메뉴 건너뛰기




Volumn 119, Issue 3-5, 2010, Pages 149-160

In vitro effects of 2-methoxyestradiol on morphology, cell cycle progression, cell death and gene expression changes in the tumorigenic MCF-7 breast epithelial cell line

Author keywords

2 Methoxyestradiol; Apoptosis; Autophagy; MCF 7

Indexed keywords

2 METHOXYESTRADIOL; ACRIDINE ORANGE; CYCLIN B; CYTOCHROME C; HOE 33342; HYDROGEN PEROXIDE; MESSENGER RNA; REACTIVE OXYGEN METABOLITE;

EID: 77950224904     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2010.02.019     Document Type: Article
Times cited : (48)

References (71)
  • 1
    • 0842269204 scopus 로고    scopus 로고
    • Mechanism of action of 2-methoxyestradiol: new developments
    • Mooberry S.L. Mechanism of action of 2-methoxyestradiol: new developments. Drug Resist. Update 2003, 6(6):355-361.
    • (2003) Drug Resist. Update , vol.6 , Issue.6 , pp. 355-361
    • Mooberry, S.L.1
  • 3
    • 69249212263 scopus 로고    scopus 로고
    • Activity of 2-methoxyestradiol (Panzem NCD) in advanced, platinum-resistant ovarian cancer and primary peritoneal carcinomatosis: a Hoosier Oncology Group trial
    • Matei D., Schilder J., Sutton G., Perkins S., Breen T., Quon C., Sidor C. Activity of 2-methoxyestradiol (Panzem NCD) in advanced, platinum-resistant ovarian cancer and primary peritoneal carcinomatosis: a Hoosier Oncology Group trial. Gynecol. Oncol. 2009, 115(1):90-96.
    • (2009) Gynecol. Oncol. , vol.115 , Issue.1 , pp. 90-96
    • Matei, D.1    Schilder, J.2    Sutton, G.3    Perkins, S.4    Breen, T.5    Quon, C.6    Sidor, C.7
  • 7
    • 70349473165 scopus 로고    scopus 로고
    • Potential vascular actions of 2-methoxyestradiol
    • Dubey R.K., Jackson E.K. Potential vascular actions of 2-methoxyestradiol. Trends Endocrinol. Metab. 2009, 20(8):374-379.
    • (2009) Trends Endocrinol. Metab. , vol.20 , Issue.8 , pp. 374-379
    • Dubey, R.K.1    Jackson, E.K.2
  • 9
    • 33749578369 scopus 로고    scopus 로고
    • 2-Methoxyestradiol suppresses microtubule dynamics and arrests mitosis without depolymerizing microtubules
    • Kamath K., Okouneva T., Larson G., Panda D., Wilson L., Jordan M.A. 2-Methoxyestradiol suppresses microtubule dynamics and arrests mitosis without depolymerizing microtubules. Mol. Cancer Ther. 2006, 5(9):2225-2233.
    • (2006) Mol. Cancer Ther. , vol.5 , Issue.9 , pp. 2225-2233
    • Kamath, K.1    Okouneva, T.2    Larson, G.3    Panda, D.4    Wilson, L.5    Jordan, M.A.6
  • 10
    • 0033209598 scopus 로고    scopus 로고
    • 2-Methoxyestradiol-induced growth suppression and lethality in estrogen-responsive MCF-7 cells may be mediated by down regulation of p34cdc2 and cyclin B1 expression
    • Zoubine M.N., Weston A.P., Johnson D.C., Campbell D.R., Banerjee S.K. 2-Methoxyestradiol-induced growth suppression and lethality in estrogen-responsive MCF-7 cells may be mediated by down regulation of p34cdc2 and cyclin B1 expression. Int. J. Oncol. 1999, 15(4):639-646.
    • (1999) Int. J. Oncol. , vol.15 , Issue.4 , pp. 639-646
    • Zoubine, M.N.1    Weston, A.P.2    Johnson, D.C.3    Campbell, D.R.4    Banerjee, S.K.5
  • 11
    • 48249145841 scopus 로고    scopus 로고
    • In vitro effects of 2-methoxyestradiol on MCF-12A and MCF-7 cell growth, morphology and mitotic spindle formation
    • Van Zijl C., Lottering M.L., Steffens F., Joubert A. In vitro effects of 2-methoxyestradiol on MCF-12A and MCF-7 cell growth, morphology and mitotic spindle formation. Cell Biochem. Funct. 2008, 26(5):632-642.
