Mammalian polyamine catabolism: A therapeutic target, a pathological problem, or both?

Journal of Biochemistry

Volumn 139, Issue 1, 2006, Pages 17-25

  Wang, Yanlin ^a   Casero Jr , Robert A ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Acetyltransferase; Oxidase; Reactive oxygen species; Spermidine; Spermine

Indexed keywords

ACYLTRANSFERASE; POLYAMINE; POLYAMINE OXIDASE; SPERMINE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; CATABOLISM; CELL TRANSFORMATION; DNA DAMAGE; DRUG TARGETING; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME MECHANISM; ENZYME SPECIFICITY; HOMEOSTASIS; HUMAN; MOLECULAR CLONING; PROTEIN EXPRESSION; SHORT SURVEY; TRANSCRIPTION REGULATION;

ACETYLTRANSFERASES; ANIMALS; BIOGENIC POLYAMINES; CLONING, MOLECULAR; HUMANS; MAMMALS; MICE; MICE, TRANSGENIC; REACTIVE OXYGEN SPECIES; SUBSTRATE SPECIFICITY; TRANSCRIPTION, GENETIC;

MAMMALIA;

EID: 32944467076     PISSN: 0021924X     EISSN: None     Source Type: Journal    
DOI: 10.1093/jb/mvj021     Document Type: Short Survey

References (76)

