR) 2 and TLR4 in the colonic mucosa of children with inflammatory bowel disease. Clin Exp Immunol 2008;151:34-41.
23. Szebeni B, Veres G, Dezsofi A, et al. Increased mucosal expression of Toll-like receptor (TLR)2 and TLR4 in coeliac disease. J Pediatr Gastroenterol Nutr 2007;45:187-193
24. European Society for Pediatric Gastroenterology, Hepatology, and Nutrition. Diagnostic criteria for food allergy with predominantly intestinal symptoms. The European Society for Paediatric Gastroenterology and NutritionWorking Group for the Diagnostic Criteria for Food Allergy. J Pediatr Gastroenterol Nutr 1992;14:108-112.
25. Stern M. Comparative evaluation of serologic tests for celiac disease: a European initiative toward standardization. Working Group on Serologic Screening for Celiac Disease. J Pediatr Gastroenterol Nutr 2000; 31:513-519
26. Kolho KL, Savilahti E. IgA endomysium antibodies on human umbilical cord: an excellent diagnostic tool for celiac disease in childhood. J Pediatr Gastroenterol Nutr 1997;24:563-567
27. Walker-Smith JA, Guandalini S, Schmitz J, et al. Revised criteria for diagnosis of coeliac disease. Report of Working Group of European Society of Paediatric Gastroenterology and Nutrition. Arch Dis Child 1990;65:909-911
28. Westerholm-Ormio M, Vaarala O, Pihkala P, et al. Immunologic activity in the small intestinal mucosa of pediatric patients with type 1 diabetes. Diabetes 2003;52:2287-2295
29. Savilahti E, Örmälä T, Saukkonen T, et al. Jejuna of patients with insulin-dependent diabetes mellitus (IDDM) show signs of immune activation. Clin Exp Immunol 1999;116:70-77
30. Walker MR, Kasprowicz DJ, Gersuk VH, et al. Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25+ T cells. J Clin Invest 2003;112:1437-1443
31. Chen W, Wahl SM. TGF-beta: the missing link in CD4+CD25+ regulatory T cell-mediated immunosuppression. Cytokine Growth Factor Rev 2003;14:85-89
32. Zheng SG, Wang JH, Stohl W, et al. TGF-beta requires CTLA-4 early after T cell activation to induce FoxP3 and generate adaptive CD4+CD25+ regulatory cells. J Immunol 2006;176:3321-3329
33. Wang J, Ioan-Facsinay A, van der Voort EI, et al. Transient expression of FOXP3 in human activated nonregulatory CD4+ T cells. Eur J Immunol 2007;37:129-138
34. Akdis M, Verhagen J, Taylor A, et al. Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen- specific T regulatory 1 and T helper 2 cells. J Exp Med 2004; 199:1567-1575
35. Bellinghausen I, König B, Böttcher I, et al. Regulatory activity of human CD4 CD25 T cells depends on allergen concentration, type of allergen and atopy status of the donor. Immunology 2005;116:103-111
36. Ling EM, Smith T, Nguyen XD, et al. Relation of CD4+CD25+ regulatory T-cell suppression of allergen-driven T-cell activation to atopic status and expression of allergic disease. Lancet 2004;363: 608-615
37. Smith M, Tourigny MR, Noakes P, et al. Children with egg allergy have evidence of reduced neonatal CD4(+)CD25(+)CD127(lo/-) regulatory T cell function. J Allergy Clin Immunol 2008;121:1460-1466
38. Schaub B, Liu J,Höppler S, et al. Impairment of T-regulatory cells in cord blood of atopic mothers. J Allergy Clin Immunol 2008;121:1491-1499
39. Radulovic S, Jacobson MR, Durham SR, et al. Grass pollen immunotherapy induces Foxp3-expressing CD4+ CD25+ cells in the nasal mucosa. J Allergy Clin Immunol 2008;121:1467-1472
40. Curotto de Lafaille MA, Kutchukhidze N, Shen S, et al. Adaptive Foxp3+ regulatory T cell-dependent and -independent control of allergic inflammation. Immunity 2008;29:114-126