    • (2008) Cell Biochem. Funct. , vol.26 , Issue.5 , pp. 632-642
    • Van Zijl, C.1    Lottering, M.L.2    Steffens, F.3    Joubert, A.4
  • 12
    • 14544273363 scopus 로고    scopus 로고
    • Differential effects of 16alpha-hydroxyestrone and 2-methoxyestradiol on cyclin D1 involving the transcription factor ATF-2 in MCF-7 breast cancer cells
    • Lewis J.S., Thomas T.J., Pestell R.G., Albanese C., Gallo M.A., Thomas T. Differential effects of 16alpha-hydroxyestrone and 2-methoxyestradiol on cyclin D1 involving the transcription factor ATF-2 in MCF-7 breast cancer cells. J. Mol. Endocrinol. 2005, 34(1):91-105.
    • (2005) J. Mol. Endocrinol. , vol.34 , Issue.1 , pp. 91-105
    • Lewis, J.S.1    Thomas, T.J.2    Pestell, R.G.3    Albanese, C.4    Gallo, M.A.5    Thomas, T.6
  • 13
    • 58849135484 scopus 로고    scopus 로고
    • Mechanism of 2-methoxyestradiol-induced apoptosis and growth arrest in human breast cancer cells
    • Fukui M., Zhu B.T. Mechanism of 2-methoxyestradiol-induced apoptosis and growth arrest in human breast cancer cells. Mol. Carcinog. 2009, 48(1):66-78.
    • (2009) Mol. Carcinog. , vol.48 , Issue.1 , pp. 66-78
    • Fukui, M.1    Zhu, B.T.2
  • 15
    • 34250869019 scopus 로고    scopus 로고
    • MDA-MB-435 cells are derived from M14 melanoma cells-a loss for breast cancer, but a boon for melanoma research
    • Rae J.M., Creighton C.J., Meck J.M., Haddad B.R., Johnson M.D. MDA-MB-435 cells are derived from M14 melanoma cells-a loss for breast cancer, but a boon for melanoma research. Breast Cancer Res. Treat. 2007, 104(1):13-19.
    • (2007) Breast Cancer Res. Treat. , vol.104 , Issue.1 , pp. 13-19
    • Rae, J.M.1    Creighton, C.J.2    Meck, J.M.3    Haddad, B.R.4    Johnson, M.D.5
  • 16
    • 27244454117 scopus 로고    scopus 로고
    • Bax/Bcl-2 expression levels of 2-methoxyestradiol-exposed esophageal cancer cells
    • Joubert A., Maritz C., Joubert F. Bax/Bcl-2 expression levels of 2-methoxyestradiol-exposed esophageal cancer cells. Biomed Res. 2005, 26(3):131-134.
    • (2005) Biomed Res. , vol.26 , Issue.3 , pp. 131-134
    • Joubert, A.1    Maritz, C.2    Joubert, F.3
  • 17
    • 24944542279 scopus 로고    scopus 로고
    • Influence of prostaglandin A2 and 2-methoxyestradiol on Bax and Bcl-2 expression levels in cervical carcinoma cells
    • Joubert A., Maritz C., Joubert F. Influence of prostaglandin A2 and 2-methoxyestradiol on Bax and Bcl-2 expression levels in cervical carcinoma cells. Biomed Res. 2005, 26(2):87-90.
    • (2005) Biomed Res. , vol.26 , Issue.2 , pp. 87-90
    • Joubert, A.1    Maritz, C.2    Joubert, F.3
  • 18
    • 33646390930 scopus 로고    scopus 로고
    • P38 Mitogen-activated protein kinases is required for counteraction of 2-methoxyestradiol to estradiol-stimulated cell proliferation and induction of apoptosis in ovarian carcinoma cells via phosphorylation Bcl-2
    • Bu S.Z., Huang Q., Jiang Y.M., Min H.B., Hou Y., Guo Z.Y., Wei J.F., Wang J.W., Ni X., Zheng S.S. p38 Mitogen-activated protein kinases is required for counteraction of 2-methoxyestradiol to estradiol-stimulated cell proliferation and induction of apoptosis in ovarian carcinoma cells via phosphorylation Bcl-2. Apoptosis 2006, 11(3):413-425.