1. 1-acetyltransferase-the turning point in polyamine metabolism. FASEB J. 7, 653-661
2. Wang, Y., Devereux, W., Woster, P.M., Stewart, T.M., Hacker, A., and Casero, R.A., Jr. (2001) Cloning and characterization of a human polyamine oxidase that is inducible by polyamine analogue exposure. Cancer Res. 61, 5370-5373
3. Vujcic, S., Diegelman, P., Bacchi, C.J., Kramer, D.L., and Porter, C.W. (2002) Identification and characterization of a novel flavin-containing spermine oxidase of mammalian cell origin. Biochem. J. 367, 665-675
4. Thomas, T. and Thomas, T.J. (2001) Polyamines in cell growth and cell death: molecular mechanisms and therapeutic applications. Cell. Mol. Life Sci. 58, 244-258
5. Gerner, E.W. and Meyskens, F.L., Jr. (2004) Polyamines and cancer: old molecules, new understanding. Nat. Rev. Cancer 4, 781-792
6. Holtta, E. (1977) Oxidation of spermidine and spermine in rat liver: purification and properties of polyamine oxidase. Biochemistry 16, 91-100
7. 1-acetyltransferase from rat liver. Biochemistry 21, 6152-6158
8. 1-acetyltransferase. J. Biol. Chem. 266, 810-814
9. 1-acetyltransferase gene (exon/intron gene organization and localization to Xp22.1). Biochem. Biophys. Res. Commun. 187, 1493-1502
10. 1- acetyltransferase mRNA in the human kidney cells infected by venezuelan equine encephalitis and tick-borne encephalitis viruses. Virology 297, 163-171
11. Kim, K., Ryu, J.H., Park, J.W., Kim, M.S., and Chun, Y.S. (2005) Induction of a SSAT isoform in response to hypoxia or iron deficiency and its protective effects on cell death. Biochem. Biophys. Res. Commun. 331, 78-85
12. 1- acetyltransferase cDNA. Biochim. Biophys. Acta 1171, 106-108
13. 1-acetyltransferase - a gene uniquely regulated by polyamines and their analogs. Biochim. Biophys. Acta 1216, 255-264
14. Maxwell, P.J., Longley, D.B., Latif, T., Boyer, J., Allen, W., Lynch, M., McDermott, U., Harkin, D.P., Allegra, C.J., and Johnston, P.G. (2003) Identification of 5-fluorouracil-inducible target genes using cDNA microarray profiling. Cancer Res. 63, 4602-4606
15. Zhang, W., Ramdas, L., Shen, W., Song, S.W., Hu, L., and Hamilton, S.R. (2003) Apoptotic response to 5-fluorouracil treatment is mediated by reduced polyamines, non-autocrine Fas ligand and induced tumor necrosis factor receptor 2. Cancer Biol. Ther. 2, 572-578
16. 1-acetyltransferase expression, depletes polyamines, and synergistically induces apoptosis in colon carcinoma cells. J. Biol. Chem. 280, 3295-3304
17. 1-acetyltransferase. Mol. Cancer Ther. 3, 813-822
18. 1-acetyltransferase in human lung cancer cells by the bis(ethyl)polyamine analogues. Cancer Res. 49, 3829-3833
19. 1-acetyltransferase activity, polyamine pool depletion, and growth inhibition in human melanoma cell lines. Cancer Res. 51, 3715-3720
20. 1-acetyltransferase in MALME-3M human melanoma cells. J. Biol. Chem. 268, 19118-19125
21. 1-acetyltransferase (SSAT) gene in human lung carcinoma cells. Biochem. J. 313, 691-696
22. 1-acetyltransferase gene transcription. J. Biol. Chem. 273, 34623-34630
23. 1-acetyltransferase gene. J. Biol. Chem. 274, 22095-22101
24. 1-acetyltransferase by polyamines. FEBS Lett. 391, 89-94
25. 12-bis(ethyl)spermine. Biochem. J. 305, 451-458
26. 1-acetyltransferase stably expressed in Chinese hamster ovary cells. J. Biol. Chem. 274, 6175-6182
27. 1- acetyltransferase. Biochem. J. 316, 697-701
28. 1-acetyltransferase and prevent its targeting to the proteasome for degradation. Biochem. J. 358, 137-145
29. 11-bis(ethyl)norspermine against human melanoma xenografts and possible biochemical correlates of drug action. Cancer Res. 53, 581-586
30. 11- diethylnorspermine administered by multiple injection or continuous infusion. Clin. Cancer Res. 1, 847-857
31. 11-diethylnorspermine. Cancer Chemother. Pharmacol. 54, 122-126
32. 1-acetyltransferase on polyamine pool dynamics, cell growth, and sensitivity to polyamine analogs. J. Biol. Chem. 275, 38319-38328
33. 1-acetyltransferase (SSAT) activity in human small-cell lung carcinoma cells following transfection with a genomic SSAT construct. Biochem. J. 373, 629-634
34. Hahm, H.A., Dunn, V.R., Butash, K.A., Deveraux, W.L., Woster, P.M., Casero, R.A., Jr. and Davidson, N.E. (2001) Combination of standard cytotoxic agents with polyamine analogues in the treatment of breast cancer cell lines. Clin. Cancer Res. 7, 391-399