41. Ou LS, Goleva E, Hall C, et al. Tregulatory cells in atopic dermatitis and subversion of their activity by superantigens. J Allergy Clin Immunol 2004;113:756-763
42. Taylor AL, Hale J, Hales BJ, et al. FOXP3mRNAexpression at 6 months of age is higher in infants who develop atopic dermatitis, but is not affected by giving probiotics from birth. Pediatr Allergy Immunol 2007;18:10-19
43. Kelsen J, Agnholt J, Hoffmann HJ, et al. FoxP3(+)CD4(+)CD25(+) T cells with regulatory properties can be cultured from colonic mucosa of patients with Crohn's disease. Clin Exp Immunol 2005;141:549-557
44. Makita S, Kanai T, Oshima S, et al. CD4+CD25bright T cells in human intestinal lamina propria as regulatory cells. J Immunol 2004; 173:3119-3130
45. Saruta M, Yu QT, Fleshner PR, et al. Characterization of FOXP3+ CD4+ regulatory T cells in Crohn's disease. Clin Immunol 2007;125: 281-290
46. Yu QT, Saruta M, Avanesyan A, et al. Expression and functional characterization of FOXP3+ CD4+ regulatory T cells in ulcerative colitis. Inflamm Bowel Dis 2007;13:191-199
47. Hölttä V, Klemetti P, Sipponen T, et al. IL-23/IL-17 immunity as a hallmark of Crohn's disease. Inflamm Bowel Dis 2008;14:1175-1184
48. Tiittanen M, Westerholm-Ormio M, Verkasalo M, et al. Infiltration of forkhead box P3-expressing cells in small intestinal mucosa in coeliac disease but not in type 1 diabetes. Clin Exp Immunol 2008;152:498-507.
49. Mowat AM. Anatomical basis of tolerance and immunity to intestinal antigens. Nat Rev Immunol 2003;3:331-341
50. Chung HL, Hwang JB, Park JJ, et al. Expression of transforming growth factor beta1, transforming growth factor type I and II receptors, and TNF-alpha in the mucosa of the small intestine in infants with food protein-induced enterocolitis syndrome. J Allergy Clin Immunol 2002;109:150-154
51. Perez-Machado MA, Ashwood P, Thomson MA, et al. Reduced transforming growth factor-beta1-producing T cells in the duodenal mucosa of children with food allergy. Eur J Immunol 2003;33:2307-2315
52. Bashir ME, Louie S, Shi HN, et al. Toll-like receptor 4 signaling by intestinal microbes influences susceptibility to food allergy. J Immunol 2004;172:6978-6987
53. Nomura F, Akashi S, Sakao Y, et al. Cutting edge: endotoxin tolerance in mouse peritoneal macrophages correlates with down-regulation of surface toll-like receptor 4 expression. J Immunol 2000;164:3476-3479
54. Wang JH, Doyle M, Manning BJ, et al. Induction of bacterial lipoprotein tolerance is associated with suppression of toll-like receptor 2 expression. J Biol Chem 2002;277:36068-36075
55. Shrestha N, Ida JA, Lubinski AS, et al. Regulation of acquired immunity by gamma delta T-cell/dendritic-cell interactions. Ann N Y Acad Sci 2005;1062:79-94.
56. Wesch D, Beetz S, Oberg HH, et al. Direct costimulatory effect of TLR3 ligand poly(I:C) on human gamma delta T lymphocytes. J Immunol 2006;176:1348-1354
57. Beetz S, Wesch D, Marischen L, et al. Innate immune functions of human gammadelta T cells. Immunobiology 2008;213:173-182
58. Savilahti E. Food-induced malabsorption syndromes. J Pediatr Gastroenterol Nutr 2000;30:S61-6.
59. Kokkonen J, Holm K, Karttunen TJ, et al. Children with untreated food allergy express a relative increment in the density of duodenal gammadelta+ T cells. Scand J Gastroenterol 2000;35:1137-1142
60. Veres G, Westerholm-Ormio M, Kokkonen J, et al. Cytokines and adhesion molecules in duodenal mucosa of children with delayed-type food allergy. J Pediatr Gastroenterol Nutr 2003;37:27-34.