    • (2006) Apoptosis , vol.11 , Issue.3 , pp. 413-425
    • Bu, S.Z.1    Huang, Q.2    Jiang, Y.M.3    Min, H.B.4    Hou, Y.5    Guo, Z.Y.6    Wei, J.F.7    Wang, J.W.8    Ni, X.9    Zheng, S.S.10
  • 19
    • 0037032474 scopus 로고    scopus 로고
    • Mechanisms for 2-methoxyestradiol-induced apoptosis of prostate cancer cells
    • Bu S., Blaukat A., Fu X., Heldin N.E., Landstrom M. Mechanisms for 2-methoxyestradiol-induced apoptosis of prostate cancer cells. FEBS Lett. 2002, 531(2):141-151.
    • (2002) FEBS Lett. , vol.531 , Issue.2 , pp. 141-151
    • Bu, S.1    Blaukat, A.2    Fu, X.3    Heldin, N.E.4    Landstrom, M.5
  • 20
    • 0040298568 scopus 로고    scopus 로고
    • Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis
    • Janicke R.U., Sprengart M.L., Wati M.R., Porter A.G. Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis. J. Biol. Chem. 1998, 273(16):9357-9360.
    • (1998) J. Biol. Chem. , vol.273 , Issue.16 , pp. 9357-9360
    • Janicke, R.U.1    Sprengart, M.L.2    Wati, M.R.3    Porter, A.G.4
  • 21
    • 0025218905 scopus 로고
    • Flow cytometric analysis of respiratory burst activity in phagocytes with hydroethidine and 2′,7′-dichlorofluorescin
    • Rothe G., Valet G. Flow cytometric analysis of respiratory burst activity in phagocytes with hydroethidine and 2′,7′-dichlorofluorescin. J. Leukoc. Biol. 1990, 47(5):440-448.
    • (1990) J. Leukoc. Biol. , vol.47 , Issue.5 , pp. 440-448
    • Rothe, G.1    Valet, G.2
  • 22
    • 0038368985 scopus 로고    scopus 로고
    • Superoxide reacts with hydroethidine but forms a fluorescent product that is distinctly different from ethidium: potential implications in intracellular fluorescence detection of superoxide
    • Zhao H., Kalivendi S., Zhang H., Joseph J., Nithipatikom K., Vasquez-Vivar J., Kalyanaraman B. Superoxide reacts with hydroethidine but forms a fluorescent product that is distinctly different from ethidium: potential implications in intracellular fluorescence detection of superoxide. Free Radic. Biol. Med. 2003, 34(11):1359-1368.
    • (2003) Free Radic. Biol. Med. , vol.34 , Issue.11 , pp. 1359-1368
    • Zhao, H.1    Kalivendi, S.2    Zhang, H.3    Joseph, J.4    Nithipatikom, K.5    Vasquez-Vivar, J.6    Kalyanaraman, B.7
  • 23
    • 34248583762 scopus 로고    scopus 로고
    • Methods for monitoring autophagy from yeast to human
    • Klionsky D.J., Cuervo A.M., Seglen P.O. Methods for monitoring autophagy from yeast to human. Autophagy 2007, 3(3):181-206.
    • (2007) Autophagy , vol.3 , Issue.3 , pp. 181-206
    • Klionsky, D.J.1    Cuervo, A.M.2    Seglen, P.O.3
  • 24
    • 4544341015 scopus 로고    scopus 로고
    • Linear models and empirical bayes methods for assessing differential expression in microarray experiments
    • (Article 3)
    • Smyth G.K. Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat. Appl. Genet. Mol. Biol. 2004, 3. (Article 3).
    • (2004) Stat. Appl. Genet. Mol. Biol. , vol.3
    • Smyth, G.K.1
  • 25
    • 12344330424 scopus 로고    scopus 로고
    • LimmaGUI: a graphical user interface for linear modeling of microarray data
    • Wettenhall J.M., Smyth G.K. limmaGUI: a graphical user interface for linear modeling of microarray data. Bioinformatics 2004, 20(18):3705-3706.