35. Barone, S., Okaya, T., Rudich, S., Petrovic, S., Tehrani, K., Wang, Z., Zahedi, K., Casero, R.A., Lentsch, A.B., and Soleimani, M. (2005) Distinct and sequential upregulation of genes regulating cell growth and cell cycle progression during hepatic ischemia/reperfusion injury. Am. J. Physiol. Cell. Physiol. 289, C826-835
36. 1-acetyl transferase activity in rat brain following transient focal cerebral ischemia and reperfusion. Neurosci. Lett. 300, 17-20
37. Zahedi, K., Wang, Z., Barone, S., Prada, A.E., Kelly, C.N., Casero, R.A., Yokota, N., Porter, C.W., Rabb, H., and Soleimani, M. (2003) Expression of SSAT, a novel biomarker of tubular cell damage, increases in kidney ischemia-reperfusion injury. Am. J. Physiol. Renal Physiol. 284, F1046-1055
38. Wang, Z., Zahedi, K., Barone, S., Tehrani, K., Rabb, H., Matlin, K., Casero, R.A., and Soleimani, M. (2004) Overexpression of SSAT in kidney cells recapitulates various phenotypic aspects of kidney ischemia-reperfusion injury. J. Am. Soc. Nephrol. 15, 1844-1852
39. Turchanowa, L., Dauletbaev, N., Milovic, V., and Stein, J. (2001) Nonsteroidal anti-inflammatory drugs stimulate spermidine/spermine acetyltransferase and deplete polyamine content in colon cancer cells. Eur. J. Clin. Invest. 31, 887-893
40. Hughes, A., Smith, N.I., and Wallace, H.M. (2003) Polyamines reverse non-steroidal anti-inflammatory drug-induced toxicity in human colorectal cancer cells. Biochem. J. 374, 481-488
41. Babbar, N., Ignatenko, N.A., Casero, R.A., Jr. and Gerner, E.W. (2003) Cyclooxygenase-independent induction of apoptosis by sulindac sulfone is mediated by polyamines in colon cancer. J. Biol. Chem. 278, 47762-47775
42. 1-acetyltransferase. J. Biol. Chem. 272, 18746-18751
43. Janne, J., Alhonen, L., Pietila, M., and Keinanen, T.A. (2004) Genetic approaches to the cellular functions of polyamines in mammals. Eur. J. Biochem. 271, 877-894
44. Megosh, L., Gilmour, S.K., Rosson, D., Soler, A.P., Blessing,M., Sawicki, J.A., and O'Brien, T.G. (1995) Increased frequency of spontaneous skin tumors in transgenic mice which overexpress ornithine decarboxylase. Cancer Res. 55, 4205-4209
45. 1-acetyltransferase. J. Biol. Chem. 273, 1964-1969
46. 1-acetyltransferase increases susceptibility to chemically induced skin carcinogenesis. Carcinogenesis 23, 359-364
47. 1-acetyltransferase. J. Invest. Dermatol. 116, 801-805
48. Kee, K., Foster, B.A., Merali, S., Kramer, D.L., Hensen, M.L., Diegelman, P., Kisiel, N., Vujcic, S., Mazurchuk, R.V., and Porter, C.W. (2004) Activated polyamine catabolism depletes acetyl-CoA pools and suppresses prostate tumor growth in TRAMP mice. J. Biol. Chem. 279, 40076-40083
49. 1-acetyltransferase. Cancer Res. 65, 5390-5398
50. Seiler, N. (2004) Catabolism of polyamines. Amino Acids. 26, 217-233
51. Vujcic, S., Liang, P., Diegelman, P., Kramer, D.L., and Porter, C.W. (2003) Genomic identification and biochemical characterization of the mammalian polyamine oxidase involved in polyamine back-conversion. Biochem. J. 370, 19-28
52. 1-acetylated polyamine oxidase. J. Biol. Chem. 278, 20514-20525
53. Wang, Y., Hacker, A., Murray-Stewart, T., Frydman, B., Valasinas, A., Fraser, A.V., Woster, P.M., and Casero, R.A., Jr. (2005) Properties of recombinant human N1-acetylpolyamine oxidase (hPAO): potential role in determining drug sensitivity. Cancer Chemother. Pharmacol. 56, 83-90
54. Ha, H.C., Woster, P.M., Yager, J.D., and Casero, R.A., Jr. (1997) The role of polyamine catabolism in polyamine analogue-induced programmed cell death. Proc. Natl. Acad. Sci. USA 94, 11557-11562
55. Bey, P., Bolkenius, F.N., Seiler, N., and Casara, P. (1985) N-2,3-Butadienyl-1,4-butanediamine derivatives: potent irreversible inactivators of mammalian polyamine oxidase. J. Med. Chem. 28, 1-2
56. 1-acetylpolyamine oxidase (PAO) is the primary source of cytotoxic H2O2 in polyamine analogue-treated human breast cancer cell lines. J. Biol. Chem. 280, 39843-39851
57. Wu, T., Ling, K.Q., Sayre, L.M., and McIntire, W.S. (2005) Inhibition of murine N1-acetylated polyamine oxidase by an acetylenic amine and the allenic amine, MDL 72527. Biochem. Biophys. Res. Commun. 326, 483-490