    • (2004) Bioinformatics , vol.20 , Issue.18 , pp. 3705-3706
    • Wettenhall, J.M.1    Smyth, G.K.2
  • 27
    • 0242333835 scopus 로고    scopus 로고
    • Normalization of cDNA microarray data
    • Smyth G.K., Speed T. Normalization of cDNA microarray data. Methods 2003, 31(4):265-273.
    • (2003) Methods , vol.31 , Issue.4 , pp. 265-273
    • Smyth, G.K.1    Speed, T.2
  • 28
    • 0001677717 scopus 로고
    • Controlling the false discovery rate: a practical and powerful approach to multiple testing
    • Benjamini Y., Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J. R. Stat. Soc. Ser. B (Methodol.) 1995, 57(1):289-300.
    • (1995) J. R. Stat. Soc. Ser. B (Methodol.) , vol.57 , Issue.1 , pp. 289-300
    • Benjamini, Y.1    Hochberg, Y.2
  • 29
    • 61449172037 scopus 로고    scopus 로고
    • Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
    • Huang da W., Sherman B.T., Lempicki R.A. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat. Prot. 2009, 4(1):44-57.
    • (2009) Nat. Prot. , vol.4 , Issue.1 , pp. 44-57
    • Huang da, W.1    Sherman, B.T.2    Lempicki, R.A.3
  • 31
    • 9444266171 scopus 로고    scopus 로고
    • CellDesigner: a process diagram editor for gene-regulatory and biochemical networks
    • Funahashi A., Morohashi M., Kitano H., Tanimura N. CellDesigner: a process diagram editor for gene-regulatory and biochemical networks. Biosilico 2003, 1(5):159-162.
    • (2003) Biosilico , vol.1 , Issue.5 , pp. 159-162
    • Funahashi, A.1    Morohashi, M.2    Kitano, H.3    Tanimura, N.4
  • 33
    • 44949185572 scopus 로고    scopus 로고
    • The human spindle assembly checkpoint protein Bub3 is required for the establishment of efficient kinetochore-microtubule attachments
    • Logarinho E., Resende T., Torres C., Bousbaa H. The human spindle assembly checkpoint protein Bub3 is required for the establishment of efficient kinetochore-microtubule attachments. Mol. Biol. Cell 2008, 19(4):1798-1813.
    • (2008) Mol. Biol. Cell , vol.19 , Issue.4 , pp. 1798-1813
    • Logarinho, E.1    Resende, T.2    Torres, C.3    Bousbaa, H.4
  • 34
    • 1842529261 scopus 로고    scopus 로고
    • Identification of two novel components of the human NDC80 kinetochore complex
    • Bharadwaj R., Qi W., Yu H. Identification of two novel components of the human NDC80 kinetochore complex. J. Biol. Chem. 2004, 279(13):13076-13085.
    • (2004) J. Biol. Chem. , vol.279 , Issue.13 , pp. 13076-13085
    • Bharadwaj, R.1    Qi, W.2    Yu, H.3
  • 37
    • 28844477797 scopus 로고    scopus 로고
    • Depletion of CPAP by RNAi disrupts centrosome integrity and induces multipolar spindles
    • Cho J.H., Chang C.J., Chen C.Y., Tang T.K. Depletion of CPAP by RNAi disrupts centrosome integrity and induces multipolar spindles. Biochem. Biophys. Res. Commun. 2006, 339(3):742-747.
    • (2006) Biochem. Biophys. Res. Commun. , vol.339 , Issue.3 , pp. 742-747
    • Cho, J.H.1    Chang, C.J.2    Chen, C.Y.3    Tang, T.K.4
  • 39
    • 0346155805 scopus 로고    scopus 로고
    • The spindle assembly and spindle position checkpoints
    • Lew D.J., Burke D.J. The spindle assembly and spindle position checkpoints. Annu. Rev. Genet. 2003, 37:251-282.
    • (2003) Annu. Rev. Genet. , vol.37 , pp. 251-282
    • Lew, D.J.1    Burke, D.J.2
  • 41
    • 0036902234 scopus 로고    scopus 로고
    • Regulation of APC-Cdc20 by the spindle checkpoint
    • Yu H. Regulation of APC-Cdc20 by the spindle checkpoint. Curr. Opin. Cell Biol. 2002, 14(6):706-714.
    • (2002) Curr. Opin. Cell Biol. , vol.14 , Issue.6 , pp. 706-714
    • Yu, H.1
  • 42
    • 33747589184 scopus 로고    scopus 로고
    • The anaphase promoting complex/cyclosome: a machine designed to destroy
    • Peters J.M. The anaphase promoting complex/cyclosome: a machine designed to destroy. Nat. Rev. Mol. Cell Biol. 2006, 7(9):644-656.
    • (2006) Nat. Rev. Mol. Cell Biol. , vol.7 , Issue.9 , pp. 644-656
    • Peters, J.M.1
  • 44
    • 8544264567 scopus 로고    scopus 로고
    • 2-Methoxyestradiol induces cell cycle arrest and apoptosis of nasopharyngeal carcinoma cells
    • Zhou N.N., Zhu X.F., Zhou J.M., Li M.Z., Zhang X.S., Huang P., Jiang W.Q. 2-Methoxyestradiol induces cell cycle arrest and apoptosis of nasopharyngeal carcinoma cells. Acta Pharmacol. Sin. 2004, 25(11):1515-1520.
    • (2004) Acta Pharmacol. Sin. , vol.25 , Issue.11 , pp. 1515-1520
    • Zhou, N.N.1    Zhu, X.F.2    Zhou, J.M.3    Li, M.Z.4    Zhang, X.S.5    Huang, P.6    Jiang, W.Q.7
  • 45
    • 4344659253 scopus 로고    scopus 로고
    • 2-Methoxyestradiol inhibits proliferation of normal and neoplastic glial cells, and induces cell death, in vitro
    • Lis A., Ciesielski M.J., Barone T.A., Scott B.E., Fenstermaker R.A., Plunkett R.J. 2-Methoxyestradiol inhibits proliferation of normal and neoplastic glial cells, and induces cell death, in vitro. Cancer Lett. 2004, 213(1):57-65.
    • (2004) Cancer Lett. , vol.213 , Issue.1 , pp. 57-65
    • Lis, A.1    Ciesielski, M.J.2    Barone, T.A.3    Scott, B.E.4    Fenstermaker, R.A.5    Plunkett, R.J.6
  • 46
    • 2442476448 scopus 로고    scopus 로고
    • Induction of apoptosis and G2/M arrest by 2-methoxyestradiol in human cervical cancer HeLaS3 cells
    • Li L., Bu S., Backstrom T., Landstrom M., Ulmsten U., Fu X. Induction of apoptosis and G2/M arrest by 2-methoxyestradiol in human cervical cancer HeLaS3 cells. Anticancer Res. 2004, 24(2B):873-880.
    • (2004) Anticancer Res. , vol.24 B , Issue.2 , pp. 873-880
    • Li, L.1    Bu, S.2    Backstrom, T.3    Landstrom, M.4    Ulmsten, U.5    Fu, X.6
  • 47
    • 34249065507 scopus 로고    scopus 로고
    • Cyclin B1-Cdk1 activation continues after centrosome separation to control mitotic progression
    • Lindqvist A., van Zon W., Karlsson Rosenthal C., Wolthuis R.M. Cyclin B1-Cdk1 activation continues after centrosome separation to control mitotic progression. PLoS Biol. 2007, 5(5):e123.
    • (2007) PLoS Biol. , vol.5 , Issue.5
    • Lindqvist, A.1    van Zon, W.2    Karlsson Rosenthal, C.3    Wolthuis, R.M.4
  • 48
    • 0033168496 scopus 로고    scopus 로고
    • Sister-chromatid separation at anaphase onset is promoted by cleavage of the cohesin subunit Scc1
    • Uhlmann F., Lottspeich F., Nasmyth K. Sister-chromatid separation at anaphase onset is promoted by cleavage of the cohesin subunit Scc1. Nature 1999, 400(6739):37-42.
    • (1999) Nature , vol.400 , Issue.6739 , pp. 37-42
    • Uhlmann, F.1    Lottspeich, F.2    Nasmyth, K.3
  • 49
  • 50
    • 19844369277 scopus 로고    scopus 로고
    • 2-Methoxyestradiol-induced apoptosis in human leukemia cells proceeds through a reactive oxygen species and Akt-dependent process
    • Gao N., Rahmani M., Dent P., Grant S. 2-Methoxyestradiol-induced apoptosis in human leukemia cells proceeds through a reactive oxygen species and Akt-dependent process. Oncogene 2005, 24(23):3797-3809.