58. Bellelli, A., Cavallo, S., Nicolini, L., Cervelli, M., Bianchi, M., Mariottini, P., Zelli, M., and Federico, R. (2004) Mouse spermine oxidase: a model of the catalytic cycle and its inhibition by N,N1-bis(2,3-butadienyl)-1,4- butanediamine. Biochem. Biophys. Res. Commun. 322, 1-8
59. Wang, Y., Murray-Stewart, T., Devereux, W., Hacker, A., Frydman, B., Woster, P.M., and Casero, R.A. (2003) Properties of purified recombinant human polyamine oxidase, PAOh1/SMO. Biochem. Biophys. Res. Commun. 304, 605-611
60. Huang, Y., Hager, E.R., Phillips, D.L., Dunn, V.R., Hacker, A., Frydman, B., Kink, J.A., Valasinas, A.L., Reddy, V.K., Marton, L.J., Casero, R.A., Jr. and Davidson, N.E. (2003) A novel polyamine analog inhibits growth and induces apoptosis in human breast cancer cells. Clin. Cancer Res. 9, 2769-2777
61. 11-[(cycloheptyl)methy]-4,8-diazaundecane (CHENSpm) by polyamine oxidase. Clin. Cancer Res. 8, 1241-1247
62. 12-bisethylspermine as a substrate. Biochemistry 44, 7079-7084
63. Tavladoraki, P., Schinina, M.E., Cecconi, F., Di Agostino, S., Manera, F., Rea, G., Mariottini, P., Federico, R., and Angelini, R. (1998) Maize polyamine oxidase: primary structure from protein and cDNA sequencing. FEBS Lett. 426, 62-66
64. Murray-Stewart, T., Wang, Y., Devereux, W., and Casero, R.A., Jr. (2002) Cloning and characterization of multiple human polyamine oxidase splice variants that code for isoenzymes with different biochemical characteristics. Biochem. J. 368, 673-677
65. Cervelli, M., Bellini, A., Bianchi, M., Marcocci, L., Nocera, S., Polticelli, F., Federico, R., Amendola, R., and Mariottini, P. (2004) Mouse spermine oxidase gene splice variants. Nuclear subcellular localization of a novel active isoform. Eur. J. Biochem. 271, 760-770
66. Cervelli, M., Polticelli, F., Federico, R., and Mariottini, P. (2002) Heterologous expression and characterization of mouse spermine oxidase. J. Biol. Chem. 278, 5271-5276
67. Bianchi, M., Amendola, R., Federico, R., Polticelli, F., and Mariottini, P. (2005) Two short protein domains are responsible for the nuclear localization of the mouse spermine oxidase mu isoform. FEBS J. 272, 3052-3059
68. Devereux, W., Wang, Y., Stewart, T.M., Hacker, A., Smith, R., Frydman, B., Valasinas, A.L., Reddy, V.K., Marton, L.J., Ward, T.D., Woster, P.M., and Casero, R.A. (2003) Induction of the PAOh1/SMO polyamine oxidase by polyamine analogues in human lung carcinoma cells. Cancer Chemother. Pharmacol. 52, 383-390
69. Wang, Y., Hacker, A., Murray-Stewart, T., Fleischer, J.G., Woster, P.M., and Casero, R.A., Jr. (2005) Induction of human spermine oxidase SMO(PAOh1) is regulated at the levels of new mRNA synthesis, mRNA stabilization and newly synthesized protein. Biochem. J. 386, 543-547
70. Cervelli, M., Polticelli, F., Federico, R., and Mariottini, P. (2003) Heterologous expression and characterization of mouse spermine oxidase. J. Biol. Chem. 278, 5271-5276
71. Parchment, R.E. and Pierce, G.B. (1989) Polyamine oxidation, programmed cell death, and regulation of melanoma in the murine embryonic limb. Cancer Res. 49, 6680-6686
72. Chaturvedi, R., Cheng, Y., Asim, M., Bussiere, F.I., Xu, H., Gobert, A.P., Hacker, A., Casero, R.A., Jr. and Wilson, K.T. (2004) Induction of Polyamine Oxidase 1 by Helicobacter pylori Causes Macrophage Apoptosis by Hydrogen Peroxide Release and Mitochondrial Membrane Depolarization. J. Biol. Chem. 279, 40161-40173
73. Xu, H., Chaturvedi, R., Cheng, Y., Bussiere, F.I., Asim, M., Yao, M.D., Potosky, D., Meltzer, S.J., Rhee, J.G., Kim, S.S., Moss, S.F., Hacker, A., Wang, Y., Casero, R.A., Jr. and Wilson, K.T. (2004) Spermine oxidation induced by Helicobacter pylori results in apoptosis and DNA damage: implications for gastric carcinogenesis. Cancer Res. 64, 8521-8525
74. Amendola, R., Bellini, A., Cervelli, M., Degan, P., Marcocci, L., Martini, F., and Mariottini, P. (2005) Direct oxidative DNA damage, apoptosis and radio sensitivity by spermine oxidase activities in mouse neuroblastoma cells. Biochim. Biophys. Acta 1755, 15-24
75. Chu, F.F., Esworthy, R.S., Chu, P.G., Longmate, J.A., Huycke, M.M., Wilczynski, S., and Doroshow, J.H. (2004) Bacteria-induced intestinal cancer in mice with disrupted Gpx1 and Gpx2 genes. Cancer Res. 64, 962-968
76. Shi, Y., Lan, F., Matson, C., Mulligan, P., Whetstine, J.R., Cole, P.A., and Casero, R.A. (2004) Histone Demethylation Mediated by the Nuclear Amine Oxidase Homolog LSD1. Cell 119, 941-953 27-33