    • (2005) Oncogene , vol.24 , Issue.23 , pp. 3797-3809
    • Gao, N.1    Rahmani, M.2    Dent, P.3    Grant, S.4
  • 51
    • 34347398891 scopus 로고    scopus 로고
    • Requirement of reactive oxygen species generation in apoptosis of leukemia cells induced by 2-methoxyestradiol
    • She M.R., Li J.G., Guo K.Y., Lin W., Du X., Niu X.Q. Requirement of reactive oxygen species generation in apoptosis of leukemia cells induced by 2-methoxyestradiol. Acta Pharmacol. Sin. 2007, 28(7):1037-1044.
    • (2007) Acta Pharmacol. Sin. , vol.28 , Issue.7 , pp. 1037-1044
    • She, M.R.1    Li, J.G.2    Guo, K.Y.3    Lin, W.4    Du, X.5    Niu, X.Q.6
  • 52
    • 37349067228 scopus 로고    scopus 로고
    • Oxidative stress induces autophagic cell death independent of apoptosis in transformed and cancer cells
    • Chen Y., McMillan-Ward E., Kong J., Israels S.J., Gibson S.B. Oxidative stress induces autophagic cell death independent of apoptosis in transformed and cancer cells. Cell Death Differ. 2008, 15(1):171-182.
    • (2008) Cell Death Differ. , vol.15 , Issue.1 , pp. 171-182
    • Chen, Y.1    McMillan-Ward, E.2    Kong, J.3    Israels, S.J.4    Gibson, S.B.5
  • 53
    • 33746932518 scopus 로고    scopus 로고
    • Activation of superoxide dismutases: putting the metal to the pedal
    • Culotta V.C., Yang M., O'Halloran T.V. Activation of superoxide dismutases: putting the metal to the pedal. Biochim. Biophys. Acta 2006, 1763(7):747-758.
    • (2006) Biochim. Biophys. Acta , vol.1763 , Issue.7 , pp. 747-758
    • Culotta, V.C.1    Yang, M.2    O'Halloran, T.V.3
  • 56
    • 34447631168 scopus 로고    scopus 로고
    • Oxyl radicals, redox-sensitive signalling cascades and antioxidants
    • Genestra M. Oxyl radicals, redox-sensitive signalling cascades and antioxidants. Cell Signal. 2007, 19(9):1807-1819.
    • (2007) Cell Signal. , vol.19 , Issue.9 , pp. 1807-1819
    • Genestra, M.1
  • 57
    • 0038531029 scopus 로고    scopus 로고
    • 2-Methoxyestradiol induces apoptosis in Ewing sarcoma cells through mitochondrial hydrogen peroxide production
    • Djavaheri-Mergny M., Wietzerbin J., Besancon F. 2-Methoxyestradiol induces apoptosis in Ewing sarcoma cells through mitochondrial hydrogen peroxide production. Oncogene 2003, 22(17):2558-2567.
    • (2003) Oncogene , vol.22 , Issue.17 , pp. 2558-2567
    • Djavaheri-Mergny, M.1    Wietzerbin, J.2    Besancon, F.3
  • 60
    • 32944467076 scopus 로고    scopus 로고
    • Mammalian polyamine catabolism: a therapeutic target, a pathological problem, or both?
    • Wang Y., Casero R.A. Mammalian polyamine catabolism: a therapeutic target, a pathological problem, or both?. J. Biochem. 2006, 139(1):17-25.
    • (2006) J. Biochem. , vol.139 , Issue.1 , pp. 17-25
    • Wang, Y.1    Casero, R.A.2
  • 62
    • 19344367959 scopus 로고    scopus 로고
    • Direct oxidative DNA damage, apoptosis and radio sensitivity by spermine oxidase activities in mouse neuroblastoma cells
    • Amendola R., Bellini A., Cervelli M., Degan P., Marcocci L., Martini F., Mariottini P. Direct oxidative DNA damage, apoptosis and radio sensitivity by spermine oxidase activities in mouse neuroblastoma cells. Biochim. Biophys. Acta 2005, 1755(1):15-24.
    • (2005) Biochim. Biophys. Acta , vol.1755 , Issue.1 , pp. 15-24
    • Amendola, R.1    Bellini, A.2    Cervelli, M.3    Degan, P.4    Marcocci, L.5    Martini, F.6    Mariottini, P.7
  • 63
    • 0024497521 scopus 로고
    • Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite
    • Keyse S.M., Tyrrell R.M. Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite. Proc. Natl. Acad. Sci. U.S.A. 1989, 86(1):99-103.
    • (1989) Proc. Natl. Acad. Sci. U.S.A. , vol.86 , Issue.1 , pp. 99-103
    • Keyse, S.M.1    Tyrrell, R.M.2
  • 64
    • 0034533986 scopus 로고    scopus 로고
    • Regulation of endothelial heme oxygenase activity during hypoxia is dependent on chelatable iron
    • Ryter S.W., Si M., Lai C.C., Su C.Y. Regulation of endothelial heme oxygenase activity during hypoxia is dependent on chelatable iron. Am. J. Physiol. Heart Circ. Physiol. 2000, 279(6):H2889-2897.
    • (2000) Am. J. Physiol. Heart Circ. Physiol. , vol.279 , Issue.6
    • Ryter, S.W.1    Si, M.2    Lai, C.C.3    Su, C.Y.4
  • 65
    • 0036211994 scopus 로고    scopus 로고
    • The Haber-Weiss cycle-70 years later: an alternative view
    • (author reply 59-60)
    • Liochev S.I., Fridovich I. The Haber-Weiss cycle-70 years later: an alternative view. Redox Rep. 2002, 7(1):55-57. (author reply 59-60).
    • (2002) Redox Rep. , vol.7 , Issue.1 , pp. 55-57
    • Liochev, S.I.1    Fridovich, I.2
  • 66
    • 33749242421 scopus 로고    scopus 로고
    • Nutrient control of macroautophagy in mammalian cells
    • Kadowaki M., Karim M.R., Carpi A., Miotto G. Nutrient control of macroautophagy in mammalian cells. Mol. Aspects Med. 2006, 27(5-6):426-443.
    • (2006) Mol. Aspects Med. , vol.27 , Issue.5-6 , pp. 426-443
    • Kadowaki, M.1    Karim, M.R.2    Carpi, A.3    Miotto, G.4
  • 67
    • 58149387218 scopus 로고    scopus 로고
    • Regulation of autophagy by reactive oxygen species (ROS): implications for cancer progression and treatment
    • Azad M.B., Chen Y., Gibson S.B. Regulation of autophagy by reactive oxygen species (ROS): implications for cancer progression and treatment. Antioxid. Redox Signal. 2008.
    • (2008) Antioxid. Redox Signal.
    • Azad, M.B.1    Chen, Y.2    Gibson, S.B.3
  • 68
    • 24944480788 scopus 로고    scopus 로고
    • The Akt-mTOR tango and its relevance to cancer
    • Hay N. The Akt-mTOR tango and its relevance to cancer. Cancer Cell 2005, 8(3):179-183.
    • (2005) Cancer Cell , vol.8 , Issue.3 , pp. 179-183
    • Hay, N.1
  • 70
    • 67649814136 scopus 로고    scopus 로고
    • PI3K/PTEN signaling in angiogenesis and tumorigenesis
    • Jiang B.H., Liu L.Z. PI3K/PTEN signaling in angiogenesis and tumorigenesis. Adv. Cancer Res. 2009, 102:19-65.
    • (2009) Adv. Cancer Res. , vol.102 , pp. 19-65
    • Jiang, B.H.1    Liu, L.Z.2
  • 71
    • 0034896098 scopus 로고    scopus 로고
    • Deficiency of caspase-3 in MCF7 cells blocks Bax-mediated nuclear fragmentation but not cell death
    • Kagawa S., Gu J., Honda T., McDonnell T.J., Swisher S.G., Roth J.A., Fang B. Deficiency of caspase-3 in MCF7 cells blocks Bax-mediated nuclear fragmentation but not cell death. Clin. Cancer Res. 2001, 7(5):1474-1480.
    • (2001) Clin. Cancer Res. , vol.7 , Issue.5 , pp. 1474-1480
    • Kagawa, S.1    Gu, J.2    Honda, T.3    McDonnell, T.J.4    Swisher, S.G.5    Roth, J.A.6    Fang, B.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.